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1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One

    • Product Name 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One
    • Alias Clonazol
    • Einecs 219-036-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    153038

    Chemical Name 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One
    Cas Number 611-27-2
    Molecular Formula C10H9ClN2O
    Molecular Weight 208.65 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 128-131°C
    Boiling Point Unknown
    Solubility In Water Slightly soluble
    Storage Conditions Store in a cool, dry, and well-ventilated place
    Synonyms Chlorantine; 2-Chloroantipyrine
    Pubchem Id 13175

    As an accredited 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed plastic bottle labeled "1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One, 100g," with hazard warnings, batch number, and manufacturer details.
    Shipping **Shipping Description:** 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One should be shipped in tightly sealed containers, protected from light and moisture. Handle as a potentially hazardous chemical. Use suitable, approved packaging and label appropriately according to local, national, and international regulations. During transport, ensure stability by securing upright and avoiding excessive heat or impact.
    Storage Store **1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One** in a tightly sealed container, protected from light, moisture, and incompatible materials such as strong oxidizing agents. Keep the container in a cool, dry, and well-ventilated area. Ensure all storage conditions comply with safety regulations, and clearly label the container to prevent accidental misuse or exposure.
    Application of 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One

    Applications of 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One in Industrial Manufacturing

    1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One serves as a vital intermediate in specialized organic synthesis. Our direct manufacturing processes have made this compound a key choice for several advanced industrial sectors that require stringent quality and regulatory compliance. The following sections detail major downstream application scenarios based on current industrial demand and regulatory frameworks.

    1. Non-Steroidal Anti-Inflammatory Drug (NSAID) Intermediate Manufacturing

    This compound acts as a building block for several pyrazolone-class NSAIDs. Downstream manufacturers incorporate it in the synthesis of phenylbutazone and related APIs for veterinary and, in select markets, human pharmaceutical use. The identity and purity of the material significantly impact the safety and performance of the final product, requiring robust analytical control at all stages.

    Industry compliance standards

    • EU GMP for Active Pharmaceutical Ingredients (ICH Q7)
    • US FDA 21 CFR Part 210/211
    • Pharmacopoeia Monographs (USP, EP; where applicable for APIs)
    • Good Laboratory Practice (GLP) for analytical procedures

    Typical usage ratio

    • 0.9–1.2 molar equivalents per target API batch, based on reaction stoichiometry and desired yield
    • Adjustment depends on downstream impurity profile control and batch scale

    Downstream process integration

    • Fed directly into pyrazolone ring condensation reactions under controlled, solvent-specific conditions
    • Stagewise addition to limit byproduct formation and enable high-purity isolation

    Final product types

    • Bulk APIs: Phenylbutazone, oxyphenbutazone, related pyrazolone NSAIDs (mainly veterinary formulations)
    • Pharmaceutical intermediates

    2. Analytical Reagent Formulation for Transition Metal Assays

    Industrial laboratories use this molecule to prepare selective chromogenic reagents for complexometric titration and spectrophotometric detection of transition metals, including iron and copper. Its ability to form colored complexes ensures sensitive and specific quantitation, particularly for technical QC and raw material analysis in heavy industry and metal finishing sectors.

    Industry compliance standards

    • ISO/IEC 17025:2017 (Testing and calibration laboratories)
    • ASTM D1068-15 (Iron in water by spectrophotometry)
    • REACH compliance for laboratory reagents
    • Technical documentation to GHS/CLP for safe handling

    Typical usage ratio

    • 0.1–0.3% w/v in aqueous or alcoholic preparation, depending on targeted detection range
    • Ratio adjusted to analyte matrix and required sensitivity

    Downstream process integration

    • Dissolution in buffer solutions for reagent preparation
    • Modular dosing in automated chemical analyzers

    Final product types

    • Analytical reagent kits
    • Chromogenic solutions for transition metal detection
    • Pre-packed titration kits for process laboratories

    3. Colorant Intermediate in Specialty Dye Synthesis

    Manufacturers in the specialty dye industry incorporate this compound as a core intermediate for synthesizing pyrazolone-based azo dyes. It determines the spectral characteristics, fastness, and solubility of the final colorants, which are applied in technical textiles and industrial coatings. Process control here focuses on reactivity and impurity minimization.

    Industry compliance standards

    • Oeko-Tex Standard 100 for textile chemicals (dye segment only)
    • ZDHC MRSL (Manufacturing Restricted Substances List) conformance
    • EU REACH Annex XVII (restricted substances in dyes)
    • ISO 9001:2015 QMS for dye production

    Typical usage ratio

    • 1.0 mole per mole of diazonium salt in azo coupling
    • Modification possible based on color depth and application substrate

    Downstream process integration

    • Introduced in the azo coupling stage, typically following diazotization under controlled pH and temperature conditions
    • Subsequent purification by crystallization and filtration to ensure dye grade quality

    Final product types

    • Water-soluble azo dyes for cellulose fibers
    • Disperse dyes for synthetic polymers
    • Technical colorants for industrial coatings

    4. Photographic Chemical Intermediate for Silver Halide Emulsions

    Downstream producers of photographic materials use this molecule as a reducing agent during the preparation of silver halide emulsions, which require precise chemical properties to achieve desired grain structure and sensitivity. Consistent batch purity directly impacts emulsion performance in both imaging and industrial X-ray films.

    Industry compliance standards

    • ISO 18911:2010 (Imaging materials — Processed photographic films — Storage practices)
    • GHS for chemical hazard labeling
    • In-house QC standards for photographic industry supply

    Typical usage ratio

    • 0.05–0.12% by mass relative to the total emulsion batch
    • Adjusted by emulsion type and targeted optical density

    Downstream process integration

    • Introduced in aqueous phase during fine division of silver halide crystals
    • Timing and concentration impact crystal morphology and light sensitivity

    Final product types

    • Silver halide photo films (industrial and medical imaging)
    • Technical print and plate manufacturing chemicals

    5. Agrochemical Active Ingredient Synthesis

    Chemical process plants formulate this compound as a key intermediate for the synthesis of pyrazolone-based herbicides and fungicides. The material’s structure modulates both activity spectrum and environmental fate, making impurity control and traceability a critical aspect for downstream users serving the regulated crop protection market.

    Industry compliance standards

    • FAO/WHO Technical Guidelines for Pesticide Specifications
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • ISO 17034 Reference Material Producer accreditation (for impurity standards)
    • GLP for development and batch scale-up

    Typical usage ratio

    • 0.95–1.05 molar equivalents in herbicide or fungicide synthesis steps
    • Correction factor used based on impurity profile of incoming lots

    Downstream process integration

    • Initial condensation reactions in multi-step synthesis of final agrochemical actives
    • Automated dosing and in-line monitoring in continuous reactors

    Final product types

    • Selective pyrazolone herbicides
    • Pyrazolone-based systemic fungicides
    • Intermediates for further agrochemical derivatization
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    Certification & Compliance
    More Introduction

    Introducing 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One: Our Perspective as the Manufacturer

    Building Quality from Raw Ingredients

    Producing 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one starts long before any reaction takes place in the plant. We watch costs and purity from the moment the chlorinated aniline shows up at our warehouse. Quality slips quickly in this piece of chemistry; we can spot off-spec shipments through smell and color alone. Fresh drums matter. Over the years, trial and error taught us that rigorous incoming inspection saves headaches during synthesis and downstream purifications. We screen every lot with in-house chromatography and keep records that stretch back years. Chemists blend hands-on experience with protocols built directly from our plant’s reality. Each drum is more than just a number in a system; it’s the foundation for a consistent product batch.

    Our Synthesis: Batch Control Is Personal

    We run glass-lined reactors and stainless vessels, rarely trusting any process automation without old-fashioned, eyes-on checks. Safety is not negotiable. Chlorinated organics can build unexpected pressure, so tight control over temperature and agitation pays dividends. Each batch shows its own personality, depending on the season, so we keep logs and learn from every deviation. Some days the reaction foams differently, on others the color in the process window signals a minor impurity. Our team learned to read those tells. We don’t push batches to maximum theoretical yield—cutting corners just increases rework, which hurts everyone. We train new technicians to spot issues before they become full-blown process upsets. Protecting yield with skill keeps both margins and safety intact.

    Purification That Matches Demanding Markets

    Clients—across pharmaceutical, fine chemical, and research sectors—expect sharp specifications. We filter and dry the crude, but invest in extra, polish-level crystallization cycles. Residual solvents and trace byproducts matter; the final appearance and purity directly affect downstream applications. Recrystallized product stays stable longer, so we keep control on water content and package under an inert blanket. Some customers call for even tighter impurity profiles, usually for medicinal chemistry or advanced research. For them, we deploy low-temperature chromatography steps, give certificates stating actual chromatograms, and maintain records to trace any deviation, batch by batch. The goal is trust built on facts, not marketing claims.

    Specifications and Consistency in Our Product

    The common standard for 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one calls for a purity level above 98%, usually determined by GC or HPLC. We can push higher when the market wants it, though such batches take more time. Moisture, color, melting point, all track alongside the main assay. We receive frequent feedback from long-term buyers about improvements desired or problems seen—sometimes something as subtle as a different crystal habit will raise flags in certain end-use formulations. Over time, we have narrowed down the specs and set up a real feedback loop with industrial and research partners. This approach makes for fewer surprises, both for us and our clients.

    Understanding Applications: Real Uses, Real Demands

    The backbone structure—a chlorinated phenyl group fused with a pyrazolone ring—puts this compound in the crosshairs of several key industries. Researchers use it as an active building block for pharmaceuticals, especially where aromatic substitution can lead to sharper biological activity. Some plant health companies sought it as an intermediate for new crop protection agents. In materials research, chemists test it for developing new chelating agents or light-sensitive systems. Sometimes, customers from new markets appear with a fresh application, requiring us to dig back into raw data and reconsider our process parameters.

    Each application brings a distinct quality demand. Medicinal chemists, in particular, ask about residual solvents, small contaminant molecules, and batch-to-batch reproducibility. They want confidence that a few grams purchased today will mirror what arrives in a bigger order next quarter. Crop science clients focus on physical form, since blending behavior matters in bulk production. It’s not just about molecular purity; handling and consistency factor into their choices.

    Comparisons and Key Differences from Related Materials

    Buyers frequently compare this molecule to other pyrazolone-based chemicals and substituted phenyl derivatives. We’ve made several. Small changes—like swapping a chlorophenyl for a methylphenyl, or moving substitution from ortho to para—shift physical and chemical properties in complex ways. Our experience shows that the ortho-chloro group increases the melting point and slightly decreases solubility in most organic solvents compared to non-chlorinated analogs. Downstream, this means easier filtration and drying, but slightly more careful dissolution work in formulation labs.

    Some buyers try to swap for simpler analogues, drawn by price, only to find that trace stability issues or byproduct formation creep into sensitive pharmaceutical work. The chlorine atom in the ortho position shows up as a benefit in certain catalytic or chelation reactions, allowing a different reaction pathway due to electronic effects. For materials chemists, these nuances can make or break a synthesis plan. Our team stands ready to troubleshoot side-by-side with these partners, piecing through spectral data and process logs until challenges get solved.

    Quality Assurance as Part of Culture

    We do not treat the quality program as an afterthought tacked onto manufacturing. Regular cross-training ensures the entire crew, from floor staff up to management, can set up, observe, and adjust key process steps. Twice a month, the morning meeting runs longer, as new findings and tricky case studies get dissected. This helps all of us keep focused, not just on specs, but on the practical realities that customers report back to us. Records help, but nothing replaces direct troubleshooting—a call with a senior chemist from the client’s team often unravels manufacturing puzzles better than any spreadsheet or report. QA and process development blend into one another naturally.

    Handling, Storage, and Packaging Based on Practical Results

    Through the years, trial shipments taught us much about how 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one behaves in the real world. Early on, we fought issues with clumping in humid conditions, and we learned fast that packaging in lined fiber drums or laminated bags, nitrogen-flushed, made a difference in shelf life. It was tempting to cut corners, but complaints pushed us to test fresh packaging methods—desiccant packs, vacuum sealing, moisture-indicator strips. The effort paid off as returns and customer calls dropped. In bulk shipments, the material can show caking after long sea freights if not handled with care. Our warehouse staff closely monitors incoming and outgoing climate, logs all anomalies, and work with downstream handlers to keep things moving smoothly.

    Logistics and Custom Orders: Meeting Diverse Demands

    No two orders run the same. Some clients require kilogram jars for rapid R&D work, while others need multi-ton deliveries for industrial-scale synthesis. Flexibility is part of our DNA. We break production runs into sub-batches for smaller shipments, securing traceability without compromising quality. For larger industrial partners, we co-develop custom blends or particle sizes, maintaining baseline specs but adjusting physical form for ease of use. Custom labeling, documentation, and regulatory support—everything gets reviewed before the shipment leaves our gates.

    International regulations shift constantly. We keep current by direct reading of official documents and by feedback from partners. We do not lean on third-party updates alone. Sometimes regulations demand minor formula changes or extra testing, often at short notice. Our team discusses these openly and takes pride in rapid adaptation. Customers notice and often come back with future business because they value a responsive partner, not just a faceless product provider.

    Environmental Responsibility Lessons

    Every chemical business faces growing scrutiny about environmental impact. Years ago, solvent recovery and waste handling were something extra to report at year-end. Now, regulators and clients alike focus on solvent selection, energy use, and emissions—right down to trace VOCs. In making 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one, we moved to higher-recovery distillation and swapped out some classical solvents for more eco-friendly substitutes, even if that pushed costs up temporarily. Our waste management process grew: we separate aqueous process streams and reuse some organic solvents, shrinking our landfill burden. None of this was free or simple, but it reflects our conviction that long-term trust also hinges on transparent environmental standards.

    More than a few clients send sustainability surveys or extra documentation requests. We answer them, discussing both achievements and limitations frankly. By collaborating, we find practical paths to minimize waste without risking safety or performance.

    Investing in Knowledge and Future Readiness

    Chemistry doesn’t stand still. Customer needs shift with new science, new regulations, and novel discovery cycles. Our R&D group runs from senior chemists with decades in organic synthesis to young team members hungry to innovate. They test alternate routes, greener platforms, and process intensification. Some methods run better at scale; others do not. Experimentation let us adjust synthesis windows and try new catalysts to trim cycle times. All progress traces back to active listening—attending symposia, joining industry groups, sitting in on process audits. The shop floor stays close to the lab, and both stay close to our clients.

    Through years of turbulent raw material markets and growing customer scrutiny, we have learned that openness and adaptability turn mishaps into learning experiences. Our notes from failed batches shape the next process review; our daily plant logs feed directly into problem-solving. No one works in isolation—outcomes matter for everyone, from the technician scraping the last crystals from a centrifuge to the procurement manager budgeting the next raw material cycle.

    The Real-World Value of 1-(2-Chlorophenyl)-3-Methyl-2-Pyrazolin-5-One

    End users consistently report the practical benefits of our approach. Medicinal chemists say they can run compact, reliable syntheses as this compound delivers predictable reactivity and physical stability. Materials chemists appreciate strict control on particle size: the compound flows well, blends smoothly, and minimizes dust losses in their processes. Commercial teams value consistent shipment schedules, clear documentation, and a lack of costly surprises. To us, this feedback isn’t just data—it closes the loop between what leaves our factory and what creates value in customers’ labs and workshops.

    Compared to related pyrazolone-based compounds, users have told us this one stands out for its straightforward purification and broad compatibility with standard organic protocols. Certain structural analogues, especially those with different halogen substitutions or none at all, often require longer purification or produce problematic byproducts in downstream chemistry. Our product’s stability, melt profile, and solubility line up with published data, and we make sure each customer gets technical support backed by both documentation and lived experience. We do not rely on a faceless certificate of analysis when a direct conversation clears up questions faster.

    Listening and Responding Builds Longevity

    One lesson from operating a manufacturing site is clear: no matter how experienced your team or advanced your equipment, customer trust can’t be commanded. It grows from transparency, ongoing communication, and a willingness to solve problems. In specialty compounds like 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one, minor process tweaks can impact downstream results, so we keep channels open for feedback and troubleshooting. We run “post-mortems” after significant events or complaints, adjusting procedures and training accordingly.

    New industry standards and best practices flow back into our process development. Regulatory shifts sometimes feel relentless, but each provides another opportunity to improve and differentiate. Over time, this culture has attracted new talent, widened our network of partners, and deepened the shop floor’s pride in knowing their work matters beyond the gate.

    Looking Ahead

    Markets for specialty building blocks like 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one change quickly, led by innovation in pharmaceuticals, crop science, and materials fields. We commit to keeping pace, whether by updating processes, investing in greener alternatives, or tightening every spec that matters. We have learned that each shipment carries more than product: it carries our reputation, and the collective diligence of our team shows in every gram. Our ongoing investments—both in technology and in people—continue to drive improvements that matter for end-users and partners alike.

    To us, the best measure of success remains the relationships we develop, batch after batch. Feedback drives our process, shared learning fuels progress, and our door stays open to new ideas and hard-earned wisdom from all those who trust our 1-(2-Chlorophenyl)-3-methyl-2-pyrazolin-5-one as a building block in their own discoveries.