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1,2-Dichloro-2-Fluoropropane

    • Product Name 1,2-Dichloro-2-Fluoropropane
    • Alias 1,2-Dichloro-2-fluoro-n-propane
    • Einecs 695-542-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    413899

    Cas Number 430-80-8
    Iupac Name 1,2-dichloro-2-fluoropropane
    Molecular Formula C3H5Cl2F
    Molecular Weight 130.98
    Appearance Colorless liquid
    Boiling Point C 98-100
    Melting Point C -64
    Density G Per Cm3 1.28
    Refractive Index N20d 1.435
    Solubility In Water Negligible
    Pubchem Id 10911

    As an accredited 1,2-Dichloro-2-Fluoropropane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 500 mL, with screw cap; bottle labeled "1,2-Dichloro-2-Fluoropropane, CAS 431-47-0, flammable, handle with care."
    Shipping **Shipping Description:** 1,2-Dichloro-2-fluoropropane should be transported in tightly sealed, clearly labeled containers. Store and ship upright, away from heat, sparks, and incompatible materials. It is typically classified as a hazardous material—ensure compliance with local, national, and international regulations including proper documentation and UN labeling. Handle with appropriate personal protective equipment.
    Storage 1,2-Dichloro-2-fluoropropane should be stored in a tightly sealed, corrosion-resistant container, in a cool, dry, well-ventilated area away from heat, sparks, open flames, and incompatible substances such as strong oxidizers. Label storage clearly and avoid excessive temperatures. Keep away from direct sunlight and sources of ignition. Use appropriate personal protective equipment when handling and ensure good ventilation in storage areas.
    Application of 1,2-Dichloro-2-Fluoropropane

    Applications of 1,2-Dichloro-2-Fluoropropane in Industrial Manufacturing

    1,2-Dichloro-2-fluoropropane serves as a specialized intermediate in multiple chemical manufacturing sectors. With regulated production and documented purity, this compound plays a key role in select downstream workflows requiring precise reactivity and reliable integration in synthesis chains.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical plants utilize this compound as a halogenated building block in the preparation of active pharmaceutical ingredients (APIs), including the synthesis of fluorinated side chains and specific intermediates for specialty drugs. It supports precise step-growth or substitution reactions where strict batch traceability and controlled impurity profiles are needed to meet regulatory expectations.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) chapter 5.4 on residual solvents
    • US FDA 21 CFR Part 211 (current Good Manufacturing Practice)
    • Japanese Pharmacopoeia, General Notices on starting materials

    Typical usage ratio

    • Applied in a range of 0.5-2.0 equivalents per target API intermediate, adjusted according to the desired fluorine or chlorine substitution pattern in the synthesis step

    Downstream process integration

    • Charged during the controlled halogenation or alkylation reaction step, following raw material qualification and pre-reaction charging procedures in jacketed reactors with automated dosing

    Final product types

    • Specialty APIs for oncology and antiviral medications
    • Fluorinated pharmaceutical intermediates
    • Contract-manufactured drug substances with labeled fluorine isotopes
    • Fine chemical intermediates for custom synthesis services

    2. Agrochemical Active Ingredient Manufacturing

    Leading crop protection manufacturers use this material in multi-step syntheses of new-generation halogenated herbicides and insecticides. Its molecular structure enables controlled introduction of chlorine and fluorine atoms into target molecules, compatible with modern process safety systems and automated material tracking.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 9001 certified production management systems
    • REACH Regulation (EC) No 1907/2006 for registration and safe handling
    • OECD Guidelines for the Testing of Chemicals in agrochemical synthesis

    Typical usage ratio

    • Rates typically range from 1.2 to 2.5 equivalents per reaction stage, calibrated based on specific halogenation and desired yield for targeted active molecules

    Downstream process integration

    • Dosed precisely in closed reaction vessels after raw material testing. Used during the core halogen exchange or nucleophilic substitution steps in technical-grade synthesis lines

    Final product types

    • Active ingredients for selective pre- and post-emergence herbicides
    • Halogenated intermediates for broad-spectrum fungicides
    • Active compounds for contact and systemic insecticides
    • Registered crop protection chemicals for global distribution

    3. Specialty Polymer Additive Manufacturing

    Polymer and plastics plants adopt this halogenated raw material as a processing modifier or functional additive precursor, predominantly in the manufacture of specialty fluorinated monomers or performance-enhancing chain extenders. It contributes to flame retardancy and chemical resistance in engineering resins for high-end applications.

    Industry compliance standards

    • UL 94 Flammability Safety Standard
    • ASTM D5511 for chemical resistance properties
    • ISO 9001 for quality management in polymer production
    • RoHS Directive (EU) 2015/863 for restricted substances in electrical and electronic equipment polymers

    Typical usage ratio

    • Blended at 2-10% weight basis depending on polymer backbone reactivity and targeted flame retardance, monitored through extrusion melt blending recipes

    Downstream process integration

    • Introduced during reactive extrusion or in-situ monomer charging, with in-line spectroscopic monitoring of composition through continuous or batch mixers

    Final product types

    • Fluorinated polyolefins for cable insulation sheaths
    • Specialty engineering plastics for automotive components
    • Composite polymer resins with enhanced weathering stability
    • Masterbatches for flame-retardant and chemical-resistant plastics

    4. Advanced Chemical Synthesis for Refrigerant Precursors

    Producers of new-generation refrigerants use 1,2-dichloro-2-fluoropropane as a starting raw material to access proprietary fluorinated intermediates. This material integrates into closed-loop synthesis trains for the development of low-global-warming-potential (GWP) hydrofluoroolefin and hydrofluorocarbon refrigerants.

    Industry compliance standards

    • AHRI Standard 700 for refrigerant purity
    • ISO 5149-1:2014 for refrigeration safety
    • F-Gas Regulation (EU) No 517/2014
    • ASHRAE Standard 34 for refrigerant classification and designation

    Typical usage ratio

    • Used at stoichiometric rates of 1.0-1.1 equivalents per mole of desired fluorinated intermediate, precisely controlled to avoid side reactions and optimize end-product yield

    Downstream process integration

    • Fed under monitored conditions at the halogen exchange or reductive elimination stage in distillation columns with vapor-phase transfer technology

    Final product types

    • Low-GWP hydrofluoroolefins (HFOs) for commercial refrigeration
    • Blended hydrofluorocarbon (HFC) refrigerant intermediates
    • Specialized blowing agents for polyurethane rigid foams
    • Formulated refrigerant mixtures for HVAC manufacturers
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    Certification & Compliance
    More Introduction

    1,2-Dichloro-2-Fluoropropane: Real-World Performance from the Manufacturing Source

    Production Commitment Backed by Everyday Results

    A chemical tells its own story by how it performs in actual industrial processes. Over the years, 1,2-Dichloro-2-Fluoropropane has earned its place through chemical stability and reliable results in synthesis applications. As producers, we measure quality not just by what’s printed on the label, but by how it runs in the reactor, how it flows, and how consistently it reacts batch after batch. When manufacturing this compound, attention starts with raw materials; every shipment of chlorinated and fluorinated feedstocks gets screened before it ever makes contact with our synthesis line. Trace water or contaminants can tweak yields and push impurities well above what our partners can tolerate. We don’t cut corners. Even one off-spec drum creates more work down the line, and nobody wants that. Integrity begins at the starting line, and that's where the value of manufacturing at source becomes transparent.

    Specifications Grounded in Practical Use

    The industry often wraps chemical descriptions in a haze of technical jargon that loses sight of what matters: how a chemical fits the process and workflow. With 1,2-Dichloro-2-Fluoropropane, purity isn’t a theoretical number. Our facility aims for minimum 99% purity with residual water tightly controlled under 500 ppm, not because it reads well on a spec sheet, but because manufacturers—our team included—have learned what happens when these thresholds slip. Slight elevation in water can compromise product shelf life or damage yield rates in further transformations. The density profile is another factor. Each batch lands reliably within 1.2–1.3 g/cm³, supporting straightforward volumetric calculations in everything from sampling to bulk tank transfers. Such specifics matter on the floor, not just on paper.

    Distinct Features from a Manufacturer’s Insight

    What really separates 1,2-Dichloro-2-Fluoropropane is how its halogen arrangement influences chemical reactivity. Chlorine and fluorine atoms create a molecular structure resistant to thermal degradation yet reactive enough for selective substitution or elimination when a catalyst is tuned correctly. This makes it suitable in specialty synthesis of advanced intermediates, including certain crop protection agents and industrial solvents. Standard chlorinated or fluorinated alkanes often behave unpredictably in the same environment. Take other dihalopropanes, for instance—they can suffer greater side reactions due to a lack of fluorine’s bond strength, even under nearly identical reaction profiles. Experience has shown us that once you swap out this compound for a mix containing only dichloropropane or difluoropropane, batch purity and selectivity both suffer.

    Batch Consistency: The Result of Rigorous Process Control

    Reproducibility carries more weight than any catalog superlative. Each run in our plant is anchored by process checks at critical control points. Our technicians monitor reaction kinetics and byproduct levels with every batch, adjusting conditions in real time before issues scale up. Feedback from production partners has reinforced the need for this discipline; many recall dealing with supplier changes that introduce unpredictability batch-to-batch. By sticking to the foundation—strict feedstock sourcing, set purification loop, targeted distillation range—and learning from feedback downstream, we keep the variance minimal. Our job isn’t just to make molecules, but to push out a drum or tank that performs just like the last one, every time.

    Handling and Transport: Balancing Volatility with Safety

    Firsthand experience with chemical logistics has taught us the importance of physical handling properties. This product moves as a clear liquid, handled in bulk or drums, and the volatility means careful attention during loading and decanting. Operators at our site keep vapor control and closed-system requirements front of mind through the entire transfer. Although storage stability is high compared to some more aggressive halogenated products, the presence of both chlorine and fluorine means we don’t treat these shipments lightly. Room for error narrows quickly if shipping containers or seals don’t hold. Our shipping protocols grew out of what we’ve seen work, not merely what regulations mandate. Teams downstream benefit. Nobody wants an unexpected vapor release in transit, which is why close communication with haulers and strict adherence to our established methods remains unshakable.

    Downstream Performance—Where Lab Data Meets Plant Reality

    Laboratory data helps in process development, but the true measure of a chemical’s value emerges in scaled production. Over the years, our partners have put 1,2-Dichloro-2-Fluoropropane to the test in reactors ranging from glassware up to multi-ton stainless plants. Observed reaction profiles point to manageable exotherms and favorable conversion factors when compared with analogs substituted at either the 1- or 3-carbon position. This is not coincidental. Subtle shifts in atom placement affect electron withdrawal and, ultimately, downstream product distributions. Our engineers routinely track solvent and raw material balances through the cycles, and hold technical exchanges with client sites who rely on our chemical’s consistent reactivity. These relationships have shown us that it’s rarely enough to simply meet a technical standard; our goal stays fixed on exceeding process reliability, even when conditions get pushed.

    Support Based on Real Production Experience

    We answer customer questions grounded in experienced troubleshooting. If a downstream reaction stalls, the team doesn’t recite theory. Instead, we draw on our track record to walk through likely causes: impurities, moisture, temperature oscillations, mixing efficiency. Sometimes, the solution demands a re-evaluation of catalyst profiles or work-up methodology, not something listed in guides. Sharing actionable advice directly from the manufacturing side builds trust and efficiency. And when customers adapt new uses, we keep the interface open, ready to compare notes on optimal run conditions and unexpected complications. This exchange supports improvement for suppliers and users alike.

    Environmental and Regulatory Realities

    Halogenated compounds demand respect in their environmental impact and handling. We monitor waste streams closely from the initial synthesis through to final bottling. Chlorine- and fluorine-bearing byproducts receive isolation in our waste system, avoiding unwanted vents, accidental releases, or downstream contamination. Over the last decade, regulations have grown tighter around both emissions and disposal, prompting investment in improved abatement and containment. We welcome this; safer and cleaner plants sustain business and community health. In operating our unit, we don’t rely on assumptions—data guides every adjustment. Every emission, every solvent recycle, feeds into a larger view of compliance and stewardship.

    Continuous Improvement Driven by Process Feedback

    No manufacturing process survives long if it becomes static. The market for specialty halogenated intermediates—especially those with both chlorine and fluorine—demands incremental improvement. Updated catalyst systems, better distillation trains, and fine-tuned temperature profiles keep us competitive, but more importantly, keep customer complaints to a minimum. Teams on the floor record every deviation and improvement opportunity. Whether we spot a slight shift in analytical data, a residue showing up in a packed column, or a recurring yield variance, these points become the starting ground for next-cycle improvements. Feedback loops don’t end in our plant; we listen closely to what users find in their production environments, whether they’re improving shelf-life, scaling capacity, or making compatibility upgrades.

    Comparisons That Matter in Real Manufacturing Environments

    What users often ask is: how does 1,2-Dichloro-2-Fluoropropane compare with similar products in side-by-side production? The answer comes from firsthand operating experience. Compounds with only chlorines, for example, can face decompositions at elevated temperatures, reducing yield and causing equipment fouling. Purely fluorinated analogs sometimes lack desired reactivity under the same synthesis regimes, requiring more aggressive conditions or resulting in product loss. The dual halogen nature of this product offers a sweet spot—sufficient chemical selectivity with manageable byproducts in multi-step synthesis. Our feedback from industrial partners confirms that while cost and availability set the foundation, long-term reliability wins the race.

    Reliability That Reaches Beyond Documentation

    Experience tells us that documentation supports process adoption, but reliability is earned through repeated cycles under production stress. Our quality team runs parallel verifications in scale-up and continuous runs. If a batch performs outside established parameters, the response is immediate review, not excuse. We retain production samples from every lot, enabling traceability and post-analysis if unexpected incidents develop at customer plants. It isn’t about simply shipping product and checking a box—it’s about standing behind every delivery and having the records and knowledge ready to support a process at any hour.

    Value Rooted in Direct Manufacturing

    Direct manufacturing grants deeper insight into product quality and performance. Sourcing from within means we control all critical variables, from temperature ramp rates during synthesis to in-line purity checks before packaging. This translates to lower defect rates, faster troubleshooting, and a shared language with production engineers who depend on every batch. Instead of deferring to third-party reports or having to double-check intermediates, our clients reach out directly, finding answers from people who have worked alongside the product day in and day out. That cycle of feedback, investigation, and action produces results no catalog can replicate.

    Future Monitoring and Industry Trends

    Markets evolve. New crop protection agents, custom polymers, and specialty coatings are always seeking moved performance targets. Our team keeps a close watch on advances in downstream chemistry. Whether regulatory landscapes change with new restrictions, or user industries demand lower impurity profiles and greener processes, we feel the effect directly. Over the years, process flexibility has helped us stay ahead—installing new purification skids, qualifying secondary containment, and sourcing alternative energy where possible. Investing in smarter controls pays off in both quality and sustainability.

    Bridging Expectations Between Production and Application

    Every project starts with clear expectations between supplier and user, and real partnership shows through problem-solving. By manufacturing 1,2-Dichloro-2-Fluoropropane ourselves, we set those expectations on mutual understanding. Whether questions arise around solubility, volatility, or reaction behavior, we give straightforward answers. If an application calls for narrow impurity tolerances or novel reactivity, trials run on our floor—not in a lab far removed from industrial pace. This approach reduces trial-to-production gaps and speeds up qualification for new and custom requirements. Trust flows strongest along these lines—manufacturer to user—where no game of telephone can muddle the facts.

    A Lasting Commitment

    Maintaining a reputation as a chemical producer is about repetition, vigilance, and an earned record. Every liter of 1,2-Dichloro-2-Fluoropropane is the product of systems built to avoid shortcuts and aimed at real-world reliability. We know plant managers, shift chemists, and process engineers rely on each order to keep lines running and schedules on track. Our role is more than making a molecule. It’s making that molecule count, batch after batch, delivery after delivery—whatever the application, whatever the complexity or specification. This principle keeps us striving, investing, and listening, year after year.