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1-(2,4-Dichloro-Phenyl)-Ethylamine

    • Product Name 1-(2,4-Dichloro-Phenyl)-Ethylamine
    • Alias Deschlorophenethylamine
    • Einecs EINECS 219-212-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    149253

    Chemical Name 1-(2,4-Dichloro-Phenyl)-Ethylamine
    Molecular Formula C8H9Cl2N
    Molecular Weight 190.07 g/mol
    Cas Number 81161-17-3
    Appearance White to off-white solid
    Purity Typically ≥98%
    Boiling Point Unspecified
    Solubility Soluble in organic solvents such as ethanol and DMSO
    Storage Conditions Store at room temperature, in a dry, well-ventilated place

    As an accredited 1-(2,4-Dichloro-Phenyl)-Ethylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle, labeled "1-(2,4-Dichloro-Phenyl)-Ethylamine, 100g," hazard symbols shown, tamper-evident seal, manufacturer's details included.
    Shipping Shipping for 1-(2,4-Dichloro-Phenyl)-Ethylamine must comply with local and international chemical transport regulations. The product is securely packed in approved containers, labeled as hazardous if applicable. Appropriate documentation, safety data sheets, and temperature control, if required, are provided to ensure safe transit and prompt delivery to the destination.
    Storage 1-(2,4-Dichloro-Phenyl)-Ethylamine should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as oxidizing agents. Keep it away from direct sunlight and sources of ignition. Store at room temperature, and ensure that proper safety labeling is present on the container. Use secondary containment to minimize spill risk.
    Application of 1-(2,4-Dichloro-Phenyl)-Ethylamine

    Applications of 1-(2,4-Dichloro-Phenyl)-Ethylamine in Industrial Manufacturing

    1-(2,4-Dichloro-Phenyl)-Ethylamine serves as a critical intermediate in several specialized chemical processes. Our direct manufacturing approach supports high-purity output and reliable batch consistency for customers in diverse sectors. Below, we detail major application routes with process, compliance, formulation, and end product specifics based on actual demand cases from industrial buyers worldwide.

    1. Pharmaceutical Intermediate for Antifungal Drug Synthesis

    This material is widely used as a building block for synthesizing active pharmaceutical ingredients (APIs), particularly for triazole-based antifungal agents such as Fluconazole analogues. Customers utilize it in multi-step organic synthesis under controlled GMP environments. The amine function enables regioselective coupling in ring-forming and alkylation reactions necessary for producing pharmaceutical-grade compounds. Material entering this process must exhibit precise impurity levels and consistent reactivity throughout scale-up, supporting regulated manufacturing of finished oral and injectable medicines.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • USP-NF Monograph Reference for API starting materials
    • EDQM CEP requirements for intermediates
    • FDA 21 CFR Part 211 (U.S. cGMP)

    Typical usage ratio

    • 5–15% of total batch mass depending on target triazole structure—customers adjust based on stoichiometry and process yield factors

    Downstream process integration

    • Entry as a key amine reactant during amide bond formation and N-alkylation
    • Introduced post-chlorination in the multi-step synthesis route
    • Reaction temperature control essential to optimize conversion and minimize by-products
    • Final purification by recrystallization or preparative chromatography before API finishing

    Final product types

    • Pharmaceutical active ingredients for antifungal tablets and parenteral solutions
    • API intermediates for contract drug manufacturers

    2. Agrochemical Intermediate for Fungicide Formulation

    Bulk buyers in agrochemical manufacturing use this compound to synthesize dichlorophenyl derivatives that feature in the production of advanced crop protection agents. The compound’s chlorinated aromatic structure adds specificity for synthesis of key azole and strobilurin fungicide actives. Production protocols require high batch reproducibility and trace metal-free origin to meet product stewardship goals in regulated export markets. Integration of this material into in-house or toll-manufacturing processes supports supply of pre-formulated and technical-grade fungicides for field application.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • China GB/T 1604: Technical Specifications for Pesticide Intermediates
    • REACH Annex VII-X Registration (export to EU)
    • OECD Good Laboratory Practice (GLP) in product development

    Typical usage ratio

    • 12–23% of initial reaction mixture for strobilurin and azole frameworks; varies by downstream chlorination and ring-closure requirements

    Downstream process integration

    • Amine charged at controlled addition rates in the technical fungicide synthesis step
    • Used during nucleophilic aromatic substitution and downstream cyclization
    • Material recovery and recycling implemented in closed-loop systems to reduce byproduct load
    • Lot sampling and residual impurity analysis part of regular QC before formulation

    Final product types

    • Technical-grade azole and strobilurin fungicide bases
    • Ready-to-use agrochemical concentrate for commercial blending

    3. Intermediate for Manufacturing Advanced Dyes and Pigments

    Our customers in pigments and specialty colorants utilize this amine as a primary aromatic source for coupling in azo and phthalocyanine dye production. Its dichloro substitution pattern supports high oxidative stability and fastness characteristics in the final pigment. The compound integrates with diazotization or Friedel-Crafts procedures and must maintain particle size distribution suitable for downstream dispersions. Extensive batch testing ensures compatibility with volatile organic content (VOC) restrictions in paint, plastic, and textile coloration sectors.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Textile chemicals)
    • DIN EN 71-3 (Safety of Toys – Migration of Certain Elements)
    • REACH SVHC compliance for pigments
    • ISO 9001:2015 certified pigment manufacturing procedures

    Typical usage ratio

    • 5–10% by weight in classic azo dye synthesis; adjusted according to molar ratios in multi-ring systems

    Downstream process integration

    • Used in initial amination or diazonium salt formation step
    • Directly charged into aqueous or solvent phase reactors
    • Rapid reaction followed by stabilization and neutralization
    • Slurry filtration, washing and drying prior to pigment finishing steps

    Final product types

    • High-stability organic pigments for paints and plastics
    • Azo dyes and textile colorants
    • Color concentrates for inks and masterbatch production

    4. Synthesis of Specialty Monomers for Engineering Polymers

    Engineering plastics manufacturers apply this raw material as an intermediate in the creation of specialty monomers, including dichloro-substituted styrenes and high-performance epoxy precursors. Its amine group supports site-specific polymerization where thermal lability and mechanical strength are critical for finished resin properties. Proprietary formulations depend on consistent lot-to-lot characteristics and compliance with high-purity and low-ash requirements. Customers integrate this compound into both batch and continuous reactors, adjusting process parameters for controlled molecular weight and cross-link density in the final polymer product.

    Industry compliance standards

    • ISO 14001:2015 (Environmental management in polymer production)
    • RoHS Directive 2011/65/EU for electrical/electronic polymers
    • ASTM D256 and D638 for mechanical properties testing
    • REACH Annex XVII for restricted substances in plastics

    Typical usage ratio

    • 3–8% of resin formulation weight; precisely defined by targeted cross-linking density and polymer chain design

    Downstream process integration

    • Introduced during monomer pre-polymerization step via amination or substitution
    • Continuous metering and monitoring critical for maintaining performance targets
    • Removal of residuals via vacuum stripping or molecular sieving
    • Blending with additional fillers and plasticizers in final compounding stage

    Final product types

    • Engineering resins for automotive and electronics applications
    • Chemical-resistant coatings and encapsulants
    • Adhesive monomers for high-performance bondlines

    5. Fine Chemical Synthesis for Analytical Reagents and Standards

    Specialty chemical producers rely on this amine for creating analytical standards, derivatization agents, and calibration chemicals used in chromatography, spectroscopy, and trace analysis. The consistent substitution pattern and high purity ensure minimal interference in sensitive measurements. Application environments typically require trace metal analysis and conformity with ISO/IEC 17025 for laboratory chemicals. Producers employ precision dosing and in-line purification steps for guaranteed representativity and repeatability in reference material manufacturing.

    Industry compliance standards

    • ISO/IEC 17025 for testing and calibration laboratories
    • OECD GLP for chemical analysis compounds
    • REACH Registration for analytical reagents
    • Certificate of Analysis (CoA) with batch-specific purity and trace impurity data

    Typical usage ratio

    • Varies from 0.1–2% as derivatization agent in analytical-grade reagent blends; set by calibration sensitivity and detection limits

    Downstream process integration

    • Added during synthesis of analytical standards or chemical probes
    • Cleanroom processing with automated weighing and dissolution
    • Purification by distillation or high-performance liquid chromatography (HPLC)
    • Final bottling in inert atmosphere packaging for stability

    Final product types

    • Certified reference materials for chromatographic analysis
    • Spectroscopic calibration reagents
    • Trace analysis chemicals for regulatory testing labs
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    More Introduction

    1-(2,4-Dichloro-Phenyl)-Ethylamine: A Closer Look From Our Factory Floor

    About 1-(2,4-Dichloro-Phenyl)-Ethylamine

    Here on the production floor, we deal with the compounds at the core of today’s innovation in specialty and fine chemical industries. One such product we have refined for consistent supply is 1-(2,4-Dichloro-Phenyl)-Ethylamine, known among chemists for its versatile role in multiple downstream applications. What sets this compound apart starts right from the first reaction in our synthesis, where every variable matters—not only to us, but to those who rely on our material to make their process work.

    Model and Specifications in Real-World Production

    Our main product line for 1-(2,4-Dichloro-Phenyl)-Ethylamine focuses on promoting reliability in synthesis and purity. We deliver batches typically exceeding established benchmarks for purity, minimizing common byproducts and contaminants which tend to challenge even experienced operators in this field. We put weight on controlling batch-to-batch variation, because even minor impurities can affect reactivity or downstream compatibility—especially in active pharmaceutical intermediates or custom synthesis routes for agrochemicals.

    Handling this material, teams in our shop adapt process conditions throughout the run. Color, odor, moisture content, and melting point all get checked, but the main story lies in the consistency of the dichloro substitution pattern. You won’t find unexpected isomers or off-target methylations because years of process tweaking have dialed in selectivity and made mishaps rare. This translates to less downstream troubleshooting for our customers, no unexpected TLC spots, and fewer headaches for chemists evaluating a new supplier lot. It is important to us because we’ve watched projects go off the rails from poor-quality feedstock.

    Everyday Usage Scenarios

    From a practical perspective, 1-(2,4-Dichloro-Phenyl)-Ethylamine finds its place in chemical manufacturing labs and scale-up reactors where reliability matters. Its structure—anchored by the 2,4-dichlorophenyl group—provides a stable backbone. That means our product sees action as an intermediate for making specialty pharmaceuticals, complex agrochemicals, and building blocks for organic materials.

    We know the challenges that come with scale-up and downstream handling. This isn’t an off-the-shelf additive for simple recipes. It slots into synthetic schemes where a clean amine group opens doors for coupling, condensation, or further functionalization. Sometimes, a single lot ends up in several R&D tracks; clients appreciate starting with a single well-documented batch, reducing the chance of spurious results. We support requests for both small R&D packs and drums suitable for kilo-scale synthesis, because the chemical’s journey from bench to pilot plant isn’t always linear.

    Chemists often aim for robust reactivity in key transformations like reductive amination, amidation, or cyclization. We keep a dialogue open with users on best solvent and temperature conditions, sharing real process feedback and addressing subtle issues like solubility or exotherm management drawn from years running similar aromatic amines. Teams new to the dichlorophenyl subclass may reach out for pointers on avoiding polymerization side reactions or managing volatility during higher-temperature distillations. Collectively, these shared experiences help dial in both process safety and yield.

    How Our Compound Differs from Off-the-Shelf Supplies

    Years of direct feedback from contract manufacturers and research customers have shaped our approach. Comparing 1-(2,4-Dichloro-Phenyl)-Ethylamine from a dedicated facility like ours versus bulk traders or catalog resellers, differences show up in more than just a certificate of analysis. Handling and shipping may not seem like front-line concerns, but mishandling can expose the product to hydrolysis or photodegradation, especially in humid or bright conditions. We load all product in air-tight, amber containers and maintain trace records of each lot’s storage timeline.

    Traceability forms the backbone of our integrity. Every drum, carboy, or flask carries not only precise assay and impurity data, but lineage back to original raw materials. We have seen so-called “commodity grade” amines emerge from high-throughput dealers; our quality control teams have dissected plenty of their product—chunks of off-odor matter from degradation, darkening on standing, wild swings in GC analysis. The industry at large must pay attention to these warning signs: a simple label does not assure reliability. Failure to address these factors can put downstream production lines at risk, especially as pharmaceutical batch manufacturing increases regulatory scrutiny and transparency demands.

    Over years of working with this family of compounds, we’ve committed to a tighter process envelope than what is considered industry baseline. The cost structure may be higher up front, but avoided disruptions, lost material, or delayed campaign launches offset sticker shock on technical-grade supplies. We welcome advanced technical questions before purchase, understanding nobody wants an unwanted contaminant showing up mid-campaign.

    Operational Challenges—and How We Face Them

    Producing aromatic ethylamines like this one doesn’t lend itself to autopilot operation. For every lot, our operators calibrate feed rates, monitor for exothermic surges around key addition points, and react quickly if in-line sampling reports a drift. Sensor calibration and in-process sampling mean we catch issues before they build up. Even with automation support, hands-on review plays a role: some subtleties simply need a human checkpoint.

    Managing waste and environmental exposure also weighs into our standard practice. Handling chlorinated phenyl alkylamines puts us on high alert for safe ventilation, collection of process water, and mitigation of halogenated residues. Waste streams are mapped and treated on site or by dedicated partners, staying ahead of changing local and international environmental standards.

    Supply chain disruptions have added a new layer of scrutiny. Over the last two years, securing key raw materials required flexibility—sourcing alternate precursors or qualifying new suppliers when geopolitical or logistic events disrupt regular supply. For a while, delays in receiving high-purity 2,4-dichloroaniline affected turnarounds. We kept routine clients informed, adjusted lead times, and in select cases even walked through process changes that helped conserve existing stocks without sacrificing end quality.

    Other industry players might opt to cut corners in difficult times; our commitment lands on investing in buffer inventories, even at higher costs, to protect reliability in forward contracts. The short-term pain of carrying extra stock beats trying to substitute critical customers’ needs with lower-graded imports.

    Common Technical Questions—And What We’ve Learned

    Chemists and engineers ask about stability during long-term storage, compatibility with common solvents, and ease of repurification. We share our own accelerated stability results and routine test outcomes, confirming adequate shelf life under recommended conditions—low moisture, sealed containers, away from direct sunlight. Analytical chemists receive raw HPLC and GC chromatograms to validate their own internal methods. For complex routes using this amine as a coupling partner, synthetic teams care about trace levels of related amines, oxidized byproducts, or residual acidity.

    As workflows evolve, clients need specifics on scaling from gram to kilo and beyond. Handling properties may change under cooling or heating—crystal formation, viscosity shifts, or emulsification hazards under fast mixing. Our process group collaborates with end users to troubleshoot and optimize parameters, drawing from scale-up runs and previous production campaigns. If downstream steps demand additional purification or salt formation, our technical service team walks through recommendations case by case.

    From pilot to commercial scale, users report on solubility shifts based on solvent and temperature. For analytical development, they care about UV/visible absorbance spectrum and any risk of false positives from side impurities in sensitive bioassays. Combined experience from multiple campaigns—across different customer sectors—bolsters technical guidance and supports application scientists as regulations and in-process analytical requirements change.

    Role in Downstream Chemical Development

    1-(2,4-Dichloro-Phenyl)-Ethylamine functions as more than just a building block; it represents a strategic lever in the hands of development teams. Its two chlorines on the aromatic ring confer unique reactivity patterns, giving it selective advantages during halogen-exchange, ring substitution, or cross-coupling reactions. In the medicinal chemistry sector, our compound underpins several patented scaffolds, chosen for both its performance and the trace documentation backing its origins.

    Some research teams leverage the clean reactivity of the ethylamine group to introduce heterocyclic rings, synthesizing new leads for oncology or central nervous system disorders. In the agrochemical field, stable dichlorinated aryl amines have gained traction for their selectivity and metabolic profiles in next-generation crop protection agents. We keep an eye on global patent trends, occasionally fielding requests for custom derivatives—such as N-alkyl substituted versions—where a client’s route depends on our established product as the parent material.

    Our ongoing commitment includes tracking new literature, appraising advances in synthetic methodologies, and sharing data or samples for academic and industrial collaborations. The fact that so many teams circle back for new product campaigns testifies to mutual trust built on technical performance and after-sale dialogue.

    Practical Lessons for Chemists and Engineers

    Working with this compound regularly, we’ve realized the importance of process design that minimizes human error or unplanned exposure. Our own teams handle it with proper gloves, face protection, and local extraction for every open transfer. This not only safeguards staff, but preserves material purity—airborne moisture or cross-contamination from adjacent product lines can cause problems a day, week, or month later. Investment in dedicated transfer and packaging lines paid off, giving users more predictable outcomes.

    For R&D projects transitioning to full-scale manufacturing, we flag potential bottlenecks early—batch sizes, safe heating rates, filtration needs, intermediate workup protocols. After years in chemical manufacturing, shortcuts rarely lead to long-term gains. We encourage process documentation, incremental scale-up, and direct feedback. Sometimes a new user uncovers a reactivity quirk or unexpected impurity pathway. Our open-door policy means we don’t shy from tough conversations about failures, and we help address them with realistic, hands-on advice, not just theoretical guidance from product bulletins.

    Supporting regulatory and environmental compliance poses its own challenges. As a manufacturer, we pay regular visits to our effluent treatment partners and evaluate waste minimization strategies at every process step. We share relevant documents and testing data with clients for their own compliance filings—appreciating that oversight from authorities grows each year. Experience shows that up-front investment in documentation and third-party validation reverses fewer headaches in audits or production reviews.

    The Road Ahead

    Demand for specialty amines continues to shift as research priorities and environmental standards evolve. Over the past decade, interest in dichloro-substituted intermediates like 1-(2,4-Dichloro-Phenyl)-Ethylamine hasn’t faded. Instead, new applications emerge from the parallel push for safer, greener synthetic routes and selective reactions. We encourage clients to reach out with unusual needs, whether it’s higher assay, tailored particle size, or additional stability testing. Our flexibility stems from direct experience and adaptability, not one-size-fits-all thinking.

    Continuous improvement—both in our processes and technical support—remains key. We invest in staff training, plant upgrades, analytical laboratory expansion, and ongoing review of regulatory guidelines. By sharing practical lessons, detailed batch records, and transparent feedback on limitations or open questions, we help every partner build more robust chemical synthesis strategies. Our direct experience with 1-(2,4-Dichloro-Phenyl)-Ethylamine stands as testimony to the skill, collaboration, and vigilant quality assurance that underpin authentic chemical manufacturing today.

    In summary, we take pride in supplying a product that does its job without surprises, because we know every project downstream counts on us as a trusted link in the chain from raw material to finished product.