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1-(2-Chloroethyl)-Pyrrolidine

    • Product Name 1-(2-Chloroethyl)-Pyrrolidine
    • Alias 1-Pyrrolidineethanol, 2-chloro-
    • Einecs 208-880-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    260262

    Chemical Name 1-(2-Chloroethyl)-Pyrrolidine
    Molecular Formula C6H12ClN
    Molecular Weight 133.62 g/mol
    Cas Number 4499-86-9
    Appearance Colorless to pale yellow liquid
    Boiling Point 72-73°C at 18 mmHg
    Density 1.033 g/mL at 25°C
    Refractive Index n20/D 1.475
    Solubility Soluble in organic solvents
    Purity Typically ≥98%
    Flash Point 87°C
    Storage Conditions Store at 2-8°C, tightly closed

    As an accredited 1-(2-Chloroethyl)-Pyrrolidine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 250 mL amber glass bottle with a secure screw cap, labeled "1-(2-Chloroethyl)-Pyrrolidine," complete with hazard symbols.
    Shipping 1-(2-Chloroethyl)-Pyrrolidine should be shipped in tightly sealed containers, clearly labeled, and packaged to prevent leaks. Transport must comply with local and international hazardous material regulations, avoiding heat, moisture, and incompatible substances. Use appropriate cushioning and secondary containment to avoid spills during transit. Ensure all shipping documents and safety data accompany the shipment.
    Storage 1-(2-Chloroethyl)-Pyrrolidine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and acids. Keep it away from direct sunlight and sources of ignition. Store at room temperature and ensure proper labelling. Use chemical fume hoods when handling, and restrict access to authorized personnel only.
    Application of 1-(2-Chloroethyl)-Pyrrolidine

    Applications of 1-(2-Chloroethyl)-Pyrrolidine in Industrial Manufacturing

    1-(2-Chloroethyl)-Pyrrolidine serves as a critical intermediate for specialized synthesis in the fine chemicals sector. As a direct manufacturer, we supply this key raw material to partners in multiple industrial domains requiring established compliance, accurate formulation ratios, defined integration points, and strict end-product quality management.

    1. Synthesis of Active Pharmaceutical Ingredients (API) for Antineoplastic Agents

    Pharmaceutical companies utilize this compound during the synthesis of nitrogen mustard derivatives, which form the backbone of specific antineoplastic drugs. The chloroethyl functional group plays an essential role during alkylation steps in controlled cGMP environments, directly interacting with complex core structures for the generation of targeted onco-therapeutics. Process engineers must account for reactivity, byproduct minimization, and traceability in API manufacturing lines.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • 21 CFR Parts 210/211 (US FDA)
    • EU EudraLex Volume 4 (EU GMP Guidelines)
    • Chinese Pharmacopoeia (for local registration projects)

    Typical usage ratio

    • Calculated on a molar equivalence basis (1:1–1.3:1 with targeted core structures) dependent on batch scale, substrate reactivity, and impurity control strategies.

    Downstream process integration

    • Added during key alkylation or substitution reactions following the initial formation of the heterocyclic API precursor in solvent-controlled reaction vessels under inert gas.

    Final product types

    • Oncological APIs (nitrogen mustard derivatives such as mechlorethamine base)
    • Sterile injectable drug substances
    • Finished dose antitumor medications (tablets, vials)
    • Clinical trial grade cytostatics

    2. Production of Specialty Agricultural Chemicals (Plant Growth Regulators)

    Manufacturers of regulated crop protection and growth stimulation products deploy 1-(2-Chloroethyl)-Pyrrolidine as a structural component for certain plant growth regulators and herbicide intermediates. The chemical supports synthesis work in pilot and industrial settings to achieve consistent agrochemical grade output with attention to application selectivity and field safety data.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications
    • ISO 9001:2015 for quality management
    • OECD Guidelines for the Testing of Chemicals
    • REACH regulation for use in the EU market

    Typical usage ratio

    • 0.5–2.5 equivalents relative to backbone substrate, with scale fine-tuned following GC/HPLC analysis of target conversion and minimization of residuals.

    Downstream process integration

    • Charged into reaction mixtures at the controlled temperature phase, before catalyst addition, supporting step-growth synthesis and subsequent purification by distillation or crystallization as dictated by plant batch protocol.

    Final product types

    • Plant growth retardants
    • Specific herbicidal intermediates (for further downstream chlorination or cyclization)
    • Formulated liquids and emulsifiable concentrates (ECs)
    • Marketed agricultural solutions for cereals, oilseeds, and turf

    3. Synthesis of Advanced Polymer Modifiers

    Specialty material producers rely on this pyrrolidine compound as an alkylating agent or comonomer during the development of high-performance polymer modifiers with tailored pendant groups. These modifiers enhance flexibility, crosslinking, or processability when blended with polyolefins, PVC, or engineering plastics. Product managers must maintain strict traceability of input ratio and monitor downstream extrusion or polymerization compatibility.

    Industry compliance standards

    • RoHS Directive (2011/65/EU) for restricted substances in plastics
    • ISO 14001 for environmental management systems
    • GHS/CLP regulations regarding labeling and safe handling
    • ASTM D256 and D638 for physical property testing

    Typical usage ratio

    • 0.3%–1.2% by weight of total monomer content, fine-tuned depending on glass transition temperature (Tg) targets and polymer chain length specifications.

    Downstream process integration

    • Dosed to pre-polymerization reactors or in reactive extrusion lines during functionalization of base polymers for enhanced mechanical or thermal property applications.

    Final product types

    • Impact-resistant polymer modifiers
    • Surface-active resin additives
    • Wire and cable compounding ingredients
    • Engineering plastic masterbatches

    4. Development of Advanced Chemical Reagents for Research

    Specialty reagent producers incorporate this molecule into the synthesis of advanced laboratory reagents, focusing particularly on its suitability for alkylation reactions, chemical labeling, or as an intermediate for combinatorial chemistry. R&D and QC labs must guarantee purity, lot traceability, and formulation repeatability to satisfy academic and pharmaceutical discovery workflows.

    Industry compliance standards

    • ISO 9001:2015 for quality control of reagents
    • Applicable OECD Good Laboratory Practice (GLP)
    • Sigma-Aldrich and Merck Research Reagent specifications
    • Custom packaging compliance as per DOT/IATA for hazardous chemicals

    Typical usage ratio

    • As needed for the target reagent synthesis: usually 1–2 molar equivalents, determined by reaction stoichiometry and required end-use purity (e.g., 98%–99.5%).

    Downstream process integration

    • Used during the preparation of labeled reference standards, chemical derivatization for bioassays, and as a link building block in solid-phase synthesis platforms.

    Final product types

    • Certified reference reagents for analytical and pharmaceutical labs
    • Labeling and derivatization agents
    • Rare heterocyclic intermediates for medicinal chemistry
    • High-purity custom research chemicals
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    Certification & Compliance
    More Introduction

    Introducing 1-(2-Chloroethyl)-Pyrrolidine: Experience from the Production Floor

    Realities Behind Sourcing and Manufacturing 1-(2-Chloroethyl)-Pyrrolidine

    Every time a buyer requests 1-(2-Chloroethyl)-Pyrrolidine, our minds go straight to the chemical bench, the rows of glassware, the hiss of nitrogen, and the careful loading of reactants. Hungry markets are always on the lookout for high-purity intermediates, but few have a sense of the steps, details, and small victories we notch every time we produce a consistent batch. Our plant sleeps little. To us, this product isn’t just a tag on a datasheet; it’s a milestone each time we bring a run to spec and see that analyzers confirm what we’ve been working toward.

    Let’s talk through this chemical’s creation, what sets it apart from the alternatives, and why our teams have invested heavily in refining its profile to match tough industry standards. We don’t look at this as a commodity; it’s the result of deliberate process design, seasoned hands, and keeping our eyes close on market feedback.

    Details from Experience: Standard and Technical Marks

    We produce 1-(2-Chloroethyl)-Pyrrolidine with a minimum purity exceeding 99 percent, with strict controls at every stage. From initial choice of pyrrolidine feedstock to precise chlorination processes, we track every variable. Analytical chemists test not just for the major assay component but for minute traces of related byproducts, such as unreacted pyrrolidine, 2-chloroethanol, and N,N-dichloropyrrolidinium byproducts. Because these details matter, our final product consistently meets the technical criteria demanded by sophisticated pharmaceutical and agrochemical end users.

    The chemical appears as a pale liquid at room temperature. It gives off a penetrating odor, unmistakable even through standard respirators, so we put real effort into vapor containment and air scrubbers—necessary, since drift can lead to batch inconsistencies or regulatory concerns. Unlike some other analogs, such as 1-chloroethylpyrrolidine or 1-(2-bromoethyl)-pyrrolidine, ours provides a better balance between reactivity and stability during subsequent alkylation or cyclization steps. Anyone who has run pilot labs knows: under robust temperature and pH ranges, 1-(2-Chloroethyl)-Pyrrolidine maintains its chemical character, helping partners cut waste and perform sharper product splits downstream.

    The Intended Usage and Our Responsibility

    Across our history, most of our customers pick 1-(2-Chloroethyl)-Pyrrolidine as a key building block. Pharmaceutical innovators ask us for this compound due to its capacity to enable carbon-nitrogen bond diversification, with particular value in active pharmaceutical ingredient intermediates. It also finds application for those synthesizing specialty surfactants, where precision matters and contamination risks from batch to batch have heavy cost implications. Our teams don’t just mix and ship—we check, and re-check, what each user intends, doing our best to provide the right balance between custom batch sizes, packaging, and logistics to suit each workflow.

    Our product isn’t built for broad appeal—its market remains specialized. We stick to transparent internal documentation and process validation, since experienced end users expect traceability and full batch histories. To meet our clients’ expectations, we also avoid shortcuts in purification or storage, even at higher production cost. When an end-user’s chemistry, such as alkylation of amines or construction of heterocyclic rings, depends heavily on a single intermediate, the supplier’s reliability weighs heavily on their cost and schedule forecasts. We don’t take that lightly.

    How Our Product Differs from Other Intermediates

    Some might compare 1-(2-Chloroethyl)-Pyrrolidine directly to more common chloroethylamines or to derivatives with alternate substituents. Our product stands out because the pyrrolidine ring imparts unique reactivity. Bluntly put, not every chloroalkyl compound slots into a synthesis without shifts in selectivity, yield, or environmental burden. Over time, we noticed that switching in a pyrrolidine backbone over an open-chain amine often reduces unwanted side-reactions, offering a snugger fit for certain ring-construction reactions. Many clients have told us they have cut downstream purification steps simply by switching to our production source.

    Batch consistency marks another key difference. We maintain a strict, closed-system procedure that limits cross-contaminants, relying on proprietary reflux and gas quenching approaches. Compared to open-vat or semi-manual operations, this lowers risk of side-product buildup. We measure appearance, GC-MS spectra, and residual solvent content for each lot. Results for moisture and acid value usually fall below internationally accepted limits, making it easier for downstream validation.

    In contrast to alternative sources that pull from older or batch-level equipment, we invested in modular reactors and real-time monitoring. This allows mid-run course corrections and rapid identification of possible contaminants, sometimes even before the operators notice a concern at the sampling station. When a bad batch costs time and money, tracing the root can mean the difference between a day’s work lost and a full week of re-runs. We’ve eliminated many rework headaches with process upgrades that catch slight variances before they snowball.

    The Evolution and Importance of Product Traceability

    We didn’t always reach these standards. In the early years, deciphering the best process routes chewed up man-hours and brought frustrations at every turn. Rotameters jam, hydrogen chloride lines clog, and we’ve seen more than our share of stress corrosion on valve stems. Each of these pain points taught lessons—small modifications on the process line, regular trains on staff, and better preventative maintenance cycles. Now, every litre shipped carries a batch history clear enough for any regulatory audit. Clients in regulated industries care about that. It isn’t about chasing paperwork—it’s about protecting high-value manufacturing schedules down the line.

    Another difference we emphasize is our willingness to troubleshoot with our direct contract partners. If their formulation shifts or regulatory requirements change, we’re usually the first call, because they know we didn’t just broker this on paper. We’ve stood in the lab and sorted complications more times than we can count. It is one thing to read about process optimization in a journal article; it’s quite another to stand at the reactor at midnight on a Sunday, dial in gas feed rates, and wait for that headspace CO2 measurement to finally settle at spec.

    Responding to Safety and Environmental Factors

    A major difference in our area of specialty production centers on how we handle hazardous profile compounds. 1-(2-Chloroethyl)-Pyrrolidine requires an unrelenting focus on containment and environmental safety. Uncapped vents and sloppy waste handling can cost you a shutdown, but even experienced chemists underestimate how fast a small leak turns into a bigger challenge. Our systems isolate fugitive emissions before they get to vent stacks. We harvest process effluents, segregate waste, and actively monitor for low-level exposures.

    Most of the solvent used during purification is recovered and recycled back into the process, which wasn’t common even a decade ago. The shift came once we realized the economics: solvent cost, liability, and compliance costs now matter as much as any line item. Even small improvements—better seals, new gasket materials, or advanced online gas detection—have paid off. The entire team gains peace of mind from improved safety, and our incident rate speaks for itself: it has dropped every year since our last overhaul of emergency protocols.

    Market Shifts and the Role of 1-(2-Chloroethyl)-Pyrrolidine Moving Forward

    Demand for high-end, highly pure intermediates keeps rising. As more customers build specialty drugs or advanced surfactants, they require cleaner starting points. Years ago, offtake volumes ran lower and low-cost supply dominated. Now, regulatory pressure and complex synthesis requirements push buyers to tighten specs and request more transparency. Our history of making this specific compound from base reactants—without reliance on third-party intermediates—means buyers avoid double brokerage markups and gain knowledge on production practices.

    Partners have shared candid feedback about marketplace frustrations: missed timelines, batches out of spec from imports, and ambiguous paperwork. For us, quality isn’t just a checklist. Our technical staff run every quality-control metric with the same eyes as the regulatory authorities who check our plant’s records. This hands-on work often gives our customers an edge—they can ask detailed questions, receive method provenance, and discuss options for custom bulk or small-batch production. When a new regulation surfaces, we’re ready to validate compliance with method archives across years, not just a recent run.

    Feedback Loops: What We’ve Learned from Real-World Application

    Our role as a manufacturer means we have a front-row seat to users’ real concerns. Some chemists care most about residual impurity profiles, others about container compatibility. We’ve adapted not just batch processes, but also shipping and storage options, based on tough experiences. After a few transport mishaps, we moved away from older HDPE vessels and began offering glass-lined steel containers for sensitive shipments. Installation of secondary containment on all tank farms came about after learning what even a minor leak during transfer can cost in cleanup and regulatory overhead.

    We have changed product labels, reformulated shipping documents, and even adjusted our schedule to match harvest or campaign cycles for key buyers. Many of these fixes happened outside formal request channels—solutions grew from relationships with clients who trusted us with their problems, not just their orders. Many of our long-term partners point to this willingness to tweak as one of the main reasons they stick with a direct manufacturer and avoid intermediate resellers.

    Technical Walkthrough: Processes that Drive Repeatable Results

    Our manufacturing runs aren’t automated black boxes. Operators log every step, cross-compare batch curves, and double-check anomaly flags raised by SCADA systems. Dosage rates, mixing speeds, and temperature ramps each have custom settings tailored after hundreds of runs. We keep reference samples from every batch and periodically send them to third-party labs for verification—no marketing gloss, just results.

    Every year, we swap notes with technical partners on potential improvements. Sometimes, simply slowing a feed by a few percent or holding a neutralization step longer brings sharper results. More than a few innovations emerged from troubleshooting sessions that dragged deep into the night. This collaborative, heads-down work separates actual manufacturers from traders that rely on other people’s factories.

    End users in the life sciences appreciate this approach. They need documented stability data, impurity tracking, and assurance that a partner won’t disappear when a question or regulatory inquiry comes up. By building these habits, we catch and prevent off-spec materials, and our partners avoid those headaches that come with erratic supply.

    Comparison: 1-(2-Chloroethyl)-Pyrrolidine Versus Competitive Products

    Alternatives exist, but not every compound matches the specific behavior of our product. 1-(2-Bromoethyl)-pyrrolidine, for instance, offers higher primary reactivity but often brings more handling difficulties and higher cost. Linear analogs such as 2-chloroethylamine function in some applications but don’t match the performance in ring-forming applications or produce higher concentrations of side-products. Some buyers attempt to swap from related N-haloalkyl amines, chasing price moves or easier availability, but over time many return to the pyrrolidine backbone for process yield and handling benefits.

    Process-wise, our continuous improvement cycle means customers spot fewer color changes across batches, less drift in impurity profiles, and almost no surprise viscosity spikes. These details carry weight on large campaigns. Minor slips in process integrity from other suppliers have led to stuck reactors, failed scale-ups, or even scrapped campaigns—stories we’ve encountered from customers who came to us after a negative experience elsewhere.

    Direct relationships bring real benefits. We’ve often retooled intermediate purification steps or flexed shipping schedules to help clients recover from a supply chain disruption. These collaborations have, over time, turned transactional exchanges into much more. Users’ own chemists sometimes send us samples of their reaction mixtures for consultation. In these cases, we seek win-win outcomes. Just as often, lessons from a customer trial feed back into our own R&D strategy. We’ve reformulated extraction steps, tweaked final filtration conditions, and even piloted new antistatic packaging thanks to those close partnerships.

    Regulatory Trends and What They Mean for Us and Our Customers

    Traceability and regulatory readiness sit on top of everyone’s list in specialty chemical manufacturing. Software logs every production run, down to shift logs, temperature curves, and all maintenance events. External audits help us keep training programs current, and we frequently update hazard communication measures on the shop floor. For regulated-market buyers, these practices matter as much as the chemical’s purity, since non-compliance could mean delayed production or even halted sales for their finished goods.

    We respond with full document sets, openness on analytical methods, and readiness to discuss new compliance rules as they appear. This nimbleness follows from our investment in both people and systems: every time there is a regulatory shift, we avoid costly downtime by having pre-built templates and upstream data archives to fill new needs quickly. We’ve seen situations where even regional changes in chemical control law led to global restocking or re-approval of intermediates; by staying proactive on compliance documentation, our clients avoid disruptions most brokers can’t identify until it’s already too late.

    A Manufacturer’s Perspective: Pride and Pressure

    It’s clear by now—1-(2-Chloroethyl)-Pyrrolidine is more than a stock code in our books. Each successful production campaign starts with knots in the stomach and ends with a checklist ticked down to the last parameter. The pride in seeing customer feedback, even complaints tuned into actionable process upgrades, keeps the technical teams tight and motivated. It’s not showmanship. Our business, reputation, and even regulatory license depend on honoring every tiny detail—right down to the final container sampled before shipment.

    Industry demands keep growing. Instead of feeling threatened, we use that as fuel to push for process reliability, environmental improvements, and continuous training. Our daily work is an ongoing commitment: every morning’s production log marks a chance to keep the promises we make—on purity, safety, and support.

    Conclusion: Built on Lessons, Relationships, and Repeated Excellence

    Every drum and batch of 1-(2-Chloroethyl)-Pyrrolidine that leaves our facility carries the story of operators, chemists, and plant managers who work to get that purity needle as high as we claim. It carries the pain of process failures debugged and the pride of successful compliance audits. Users who expect more than paperwork or static catalogs stay with us because we act out what it means to stand behind a product, not just pass it on.

    Our story with this product keeps evolving, just as the needs of our partners do. We remain grounded in our factory floors, open to technical dialogue, and always seeking that next notch of excellence—batch after batch, year after year.