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1,2-Dibromobutane

    • Product Name 1,2-Dibromobutane
    • Alias 1,2-Dibutylene bromide
    • Einecs 203-899-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    726606

    Name 1,2-Dibromobutane
    Molecular Formula C4H8Br2
    Cas Number 628-21-7
    Appearance Colorless to pale yellow liquid
    Boiling Point Celsius 155-157
    Melting Point Celsius -40
    Density G Per Cm3 1.991
    Refractive Index N20 1.502
    Flash Point Celsius 60
    Solubility In Water Insoluble
    Canonical Smiles CCCC(Br)Br

    As an accredited 1,2-Dibromobutane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1,2-Dibromobutane is packaged in a 500 mL amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 1,2-Dibromobutane should be shipped in tightly sealed, corrosion-resistant containers, clearly labeled as hazardous material. Transport must comply with relevant regulations (such as DOT or IMDG codes) due to its flammable and toxic properties. Proper ventilation, avoidance of heat sources, and spill containment measures are essential during transit to ensure safety.
    Storage 1,2-Dibromobutane should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, or incompatible substances such as strong oxidizers. Keep the container clearly labeled and protected from direct sunlight. Store at room temperature and avoid exposure to moisture. Ensure access is restricted to trained personnel, following all safety protocols.
    Application of 1,2-Dibromobutane

    Applications of 1,2-Dibromobutane in Industrial Manufacturing

    As a direct manufacturer of 1,2-dibromobutane, we support key chemical sectors with material that meets rigorous industrial standards. The applications below highlight critical downstream routes in the production of specialty intermediates and functional materials that require consistent quality and technical support.

    1. Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical manufacturers utilize 1,2-dibromobutane as an effective alkylating agent in the construction of complex heterocyclic and N-alkylated intermediates during API synthesis. Its dibromo functionality delivers controlled reactivity in regulated batch manufacturing, enabling production of key intermediates for anti-infective or cardiovascular drugs. Custom formulations require careful monitoring of reaction exotherms and bromide byproduct management to comply with cGMP guidelines and pharmaceutical impurity limits.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • 21 CFR Parts 210/211 (FDA: cGMP for Finished Pharmaceuticals)
    • USP-NF Monographs (where relevant intermediates are listed)
    • EU GMP Directive 2003/94/EC

    Typical usage ratio

    • 0.4–0.8 molar equivalents per target intermediate, adjusted based on substrate chain length and ring closure requirements

    Downstream process integration

    • Charged in dedicated glass-lined synthesis vessels during the key alkylation step
    • Dosed under nitrogen atmosphere to minimize hydrolysis
    • Bromide salts removed by aqueous extraction phases

    Final product types

    • Hydrazine derivatives for anti-HCV drug precursors
    • Piperazine-based intermediates
    • N-(alkyl) substituted benzimidazoles
    • API building blocks for contract manufacturing

    2. Component in Organic Synthesis for Agrochemical Intermediates

    Producers of agrochemicals deploy 1,2-dibromobutane in the stepwise functionalization of aliphatic precursors, where bromoalkyl intermediates allow for subsequent thiolation, amination, or cyclization to create herbicide or fungicide actives. The material’s dual bromine atoms enable efficient two-point substitution, which is critical for structure-activity optimization in crop protection R&D and pilot scale-up.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 9001:2015 (Quality Management Systems)
    • REACH Registration (EC No. 201-084-3 for 1,2-dibromobutane)
    • GLP (OECD Principles of Good Laboratory Practice)

    Typical usage ratio

    • 10–18% by weight in stepwise reaction mixtures, adjusted to target difunctional conversion; precise level set by intended substitution yield and downstream chain length

    Downstream process integration

    • Fed as neat liquid or dissolved in non-reactive organic solvent during bromoalkylation or chain extension steps
    • Reacted under controlled temperature (< 55°C) to optimize selectivity for desired intermediates
    • Halide scavengers or bases added post-reaction to facilitate bromide removal

    Final product types

    • Thiazole-based fungicide intermediates
    • Alkylated triazole herbicide precursors
    • Pyridine-substituted insecticide chains
    • Custom contract intermediates for crop protection actives

    3. Polymer Crosslinking Agent in Specialty Elastomer Formulation

    Industrial compounders of specialty elastomers employ 1,2-dibromobutane as a crosslinking co-agent for nitrile, chloroprene, and epichlorohydrin rubber systems. Its short-chain, di-bromo functionality delivers controlled crosslink density, enhancing oil resistance and mechanical stability for automotive seals and vibration dampers. The crosslinking reaction requires careful integration with peroxides or other radical initiators under tightly monitored compounding conditions.

    Industry compliance standards

    • ASTM D2000 (Classification System for Rubber Products in Automotive Applications)
    • ISO 14001 (Environmental Management Systems)
    • RoHS EU Directive 2011/65/EU (restriction of hazardous substances)
    • ISO 6943 (Determination of tension fatigue in vulcanized rubbers)

    Typical usage ratio

    • 1.0–2.2 parts per hundred rubber (phr), optimized by target tensile properties and elastomer base polymer

    Downstream process integration

    • Added during final mixing stage in internal mixer or open mill with curatives
    • Heated under pressure (160–180°C) during vulcanization
    • Monitored for residual bromine content in QC testing

    Final product types

    • Oil-resistant gaskets and seals for automotive applications
    • Specialty molded vibration isolators and mounts
    • Hydraulic hose linings
    • Chemical process pump diaphragms

    4. Alkylating Reagent for Industrial Surfactant Manufacture

    Chemical formulators integrate 1,2-dibromobutane as a bifunctional alkylating agent to attach C4 chains onto amines, phenols, or polyoxyalkylene backbones, producing specialty cationic and amphoteric surfactants. This dual reactivity supports the development of phase-transfer agents and emulsifiers needed in refinery, textile, and cleaning formulations, where precise hydrophobic-hydrophilic balance is critical. The material’s direct functionalization improves batch throughput and reduces byproduct formation compared to stepwise syntheses.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals (for surfactant environmental fate & toxicity)
    • EN 14769 (Surfactants – Determination of surface tension)
    • ISO 9001 Quality Management (for bulk surfactant manufacture)
    • US TSCA Inventory Compliance (Toxic Substances Control Act)

    Typical usage ratio

    • 5–12 mole% per batch, with ratio adjusted based on feedstock molecular weight and desired surfactant HLB value

    Downstream process integration

    • Dosed directly into stirred-tank reactors after base neutralization of reactants
    • Reaction time and agitation optimized for completion of alkylation without excess heat generation
    • Crude surfactant mixture undergoes phase separation and final purification via distillation or extraction

    Final product types

    • Phase-transfer catalysts for chemical synthesis
    • Alkylated amphoteric surfactants used in oilfield and textile auxiliaries
    • Emulsifying agents for water-based industrial cleaners
    • Cationic surfactants for personal care blends (IND only, not for consumer use without further approval)

    5. Chemical Intermediate for Brominated Flame Retardant Production

    Brominated flame retardant producers use 1,2-dibromobutane as a source of reactive bromine in the synthesis of aliphatic and aromatic flame retardant additives for plastics. This intermediate enables precise incorporation of bromine atoms into base polymers or precursor molecules, maximizing char-forming properties and thermal stability. The process requires inline bromine mass balance calculations and adherence to strict product purity testing for electronics and building material markets.

    Industry compliance standards

    • UL 94 (Standard for Tests for Flammability of Plastic Materials)
    • IEC 60695 (Fire hazard testing for electrical safety)
    • REACH Annex XVII (Restrictions on certain dangerous substances)
    • ISO 16000-9 (Indoor Air – Emission of flame retardants)

    Typical usage ratio

    • 15–25% by weight as functional bromine donor per batch, based on targeted V0 or V1 flammability rating and host polymer requirements

    Downstream process integration

    • Fed continuously into bromination reactors under halogenated solvent conditions
    • Reacted at 70–120°C with aromatic or aliphatic base compounds
    • Purified by distillation or crystallization to reach residual bromide content limits for electronics grade

    Final product types

    • Brominated alkane flame retardants for polypropylene and ABS
    • Aliphatic flame retardant synergists for polyamides
    • Masterbatch additives for cable insulation
    • Intumescent coating intermediates for building panels
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    Certification & Compliance
    More Introduction

    1,2-Dibromobutane: Direct from the Manufacturer’s Perspective

    Understanding 1,2-Dibromobutane Beyond the Basics

    Our work with 1,2-dibromobutane (CAS No. 533-98-2) has shown us the true difference that careful synthesis and real-world know-how make. This clear, colorless liquid belongs to the family of alkyl bromides and finds its value not because it sounds exotic but because it delivers reliable results in real-use cases across the globe. On the surface, it appears as another halogenated compound, but for us as a manufacturer, its character goes deeper – revealed by the purity, the consistency batch-to-batch, and how our partners on the application side benefit from it.

    From Raw Chemical to Critical Ingredient

    Right down to the reaction vessels and distillation columns, we see how 1,2-dibromobutane fits into chemical synthesis routes. In many of our partner industries, it serves as an alkylating agent, helping build more complex molecules for both academic research and commercial production. Due to the two bromine atoms attached along the butane backbone, it’s especially useful where controlled reactivity is desired. Its effectiveness is not just about structure, but also about the trace impurities—or lack thereof—after synthesis. Our refining steps make sure each drum or container matches the quality our long-term customers expect, minimizing possible side reactions in subsequent steps.

    Specifications Rooted in Manufacturing Experience

    Manufacturing chemistry isn’t just about meeting a published specification; it’s about understanding what spec really matters for the process in which the compound ends up. With 1,2-dibromobutane, purity remains a headline feature, often quoted in the high ninetieth percentile (99% or better by GC). Water content and color are tightly controlled; even minor discolorations can signal the wrong sort of byproducts. Over the years, we’ve found that storage conditions, container liners, and even slight temperature variations in the warehouse can influence long-term stability. We avoid using generic packaging solutions and instead opt for containers lined to resist corrosion and moisture ingress, keeping the product as fresh as it was the day it left our reactor.

    Customers with decades in the business have taught us the value of small details. For example, a batch destined for pharmaceuticals must pass additional scrutiny—not just for purity over 99%, but also for residual solvents, heavy metals, and unexpected stabilizers. Certain applications, such as specialty polymer production or advanced agrochemical intermediates, look for a predictable response in downstream reactions. One outlier in impurity content throws off a catalyst or leads to yellowing in an end polymer. Our analytical routines track batches long after shipment, helping identify rare outliers before they cause headaches on the customer’s production floor.

    Major Uses Influenced by Real Needs

    In rubber vulcanization, 1,2-dibromobutane shows up as an effective curing agent, especially where the goal is to modify properties without introducing sulfur-based crosslinkers. Rubber technologists prize its ability to fine-tune flexibility, aging resistance, and adhesion in specialty seals or hoses. Performance hinges on batch-to-batch quality and on the absence of halogenated debris that could migrate or weaken final mechanical strength.

    Flame retardant chemistry forms another cluster of usage. Here, the bromine content enables the formulation of compounds that interrupt combustion. We’ve watched regulatory landscapes change over the years, with certain brominated products phased out for toxicity reasons. With 1,2-dibromobutane, regulatory teams appreciate clear documentation and transparency in impurity profiles. This has become non-negotiable, especially as downstream certifications and end-market labeling get stricter. Usage in this sector demands absolute transparency on manufacturing lineage, and we trace back each batch to raw materials sourced under vetted supply-chain programs.

    Organic synthesis is the third pillar. At the bench and at scale, researchers use 1,2-dibromobutane as a source of straight-chain alkylation, double elimination, or as a key intermediate for building blocks in sophisticated syntheses. The flexibility provided by symmetry in the molecule means it stands apart from mono-bromo or tri-substituted derivatives. Chemists working under tight time constraints, such as those in contract research or pilot plant operations, rely on consistent product quality. We field a surprising number of calls seeking advice on atypical reactions—this reflects the real-world trust that grows when issues are handled promptly from the manufacturer’s side.

    Key Differences Compared to Related Haloalkanes

    Many compare 1,2-dibromobutane to other brominated butanes or to chlorinated analogues, thinking properties and uses are interchangeable. Experience shows otherwise. Mono-bromobutanes, such as 1-bromobutane, lack the same level of bifunctionality. They may suffice for certain alkylations but cannot deliver the dual reactivity needed in di-substitution schemes or in the formation of cyclic intermediates. On the other hand, 1,4-dibromobutane places the bromine atoms at opposite ends, making it preferred in polymer chain extension, but less useful in centrally bridging two reactive sites.

    Chlorinated counterparts come with their own challenges: less reactivity due to the difference in carbon-halogen bond strength, and sometimes different toxicity profiles. Manufacturers like us see lower boiling points for chlorinated butanes and deal with higher volatility and increased losses during transport or blending. 1,2-dibromobutane, with its optimal balance of weight, boiling point, and reactivity, hits a sweet spot for those who need efficient, resolved reactions rather than dealing with side products or complex purification steps.

    Challenges and Practical Solutions from a Production Standpoint

    Each time we scale up production or switch a plant from another haloalkane to 1,2-dibromobutane, we revisit the realities of health, safety, and environmental stewardship. Brominated compounds demand robust containment. Our team has learned that simple over-or under-maintenance of exhaust systems and seals changes exposure risks for operators. Investing in advanced vapor capture and neutralization has been worth every dollar, reducing fugitive emissions and improving worker safety.

    Supply chain risk pops up frequently. Bromine availability, changes in global freight lanes, and evolving environmental rules make stable sourcing a moving target. We buffer these risks through early supply contracts for raw bromine, and by working closely with regional authorities to maintain compliance with transportation rules. These are not just paperwork exercises; they are hard-won lessons that keep downstream customers supplied even in turbulent markets.

    Waste minimization remains a theme in every board meeting. Instead of simply passing final processing effluent into third-party treatment, our operations recycle brominated stream residues into new reaction feeds wherever purity allows. This does more than tick a compliance box; it keeps costs down and ensures our processes remain competitive against newer synthesis methods that promise “greener” routes but often lack commercial viability or scalability. We regularly meet with our largest customers' EHS teams, reviewing solvent recovery, water usage, and closed-system approaches that minimize offsite waste transport.

    From Floor to Laboratory: Real Value Over Time

    Over the decades, we have worked alongside not just procurement teams, but chemists, process engineers, and product developers who demand more than delivering the minimum. The honest feedback we get—sometimes straightforward, sometimes pointed—pushes us to keep refining how we produce and deliver 1,2-dibromobutane.

    This runs deeper than surface-level "quality". One year, a customer flagged intermittent yellowing in an end-use polymer, which lab data traced back to a trace chlorine impurity—not directly harmful, but enough to catalyze color changes under certain conditions. Since then, we’ve tightened raw material pre-qualification and rolled out in-line monitoring during bromination steps. The goal is not to just patch issues after the fact, but to build infrastructure that catches anomalies in real time.

    Another key lesson involves packaging and shipment. In the early years, simple drum shipment led to complaints about slight odor on arrival and possible off-gassing. Transitioning to better-sealed, lined drums and educating logistics partners about rapid unloading reduced complaints dramatically. In hotter climates, this step has become critical; containers vented to the right standards prevent minor but unacceptable losses.

    Adapting to Regulatory and Market Shifts

    Over time, regulatory scrutiny of brominated flame retardants has changed how we operate. While 1,2-dibromobutane itself is not currently classified under some of the more restrictive listings, downstream transformations can bring it under watchful eyes. We do not wait for a new regulation to roll out; instead, we proactively supply certificates of compliance, change notification protocols, and offer full traceability documents. This openness not only supports our customers during their audits but speeds up global distribution—clearing customs faster and reducing cost-to-market overhead.

    Non-halogen alternatives are gaining attention in some application sectors. We get continual requests for sustainability data, waste management protocols, and lifecycle assessment information for 1,2-dibromobutane. Our team brings together R&D and EHS to answer these questions with transparency, using real plant data rather than marketing claims. If a process using our product can be greener through solvent switch, process intensification, or catalyst recycling, we participate actively—our goal isn’t ever to trap a partner in a legacy chemistry cycle, but to let facts and genuine value drive decisions.

    Few products escape the compliance net in today's market. 1,2-dibromobutane remains in demand largely because it solves practical problems, not because it’s newly marketed. We attend regulatory roundtables, trade association meetings, and customer sustainability workshops to keep the lines open and ensure our practices reflect the letter and spirit of evolving safety rules.

    Partnerships Built on Experience, Not Just Price

    Competing solely on price leads to shortcuts, and we have seen how poorly that ends, especially when a compromised batch sets off a production upset downstream. Our long-term partners value access to technical staff willing to troubleshoot—not just a product sheet or a standard COA sent with every lot. Our teams have flown out to review customer reactors, checked feed line compatibility, and even run collaborative pilot trials to iron out unexplained issues. This hands-on involvement builds connections that last beyond single transactions.

    Every manufacturer has war stories about supply disruptions, price spikes, or sudden regulatory changes. Our business absorbs lessons from each event, learning that full transparency, backup inventory, and clear planning with customers protect all sides of the partnership. Especially in specialty areas like pharmaceuticals or precision electronics, delay in receiving a batch or inconsistency can cost more than any saved pennies on the invoice.

    Our approach to after-sale service with 1,2-dibromobutane does not begin and end with a delivery truck. We work with partners to solve, not dodge, the questions that arise once the drum or ISO tank is on-site—installation checks, safe pumping, batch certifications, and honest discussion of possible improvement. Every interaction gives us more insight into how to design the next batch, upgrade a filter, or introduce a process modification in the plant itself.

    Bring the Manufacturer’s Knowledge to Your Table

    In our years producing and supplying 1,2-dibromobutane at scale, the market’s needs have grown and shifted, but the demand for reliability and quality has only intensified. Whether the application is synthetic chemistry, performance materials, or specialty flame retardants, users want more than a barebones buy-sell relationship—they need a resource in the manufacturer’s technical team, ready to discuss not just what the product is, but how it behaves under real-world conditions.

    We make decisions and improvements not in isolation, but informed by direct feedback from customers large and small. Pilots, lab trials, and full-scale launches uncover new ways this molecule interacts in unique formulations and under stress conditions never anticipated in early literature or technical bulletins. We see how subtle variations in synthesis, storage, and shipment affect real-world use, leading to incremental but meaningful innovations year after year.

    Delivering 1,2-dibromobutane is more than a transaction to us. The responsibility begins in the manufacturing plant, extends through QA, and becomes part of each partner’s own operation. This product’s real story plays out in the efficiency of a chemical reaction, the longevity of a polymer, and in how customers build trusted supply lines in a volatile world. Our credibility doesn’t grow from glossy marketing or web-ready talking points, but from real experience earned in tanks, lines, and vessels across decades of steady supply.

    Looking Forward: Insight Through Hands-On Practice

    We see each technical request, order specification, and on-site visit as a chance to build the future of chemicals production. The manufacturing world is not static; it shifts with the science, regulation, and the demands of the market. 1,2-dibromobutane stands as a good example of this evolution: not just as a molecule, but as a story of process improvement, partnership, and finding ways to help others achieve their end goals with confidence and transparency.

    Direct input from users still shapes how we control the details—be it a tweak in synthetic route to reduce minor side products, a switch in liner materials to match new environmental codes, or even developing alternate grades for innovative tech applications. Those who work with us get a partner as invested in their process as they are in their own product.

    We measure our success not just by volume or purity, but by the consistency with which our 1,2-dibromobutane supports demanding customers facing evolving real-world challenges. This ongoing process, informed by what happens on actual production floors and in working labs, makes every container shipped part of a larger, more important mission.