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1-(2-Chlorophenyl)Imidazole

    • Product Name 1-(2-Chlorophenyl)Imidazole
    • Alias 1H-Imidazole, 1-(2-chlorophenyl)-
    • Einecs 629-460-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    121389

    Productname 1-(2-Chlorophenyl)Imidazole
    Casnumber 143218-48-8
    Molecularformula C9H7ClN2
    Molecularweight 178.62
    Appearance White to off-white solid
    Meltingpoint 80-84°C
    Solubility Soluble in organic solvents (e.g., DMSO, ethanol)
    Purity Typically ≥98%
    Smiles c1ccc(c(c1)Cl)n2ccnc2
    Inchi InChI=1S/C9H7ClN2/c10-8-4-2-1-3-7(8)12-6-5-11-9-12
    Synonyms 2-Chlorophenylimidazole
    Storagetemperature 2-8°C (refrigerated)

    As an accredited 1-(2-Chlorophenyl)Imidazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-(2-Chlorophenyl)Imidazole, 25g: Supplied in a sealed amber glass bottle with tamper-evident cap and detailed safety labeling.
    Shipping 1-(2-Chlorophenyl)Imidazole is shipped in compliant, sealed containers to protect against moisture and contamination. Packaging adheres to regulations for chemical safety, with clear labeling for identification and hazard information. The product is typically dispatched via ground or air transport, following all applicable domestic and international shipping guidelines for laboratory chemicals.
    Storage Store **1-(2-Chlorophenyl)imidazole** in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances like strong oxidizers and acids. Keep away from direct sunlight and sources of ignition. Ensure proper labeling and secure shelving to prevent spills. Use appropriate personal protective equipment when handling to avoid contact and inhalation.
    Application of 1-(2-Chlorophenyl)Imidazole

    Applications of 1-(2-Chlorophenyl)Imidazole in Industrial Manufacturing

    1-(2-Chlorophenyl)Imidazole is an important chemical intermediate with significant use in the synthesis of advanced industrial and pharmaceutical compounds. As an established producer, we supply this material to manufacturers in highly regulated and performance-driven sectors. Below we detail core downstream application areas, presenting precise compliance frameworks, process details, and final output types.

    1. Synthesis of Triazole Agrochemical Fungicides

    Manufacturers of triazole-based crop protection agents use 1-(2-Chlorophenyl)Imidazole as a vital building block for introducing specific imidazole substructures into their active formulations. The compound reacts with triazinone and other ring-closing agents to generate protective fungicides with high selectivity and low environmental residuals. It remains essential in producing industrial batches of protective solutions for cereal, fruit, and vegetable crops. Formulators must ensure purity and consistent integration to comply with safety and efficacy demands in regulated agricultural applications.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • European Union REACH Regulation (EC 1907/2006)
    • United States EPA Pesticide Registration Requirements (40 CFR Part 158)
    • OECD Guidelines for Testing of Chemicals

    Typical usage ratio

    • 5–15% of active ingredient mass; varies with target fungicide formulation and synergy with triazole intermediates

    Downstream process integration

    • Stagewise inclusion during the heterocyclic intermediate synthesis stage
    • Participates in condensation reactions and ring-closure with base triazole or triazinone substrates
    • Feeds directly into formulation reactors for batch or continuous process
    • Subject to inline NMR and purity monitoring before compounding

    Final product types

    • Protective triazole fungicide formulations (liquid concentrates, wettable powders, granules) for agriculture
    • Seed treatment products for crop protection
    • Pre-formulated tank-mix partners for systemic disease control
    • Post-harvest fungicidal solutions for fruit storage facilities

    2. Pharmaceutical Intermediate for Systemic Antifungal Agents

    Major pharmaceutical plants engage this material in multi-step syntheses aimed at generics and patent-protected antifungal drugs. Imidazole-based APIs require highly consistent starting intermediates to achieve target pharmacological properties and impurity profiles. The compound enters the synthetic route for azole antifungals, undergoing strict GMP-controlled steps such as bromination and selective N-alkylation. Manufacturers monitor the residuals to uphold monograph and clinical standards before final dosage form production.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) standards
    • European Pharmacopoeia (Ph. Eur.) monographs
    • China Pharmacopoeia (ChP) guidelines

    Typical usage ratio

    • 10–18% of total mass in imidazole API synthesis; adjusted for target reaction pathway and batch scale

    Downstream process integration

    • Charged as a principal reactant during initial ring functionalization
    • Subjected to controlled bromination or chloro-alkylation in closed-reactor systems
    • Purified via solvent extraction and crystallization before entering main API assembly
    • Critical parameter in impurity profiling pre-QC release

    Final product types

    • Systemic antifungal APIs such as clotrimazole, miconazole, and econazole derivatives
    • Bulk pharmaceutical raw materials for contract drug manufacturing
    • OTC and Rx antifungal finished dosage forms (tablets, creams, sprays)
    • Active substance intermediates for veterinary antifungals

    3. Specialty Dye and Pigment Synthesis

    Producers of advanced pigments and technical dyes for polymers and packaging films integrate this imidazole derivative to achieve electron-rich, halogenated aryl cores that enhance UV stability and color intensity. The compound enables nucleophilic substitutions and coupling reactions for the construction of high-performance pigment molecules. Industrial users require reliable particle reactivity and minimal trace contaminants to optimize colorfastness and stability in end-use applications, supporting extended outdoor exposure requirements.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • German DIN EN 71-3 Safety of Toys: Migration of certain elements
    • EU Regulation (EC) No 1272/2008 (CLP) on Classification, Labelling and Packaging
    • RoHS Directive 2011/65/EU for electronics pigment integration

    Typical usage ratio

    • 2–8% based on selected pigment formation pathway and final application (masterbatch, ink, film)

    Downstream process integration

    • Introduced at the coupling or condensation reaction stage with nitroanilines or azo precursors
    • Undergoes chlorination-activated substitutions within pigment intermediates
    • Filtered and milled post-synthesis for particle size adjustment
    • Quality-verified prior to blending with polymer carriers

    Final product types

    • Light-stable polymers colorants for automotive and packaging films
    • Technical printing ink pigments
    • Plastisol pigment dispersions
    • Color masterbatches for PVC, polyolefins, and engineered plastics

    4. Chemical Catalyst Component in Fine Chemical Synthesis

    Advanced synthesis plants deploy 1-(2-Chlorophenyl)Imidazole as a ligand and chemical initiator in catalytic processes, including transition metal-catalyzed cross-coupling reactions. The imidazole moiety coordinates with metals such as palladium or ruthenium, modulating electron donation and ligand field strength for higher selectivity and conversion rates. Specialty chemical producers rely on low residual metal-contaminant grades for catalyst recovery and re-use cycles. Tight process controls prevent isomerization or decomposition during high-temperature batch operation.

    Industry compliance standards

    • European Union REACH (EC 1907/2006) Substance Registration
    • ISO 14001:2015 Environmental Management Systems
    • Chemical Facility Anti-Terrorism Standards (CFATS), United States
    • Substance Inventory Control under Japanese Chemical Substances Control Law (CSCL)

    Typical usage ratio

    • 0.2–1.0 mol% relative to metal catalyst in batch or continuous processes; ratio based on specific synthetic pathway

    Downstream process integration

    • Dosed as a ligand modifier at the start of reaction set-up
    • Coordinates into in-situ-formed metal complexes for Suzuki or Heck reactions
    • Subject to in-process monitoring for conversion and ligand retention
    • Removed/recovered post-reaction via liquid-liquid extraction

    Final product types

    • Pharmaceutical-grade arylamines and diaryl ethers
    • Photoactive sensor chemical intermediates
    • Advanced OLED and electronic material subunits
    • Research-grade fine chemicals for catalyst development
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    Certification & Compliance
    More Introduction

    1-(2-Chlorophenyl)Imidazole: Perspective from Our Manufacturing Floor

    Introduction to a Trusted Intermediate

    Every week in our production hall, we see barrels of 1-(2-Chlorophenyl)Imidazole move from synthesis to quality analysis. This compound, a staple in our batch lines for over five years, carries a lot more significance than its CAS number or a place in a chemical dictionary. Years of hands-on work with this chemical have shown its steady demand as a building block for pharmaceuticals and agrochemicals. That’s not just an industry claim. Each batch we synthesize ends up at a downstream factory for further processing — mostly pharmaceutical actives, antifungal agents, and research analogues.

    Our team deals daily with questions about purity and consistency. Colleagues working in the lab understand why a slight deviation in quality can stall someone’s project at the formulation level. So, the focus isn’t just in churning out volumes. It’s about understanding why clients who order 1-(2-Chlorophenyl)Imidazole trust the product to perform identically, month after month. We keep analytical data logged for each batch — high-performance liquid chromatography, gas chromatography, moisture content, and trace metals. Through experience, we know that meeting or beating 99% purity (by HPLC) makes the real market difference, especially when others settle for less rigorous specs.

    Production Details and Working Realities

    Manufacturing this imidazole derivative provides a clear-cut lesson in chemistry’s practical side. Staff here know well that the route starts from o-chloroaniline. Each step, from condensation with glyoxal to cyclization, leaves a signature in the end product’s quality. It’s not only about following SOPs; sometimes, even minor tweaks in pH control or feed rates during cyclization make a difference in particulate matter or residual starting material. People with feet on the factory floor see the impact of temperature drift or timing on the final crystallization.

    Unlike traders or resellers, our input isn’t just a price point or certificate. Every batch released is tied to production logs, step monitoring, continual product improvement from operator feedback, and repeat sampling. Our quality analysts have direct communication with the synthesis and engineering teams. This real-time feedback loop isn’t marketing fluff — it shows up in how fast we catch impurities, refine crystallization timing, and meet regulatory standards.

    Why Consistency in 1-(2-Chlorophenyl)Imidazole Matters

    Anyone developing pharmaceuticals faces constant supply chain anxieties. Our experience tells us that process developers rank batch-to-batch reproducibility above most other traits. Many customers come to us after running into trouble with inconsistent materials from brokers—unexpected byproducts, variable melting point, or off-specification impurity profiles. As a manufacturer who runs repeated stability and analytical studies, we have seen projects resolve only after consistent input of 1-(2-Chlorophenyl)Imidazole.

    We process every order with tight in-house tracking. Each batch we release features a full analytical report — not just a COA, but chromatograms and impurity mapping. In the early years, we noticed that small changes in retention time or precipitation steps made bigger downstream problems than initially expected. This drove us to allocate time, space, and people for revalidation whenever raw material sources change.

    Some manufacturers focus on commodity quantity. From our side, many customers actually pay a premium for stability and transparency in process. Once, a biotechnologist visiting our site tested two samples of 1-(2-Chlorophenyl)Imidazole, one from our reactors, another from a generic overseas supplier. The melting point difference and purity gap measured small — less than 0.5%. Her own project, however, failed with the generic material due to micro-impurities she later traced in the supply. Repeat results in their lab came only after switching entirely to our material with tracked lots and direct quality communication.

    Specifications Shaped by Real Demands

    Purity profiles always lead the list during technical meetings. Our team produces 1-(2-Chlorophenyl)Imidazole under specifications aligned with the demand in active ingredient synthesis. Most buyers, after initial trials, request >99% HPLC purity, moisture under 0.2%, and low mono-chlorinated byproducts. The best results according to our supporting evidence use material meeting these specs.

    Lab specialists here routinely check melting points, run HPLC routines, and watch every result for anomalies. Because this intermediate is used in regulated settings, catching a non-conforming lot before shipment is critical. Sometimes, only extensive side-by-side analysis with previous batches reveals shifts requiring investigation. By always keeping analytical reference samples and calibrating our instruments against certified standards, we detect and correct drift long before final product ships.

    Our standard product comes as an off-white to light beige crystalline powder, packaged in double-sealed polyethylene bags within fiber drums — a format informed by years of shipping experience to major pharmaceutical R&D centers. Moisture ingress, static charge, and packaging contamination are real risks we eliminate after learning these lessons through field feedback and client audits.

    Working with Synthesis Teams: Usage Drives Everything

    Seeing 1-(2-Chlorophenyl)Imidazole’s pathway into downstream actives gives direct insight into its handling requirements. This doesn’t come from a sales sheet, but from long hours assisting process chemists with tech transfer or troubleshooting. In our experience, the compound sees most use in triazole antifungal chemistry, where even trace levels of byproducts can sabotage yield.

    Research groups regularly ask us about reactivity and solubility. We document, from our ongoing bench trials, how this imidazole derivative persists through coupling reactions, nitrogen-protecting group manipulations, and scale-up to pilot plant. Handling research volumes or multi-ton commercial orders, our focus remains on confirming every lot’s chemical integrity and minimizing trace impurities that would otherwise disrupt selective alkylation or acylation.

    For those scaling up, our in-house synthesis support team shares handling experience — optimal solvent choices, recommended dissolution techniques, and storage conditions. Sharing our own process control and timelines during pilot runs often helps customers design robust manufacturing trains, reducing the risk of forced shutdowns from unplanned off-spec material.

    How Quality Marks Us Apart from Alternatives

    1-(2-Chlorophenyl)Imidazole might seem available from countless sources, especially in today’s global chemical market. Direct competitors often offer lower, commodity-grade prices with minimal customer support. Based on feedback from end-users who tested side-by-side lots, we know that color, odor, and impurity streaks differ significantly from supplier to supplier. Our facility’s tight environmental control means no persistent aromatic residues, and reprocessing thresholds are set far above industry minimums. Only tight operational discipline allows us to commit to this standard.

    Competitor samples evaluated in our in-house comparative studies have revealed benzaldehyde or unreacted starting materials above 0.5% by GC. In contrast, our material typically falls below 0.1%, leading to fewer failed reactions or downstream purification steps for our buyers. Several pharmaceutical process engineers tell us every quarter that this repeatability allowed them to shift their batch-wise operations to continuous processing — a move that saves major production costs per annum.

    Traceability, Transparency, and Client Choice

    Every container of 1-(2-Chlorophenyl)Imidazole we release is backed by a full synthesis and analytical documentation chain. This commitment didn’t come from regulatory pressure — it has been a direct outcome of our long-term business relationships with drug developers and research groups. Years spent tracing failed reactions or contamination episodes always showed us the value of direct traceability and open process documents. Our plant integrates sample archiving systems, digital batch tracking, and GMP-aligned logbooks. If a compound ever comes under question in your own analysis, our team answers with raw analytical data immediately, not canned responses or vague statistics.

    Customers who care about process transparency often visit our site. Engineers find it easier to troubleshoot real-world process issues by having honest exchanges with our own operators and QC analysts — people who actually handle the substance on a daily basis. These interactions frequently shape future revisions of our internal protocols. Traceability becomes not just a checkbox for audits but a foundation for problem-solving.

    Safety Built from Firsthand Practice

    Experience matters most when dealing with reactive intermediates. Our operators and engineers handle 1-(2-Chlorophenyl)Imidazole in glove boxes and closed systems, a practice learned after routine powder handling tests showed airborne dust risk. We don’t offer safety assurances based only on literature or regulatory data. Protocols change here in real time based on incident logs and peer reviews — one near miss leads to new transfer procedures, better protective gear, or improved air monitoring.

    Those buying the compound for their own synthesis efforts receive, on request, a practical handling guide. This includes not just the official safety data but also tips learned from our own operators — how to minimize clumping, reduce static buildup in colder climates, or dispose of residues safely. Regulatory safety compliance comes built-in, but practical experience leads the way.

    Lessons Learned: Why Direct Manufacturing Focus Matters

    Markets keep shifting, and so do expectations for intermediates. Having a steady flow of requests for analytical method validation or new impurity profiles gives us constant exposure to evolving requirements in the field. Direct communication with buyers and hands-on problem-solving have shaped how we invest in better filtration, automation, and software tracking. Over several product cycles, we replaced older batch reactors with automated control to cut human error and ensure reproducibility.

    Many buyers used to treat 1-(2-Chlorophenyl)Imidazole as a routine commodity. But over time, failures in downstream synthesis or regulatory audit issues changed their priorities. Material that met generic minimum standards often caused scale-up problems or product recalls. By focusing on customer feedback, we improved our analytical coverage, introduced more frequent operator training, and refined handling protocols.

    Practical Support for Real-World Challenges

    Our responsibility doesn’t end at shipment. In the past, some of the most challenging troubleshooting requests have required joint analysis at the bench, not just suggesting phone advice. When researchers report issues with catalysis or crystallization using our material, our technical team works directly with theirs, running duplicate experiments and sharing root cause analysis.

    Direct experience in resolving problems — from unexpected solid formation during scaling to interference in analytical quantitation — has taught us the value of regular customer check-ins. Many persistent problems get solved not by new products, but by better communication and process adaptation. We share our own experiences, whether they involve seasonal shifts in raw material supply, shipping-related storage changes, or recurrent equipment faults.

    Differences That Count: What Sets Our 1-(2-Chlorophenyl)Imidazole Apart

    As a manufacturer who runs and continuously upgrades the entire production process for 1-(2-Chlorophenyl)Imidazole, we see firsthand the differences that matter: analytical rigor, traceable provenance, operational flexibility, and direct support in solving actual end-use problems. Compared to third-party traders or brokers, our process means buyers know the origin, history, and test results for every kilogram they purchase. Market offerings from generic sources may appear competitive on price, but too often, off-spec impurity profiles, poor documentation, or delayed response to technical queries undermine the value.

    A company looking to advance its pharmaceutical, veterinary, or crop science program using this intermediate benefits from supplier reliability, factual transparency, and real technical support. From the first inquiry through the final delivery, our team stands ready to provide not only the compound but also the working expertise to help research and production teams meet their goals without delay or surprise.

    Building Confidence Through Direct Experience

    In our plant, we treat every batch of 1-(2-Chlorophenyl)Imidazole as more than a product line item. The human effort, experience, and accountability built around its synthesis echo through our customer relationships and technical partnerships. Our chemists and production engineers safeguard process accuracy with each step, knowing the downstream importance for product performance and reputation.

    That’s the real difference for end users: not just a chemical, but a tested commitment to quality, reliable supply, and continuous knowledge sharing. Working directly with the manufacturer, researchers and production engineers gain access to real people solving real challenges — a far cry from the arm’s-length approach of generic suppliers or traders with no production insight.

    The Path Forward

    Continual investment in process, documentation, and customer dialogue strengthens our approach to producing 1-(2-Chlorophenyl)Imidazole. The market will no doubt keep evolving, demanding new purity marks, regulatory alignment, and tighter logistical timelines. Hands-on experience, both in the plant and in collaboration with global partners, shapes each annual upgrade to our methods.

    Direct manufacturing offers more than cost-controlled output; it delivers accountability, problem-solving, and partnership. Buyers who select their source carefully often find that reliability, reproducibility, and clear technical communication make all the difference. Our goal remains clear: deliver 1-(2-Chlorophenyl)Imidazole with a level of practical support and quality assurance that matches and supports the challenges our customers face — every time, for every project.