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1-(2-Chlorophenyl)-2-Nitroethylene

    • Product Name 1-(2-Chlorophenyl)-2-Nitroethylene
    • Alias β-Nitrostyrene
    • Einecs 401-090-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    475551

    Chemical Name 1-(2-Chlorophenyl)-2-nitroethylene
    Molecular Formula C8H6ClNO2
    Cas Number 63921-08-0
    Appearance Yellow to orange crystalline solid
    Melting Point 86-89°C
    Solubility Slightly soluble in organic solvents
    Density Approx. 1.34 g/cm3
    Smiles C1=CC=C(C(=C1)Cl)C=CN(=O)=O
    Synonyms 2-Chlorobenzalnitroethylene
    Iupac Name 1-(2-chlorophenyl)-2-nitroethene

    As an accredited 1-(2-Chlorophenyl)-2-Nitroethylene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 1-(2-Chlorophenyl)-2-Nitroethylene, sealed with a screw cap and labeled with hazard warnings.
    Shipping 1-(2-Chlorophenyl)-2-Nitroethylene must be shipped in accordance with relevant chemical transport regulations. Package securely in airtight, chemically resistant containers. Label clearly as a hazardous material. Use secondary containment to prevent leaks, and include appropriate documentation. Ship at ambient temperature unless otherwise specified in the safety data sheet (SDS). Avoid exposure to heat or direct sunlight.
    Storage 1-(2-Chlorophenyl)-2-nitroethylene should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible materials such as strong oxidizers and bases. Keep the container clearly labeled and protected from physical damage. Store under inert atmosphere if needed, and avoid exposure to moisture, heat, and sources of ignition.
    Application of 1-(2-Chlorophenyl)-2-Nitroethylene

    Applications of 1-(2-Chlorophenyl)-2-Nitroethylene in Industrial Manufacturing

    As a direct manufacturer of 1-(2-Chlorophenyl)-2-Nitroethylene, we supply this intermediate to multiple high-value industrial sectors. Each downstream application utilizes specific compliance, process routing, and quality controls to ensure performance in end-use products. The following sections detail key application scenarios based on real industrial consumption and regulatory practice.

    1. Synthesis of Pharmaceutical Intermediates for Anti-Infective Drug Production

    This nitroethylene compound acts as a strategic building block in the synthesis of chloro-substituted phenyl compounds, critical in anti-infective drug active pharmaceutical ingredient (API) assembly. Direct acylation, selective reduction, or further functionalization steps require precise batch control and analytical verification. Manufacturers utilize its reactivity in constructing core scaffolds for nitroaromatic pharmaceuticals, with controlled purity ensuring minimal by-products and side-reactions.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP), ICH Q7 (APIs)
    • European Pharmacopoeia Monographs (for related intermediates)
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals)
    • REACH (EC No 1907/2006), Registration for use in pharmaceutical synthesis

    Typical usage ratio

    • 0.8–1.3 mole equivalent relative to target precursor
    • Specific charge determined by target step yield and impurity thresholds

    Downstream process integration

    • Charged in the primary reaction vessel during condensation with amines or other nucleophiles
    • Participates as an electrophile in regioselective C–C or C–N coupling reactions
    • Purification via recrystallization or chromatography in intermediate isolation

    Final product types

    • Nitro-aryl active pharmaceutical ingredients for anti-infectives
    • Protected phenylamine pharmaceutical intermediates
    • Specialty medicinal building blocks for contract development

    2. Agrochemical Intermediate in Selective Herbicide Synthesis

    Chlorinated nitroethylene raw material is incorporated by agrochemical producers as a core intermediate for constructing certain selective herbicides. Its electron-withdrawing profile supports ortho-directing transformations. Process engineers dose this compound in controlled reaction stages—often in the presence of strong bases and condensation agents—to maximize conversion of the target agrochemical backbone. Compliance with agricultural chemical registration drives trace impurity scrutiny.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (FAO/WHO)
    • ISO 9001:2015 (Chemical Quality Management for Pesticide Synthesis)
    • China ICAMA agrochemical registration (when applicable)
    • EPA 40 CFR Part 158 (Data Requirements for Pesticides)

    Typical usage ratio

    • 2–5% w/w based on finished product batch mass
    • Level optimized per allowed residue limit and yield

    Downstream process integration

    • Added during early condensation or cyclization to build heterocyclic herbicide motifs
    • Subjected to controlled reduction, halogenation, or alkylation depending on product design
    • Subsequent work-up to remove excess starting material trace

    Final product types

    • Pre-emergent or post-emergent phenyl-based herbicides
    • Special crop-safe agrochemical APIs
    • Custom plant growth regulators with nitroaromatic cores

    3. Colorant Intermediate for Specialty Dye Manufacturing

    Producers of high-performance dyes incorporate this material as an activated precursor in azo and arylazo pigment synthesis. It reacts under basic or reductive conditions to yield intense, color-stable chromophores. Batch protocols require careful monitoring of pH, reactant order, and temperature to achieve desired pigment properties. Regulatory oversight governs the handling and trace analysis of nitro-organic dye intermediates across global pigment markets.

    Industry compliance standards

    • REACH (EC No 1907/2006), Registration for use in pigment/dye production
    • OEKO-TEX® Standard 100 (Textile Dye Safety)
    • EN 71-3 (Toy Safety – Migration of Certain Elements for pigments)
    • TSCA Inventory Compliance (USA), for dye intermediate supply chain

    Typical usage ratio

    • 3–8% w/w of total pigment precursor charge
    • Adjusted to color intensity, bath shade, and application format

    Downstream process integration

    • Dosed in controlled diazotization reactions or as coupling partners for azo pigment synthesis
    • Subsequent crystallization, filtration, and drying conducted for pigment isolation
    • Blend with stabilizers or extenders before packaging

    Final product types

    • High-fastness orange, red, and brown dyes for textile coloration
    • Specialty printing inks with enhanced solvent resistance
    • Azo pigment concentrates for plastics and coatings

    4. Intermediate for Electronic Chemical Synthesis

    Manufacturers of specialty chemicals for microelectronics use this compound to construct nitro-functionalized aryl intermediates, which play a role in dielectric material and specialty resin synthesis. Downstream processing involves controlled reduction and substitution to modulate electronic properties. Strict contamination controls and batch traceability allow compliance with sector-specific reliability and purity standards.

    Industry compliance standards

    • JEITA Guidelines for Electronic Chemical Purity (Japan Electronics and Information Technology Industries Association)
    • IEC 62474 Material Declaration for custom electronic materials
    • RoHS 2 (2011/65/EU) – Restriction of Hazardous Substances
    • SEMATECH Chemical Quality Standards – Microelectronics manufacturing

    Typical usage ratio

    • 0.2–1.0% w/w per resin or dielectric precursor batch
    • Adjusted to final product purity and electrical performance criteria

    Downstream process integration

    • Added as a functional group donor in controlled addition steps for aryl nitro compound synthesis
    • Processed via hydrogenation or nucleophilic substitution as required by the dielectric design
    • Isolation and quality testing before inclusion in electronic grade resin

    Final product types

    • Dielectric materials for printed circuit boards
    • Electron-transport intermediates for OLED and display manufacturing
    • Custom electronic grade resins and bonding agents
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    Certification & Compliance
    More Introduction

    1-(2-Chlorophenyl)-2-Nitroethylene: Stepping Forward with Reliable Performance

    Building Experience into Every Batch

    In our daily work at the plant, attention to the fine details shapes every kilogram of 1-(2-Chlorophenyl)-2-Nitroethylene that leaves the reactor. Drawing from hands-on experience, each run brings subtle improvements. Even something as ordinary as the way reactants are introduced—or the precise control of temperature in crystallization—can make a difference in the final material. This compound has become a staple for those who need predictable reactivity and a clean profile in subsequent synthesis steps.

    The Role of 1-(2-Chlorophenyl)-2-Nitroethylene

    We’ve watched demand for this nitroalkene rise mostly from folks working in the field of fine chemicals and for those who need a solid starting point for building more complex molecules. Its core structure—the nitroethylene group sitting next to a chlorinated phenyl ring—offers a unique reactivity not always matched by other nitroethylenes. Whether involved in pharmaceutical research or advanced materials development, chemists have continually flagged its usefulness at the bench and in pilot studies. Ask those who run actual reactions, and it’s the compound’s reliability that comes up time after time. Each bottle reflects real effort spent refining both process and quality assurance.

    From Sourcing to Shipping: Our Path

    Raw material selection sets the foundation. Years of sourcing have taught us to build strong relationships with primary producers—no shortcuts, no oddball brokers. As product flows through our facility, it’s a blend of skilled hands and strong process controls that gets you a consistently bright, crystalline powder—free-flowing and true to form. We noticed early on that trace byproducts from marginal purification techniques often show up later on as stubborn impurities in downstream work. Strict wash protocols and well-maintained equipment have proven their worth batch after batch, reducing these headaches for our users.

    Specifications and Process Notes

    Chemists working with 1-(2-Chlorophenyl)-2-Nitroethylene seek clear, trustworthy information about what goes into the package. We keep carbon content and residual solvents tightly in check. A melting point in the expected narrow range signals proper crystallization and absence of co-crystal formation. Packing lots come with full certificates, but our QA staff vigilantly tests for any sign of decomposition or color change before release. Nobody wants an unexpected spot on their TLC plates or ghost peaks in their NMR spectra. Call it pride or simple practicality, but that attention has paid long-term dividends in customer trust.

    How 1-(2-Chlorophenyl)-2-Nitroethylene Gets Used

    In synthesis labs, this building block often gets chosen for its ease of integration into condensation reactions. The nitro group activates the adjacent double bond, making it desirable for advanced coupling and transformation steps. We hear repeated praise from R&D teams in pharma for its clean conversions and low noise in analytical readings. Others in specialty pigment work use it for its unique reactivity, achieving hues and properties not found with alternative nitro alkenes. For those producing intermediates that move further up the complexity scale, trust in the starting material matters—a single out-of-spec lot can derail weeks of planning.

    We’ve also watched labs leverage its structure for synthesis of heterocyclic systems, especially where a phenyl ring bearing both a nitro and chloro group brings selectivity in ring formation. Academic groups sometimes write to share their successes and even an occasional mishap—a mis-weighed batch, a sticky filtration step—reminding us that real-world chemistry stays unpredictable no matter how tight our specs run.

    What Sets This Product Apart

    Not all nitroethylenes behave the same in reaction flasks. Through side-by-side testing over the years, our teams have tracked how minor impurities or even crystal habit affect downstream chemistry. Some alternatives from other production lines carry a faint odor or show slight yellowing—often a sign of incomplete purification. That translates directly to yield losses for those needing crisp, colorless end-products.

    Thermal stability in our batches remains one of the silent benefits, especially in larger synthesis runs with scale-up pressures. We’ve worked through enough scale translation headaches—heat transfer, mixing, isolation bottlenecks—to know that a more robust material saves time and rework. And while other sources might shave hours from a purification step, our repeat customers tend to prefer reproducibility over speed.

    It’s the real-time reports from user labs that keep us honest: fewest clogs in filtration; no weird residues in reflux set-ups; and, most personally satisfying, reorders from teams who say the material just behaves better in their hands. Direct feedback shapes what we do—from updating packing materials that reduce static cling in dry rooms, to altering particle size distribution for easier weighing in micro-scale prep.

    Handling and Storage: Common-Sense Protocols

    Seasoned chemists value straightforward, reliable handling. Working with 1-(2-Chlorophenyl)-2-Nitroethylene requires care similar to other nitro compounds—keep it dry, shielded from direct light, and at ambient temperature when not in use. Through practice, we’ve learned that vacuum sealing and robust containers protect against moisture pickup, which can promote degradation. Many of our longtime customers have kept drums intact for extended periods using our upgraded closure systems. Large-scale users often ask us about shelf life; the answer is simple: clean chemistry at the outset extends storage, and we build formulations with this principle top of mind.

    Why Consistency Matters

    Walking the production floor brings a constant reminder of why details like homogeneity, color, and texture matter to downstream users. Every step, from monitoring reactants to controlling filter pressure, shapes the finished lot’s quality. Working closely with technical partners, we test each run for both gross and trace contaminants that may affect reactivity. Chemists will notice the difference: lower side-product formation and fewer purification headaches.

    Living up to expectations doesn’t come from luck. It flows from feedback—phone calls about a slow dissolution, notes about an unplanned precipitate, questions from scale-up teams curious about batch-to-batch performance. Each message prompts review and sometimes minor adjustments, reinforcing our focus on steady, dependable output.

    Comparing Against Alternatives

    Chemists have choices, but they come back to 1-(2-Chlorophenyl)-2-Nitroethylene for good reasons. Similar compounds either lack the same balance of electrophilicity and stability, or they introduce impurities that show up in test runs. We have run comparison syntheses using various chlorinated nitroethylenes from different sources. Often, yield differences matter less than reproducibility—some alternatives behave unpredictably once you scale up past a few grams. Unanticipated byproducts add layers to downstream purification, and time gets wasted troubleshooting spots that were never supposed to appear.

    Some buyers look for generic or off-spec versions seeking short-term gains, only to circle back after seeing drop-offs in process reliability. Over nearly two decades of production, our best customers have gravitated to higher-value work, leveraging the material’s cleanliness and ease of workup to hit tighter specs and avoid project overruns. In-house, we maintain a steady dialogue with production chemists, always learning about quirks and preferences in different processes, so we can fine-tune batch characteristics.

    Troubleshooting and Continuous Improvement

    Nobody pretends complex syntheses run perfectly every time. Real chemistry involves hot plates running late, glassware clattering, and at times a dose of luck. We’ve seen the pitfalls that come from marginal intermediates—including our own, before we tightened up earlier steps. These hard lessons prompted deeper dives into kinetics, solvent effects, and impurity mapping. In turn, these insights led us to fix bottlenecks, train staff more thoroughly, and put clear lines of communication between lab and plant.

    On occasion, a customer points out an unexpected sulfur trace or out-of-range analytic. These pointers shape process adjustments, and sometimes trigger supplier reviews. Over time, we’ve developed checklists customized for each end-use: pigment work gets slightly different drying conditions than fine pharma intermediates. What we learn in one area often pays off unexpectedly elsewhere—across the board, a tighter process equals fewer headaches for the next chemist.

    Investing in Quality

    Quality doesn’t surface spontaneously. From screening raw materials for residual metals to verifying batch uniformity, diligence at every stage supports a clean, reliable product. We regularly run our lots through stress testing—thermal cycling, accelerated aging studies, exposure to common solvents—to pinpoint vulnerabilities before they can cause trouble during our customers’ work. Researchers know which suppliers cut corners; returns and complaints elsewhere are a steady reminder of the costs saved by not resetting crystallization or re-polishing a drum.

    Responsibility and Compliance in Every Shipment

    Product stewardship stays central to our operation. Regulatory and safety documentation comes baked-in, not tacked on after release. Each year brings fresh reviews of local and global requirements, and we’ve built a library of supporting paperwork—down to environmental and transport declarations—so chemists and logistics teams stay a step ahead. Research teams appreciate answers they can trust about handling, storage, and disposal, shaped by our own years of direct, hands-on practice with the compound.

    As regulations shift and customer projects change, we adapt our plant protocols to match. Regular review cycles check that process controls, training modules, and lab documentation pass both internal standards and outside audits. In many instances, a delayed project or shipment comes down to a missing certificate or incomplete form; our approach reduces that risk for our customers.

    Feedback-Driven Development

    Nothing replaces experience in refining a chemical process, and the best improvements always trace back to open ears and quick follow-up. After working with a pharmaceutical company that struggled with microscale filtering due to static, our team trialed and ultimately redesigned the packaging in cooperation with their bench scientists. Another long-term partner in the colorant industry triggered an upgrade in our drying cycle, based on their own moisture analysis. Improvements go out to all customers, not just the one who spoke up—the benefits ripple outward.

    Fielding technical questions has been a constant motivator to keep learning. Chemists call about process changes, impurity tracking, or even obscure failure modes. As a manufacturing team, responding to these queries keeps us sharp. If a new use case or regulatory hurdle emerges, our staff channels these lessons into updated production SOPs and training for the line team.

    Supporting Innovation and Sustainability

    As chemistry evolves, so must the way we manufacture building blocks like 1-(2-Chlorophenyl)-2-Nitroethylene. Routine conversations with customers exploring next-generation pharmaceuticals, specialty coatings, or advanced functional materials keep us alert to future needs. That means routine investments in waste minimization, raw material efficiency, and energy conservation. In every shipment, there’s a balance—supporting researchers, hitting technical targets, and cutting down environmental footprint. Whenever bulk users approach us with new specifications, the answer usually draws on experiments or improvements already underway.

    Our Mantra: Value in the Details

    Every kilogram counts. Years of supplying 1-(2-Chlorophenyl)-2-Nitroethylene taught us not to underestimate the impact of process details or customer habits. Transparency, listening, and technical honesty keep us correcting, learning, and delivering a building block that holds up to the realities of benchwork, scale-up, and manufacturing. Chemists depend on suppliers who pay attention, and we measure our value by the trust earned, one run, one batch, one experiment at a time.