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1-(2-Chloroethyl)-4-Methoxybenzene

    • Product Name 1-(2-Chloroethyl)-4-Methoxybenzene
    • Alias p-Methoxyphenethyl chloride
    • Einecs 202-236-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
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    VTB
    Specifications

    HS Code

    712417

    Iupac Name 1-(2-chloroethyl)-4-methoxybenzene
    Cas Number 6745-61-9
    Molecular Formula C9H11ClO
    Molecular Weight 170.64 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 252-254 °C
    Density 1.120 g/cm³
    Refractive Index 1.532
    Smiles COC1=CC=C(C=C1)CCCl
    Inchi InChI=1S/C9H11ClO/c1-11-9-4-2-8(3-5-9)6-7-10/h2-5H,6-7H2,1H3
    Solubility In Water Insoluble
    Flash Point 109 °C
    Synonyms 4-Methoxyphenethyl chloride

    As an accredited 1-(2-Chloroethyl)-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 1-(2-Chloroethyl)-4-Methoxybenzene, labeled with hazard warnings, chemical name, and CAS number.
    Shipping 1-(2-Chloroethyl)-4-Methoxybenzene should be shipped in tightly sealed, chemically resistant containers, protected from light, heat, and moisture. It must be handled according to local regulations for hazardous chemicals and labeled appropriately. Transportation should utilize proper cushioning and secondary containment to prevent leaks or spills during transit.
    Storage Store **1-(2-Chloroethyl)-4-methoxybenzene** in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and incompatible materials such as strong oxidizing agents. Protect from direct sunlight and moisture. Ensure proper chemical labeling and keep away from food and drink. Wear appropriate personal protective equipment when handling.
    Application of 1-(2-Chloroethyl)-4-Methoxybenzene

    Applications of 1-(2-Chloroethyl)-4-Methoxybenzene in Industrial Manufacturing

    As the direct producer of 1-(2-Chloroethyl)-4-Methoxybenzene, we supply large-scale manufacturers with consistent, high-purity material designed for precise downstream usage. Below, we detail the compound’s established industrial applications across four major markets. Each scenario aligns with real-world manufacturing practices, integrating compliance, dosage, and process controls essential for QC and regulatory approval in targeted sectors.

    1. Pharmaceutical Intermediates for Selective β-Blocker Synthesis

    The compound serves as a key alkylating intermediate in multi-step syntheses for certain β-adrenergic antagonists, specifically in pathways requiring para-methoxy substituted phenethyl molecules. Pharmaceutical producers depend on its reactivity with amine functional groups under controlled conditions to achieve selective side-chain modifications necessary for active pharmaceutical ingredient (API) frameworks.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia monographs (in API synthesis context)
    • 21 CFR Part 211: US FDA regulations for drug manufacturing processes
    • ISO 9001:2015 for bulk input material traceability

    Typical usage ratio

    • Stoichiometric ratios ranging from 1.1 to 1.25 molar equivalents relative to primary amine substrate, depending on targeted substitution efficiency and minimization of side-products

    Downstream process integration

    • Charged during second or third synthetic transformation in multi-stage batch reactors; typically introduced post-deprotection/pre-cyclization steps for alkylation under inert atmosphere with solvent control

    Final product types

    • API intermediates for metoprolol, bisoprolol, and structurally related β-blocker agents
    • N-alkylated precursor compounds requiring additional downstream purification

    2. Agrochemical Intermediate in Herbicidal Ether Synthesis

    This material integrates into the etherification sequence during scalable synthesis of select alkoxybenzene-based herbicides. Process chemists leverage its chloroethyl functionality to form bridging units critical in the construction of pre-emergent weed control active compounds, particularly for crop protection formulations requiring temperature tolerance and stability.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • China GB/T 19107-2018: Pesticide Active Ingredient Requirements
    • REACH Regulation (EC) No 1907/2006 compliance for registration in the EU market
    • ISO 17025: Laboratory testing of raw and intermediate materials

    Typical usage ratio

    • 5–12% by weight in concentrated herbicide intermediate formulations; adjusted according to downstream etherification yield targets and impurity profiles

    Downstream process integration

    • Added as a core reactant in the initial reactor charge; undergoes nucleophilic substitution followed by subsequent coupling and formulation steps

    Final product types

    • Precursor intermediates for phenoxyacetic acid herbicides
    • Technical-grade bulk actives for further formulation into emulsifiable concentrates and wettable powders

    3. Fine Chemical Synthesis for Custom Fragrance Structurants

    The molecule is employed in fine chemical production as a building block to construct alkoxybenzene derivatives with long-lasting aroma characteristics. It is specifically reacted in controlled steps to develop molecular frameworks serving as fixatives or enhancement agents in fragrance blends for industrial and luxury applications.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association) for restricted raw material usage
    • EU Cosmetics Regulation (EC) No 1223/2009 for cosmetic ingredient manufacturing
    • ISO 9001:2015 certified quality systems for traceability
    • REACH registered for safe handling throughout the fine chemical supply chain

    Typical usage ratio

    • 8–15% by mass in semi-batch reaction systems for the target fragrance precursor; ratio directed by desired olfactory profile and process throughput

    Downstream process integration

    • Charged as a key ether donor during the etherification or Friedel–Crafts alkylation step; process performed under anhydrous conditions with catalyst selection tailored to aroma end-use

    Final product types

    • Methoxybenzene-based fragrance fixative intermediates
    • Specialty aroma chemicals for perfume compositions and scenting agents for air care or personal care markets

    4. Functional Monomer Intermediate for Ion-Exchange Resin Manufacturing

    Ion-exchange resin developers utilize the compound as a functionalized aromatic monomer or as a precursor for grafting hydrophilic side chains onto polystyrene-divinylbenzene matrices. The unique chloroethyl and methoxybenzene structure enables targeted modifications, supporting the production of resins with defined exchange capacities for water treatment and specialty separation processes.

    Industry compliance standards

    • NSF/ANSI 61: Drinking Water System Components – Health Effects
    • ISO 9001:2015 quality management for resin production facilities
    • EU Risk Assessment Reports for intermediate monomers under REACH
    • US EPA guidelines for resin trace contaminants

    Typical usage ratio

    • Incorporation at 2–6% relative to total monomer mass during resin copolymerization; fine-tuned by desired ion-exchange group density and resin porosity requirements

    Downstream process integration

    • Fed as an initiating co-monomer during the polymerization phase or introduced in post-polymer modification via chloromethylation for further functionalization

    Final product types

    • Strong base and weak base anion-exchange resins for municipal water treatment
    • Specialty separation resins for pharmaceutical purification or food processing applications
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    Certification & Compliance
    More Introduction

    1-(2-Chloroethyl)-4-Methoxybenzene: Insights from the Manufacturer's Bench

    Understanding the Substance

    Day after day, our team stands in the shift room, tallying notes, checking pressure gauges, and watching the birth of 1-(2-Chloroethyl)-4-Methoxybenzene in real time. From the synthesis kettle to the filtration drum, each pound carries the weight of experience. We shape this chemical through controlled chlorination and careful adjustment to temperature swings. We track its molecular fingerprint at every stage, ensuring the presence of the telltale chloroethyl and methoxy groups flanking the benzene ring. Our batches consistently meet industry-pure standards, with purity tests confirming the absence of unwanted byproducts and residual solvents. We've long known that off-coloration or haze signals trouble, so our crew understands the difference between a minor deviation and a costly mistake before QC even picks it up.

    The Product at a Glance

    This compound, with a molecular formula of C9H11ClO, offers a versatile platform for organic synthesis. Each shipment from our site carries a spectral analysis report, proving identity and stating impurity levels—measured not just to tick regulatory boxes, but because end customers depend on solid, repeatable results. Analysts in our in-house quality suite assess melting point and GC-MS data, making quick judgments on batch consistency. In every corner of the facility, you'll see clear, pale yellow crystals moving along, packed with minimum fuss and maximum attention to contamination controls. Any deviation, even a misstep in temperature during the chloroethyl group installation, shows up immediately as a drop in yield and an uptick in byproducts.

    Application Patterns Based on Field Experience

    Our experience shows that the primary draw for 1-(2-Chloroethyl)-4-Methoxybenzene continues to be its role as a building block for specialty chemicals. Intermediate manufacturers have come to us with requests for modifications and blending, providing feedback on downstream compatibility and challenges. This product appears most often in the early phases of producing pharmaceuticals and advanced performance materials—usually those needing high specificity in aromatic substitution. A project manager from a major process chemicals company once remarked that converting the molecule into innovative active intermediates offered smoother scale-up than other similar reagents. They cited fewer side reactions and improved control during subsequent derivatizations, which is no small feat at commercial scale. Based on feedback, customers have managed to shorten processing cycles within their hydrobromide substitution lines, cutting time and cost.

    Where 1-(2-Chloroethyl)-4-Methoxybenzene Succeeds—And Where Trouble Starts

    From the viewpoint of a plant operator, consistency is the difference between a smooth-running shift and a late-night call to maintenance. Over years of manufacturing this compound, we've honed in on several issues. Product stability stands up well under recommended storage, resisting both light and moisture. The crystalline form survives longer journeys, maintaining integrity across a range of climate conditions. Where we have seen users run into trouble involves mixing protocols and solvent choice. Ineffective solvent removal in downstream synthesis sometimes leads to contamination. Sometimes clients try to shortcut temperature profiles, ending up with unreacted starting material or excessive byproduct formation. As a manufacturer, we advise a slow heating ramp for initial dissolution, as this reduces local concentration spikes that drive unwanted reactions. Direct feedback from process chemists using our material has prompted us to refine drying and filtering steps—always looking for cleaner filtration and easier re-dissolution on their end.

    Differentiators That Come from the Shop Floor and Lab Bench

    Walking through competitor trade shows or reading spec sheets might suggest little difference between suppliers. The reality, from our station by the reactors, is that not all 1-(2-Chloroethyl)-4-Methoxybenzene is created equal. Production routes play a huge role: some use bulk chlorination techniques prone to variable substitution patterns and resulting mixtures. We focus on controlled, staged reactions with routine residuals analysis, locking our output into tighter purity bands. Our longest-serving plant lead once pointed out that yields may look the same on paper, but downstream, subtle differences can spell the end for a multi-step synthesis. Unseen levels of dimerization or the wrong isomer ratio demand extra purification and cause headaches for those on the receiving end.

    Drilling down, we don’t hide behind generic process statements. The balance between purity and processability translates straight to plant economics for customers. In one case, a specialty intermediate client reported a 20 percent drop in off-spec material compared to past batches from unrelated vendors. A few adjustments to the halogenation step, guided by years of scale-up data, made that possible. The in-plant difference is tangible: less rework, higher yield, fewer complaints on trace impurities showing up in analytical spec sheets. Feedback keeps us grounded. It’s not the catalog data that keeps business coming in; it’s each raw batch report and shipment tracking update that matters to our partners.

    Facing Challenges: Real-World Solutions in Production and Delivery

    From our control room, we see a long list of challenges each cycle. Transportation of sensitive aromatic chlorides means strict drum sealing and frequent documentation checks. Humidity spikes in the loading dock motivate extra rounds of desiccant and carefully timed transfers. Still, the biggest questions often concern scalability and the effect on end-product quality. Our process engineers have developed a tight feedback loop: quick communication with end users and rapid process trialing to iron out any surprises. Sometimes a single upstream impurity, if unchecked, poisons an entire downstream batch for a formulator. We run multiple GC checks on inventory before shipment, knowing it’s far easier to halt a local dispatch than to answer questions downstream about unwanted reactivity or batch failures.

    Our recent upgrades to distillation equipment have made a world of difference. By reducing residence time at elevated temperatures, we see fewer side products and snappier crystallization, with tighter end-point color and melting point distribution. Temperature, pressure, and the quality of each input chemical drive outcomes every time—and we rarely trust a theoretical spec over a few decades’ worth of plant sense and batch records.

    Why 1-(2-Chloroethyl)-4-Methoxybenzene Remains a Preferred Tool—Practical Insights

    Our main clients cite reliability, ease of reaction control, and a record of successful integration into both big molecule and small molecule syntheses. In direct feedback, a pharmacological research team noted a measurable decrease in handling loss and an uptick in desired yield after a switch to our batches. They traced it to fewer particulate inclusions and easier dissolution in the initial step. The hands-on difference at the beaker and kilo lab level rolls up into fewer failed reactions and tighter batch-to-batch control.

    In contrast, less controlled or lower-purity analogs available in the market often bring along ghost peaks on an HPLC trace and require extra washing, filtration or in some cases re-synthesis. More than once, a downstream user highlighted those risks—explaining that inconsistent quality at the benzene substitution stage caused entire production lines to stall. From what we observe, minimizing these headaches starts with process rigor: temperature probe calibration, vigilant filtration, and real-time batch records.

    Maintenance supervisors point out that reliable feed material improves plant uptime. Whenever our 1-(2-Chloroethyl)-4-Methoxybenzene runs as the sole reagent for alkylation or etherification, the maintenance log stays thinner. Filter presses show longer runtimes before blinding, and downstream vessels need less manual cleaning. These gains rarely show up in a catalog listing but matter hugely for the round-the-clock operations managers juggling yield reports and cleaning schedules.

    Comparing Alternatives: What the Hands-On User Notices

    Throughout years of collaboration with both research and industrial customers, side-by-side evaluations have become routine. We supply comparison samples, walking customers through subtle, meaningful distinctions—sometimes only catching differences in reactivity after repeated pilot trials. Similar halogenated aromatics or methoxy-benzene compounds might show comparable bench chemistry but diverge sharply in downstream purity and ease of isolation. Operators highlight reduced color throw in end products or crisper phase separation when using our material, compared to multi-component commercial sources. Such differentiation offers very real project savings: fewer post-reaction workups, improved selectivity in coupling steps, and better control during scale-up.

    One downstream application—targeting a valuable pharmaceutical intermediate—regularly exposes variabilities in the quality of starting materials. Chemists who’ve tried alternatives end up spending excess time purifying intermediates, or struggling to explain failing yields to their project leaders. That frustration drives the search for a more disciplined supply chain where our product, batch-tracked and performance-tested, offers peace of mind.

    Our floor operators can trace this quality up and down the chain. Early feedback loops—reading complaints, logging minor process tweaks, cross-talking with R&D—move quickly from anecdote to best practice. So, when an analytical result shows a spike in an extraneous peak, it doesn’t become a recurring expense. Careful process maintenance—batch log reviews, repeated spectral verification—ensures we don’t deliver unpleasant surprises to anyone on the receiving line.

    Advice for Industry Colleagues on Successful Use

    As manufacturers living with these processes every hour of every day, we recommend working up laboratory protocols to small pilot lots before full-scale runs. Too often, we’ve seen firms assume drop-in compatibility, only to encounter reaction stalling or incomplete conversion due to subtle but critical differences in starting material. Most headaches arise from skipping the verification step—either in pre-heating, reagent addition sequence, or solvent pairing. Our tech team remains available for calls not just about supply, but honestly about best-practices learned facing real shelf-life and compatibility issues.

    Inventory supervisors tell us that planning storage for aromatic halides pays for itself, through reduced product degradation and fewer blending mishaps. This isn’t a theoretical guideline; it comes from replacing prematurely darkened product far too many times after exposure incidents in default racking. Light-protected, dry storage pays dividends in stability, yield, and QC sign-off rate.

    Beyond the plant gate, decision makers purchasing this compound should plan materials handling around the true sensitivity of aromatic halides. Direct field experience supports prioritizing rapid use from receipt and maintaining an efficient in-house testing protocol. Process engineers who watch waste records closely see the payoff when a high-integrity intermediate feeds downstream runs—less time spent addressing contamination, more focus on value-added process work.

    Continuous Evolution: Pursuing Improvement and Supporting Innovation

    Few things remain static in chemical manufacturing. Each year, customer requirements evolve and new analytical trends push us to revisit core parameters. We keep at the grind, reviewing feedback with our process engineers, extending pilot lines, and chasing tighter process control. Recent investments have focused on better online monitoring, supporting rapid production pivots and catching issues in real time rather than after full batch cycles. Output variability drops when plant personnel understand the chemistry’s quirks and how each tweak shifts the reactivity profile.

    We also keep a close eye on developing regulatory frameworks, keen to anticipate new documentation or purity requirements. Years of dealing with compliance audits teaches you that a single missing lot number can waste entire afternoons tracing paperwork. Up-to-date records and transparency support not just compliance but deliver honest, traceable shipments—critical to keeping long-term customers and moving forward on new projects.

    Long-time shop floor staff have driven crucial improvements, adapting filtration schedules, investigating catalysis alternatives, and even recommending new packaging methods to keep up with harsh transit conditions. Their contribution lands squarely in end-user satisfaction: easier handling, longer shelf life, and less fuss during integration steps. It’s not about meeting a spec—it’s about seeing the real-world impact on a customer’s downstream process.

    Industry Responsibility: Quality, Safety, and Mutual Success

    As a manufacturer, we shoulder the responsibility for what leaves our site. Many chemical professionals prefer strict silence about batch failures or near-misses, but internally we face faults head-on. High standards for 1-(2-Chloroethyl)-4-Methoxybenzene deliver not just compliance with shelf-stable packaging rules, but confidence for customers working late shifts and under economic pressure. Weekly plant meetings cover small adjustments that mark the difference between average and exceptional output: from incremental cooling steps to timely analytical verification that avoids accidental shipment of off-spec material.

    Transparency, careful planning, and a willingness to improve drive field-level trust. Sharing lessons on batch fouling, filtration hiccups, or material compatibility issues offers genuine support to partners and helps us keep process stability for new project trials. We document these lessons, seek feedback, and routinely measure our reports against those of customers, always chasing a common goal—turning risk into opportunity, and raw materials into reliable solutions.

    Final Thoughts from the Manufacturing Floor

    Chemical manufacturing grows through constant attention and practical wisdom—not just through tight documentation or high laboratory purity. Our experience producing 1-(2-Chloroethyl)-4-Methoxybenzene has highlighted the value of transparency, active process management, and skilled personnel willing to learn from each cycle. Success comes from knowledge sharing and process improvements, from guaranteeing stable performance at scale, and from listening to those who use our compound in real factories, real labs, and real applications.

    Colleagues relying on this chemical depend on supply that translates into repeatable, safe, and productive runs. To meet that expectation, we measure more than specification sheets—we measure outcomes, listen to feedback, and build relationships around honest reporting and shared innovation. Every batch stands as a record of those ongoing efforts, and as a promise to do better with every shipment.