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1,2-Dimethylpropylamine

    • Product Name 1,2-Dimethylpropylamine
    • Alias isohexylamine
    • Einecs 206-401-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    644593

    Chemical Name 1,2-Dimethylpropylamine
    Molecular Formula C5H13N
    Molar Mass 87.16 g/mol
    Cas Number 13344-01-5
    Appearance Colorless liquid
    Boiling Point 74-76 °C
    Density 0.73 g/cm3
    Refractive Index 1.393
    Flash Point -7 °C
    Solubility In Water Miscible
    Smiles CC(C)CCN
    Iupac Name 2-Methylbutan-2-amine
    Pubchem Cid 123332
    Inchi InChI=1S/C5H13N/c1-5(2,3)4-6/h4,6H2,1-3H3

    As an accredited 1,2-Dimethylpropylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1,2-Dimethylpropylamine is supplied in a 250 mL amber glass bottle with a secure screw cap and chemical hazard labeling.
    Shipping **1,2-Dimethylpropylamine** should be shipped in tightly sealed containers, away from heat and sources of ignition, in accordance with local, national, and international regulations. The chemical must be labeled properly, handled as a flammable and potentially hazardous liquid, and transported by qualified carriers with relevant safety documentation.
    Storage 1,2-Dimethylpropylamine should be stored in a cool, dry, well-ventilated area away from incompatible substances such as oxidizers and acids. Keep the container tightly closed and properly labeled. Store away from sources of ignition as the chemical is flammable. Use chemical-resistant containers, and ensure proper grounding and bonding for bulk storage to prevent static discharge.
    Application of 1,2-Dimethylpropylamine

    Applications of 1,2-Dimethylpropylamine in Industrial Manufacturing

    1,2-Dimethylpropylamine functions as a high-purity intermediate and process aid within select chemical value chains. As a specialized manufacturer, we support international customers with this amine for consistent downstream output across regulated industrial sectors. Below, we detail main application scenarios, including direct compliance, usage ratios, integration points, and end-use product types.

    1. Agrochemical Synthesis: Production of Selective Herbicide Actives

    1,2-Dimethylpropylamine acts as a primary alkylating agent for forming amide or ester links in crop protection formulations. Its use is integral to the synthesis of certain selective herbicidal actives. Manufacturers in this sector prioritize amine quality, low moisture, and batch reproducibility to maintain compliance and yield in multi-step synthesis. Operators add it at the amide-forming stage, closely monitoring temperature and stoichiometry due to regulatory residue limits in the final agrochemical. The resulting herbicide compounds are registered for large-scale field and post-emergence weed control applications.

    Industry compliance standards

    • FAO/WHO specifications for pesticide technicals
    • REACH Annex XVII SVHC exemption (where applicable)
    • ISO 17025-compliant QC documentation
    • Country-specific agrochemical registration (EU 1107/2009, US EPA FIFRA)

    Typical usage ratio

    • 0.7–1.2 molar equivalents relative to acid chloride or acid precursor in amide synthesis
    • Ratio adjusted based on conversion and impurity controls; excess amine may be used for quenching strategies

    Downstream process integration

    • Added to reactor after charging of acid chloride; often run under inert atmosphere
    • Monitored for batch purity via in-process HPLC and nitrogen content titration
    • Amine recovery or neutralization managed as part of effluent treatment

    Final product types

    • Selective post-emergence herbicides (e.g., amide-type, pyridine-ester herbicides)
    • Technical-grade herbicidal active ingredients, preformulated with inert carriers
    • Custom pesticide intermediates for global agrochemical formulators

    2. Pharmaceutical Intermediate: Synthesis of API Building Blocks

    Within pharmaceutical chemistry, 1,2-Dimethylpropylamine serves as a key intermediate or reactant for API side-chain assembly, particularly in the synthesis of non-aromatic amine fragments. Facilities performing cGMP synthesis employ it during alkylation and amide-coupling sequences. Quality assurance requires full traceability, residual solvent analysis, and adherence to multi-compendial standards. The intermediate typically enters the process after protecting group introduction on the core API scaffold, contributing for instance to beta-blocker or CNS-active substance synthesis. Final APIs must meet strict impurity and residual amine limits before finished formulation.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • Pharmacopoeial requirements: USP, EP, JP, ChP where relevant
    • FDA 21 CFR Parts 210/211 for drug components
    • EU GMP Part II (APIs), Module 3 (impurities)

    Typical usage ratio

    • 1.0–1.5 equivalents versus electrophilic partner in alkylation or amidation steps
    • Ratio depends on route optimization, reagent strength, and impurity control (amines often used in slight excess for full conversion)

    Downstream process integration

    • Charged in controlled nitrogen-purged reactors with online GC-MS monitoring
    • Process streams segregated according to validated cleaning protocols
    • Final intermediate and API both assessed for amine residuals and related substances by LC-MS

    Final product types

    • Pharmaceutical active ingredients for cardiovascular and CNS categories
    • Key amide and amine intermediates in complex heterocycle synthesis
    • Regulated bulk API for tablet, capsule, and injectable medicinal products

    3. Rubber Chemicals: Vulcanization Accelerator Production

    1,2-Dimethylpropylamine supplies the nitrogen source in the manufacture of specialty vulcanization accelerators. Its controlled reactivity supports synthesis of thiazole- and sulfenamide-type curing agents, used within silica and carbon black-filled elastomer systems. Mixing and reaction parameters directly impact product color, purity, and dispersibility, while batch testing meets rubber compounding standards. Producers charge the amine during condensation with sulfur or corresponding chlorides, ensuring integration in batch or continuous accelerator plants. Final accelerators enable fine-tuning cure rates and mechanical properties for high-performance tire and technical rubber goods.

    Industry compliance standards

    • ISO 9001:2015 for quality management in chemical synthesis
    • ASTM D4670 for rubber chemical analysis
    • DIN EN 2000 for accelerator residue testing
    • EU REACH pre-registration for manufacture/import (10–100 tonne band)

    Typical usage ratio

    • 0.9–1.1 equivalents relative to thioamide or sulfenyl chloride substrate
    • Ratio adjusted with respect to feedstock purity and yield targets; monitored by elemental nitrogen balance

    Downstream process integration

    • Amine charged in agitated reactors at controlled temperature (under 40°C for sulfenamides)
    • Pilot-scale continuous addition for multi-tonne accelerator runs
    • Process effluent and byproducts neutralized before discharge

    Final product types

    • Rubber vulcanization accelerators: thiazole and sulfenamide derivatives
    • Masterbatch additives for radial and bias tire production
    • Specialty curing agents for technical rubber goods and seals

    4. Water Treatment: Quaternary Ammonium Compound Manufacture

    In advanced water treatment chemistry, 1,2-Dimethylpropylamine forms the amine component for synthesizing aliphatic quaternary ammonium compounds, widely used as antiscalants, antimicrobials, and flocculants. Process control covers feedstock purity, chlorination efficiency, and quaternization conversion for consistent charge density. The amine is reacted with alkylating agents under controlled pH and temperature via batch synthesis, followed by product neutralization and phase separation. End products target specific polymeric dispersants or disinfectant additives in industrial and municipal water applications.

    Industry compliance standards

    • NSF/ANSI Standard 60 for drinking water treatment chemicals
    • ISO 22241 for water-soluble additives and purity
    • US EPA registration for biocidal activity (if relevant)
    • Local effluent chemical oxygen demand (COD) limits

    Typical usage ratio

    • 1.0 equivalent versus alkylating agent in quaternization reactions
    • Excesses up to 1.2 equivalents for maximizing mono-quat product ratios; process waste minimized via in-process recovery

    Downstream process integration

    • Amine solution introduced to quaternization reactors at maintained pH 7–9
    • Reaction profiled by titration and NMR for full conversion
    • Product filtered, washed, and QC assessed for active content and residual amine

    Final product types

    • Polymeric quaternary ammonium flocculants for water clarification
    • Bacteriostatic cleaning additives for CIP systems
    • Industrial-scale scale inhibitors and dispersants in cooling tower water

    5. Coatings Additives: Synthesis of Functional Isocyanate Blocking Agents

    1,2-Dimethylpropylamine provides the amine function in specialty blocking agent synthesis for polyurethane prepolymers used in industrial coatings. Its compatibility with isocyanate groups allows formation of stable blocked adducts, which unblock at elevated cure temperatures. Manufacturers ensure precise molar ratios and minimal byproduct amines to meet coating industry migration and performance regulations. The amine integrates during the isocyanate addition stage, often under dry and inert conditions. The resulting blocked prepolymers or crosslinkers give end-users improved shelf stability and controlled reaction profiles in automotive, aerospace, and protective coatings.

    Industry compliance standards

    • ISO 16000-9 for VOC emission in coatings
    • REACH Article 31 extended SDS requirements
    • US EPA TSCA listing for industrial coatings chemicals
    • ISO 9001 traceability in synthesis and QC release

    Typical usage ratio

    • 1.0 equivalent amine per isocyanate group for blocking reactions
    • Ratio tuned to NCO content and desired unblocking temperature; over-stoichiometric amine minimized for regulatory compliance

    Downstream process integration

    • Batchwise addition to polyisocyanate under nitrogen blanket
    • Reaction run at 50–80°C with in-line FTIR to monitor NCO blockage
    • Blocked agent isolated and QC tested for free amine and NCO content

    Final product types

    • Blocked isocyanate curing agents for 2K polyurethane coatings
    • Protective and transportation coatings requiring long pot-life
    • Crosslinker masterbatches for OEM automotive refinishing
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    Certification & Compliance
    More Introduction

    Understanding 1,2-Dimethylpropylamine from the Manufacturer’s Perspective

    What Sets 1,2-Dimethylpropylamine Apart

    Walking through the aisles of chemical synthesis, 1,2-Dimethylpropylamine stands out for its streamlined molecular structure and dependable performance in a range of applications. Manufactured in-house, this amine comes with a chemical formula of C5H13N, and in day-to-day operation, our technicians rely on its consistency and adaptability far beyond the basic data in a spec sheet. Our production line turns out a clear, colorless liquid with a slightly fishy odor, familiar to every team member who’s spent time monitoring the reactors or checking the collection units. The boiling point hovers near 61°C under atmospheric pressure, and as anyone who has worked batch processes knows, minor deviations can skew recovery efficiency. With a density of about 0.74 g/cm³, it pours and transfers easily, minimizing waste and facilitating smooth blending for downstream reactions.

    The Driving Force Behind Its Production

    Interest in 1,2-Dimethylpropylamine often comes from specialty manufacturers and R&D teams working in fields like agrochemicals, pharmaceuticals, and custom syntheses. Rather than fitting into every workflow, its hallmark lies in maximizing alkylation and amination reactions where a branched amine like this is favored for steric reasons. Requests for this compound started gaining momentum as synthetic chemists noticed that it could provide unique selectivity or be coupled with deactivation steps for fine-tuned product control. On our production floor, strict process monitoring is not a formality; it’s an integral step to maintain the purity many research applications require, and hands-on quality checks run right alongside automated systems.

    A Closer Look at Specifications Through Experience

    Specifications mean more to us as a manufacturer than just meeting requested purity percentages. Purity ratings above 98 percent are achievable with robust distillation and careful avoidance of secondary amines or byproducts. Technicians watch for color and odor changes with seasoned precision between batch runs—these simple cues can point to non-obvious process issues that would elude a less vigilant eye.

    Storage and packaging also get close attention. 1,2-Dimethylpropylamine reacts easily with acids, oxidizers, and even certain polymers, setting it apart from more inert amines. For this, we stick with lined drums and high-density polyethylene containers to avoid contamination, minimize evaporation, and keep volatility-controlled. Our team doesn’t just prepare containers for transit, we handle them with the understanding that any staff further down the supply chain depends on our attention to cleanliness and sealing. Temperature spikes in warehousing can cause unexpected pressure build-up, so climate-controlled logistics is not just a selling point—it’s a necessity we achieved after fielding calls from customers in regions with extreme temperature swings.

    Key Uses and Why Customers Choose It

    Users in the field often find 1,2-Dimethylpropylamine works as an intermediate for synthetic projects that need a balance of volume and reactivity. It’s no secret that pharmaceutical research demands materials that can handle selective alkylation, and that’s where this amine draws strong interest. In pesticide synthesis, it excels in building blocks where steric hindrance can direct reactivity away from undesired pathways, supporting yield improvements in the final formulation. Over several production cycles, we learned what matters most isn’t just purity, but consistent reactivity and freedom from trace contaminants—qualities that come from paying attention to every variable from raw input quality to reactor agitation speed.

    Some clients value the customizable batch runs possible with a flexible manufacturer. We regularly field requests for small lots with tailored specifications, especially for early-stage research or pilot runs. Our production expertise allows us to pivot toward these niche volumes without disrupting supply to large-scale clients, and this flexibility comes from years of refining shift schedules, maintenance cycles, and logistics.

    Handling, Safety, and the Realities of Day-to-Day Operations

    Safety is not just regulatory compliance—our plant’s team members expect thorough handling protocols because they live with the consequences of spills or inhalation exposure. 1,2-Dimethylpropylamine requires diligent attention to personal protective equipment: gloves, goggles, and well-ventilated workspaces are part of every shift change checklist. We train our operators and warehouse crew on the consequences of improper handling, such as skin and eye irritation, and ensure that all containers are clearly labeled and traceable.

    The storage rooms are always equipped with spill kits and ventilation monitors. Practical know-how has been built over years—not just onboarding training but through feedback loops among the shop floor teams. We’ve seen up-ticks in off-odors due to minor breaches in container seals, so routine inspection and double-sealing practices became standard. In transit, the chemical’s volatility means we closely coordinate with logistics suppliers, choosing routes that avoid delays and minimize exposure to temperature extremes.

    Differences Compared to Other Alkylamines

    Manufacturing experience gives clear insights into how 1,2-Dimethylpropylamine compares with related amines like isopropylamine, tert-butylamine, or n-butylamine. Structural branching matters—a feature seen in both product behavior in the lab and the plant. Unlike straight-chain n-butylamine, which readily participates in nucleophilic reactions, the added methyl groups on 1,2-Dimethylpropylamine can slow reaction rates in certain catalytic cycles. For chemists looking to avoid overreaction or need to steer a process toward a specific regioisomer, this branched amine’s characteristics are a major draw.

    Another noticeable difference emerges in solubility and volatility. Our staff quickly recognizes that 1,2-Dimethylpropylamine’s lower boiling point simplifies certain distillation steps but can require faster, well-coordinated collection processes to preserve product purity. It’s less hygroscopic than some primary amines, so it fares somewhat better in short-term open-air handling, though any seasoned operator will still stick to closed systems because prolonged exposure means unnecessary risk and product loss.

    Odor is another practical consideration. All amines have a pungency, but the sharpness of 1,2-Dimethylpropylamine seems less aggressive compared to its lower-chain cousins, making routine handling a bit less challenging. This subtle quality can mean a more agreeable working atmosphere for those on extended syntheses, and it’s a feature that, while not measured on a spec sheet, becomes evident with time in production.

    Supporting Sustainable Practices on the Production Floor

    Producing 1,2-Dimethylpropylamine presents opportunities to reduce chemical waste. Our operators collect fractions from distillation sequences and analyze potential reuse in compatible product lines, which cuts down on disposal costs and serves our environmental responsibility goals. Transitioning to closed-loop systems and solvent recovery programs wasn’t achieved overnight. We adjusted heating and cooling systems, fine-tuned recycle rates, and monitored waste streams for months before the improvements paid off.

    Staff input has led to several important upgrades—simple tweaks like improved gasket materials on storage tanks have yielded lower leak rates, and enhanced filter cartridges reduce impurities returning through recycle loops. We keep documentation open and accessible for teams pursuing projects in lean manufacturing and energy savings, setting a culture that prioritizes long-term gains over quick fixes. In response to external audits, site tours have become more transparent, letting customers see progress firsthand. Demonstrating compliance is just part of the job; day-to-day accountability to each other is what drives our improvement cycles the most.

    Addressing Common Production and Supply Challenges

    Demand for 1,2-Dimethylpropylamine isn’t always predictable. Sudden requests tied to breakthroughs in pharma pipelines or changes in agrochemical regulations force us to respond quickly. Having a built-up repository of raw materials and a cross-trained workforce makes all the difference during these peaks. Lessons learned from past supply disruptions—material shortages, unforeseen downtime, or regulatory bottlenecks—have led to investment in redundant critical systems and frequent reviews of supplier performance.

    Out on the plant floor, planned downtime aligns closely with demand forecasts and storage capacities. We avoid overproduction by tracking order velocity and customer feedback, so material spends less time in storage and reaches users with optimal shelf life. Technicians collaborate with scheduling managers to test and adapt batch processes, rather than sticking to static routines. This approach has reduced cycle times on short runs and kept large campaigns on track, which in turn has built trust with long-term customers who rely on reliability over the long haul.

    Transparency in Quality and Traceability

    From manufacturing through distribution, lot traceability and transparency remain top priorities. Barcoding each drum, logging key process data, and synchronizing with digital inventory management help catch anomalies before products leave the facility. Our teams can pull up batch histories instantly to address customer questions about origin, testing methods, or handling practices. Certificates of analysis arrive with each shipment, not just as a check-box, but as a documented promise that someone in the plant signed off after witnessing the checks firsthand. This level of openness comes from knowing how disruptions or recalls ripple through a customer’s workflow, and from the pride that comes with consistent performance.

    Routine audit cycles, both internal and by external bodies, keep pressure on us to hold up standards. Instead of dreading these reviews, we use them as checkpoints. If an outside auditor spots a weak spot, we treat it as an action item, not a mark against us. Over time, our team has seen improvements in corrective actions cut risk and cost, strengthening future production runs.

    Learning from Customer Feedback

    Nothing shapes our production approach like honest conversations with end users. Time and again, customers point out subtleties in performance we would never detect in a bench test alone. One pharma partner flagged an unexpected side-product in their synthesis, which led to a re-examination of our inert gas purge rates during packaging. Implementing a higher flow and an improved valve design led to immediate improvement, and we shared the process change across several other product lines.

    Other times, agricultural researchers have requested alternate container sizes for easier pilot field trials. Responding to these requests, we added more flexible container options on short lead times. Even minor shifts in weather during shipping periods prompted us to update insulation and tracking services, driven not by complaints but by direct suggestions from logistics teams working with our chemicals in challenging climates.

    As a manufacturer, these lessons stay with us. It’s not about chasing every trend, but about keeping communication flowing and knowing that every batch carries both our name and responsibility to everyone down the line.

    The Role of Regulatory Compliance

    Regulatory changes shape the way we manufacture and deliver 1,2-Dimethylpropylamine. We navigate global frameworks including REACH, TSCA, and local environmental regulations, and our approach has evolved from simply checking boxes to building compliance into our everyday decisions. Teams participate in ongoing training, keeping up with hazard labeling, transportation protocols, and process documentation expectations.

    Whenever an update rolls in—like a new threshold for trace amounts of certain byproducts—production lines adapt, and data collection protocols ramp up. We’ve seen how proactive compliance both shields us from shipment delays and earns trust with buyers seeking long-term business partners. Drafting documentation in clear, accessible language helps bridge the gap between technical experts and safety coordinators, making our facilities safer and easier for new team members and auditors to navigate.

    The Value of In-House Expertise and Equipment Investment

    Years of continuous operation have taught us to value the right equipment as much as raw material supply. Regular investments in improved distillation columns, real-time spectrometry, and automated dosing systems help maintain high-purity products like 1,2-Dimethylpropylamine. Experienced staff track subtle shifts in temperature and pressure, intervene long before problems scale, and cross-check analytical results against product benchmarks. In unforeseen events—such as power interruptions or local equipment failures—having both technical know-how and robust backup protocols allows us to minimize downtime and keep customer confidence high.

    We operate with a blend of tradition and technology, retaining practical insights from veteran team members and matching them with the analytical precision needed for international quality expectations. Feedback from team meetings feeds directly into capital investment reviews, ensuring every upgrade in technology serves practical, daily needs and not just glossy catalog promises.

    Looking Toward the Future of Manufacturing

    The chemical industry shifts continually, and our commitment is to future-proof our processes for quality and adaptability. Ongoing improvements in energy efficiency, raw material sourcing, and emissions control go hand in hand with our work on 1,2-Dimethylpropylamine. We share detailed environmental data with stakeholders, reflecting our confidence in both our process controls and willingness to engage with broader sustainability discussions.

    Customer requirements shift as innovations emerge in pharmaceuticals, materials science, and agricultural chemistry. Our teams track literature, connect with researchers, and attend professional conferences to anticipate changes in demand or specification. Flexibility in production scheduling, coupled with robust safety and documentation, positions us to support both established and new applications of branched alkylamines.

    At the core, our responsibility as the manufacturer remains unchanged: deliver high-quality, consistent 1,2-Dimethylpropylamine every run, every container, every time. We treat each shipment as a reflection of weeks—sometimes months—of careful planning, technical skill, and teamwork. The compound often leaves our gates bound for complex syntheses and application tests, but long before that, it’s shaped by the collective experience and pride of the people who make it.