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1,2-Dihydroxynaphthalene

    • Product Name 1,2-Dihydroxynaphthalene
    • Alias Naphthalene-1,2-diol
    • Einecs 202-321-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    140484

    Name 1,2-Dihydroxynaphthalene
    Molecular Formula C10H8O2
    Molar Mass 160.17 g/mol
    Cas Number 575-38-2
    Appearance White to light beige crystalline solid
    Melting Point 144-146 °C
    Solubility In Water Slightly soluble
    Density 1.332 g/cm³
    Iupac Name Naphthalene-1,2-diol
    Pubchem Cid 10233
    Smiles C1=CC=C2C(=C1)C(=CC=C2)O

    As an accredited 1,2-Dihydroxynaphthalene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25g amber glass bottle labeled “1,2-Dihydroxynaphthalene,” sealed with a screw cap and hazard symbols, packaged securely.
    Shipping 1,2-Dihydroxynaphthalene should be shipped in tightly sealed containers, protected from light and moisture. It must comply with local and international regulations for chemical transport. Ensure proper labeling and documentation. Handle with care to avoid spills, and store away from incompatible substances during transit to guarantee safe delivery.
    Storage 1,2-Dihydroxynaphthalene should be stored in a cool, dry, well-ventilated area away from sources of ignition and direct sunlight. Keep it in a tightly sealed container, protected from moisture and incompatible substances such as strong oxidizers. Clearly label the storage area and ensure access is restricted to authorized personnel only. Use appropriate secondary containment to prevent spills or leaks.
    Application of 1,2-Dihydroxynaphthalene

    Applications of 1,2-Dihydroxynaphthalene in Industrial Manufacturing

    As the direct manufacturer of 1,2-dihydroxynaphthalene, we supply this intermediate to leading industrial plants worldwide. Our clients formulate it into high-performance materials across specialty pigments, advanced polymers, pharmaceutical synthesis, and electronic chemicals. Each application applies precise integration, industry-compliant standards, and strict formulation control.

    1. Organic Pigment Intermediates for Dye Synthesis

    Producers of synthetic organic pigments, including azo and anthraquinone classes, rely on 1,2-dihydroxynaphthalene as a key coupling and chromophore-forming intermediate. Its dihydroxy structure enables direct insertion into multi-step dye coupling reactions, allowing for the production of nuanced reds, violets, and brown pigments. End-users select it for its high tinctorial strength, lightfastness, and compatibility with textile and plastics coloration. The material introduces during diazotization and coupling stages under controlled temperatures, at precisely monitored pH, aligning with international colorant manufacturing standards. Our technical support ensures consistent batch quality and processability for global pigment houses.

    Industry compliance standards

    • EN 71-3:2019 for toy colorant safety
    • OEKO-TEX® Standard 100 – textile colorant conformity
    • ISO 9001:2015 certified pigment manufacturing facilities
    • REACH Regulation (EC) No 1907/2006 Annex XVII restrictions on aromatic amines

    Typical usage ratio

    • 5-30% by mole in dye molecule formation, based on coupling system and desired hue depth; precise dosage determined by target chromatic properties and final pigment purity

    Downstream process integration

    • Added after naphthalenesulfonation or alkylation reactions
    • Reacted directly with diazonium salts in batch or semi-continuous pigment synthesis reactors
    • Subjected to controlled oxidation or coupling stages
    • Followed by filtration, rinsing, and drying before downstream dispersion

    Final product types

    • High-performance azo pigments for plastics and inks
    • Anthraquinone-based textile dyes
    • Print ink dispersions for industrial packaging
    • Pigment concentrates for automotive coatings

    2. Pharmaceutical Intermediate for Antineoplastic and Antimicrobial Agents

    Our material serves as a regulated building block in the synthesis of active pharmaceutical ingredients, especially those in the naphthalene-derivative class. This includes intermediates for topoisomerase inhibitors and selective antimicrobial agents. The compound’s hydroxy functionalities allow for selective acylation or aromatic substitutions, streamlining synthetic routes to numerous APIs. Pharmaceutical clients process under cGMP conditions, following ICH Q7 guidelines, and implement extensive traceability and impurity profiling. We provide batch-specific COAs aligned with pharmacopeial and regulatory demands.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211 (FDA cGMP regulations)
    • EU GMP Vol 4, Annex 1
    • USP/NF monograph raw material specifications

    Typical usage ratio

    • 0.15-0.35 molar equivalents per API batch; adjusted for downstream conversion yields and purity requirements set by the synthetic route

    Downstream process integration

    • Activated by halogenation or sulfonation pre-API coupling
    • Feeds directly into stepwise aromatic ring modification
    • Serves as a key intermediate for naphthylamine or naphthoquinone product lines
    • Subsequent purification by preparative crystallization or chromatography

    Final product types

    • Topoisomerase inhibitor APIs (e.g., amsacrine intermediates)
    • Broad-spectrum naphthalene-based antimicrobial drugs
    • Pilot-scale pharmaceutical research compounds
    • Reference standards for quality control labs

    3. Polymer Crosslinking Agents and Resin Modifiers

    In specialty polymer production, 1,2-dihydroxynaphthalene acts as a crosslinking monomer and chain terminator for certain phenolic and polyimide resins. The ortho-dihydroxy structure imparts improved thermal stability, flame-retardant performance, and oxidative resistance in engineering plastics and high-end varnishes. Resin compounders incorporate the material at pre-defined stages of condensation or co-polymerization, with careful attention to monomer balance and catalyst compatibility. Our technical team collaborates with clients to meet ISO and ASTM test protocols for cured polymer properties and process residues.

    Industry compliance standards

    • UL 94: Flammability of plastic materials for parts in devices and appliances
    • RoHS Directive 2011/65/EU compliance for end-use electronics
    • ISO 178:2019 for polymer flexural strength
    • ASTM D7767 for high performance resin composites

    Typical usage ratio

    • 1.0-10 wt% in resin formulations, modulated by desired crosslink density and blend partner monomers

    Downstream process integration

    • Introduced during pre-polymer mixing for thermosetting phenol-formaldehyde resins
    • Blended prior to catalyst addition and temperature ramp-up
    • Used in co-polymerization with dianhydride or diamine monomers for polyimide manufacture
    • Integrated before VAC evacuation in molding or varnish manufacturing lines

    Final product types

    • Flame-retardant resins for circuit board laminates
    • High-temperature stable coatings
    • Specialty adhesives for aerospace
    • Protective electrical insulation varnishes

    4. Chemical Intermediate for Agrochemical Synthesis

    Major agrochemical producers employ 1,2-dihydroxynaphthalene as an intermediate for the construction of naphthalenic herbicides and fungicides. Its molecular structure supports regioselective substitutions and oxidative couplings, facilitating synthesis of active compounds for crop protection. Plants handle the material under ISO 14001 environmental management controls, incorporating it directly into closed-reactor systems during the early synthesis stages. Our product meets strict impurity and trace element limits to prevent downstream contamination of agricultural formulations.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 14001:2015 Environmental Management System
    • EU Regulation (EC) No 1107/2009 on placing plant protection products on the market
    • OECD Guidelines for the Testing of Chemicals

    Typical usage ratio

    • 0.10-0.25 molar equivalents per active ingredient batch; ratio determined by synthetic complexity and functional group conversions

    Downstream process integration

    • Chlorinated or alkylated prior to ring-closure reactions
    • Feeds into multi-step synthesis for naphthyl-based crop treatment actives
    • Intermediate isolation by solvent extraction and phase separation
    • Final compound subject to crystallization and granulation before formulation

    Final product types

    • Naphthalenic herbicide actives
    • Fungicidal ingredients for broad-acre crops
    • Seed treatment API concentrates
    • Technical-grade pesticide pre-mixes

    5. Analytical Reagent and Chemical Standard Production

    Reference material manufacturers and certified analytical labs use this compound in the development of calibration reagents and traceability standards, especially for spectrophotometric assay kits and HPLC diagnostics. Its high chemical purity supports reliable method validation and cross-laboratory reproducibility. Material enters direct dissolution and dilution protocols under ISO 17034 procedures. Every batch receives multi-method purity certification and meets contaminant specifications as demanded by international proficiency testing schemes.

    Industry compliance standards

    • ISO 17034:2016 for production of reference materials
    • ISO/IEC 17025:2017 laboratory testing standards
    • USP General Chapters <11> Reagents, Indicators, and Solutions
    • OECD Good Laboratory Practice (GLP) Principles

    Typical usage ratio

    • 0.01-0.1 mg/mL as stock solution for calibration standards; concentration tailored for target detection limits and analyte matrix

    Downstream process integration

    • Dissolved in high-purity solvents for analytical solutions
    • Aliquoted into pre-cleaned ampoules under controlled environment
    • Assayed by HPLC and mass spectrometry for batch certification
    • Delivered with full traceability documents for laboratory clients

    Final product types

    • HPLC calibration standards
    • Spectrophotometric color developer kits
    • Certified chemical reference solutions
    • Proficiency testing reagents for external QA schemes
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    Certification & Compliance
    More Introduction

    1,2-Dihydroxynaphthalene: Insights from the Manufacturer

    Our Direct Experience with 1,2-Dihydroxynaphthalene

    Walking through our production floor, you catch the scent only a naphthol derivative can deliver—a specific note, sharp but not offensive, trailing from the crystallization line where 1,2-dihydroxynaphthalene takes shape. This is not a product routed through countless hands or batch-split among brokers; it’s the result of monitored synthesis, hands-on adjustments, and direct oversight, right from the raw naphthalene to the purified dihydroxy compound.

    In our line of work, insight matters more than paperwork. Colleagues discuss the process modifications we introduced to boost yield last spring, debating whether steam stripping or vacuum brings more out of a fraction. Those details, learned by watching the color and melting profile of each batch, form our edge in producing a product free of unwanted tars or excessive color bodies. From our plant to your process, the quality of 1,2-dihydroxynaphthalene rests on daily attention—not on generic parameters copied between suppliers.

    Model and Specifications Born from Production

    On paper, 1,2-dihydroxynaphthalene is C10H8O2, melting near 183° Celsius, with solubility and reactivity suited to downstream transformations. Our batches anchor close to 99% assay by HPLC, since our in-process controls catch off-spec fractions before they reach packaging. Experienced workers scan the appearance: a pale cream crystal, no dark specks or brown residues, since oxidative degradation during isolation can leave a visible trace. We run each batch through drying until the moisture line sits below 0.2%, to suit reactors where excess water would stall condensation or color formation.

    Chemistry doesn’t respect shortcuts. Our experience taught us that even slight impurities—naphthoquinones or mono-phenols—can cause headaches downstream, so we refine using a staged process: acid wash, vacuum filtration, recrystallization, then final quality verification. Achieving a melting range under 2°C signals a tight product profile and confirms the absence of significant contamination. Years of troubleshooting have led to this protocol. Specs on a sheet never tell you how easy it is to lose product yield to a sudden pH drift, or how fast a hot solution will cloud if you miss temperature by a degree. Only by running dozens of trials each season do we keep the process stable and cost-effective for users expecting consistency in every drum.

    Understanding the Day-to-Day Importance of Purity

    Our customers rarely want surprises mid-synthesis. Manufacturing 1,2-dihydroxynaphthalene without wide fluctuation in purity stands as the foundation for reliable dye intermediates, pharmaceuticals, and specialty chemicals. I remember a panel dye run stopped cold by a trace of dichloronaphthalene that simply should not have crept in. Since then, we’ve installed new gas scrubbers and distillation heads to keep those chlorinated byproducts out completely. Hands-on improvement keeps those hiccups from growing into expensive shutdowns down your line.

    This product sees use in oxidative coupling for colorants, where even a tiny contaminant will skew shade or reduce color yield. Some synthesis partners push it further, coupling with aromatic aldehydes for advanced pharmaceutical scaffolds. They come to us not for mere specification promises, but for a string of lot reports where the impurity profile is already transparent. By managing our own upstream naphthalene sourcing, we control the impurity baseline from the ground up.

    Differences from Other Naphthol Isomers

    A chemist might ask: Why not use 1,4-dihydroxynaphthalene or another isomer instead of 1,2-dihydroxynaphthalene? While both share the naphthalene backbone, their reactivity offers a world of difference. Our pattern of hydroxyl group placement leads to unique hydrogen bonding and resonance stabilization, directly impacting how this molecule engages with electrophiles and radicals. I’ve watched partners try to swap in a similar product, only to find reaction yields plummet or byproduct patterns shift unpredictably.

    1,4-Dihydroxynaphthalene, for instance, tends to polymerize and oxidize rapidly, giving deep coloration and complicating purifications. Our 1,2-dihydroxy isomer, handled correctly, stays stable through storage and typical environmental changes. Differences in melting and solubility affect not just your process design, but also the cost efficiency in multi-step synthetic schemes. When you design around 1,2-dihydroxynaphthalene, you count on orthogonal placement of hydroxyls to guide specific condensation or redox patterns—something no positionally shifted isomer will offer reliably.

    We’ve compared analytical fingerprints across similar products on our own FTIR and NMR spectrometers. Those who have worked at the bench know that subtle isomeric differences change spectrum lines. Our crystalline 1,2 structure gives a clean fingerprint—easy to track during multi-step synthesis, since overlapping signals are less likely. Our partners depend on this clarity, especially during scale-ups where trace contamination can complicate downstream QA checks for their own customers.

    Why We Keep Ownership of the Full Chain

    We believe you cannot solve process issues from a distance. Owning our equipment, managing our staff, and controlling process variables allows us to intervene the moment temperature, pressure, or purity readings move off target. Our technical teams act quickly—not weeks after a problem, not by hearsay, and without waiting on a response from an overseas warehouse. If our naphthalene stream changes due to seasonal sourcing, we catch it within hours, trace the variance, and make the adjustment. Only this way do we deliver product that doesn’t fluctuate unpredictably between lots.

    Intimate involvement in our process also lets us offer technical advice grounded in practical reality. For instance, if you plan to oxidize 1,2-dihydroxynaphthalene towards quinones, we can advise you on solvent compatibility issues and safety controls that we already handle in-house. We never defer these conversations to agents or shippers. Clients with specific downstream transformations often face yield drops because of minor solvent residues; we solved this by modifying our solvent recovery loops and installed dedicated post-crystallization wash tanks.

    This hands-on approach reduces delivery timelines and keeps communication lines direct. One year, a large pharma customer flagged a new impurity peak during their pilot run. Our techs responded by matching spectra and tracing it to a minor chlorinated naphthalene carried over from a change in supply chain. Correcting at the source, we not only salvaged the order, but also learned how a change seemingly outside our core production could affect the downstream process. Experience taught us to stay in the loop from raw material to drum.

    Our Product in Real-World Use

    Much of our 1,2-dihydroxynaphthalene finds its way into specialty dye manufacturing, where reaction consistency decides whether production batches meet target color grades or wind up as waste. Some customers require particularly low ash or inert content, targeting specific notes for organic electronics, advanced pigments, or even research in supramolecular assemblies. Those needs emerged from years of back-and-forth testing, as partners shared their trial outcomes and we adjusted process flows. Instead of making generalized claims, we listen directly to feedback and adjust crystallization schedules, or swap out filter media if residue character shifts across several lots.

    An interesting case came from a developer working on new ionic conductors for battery research. Their requirements for particle size distribution, surface area, and batch-to-batch consistency pushed us to tighten our sieving lines and retool drying cycles. Innovators in their sector wanted confidence that each sample would perform as expected, free from lingering fines or agglomerates that would otherwise hinder phase uniformity in composite films. Their trust proved the value of full traceability and direct feedback loops between end user and manufacturer.

    From pharmaceuticals to advanced functional dyes, 1,2-dihydroxynaphthalene enables transformations not supported by less selective—often cheaper—substitutes. The specificity required in certain hydrogenation or oxidative coupling steps cannot be achieved with loose product specifications. We get calls about cheaper options all the time, but cost savings evaporate fast if off-spec material stalls a reactor or ruins a precious pilot batch. Watching a hundred kilograms go to landfill, which happened in our early days, is a lesson still etched in everyone’s memory.

    Troubleshooting: Lessons We Learned on the Line

    Manufacturing specialty chemicals rarely goes off without a hitch. When running a 300-liter batch on a summer morning, we once saw full gel formation during the cooling step, a problem traced to a spike in dissolved metal ions from incoming water. Since that episode, we now test and filter every water and solvent charge before it enters any batch. These incremental controls only come from long-term process ownership, not from reselling third-party goods. Only those present during a real process deviation build the intuition to see problems coming in advance.

    Another practical finding involves packaging. Certain drums introduced unseen static charges, which seemed to accelerate surface oxidation in product stored above 30 degrees Celsius for more than one month. Recognizing the danger, we shifted to foil-lined bags and set mandatory warehouse temperature and humidity controls. It’s one lesson to see a complaint cross your inbox—a different story to see your team pull apart dozens of drums to find a source of instability.

    Working directly with large-scale processors, we’ve learned to spot small changes—like a dullness in crystal mass or a faint tint creeping in—that might, unchecked, scale up to a major bottleneck in evaporation, blending, or inline analysis. Technical teams at many smaller chemical users face resource constraints; we pitch in not just by shipping clean, consistent material but by offering troubleshooting support honed across hundreds of batches each year.

    Handling Regulatory and Safety Challenges

    1,2-Dihydroxynaphthalene, as with all aromatic intermediates, comes under scrutiny from customers, regulators, and local communities. We structure our entire production around documented compliance, from occupational exposure limits to consistent waste stream segregation. No batch leaves unless it meets protocol on handling safety, ventilation control, and containment—all managed on-site, not outsourced to unvetted partners. Our experienced EHS staff walk the production line, not just sign paperwork after the fact.

    Years ago, a formaldehyde release in a sister facility in the region led us to redesign our local containment and alarm system to meet international best practices. The burden of proof, and responsibility, sits directly on us as the manufacturer. Adapting continuously, we install upgraded monitoring sheets and carry out unannounced safety training for all staff—operators, maintenance, and shipping crews all included. By fostering a strong in-house safety culture, we help to justify end-user trust in both chemical quality and supply reliability.

    We aim for transparent documentation, regardless of customer request: certificate of analysis, batch-internal traceability, and clear annotation on storage timelines. Technical documentation serves not just reputation, but helps you avoid regulatory headaches with confidence. Manufacturers, not distributors, endure the consequences of product recall or regulatory infraction. From our side, keeping full chain-of-custody records ties every drum back to individual operators and process batches—a real safeguard for our partners and ourselves.

    Reducing Environmental Impact

    Chemical production brings environmental challenges that call for direct, methodical attention. We’ve invested in closed-loop solvent recovery for all critical process steps, not just to comply with tightening regulations, but to maintain credibility with clients who themselves face emission targets. Decades back, solvent losses consumed several percent of our throughput; now we’ve slashed vented organics below 0.5% through staged condensation and improved scrubber media. Genuine improvements here mean less waste both for us and for communities nearby.

    Years of experience put us ahead when handling process byproduct streams. Sometimes regulatory pressure exposed gaps in our wastewater neutralization—discolored water hinting at over-acidification or incomplete flocculation. Improved pH control and staged filtration followed. Nothing beats routine, in-person inspections for identifying and correcting emerging issues before serious compliance headaches appear.

    Users can order 1,2-dihydroxynaphthalene from many sources. Choosing a manufacturer committed to direct stewardship of the environment, not indirect reselling, aligns your own brand with meaningful, traceable action on emissions and resource conservation. Those claiming green chemistry must show their record; we choose to publish real numbers and welcome third-party checks at any time.

    Staying Relevant in a Changing Market

    The chemical industry faces rapid changes: increased demand for higher purity, calls for greener intermediates, tighter controls on hazardous shipments. We keep pace not by waiting for orders, but by seeking out technical collaboration with users from emerging markets—battery developers, advanced pigment houses, formulation labs tackling novel active ingredients. Every feedback loop from pilot to full-scale roll-out enters our process improvement database, overseen by people who know what keeps a reactor stable, not just what looks good in a quarterly report.

    One recent trend involves single-digit ppm trace control—elimination of sulfur or iron as customers attach direct measurement at every synthesis step. Achieving this required not only finer raw material screening, but also full process tank passivation and post-synthesis trace cleaning. Real improvements in this arena never come from copy-pasting what worked for unrelated chemicals. Only teams with true manufacturing control—those who carry out the work and see first-hand what each process variable shifts—know what needs to give for tomorrow’s targets.

    Growth in demand for advanced organic materials and selective intermediates continues to push us forward. Many labs and large plants—constrained by regulatory or cost challenges—seek new pathways to the products currently based on 1,2-dihydroxynaphthalene. Our role means proactive adjustment, transparent dialogue about what is possible, and continuing direct investment in plant, people, and process.

    Supporting Innovation Beyond the Product

    Supplying 1,2-dihydroxynaphthalene goes beyond shipping a drum of clean crystals. We see our job as supporting each customer’s technical journey, sharing deep process knowledge built step by step, batch by batch. Sometimes that means providing analytical standards to ease a customer's QC development, sometimes fielding a call at midnight to decode a process deviation report. Many of the strongest innovations in organic synthesis, pigment engineering, or advanced organic semiconductors started with informal technical conversations and direct in-plant support.

    We keep our R&D team busy validating new uses, bettering aging protocols, and testing alternatives that keep your process—from benchtop to pilot—running as planned. We welcome pilot-scale partners who want deeper control, not just low price per kilo. Our slogan is not “just ship what moves”; it’s “solve at source.” Decades as direct manufacturers mean we know what headaches lurk at every tank, filter, and separation, and we address those before they reach your line.

    Why True Manufacturing Experience Matters

    Markets will always offer cheaper, less controlled sources working from blended or reprocessed intermediate streams. Our focus remains on real manufacturing, where knowledge of the product begins with the first flask and ends with direct delivery—a closed, traceable, and repeatable chain. Partnering with us means working directly with those who have shaped the process, learned from every setback, and refined their craft over years of hands-on work. Every shipment comes with the confidence that only those present from raw material to finished pack can provide.

    Trust builds slowly, one batch at a time. Each user of 1,2-dihydroxynaphthalene—pharma, colorant, specialty chemical—leans on the record of consistency, safety, and technical insight that comes not from trading, but from manufacturing at source. We maintain this tradition every day, in every tank, with every batch.