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1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One

    • Product Name 1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One
    • Alias CQI
    • Einecs 624-76-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    650056

    Chemical Name 1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One
    Molecular Formula C9H9ClN2O
    Molecular Weight 196.63 g/mol
    Cas Number 23810-74-4
    Appearance White to off-white solid
    Melting Point 140-144 °C
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically >98%
    Storage Temperature Store at 2-8 °C
    Synonyms 2,3-Dihydro-1-(2-chloroethyl)-1H-benzimidazol-2-one
    Smiles O=C1NC2=CC=CC=C2N1CCCl
    Ec Number 245-915-6

    As an accredited 1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White HDPE bottle labeled "1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One, 25 grams, For laboratory use only" with hazard symbols.
    Shipping **Shipping Description:** 1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One should be shipped in tightly sealed containers, protected from moisture and direct sunlight. Handle as a potentially harmful compound—use gloves and eye protection. Transport in accordance with local, national, and international regulations for hazardous chemicals, ensuring proper labeling and documentation are included with the shipment.
    Storage **Storage for 1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one:** Store in a tightly sealed container in a cool, dry, and well-ventilated area, away from heat, ignition sources, and strong acids or bases. Protect from moisture and direct sunlight. Ensure proper chemical labeling. Access should be restricted to trained personnel and appropriate spill containment measures should be in place. Wear suitable personal protective equipment when handling.
    Application of 1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One

    Applications of 1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One in Industrial Manufacturing

    1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one serves as a specialized intermediate in several tightly regulated downstream sectors. As a direct manufacturer, we emphasize its performance in a select range of industry-specific production streams where its molecular functionality delivers both process efficiency and compliance with advanced regulatory demands.

    1. Pharmaceutical Intermediate Synthesis – Anticancer Agent Manufacturing

    In the pharmaceutical industry, this compound enters the synthesis pathway for select benzimidazole-based anticancer drugs. Manufacturers employ it during multi-step chemical transformations, requiring strict adherence to both purity and trace impurity control. Production utilizes closed-system reactors for condensation and alkylation, fully aligning with batch traceability and quality benchmarks unique to small-molecule oncology actives.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Part II (APIs)
    • US FDA 21 CFR Part 211
    • Relevant local Pharmacopeia monographs (e.g., USP, EP as referenced in DMFs)

    Typical usage ratio

    • Used at 0.9–1.1 molar equivalents as an input for active ingredient production; precise equivalents depend on stoichiometry in route design and impurity control criteria.

    Downstream process integration

    • Introduced during early-stage heterocyclic core assembly, directly after initial aromatic amine activation; subsequent steps include chlorination, coupling, and purification prior to formulation.

    Final product types

    • API-grade oncology agents (antineoplastics, alkylating agents in compliance with DMF/CEP/ANDA requirements)

    2. Agrochemical Intermediate – Synthesis of Fungicidal Active Ingredients

    Agrochemical producers incorporate this raw material in the route to specific benzimidazole-structured fungicides. Its reactivity profile promotes efficient cross-linking during the active ingredient formation phase, enabling tight control of physicochemical properties critical for field application. Processing typically occurs under inert gas at controlled temperatures to maintain quality and consistency of active powder output.

    Industry compliance standards

    • FAO/WHO International Code of Conduct on Pesticide Management
    • ISO 9001:2015 (QA for agrochemical manufacturing)
    • Chinese GB 2763-2021 (MRL provisions for pesticides)
    • REACH Regulation (EC) No 1907/2006 (pre-registration for Europe)

    Typical usage ratio

    • Employed at 1.0–1.05 molar ratio in active ingredient synthesis steps; ratio adjusted based on yield optimization and target purity for downstream formulation.

    Downstream process integration

    • Charged during the key cyclization stage, following halogenation of aromatic precursors; followed by crystallization and drying prior to blending into final agrochemical formulations.

    Final product types

    • Benzimidazole-structured fungicide technical concentrates and wettable powders for crop protection

    3. Specialty Polymers – Functional Additive for High-Performance Polybenzimidazole (PBI)

    Polymer producers utilize this raw material as a functional modifier during polybenzimidazole (PBI) synthesis for engineering plastics and fiber applications. It acts as a controlled chain-terminating agent, modifying molecular weight distribution and imparting targeted thermal and chemical stability. Careful dosing within the condensation polymerization step allows for reproducible adjustment of end-use performance specifications.

    Industry compliance standards

    • ISO 9001:2015 (polymer production quality systems)
    • ASTM D5226 (Molecular Weight Determination for PBI)
    • Applicable RoHS directives (on halogen/Chlorine content in electronics-grade plastics)
    • UL 94 certification (flame retardancy testing for finished PBI parts)

    Typical usage ratio

    • Added at 0.5–2.0 wt% relative to aromatic tetraamine inputs, with exact loading dependent on chain length and target thermal/mechanical properties of the final polymer.

    Downstream process integration

    • Introduced during initial monomer mixing, preceding polycondensation; monitored in-line by viscosity and molecular weight QC checks to ensure reproducible end-group incorporation.

    Final product types

    • High-temperature PBI resin pellets, flame-resistant fibers, and specialty molded electrical components

    4. Specialty Chemical Crosslinker – Epoxy Resin Systems in Aerospace Coatings

    Aerospace coating formulators employ this compound as a specialty crosslinking agent within select epoxy resin systems. Its unique structure introduces secondary crosslink points, enhancing chemical resistance and adhesive strength under extreme thermal cycling. Manufacturers deploy it during the resin pre-cure blending phase to deliver consistent film durability on demanding aerospace assemblies.

    Industry compliance standards

    • AS9100D (Aerospace Quality Management Systems)
    • ISO 9001:2015 for coatings
    • REACH SVHC disclosure for chemical safety
    • OEM aerospace paint specifications (e.g., Boeing BMS 10-60, Airbus IPS 02-510)

    Typical usage ratio

    • Incorporated at 0.3–1.0 phr (parts per hundred resin) depending on required crosslinking density and end-use specification for chemical/thermal stability.

    Downstream process integration

    • Metered into epoxy pre-mix immediately prior to catalyst addition and final blending; post-blend QC verifies crosslink density through solvent resistance and mechanical property testing.

    Final product types

    • High-temperature aerospace primer and topcoat systems designed for use on airframe and engine components
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    Certification & Compliance
    More Introduction

    1-(2-Chloroethyl)-2,3-Dihydrobenzimidazol-2-One: Practical Insights from Our Factory Floor

    Understanding the Material Through Hands-On Experience

    Running a chemical production line means learning the personality of every molecule we make. With 1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one, experience shapes how we approach every step, from raw material preparation to delivery. Lab formulas tell part of the story, but handling the compound in bulk reveals far more about its stability, reactivity, and the caution required during its handling. We have spent years refining not only our reaction conditions, but our cleanup and quality checkpoints, simply because slight differences in starting materials or reaction times show up in the purity and consistency that end-users depend on.

    Why Our Teams Value Purity and Precision

    Every batch of this compound carries the cumulative attention of our chemists and operators. Purity holds central importance for those relying on the compound in pharmaceutical research, specialty synthesis, or fine chemical manufacturing. Achieving rigorous purity targets isn't just about filtering and drying. We watch for specific byproducts, those small contaminants that sneak in from overly aggressive conditions or minor contamination. These impurities impact downstream reactions, and our crews trace any variance with analytical tools as soon as a batch shows out-of-spec readings. Years ago, we updated our crystallization process after a routine QA sample found something unexpected. Now, repeat testing anchors every shift, not just for regulatory compliance but for our own peace of mind.

    Material Characteristics Shaped by Daily Practice

    The model of 1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one we produce reflects a signature physical form: a crystalline or slightly granular solid, uniform off-white in color. Temperature and humidity shifts in the plant can affect its texture. Every operator on the line understands the dangers of inconsistent drying, which can result in clumping and affect ease of handling. We oversee every kilogram by controlling not just oven temperatures but airflow and tray spacing—letting no shortcut pass. Consistent melting point and solubility profiles follow close on the heels of careful drying and sieving, and each bulk lot earns its place in the warehouse through performance in downstream synthetic steps.

    The Uses We See and the Needs We Meet

    Demands for 1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one have grown with the rising complexity of process development in pharmaceuticals and chemical synthesis. This compound’s reactivity, shaped by the chloroethyl group and benzimidazol-2-one ring, gives it a role as an intermediate where more basic building blocks fall short. R&D teams working on antitumor agents, or on functionalized heterocyclic compounds, often face bottlenecks without dependable supplies of intermediates like this one. We engage with researchers, gathering feedback on reactivity and compatibility in specific transformations—those insights feed directly back into how we measure and guarantee product performance. There is no substitute for that direct line of communication between bench chemists and plant floor.

    Seeing the Product in Action—No Room for “One Size Fits All”

    Few intermediates serve such a wide range of technical needs. Customers often call asking how this compound differs from similar chloroethyl benzimidazoles or other haloalkyl uracil-based molecules. The difference lies in both the substitution pattern and the reactivity balance. In practice, one group needs maximum functional group tolerance, another needs tunable reactivity for scale-up. We walk through the design of their process—how side reactions can wreck yield, why handling conditions adjust to fit moisture or temperature controls, when to watch for byproduct formation. Our teams recall feedback from clients who faced decomposition issues with imported materials, finding our in-plant stability testing helped them improve their yields. These real-world details set the product apart more than catalog entries or theoretical comparisons ever could.

    Problems We Face—And How Experience Offers Solutions

    We rarely see a year without new operational hurdles. Some lots show more tendency to absorb moisture on humid days, which stirs up handling problems and shelf life concerns. A decade ago we tried to ignore this, blaming it on shipping conditions, but soon invested in climate controls at the packaging stage. We keep desiccant protocols under constant review and run shelf-life studies aligned with the actual packaging conditions found in our clients’ transit networks, not just idealized lab settings.

    Safety practices build up in layers. Our older staff still tell stories about the days before automated scrubbers, when chemical odors and contact risks could not be dismissed as someone else’s concern. Today’s operators rely on closed system transfers, dual verification on storage drums, and live monitoring for any trace chloroalkyl vapor. Near-misses from earlier years taught us that equipment upgrades and training are not options—they’re essentials for keeping accident rates low and insurance premiums reasonable. These stories pass from shift to shift, teaching new hires why every glove and respirator matters.

    Key Distinctions from Similar Intermediates

    Not all benzimidazole derivatives behave the same way, no matter how close they look on paper. We receive comparison requests from buyers who work with 1-(2-bromoethyl) or 1-(3-chloropropyl) analogs. The chloroethyl group alters reaction speed, selectivity, and downstream stability, in ways too subtle for catalog data to capture. Our focus on batch analytics has revealed that some isomers behave better in condensation reactions while others cause more undesired side products. Our close look at melting points, color indices, and chromatographic fingerprints exposes these distinctions quickly, saving customers time in troubleshooting.

    Supply chain security also matters. We control every batch from our supply of starting anilines through to final drum closure, offering a chain of custody many traders cannot match. For customers worried about regulatory compliance or origin certification, our in-house records provide clarity, and our staff responds quickly to documentation requests. Years of witnessing disruption from poorly documented imports drive our insistence on this approach.

    Why Technical Support Cannot Be Outsourced

    Our chemists draw on decades working with heterocyclic intermediates, so questions coming in from clients don’t go to a remote help desk or a generalist catalogue manager—they go right to someone who knows what a misbehaving batch looks like, or can spot a problem in a reaction sequence from just a few details. Customers facing solubility issues or low conversion rates find it more useful dealing with a team who have run scale-up trials with their own hands. We host visits, share in-plant data, and sometimes run parallel reaction setups to pin down the source of a technical setback. These practices build real trust, turning one-off purchases into long-term partnerships.

    Scaling Up Production—Lessons Learned from Customers and Colleagues

    Scaling fine chemicals rarely follows a perfectly predictable curve. Different lot sizes bring out quirks that micro or pilot scale reactions never reveal. One job revealed this compound’s sensitivity to trace acid contamination, so we invested in acid-washed reactors and real-time pH logging. Installing larger crystallizers highlighted the need for finer control on cooling rates. Our shift leaders share lessons across teams, because feedback from QC and complaints from the shipping desk both shape how we tweak conditions on the line.

    Feedback loops with customers also guide optimization. We have dropped yields chasing higher purities, then learned to trade some yield for batch-to-batch consistency, because process chemists value predictability over theoretical maximums. Every scaling problem forces us to re-examine not only synthesis but logistics—shifting warehouse inventory flow, updating lead time calculations, and building better coordination with shippers to minimize customs delays. You learn quickly that delivering a kilogram or a ton of this compound depends as much on timing and communication as on technical know-how.

    Environmental Management—Realities from the Factory Perspective

    Solvent handling and effluent management drive both cost and compliance. Our site engineers monitor every cleaning cycle, tracking water and solvent use as strictly as raw materials. No environmental plan survives first contact with an actual chemical operation, and every waste stream requires regular review. We’ve seen regulations tighten or shift, forcing us to adopt greener solvents, improve distillation for reuse, and upgrade fume treatment. Small changes—better lids, newer pumps, well-sealed drains—build up over years to reduce both risk and waste.

    Attempts to cut corners with waste handling always backfire. Once, delayed drum pickup triggered odor complaints from neighbors, sparking an urgent review of our scheduling and container labeling. That experience still shapes how we train staff and select suppliers for waste management. Environmental compliance means more than passing an annual audit; it’s a running test of reliability and adaptability. Customers care, too—they often request chain of custody on environmental certificates, and we’re ready to provide such details up front.

    Worker Safety and Skill—Stories That Stick

    Our teams bring both skill and caution to the plant each day. Mistakes early in someone’s career—an overfilled filter, a missed valve—create strong memories and improved safeguards. Veteran operators pass down these lessons both formally and informally. They reinforce daily checks, chemical container labeling, spill preparation, and detailed documentation. We know that the difference between a near-miss and an incident often comes down to timing and communication. A well-led shift moves with calm efficiency, each member trusting the others to watch for off-spec reactions or equipment noise.

    Training doesn’t end with initial certification. We update hazard drills and review real incident reports from other sites so that everyone knows why our rules exist. Over the years, we have nudged our procedures, sometimes painfully, so that strict safety becomes second nature. No one in our plant doubts the importance of personal protective equipment—occasional reminders from minor burns or skin exposures keep us humble and committed.

    Why Supply Relationships Matter for Both Sides

    Our regular customers come to value reliability as much as technical features. Years of experience show that chemicals bought on price often lead to downtime or failed batches—hidden impurities, poor documentation, or unstable over-the-road shipments. When production lines depend on uninterrupted supply, delays or rework mean missed deadlines and avoidable costs. By building stable procurement partnerships with our suppliers, and extending the same predictability to our customers, we buffer everyone against market and logistics volatility. This stability opens space for open technical dialogue; clients trust us to flag any concerns and know we’ll do the same.

    Stories from disruptions—a short-shipped container or a customs holdup—live in the memories of our managers. Each such story becomes a driver for tighter documentation, more careful inventory management, and closer attention to global events that could reshape our supply calendar. We keep customers closely updated because surprises breed more problems than honest delays.

    Continuous Improvement—How Our Careers Led Here

    Many operators and chemists in our plant have guided the company through cycles of change. We’ve invested in automation, digital monitoring, and advanced analytics, but nothing replaces first-hand judgment honed by years handling this and other specialized intermediates. Each team member knows the feel of a well-qualified batch—the subtle clues that tell you when things are right or wrong. These habits drive our technical edge and keep downtime low.

    Continuous improvement for us means chasing tighter batch-to-batch tolerances, refining process steps, and catching inefficiencies before they grow into problems. In some seasons, customer feedback on formulation or application has led us back to the lab to test out tweaks, producing data that benefits the next generation of users. The evolution never really ends, because each lesson, from failed trials to client praise, shapes the next day’s production.

    Knowledge Transfer—Why Industry Experience Beats Catalog Copy

    Technical data and catalog numbers tell only part of the story. Nearly every production challenge, supply issue, or application bottleneck we’ve seen has built our current depth of understanding. We encourage clients to share their process setups, strange observations, and even failures, because these authentic exchanges fuel shared solutions. Factory visits reveal more than specifications: they bring home the texture, odor, and every nuance of the material.

    Success with specialized chemicals such as 1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one depends on this industry-specific knowledge-sharing. When a project stalls, a troubleshooting session with our crew can shave weeks off a development timeline. Our focus stays fixed on tangible results—pure, reliable material in the quantities promised, plus transparent support through each challenge. That approach has won us allies, not just customers.

    Shaping Tomorrow’s Standards—Driven by Real Experience

    Years on the plant floor and test bench give our people a unique perspective on product improvement and user needs. Industry standards keep evolving, but external rules and protocols rarely move as fast as the challenges faced on production lines or in scaling new syntheses. By documenting real issues, proposing and adopting new in-house best practices, and sharing these openly with collaborators, we push beyond basic compliance toward something more sustainable and beneficial for all.

    We see proof in the adoption of our suggested updates by competitors and clients alike. Operational transparency, willingness to report batch histories, and engagement with ongoing industry discussions keep our compound and many others aligned with the expectations of today and tomorrow. It’s this living commitment to integrity, adaptability, and technical competence that defines both the product and the people behind it.

    Partnering With Practitioners—Not Just Meeting Market Demand

    The people who rely on our materials are building complex new molecules, not just placing purchase orders. Applications change—sometimes driven by regulation, often by user innovation, occasionally by global events outside anyone's control. Our job remains steady: make top-quality 1-(2-Chloroethyl)-2,3-dihydrobenzimidazol-2-one, with support born of direct hands-on practice, shared experience, and mutual respect.

    That real-world understanding, more than any laboratory writeup or spreadsheet, continues to anchor our work. We look ahead by building stronger connections, staying open to every learning opportunity, and keeping the expertise where it belongs—on the production floor, in the lab, and always in service of those who trust us with their most demanding projects.