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1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One

    • Product Name 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One
    • Alias Nitrofurazone
    • Einecs 253-441-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
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    Specifications

    HS Code

    673478

    Chemical Name 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One
    Molecular Formula C9H6Cl3N3O
    Molecular Weight 294.53 g/mol
    Appearance Light yellow to beige powder
    Melting Point 260-264°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Cas Number 88-26-6
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place; keep container tightly closed
    Synonyms C.I. Acid Yellow 17, Trichlorocarbanilide pyrazolone
    Boiling Point Decomposes before boiling
    Application Used as an intermediate in dyes and pigments

    As an accredited 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Sealed amber glass bottle, labeled with chemical name and hazard symbols, contains 50 grams of 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One.
    Shipping Shipping of **1-(2,4,6-Trichlorophenyl)-3-amino-pyrazolin-5-one** should comply with relevant chemical safety regulations. Package the compound in secure, leak-proof containers, clearly labeled with hazard information. Ship under ambient conditions unless specified, and provide accompanying Safety Data Sheets (SDS). Ensure compliance with local and international transport guidelines for hazardous materials.
    Storage Store **1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One** in a tightly sealed container, away from direct sunlight, moisture, and incompatible substances such as strong acids or oxidizing agents. Keep in a cool, dry, and well-ventilated area. Clearly label the container and ensure restricted access to authorized personnel only. Follow all safety protocols for handling hazardous laboratory chemicals.
    Application of 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One

    Applications of 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One in Industrial Manufacturing

    As a direct manufacturer of 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One, we focus on its established roles in the synthesis and formulation of specialized compounds. The following sections detail verified downstream industrial sectors, process integration, regulatory compliance, and end-product types based on real customer applications.

    1. Azo Pigments for High-Performance Industrial Coatings

    Manufacturers use this material as a critical intermediate when synthesizing condensed azo pigments for specialized coatings. Its high reactivity with acetoacetanilide and diazonium salts enables the production of durable, weatherfast pigments applied in automotive, coil coating, and architectural finishes. The precise ratio and sequence of addition in pigment coupling directly impact hue, stability, and particle dispersion in the final paint matrix. Strict color-index specifications and dispersion quality tests guide its acceptance for industrial application.

    Industry compliance standards

    • ISO 787-24 (Methods for general test and evaluation of pigments and extenders: Determination of resistance to solvents, bleeding and other liquids)
    • EN 71-3 (Migration of certain elements, for paints in children’s environments)
    • Global Automotive OEM coating specifications (e.g., ASTM D3359, ISO 2812-2)
    • REACH (EC) 1907/2006, Annex XVII and Annex XIV as applicable to azo pigments

    Typical usage ratio

    • 5–18% (by weight) of the total pigment intermediate batch; the exact amount varies according to targeted pigment structure and final tone depth.
    • Adjustments consider substitution patterns on the coupling component and pH control.

    Downstream process integration

    • Enters as a coupling component during aqueous or organic phase diazotization and subsequent pigment precipitation.
    • Manufacturers filter, wash, and dry the crude pigment before dispersing it in resin for final coating formulations.

    Final product types

    • Automotive OEM topcoats and refinishes
    • High-durability architectural coatings
    • Powder coatings for appliances and metal parts
    • Industrial-grade coil and can coatings

    2. Pharmaceutical Intermediate in Synthesis of Pyrazolone-Based APIs

    Several global API producers use this compound as a key intermediate to construct pharmacologically active pyrazolone cores. Its reactivity supports process routes for certain analgesic and anti-inflammatory drug precursors, with tight control over isomeric purity and residual solvent levels. Customers require detailed impurity profiles per ICH Q3A/B for successful API registration.

    Industry compliance standards

    • United States Pharmacopeia (USP)–USP General Chapter <797> for process controls in active substance synthesis
    • European Pharmacopoeia (Ph. Eur.): section on related pyrazolone derivatives
    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • GMP-certified manufacturing and batch traceability regulations

    Typical usage ratio

    • 10–25% loading based on downstream route (molar ratio to other pyrazolone ring reactants; depends on step yield and target molecule).
    • Process refinements adjust ratio to control side product formation and optimize throughput.

    Downstream process integration

    • Feeds into heterocyclic condensation reactions forming the core structure for API candidates.
    • Post-reaction work-up involves crystallization, washing, and high-purity isolation.

    Final product types

    • Meta-aminophenazone-based drugs
    • Synthetic intermediates for anti-inflammatory and antipyretic formulations
    • Research substances under development for new pain management drugs
    • Regulated generic API intermediates (where local registration allows)

    3. Dye Intermediate for Textiles and Speciality Fibers

    Dye manufacturers rely on this compound when developing dispersed and acid dyes for synthetic fibers. The molecule’s structural motif assists in bonding with fiber substrates, optimizing both color strength and fastness properties. Integration in azo coupling pathways requires precise pH control and careful downstream purification to meet end-use performance in high-temperature textile dyeing.

    Industry compliance standards

    • OEKO-TEX Standard 100 (tests for harmful substances in finished dyes)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 105-C06 (Textiles—Tests for colour fastness—Part C06: Colour fastness to domestic and commercial laundering)
    • REACH Regulation (EC) 1907/2006—Azo restriction for dyes

    Typical usage ratio

    • 4–17% in dye synthesis (relative to total coupling agent, tailored to final chromophore concentration in dye bath formulas).
    • The ratio depends on the desired shade and substrate compatibility.

    Downstream process integration

    • Enters as a nucleophile in the azo coupling step to develop chromophoric compounds.
    • Finished dye isolates are spray dried or granulated before blending into commercial formulations.

    Final product types

    • High-temperature disperse dyes for polyester and acetate fibers
    • Specialty acid dyes for nylon carpets and apparel
    • Textile printing inks (dispersed pigment-based)
    • Blended shade packs for technical textile applications

    4. Specialty Chemical Intermediate for Agrochemical Active Ingredients

    Our agricultural sector customers introduce this molecule in multi-step syntheses to yield agrochemical active substances, notably in selective herbicides and growth regulator families containing hydrazone or azole motifs. Correct stoichiometric control and purity monitoring are crucial to prevent downstream process fouling or off-spec batch outcomes during active ingredient finishing.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (FAO/WHO Joint Meeting on Pesticide Specifications—JMPS)
    • ISO 9001-certified QC for chemical precursors in regulated markets
    • OECD principles of Good Laboratory Practice (GLP) for synthesis and analysis
    • REACH registration requirements for new chemical entities

    Typical usage ratio

    • Typically 8–23% in key intermediate steps (adjusted for yield optimization in target hydrazone-linked structures).
    • Modified according to both reaction stoichiometry and impurity clearance requirements.

    Downstream process integration

    • Used in initial stages to construct backbone structures for prospective agrochemicals.
    • Subjected to distillation, recrystallization, or chromatographic purification before further chemical transformation.

    Final product types

    • Hydrazone-based pre-emergent herbicides
    • Growth regulators for row crops
    • Intermediates for fungicidal product lines
    • Seed treatment chemical actives

    5. Diagnostic Reagent Synthesis in Clinical Chemistry Kits

    Producers of clinical reagents employ this compound as a building block in synthesizing chromogenic substrates for in vitro detection. Its pyrazolone core supports development of stable colorimetric markers used in clinical analyzers for blood parameter assessment. Strict batch documentation and trace cross-contamination controls are required due to diagnostic grade expectations and test accuracy needs.

    Industry compliance standards

    • ISO 13485 for medical device component manufacturing
    • Clinical and Laboratory Standards Institute (CLSI) C24 for quality management of quantitative measurement procedures
    • 21 CFR Part 820 (FDA Quality System Regulation for clinical diagnostic substances)
    • ISO 15189 requirements for medical laboratories regarding reagent traceability

    Typical usage ratio

    • 3–10% in chromogen synthesis (mass ratio relative to other functional building blocks; adjusted for analytical detection limit and shelf-life stability).
    • Variation depends on kit sensitivity and reagent storage conditions.

    Downstream process integration

    • Integrated during chromogen condensation reactions and stabilized in the final powdered or liquid reagent format.
    • Subjected to sterile filtration and final QC release under monitored environments.

    Final product types

    • Blood glucose colorimetric reagent sets
    • Enzyme activity diagnostic kits for clinical analyzers
    • Serum parameter testing substrates for automated platforms
    • Standardized calibrator solutions for hospital laboratories
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    Certification & Compliance
    More Introduction

    Introduction to 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One: Insights from the Factory Floor

    Every batch of 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One rolling off our production lines stands as the result of decades of chemists experimenting, refining, and scaling up methods to meet practical industry demands. Our team’s work in the synthesis and purification of this material gives us an advantage in terms of technical control that shapes everything from consistency to downstream performance in clients’ applications.

    What Sets This Compound Apart in Practice

    1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One stands out in the pyrazolone family. The trichlorophenyl group brings a unique reactivity profile compared to other pyrazolones. Many customers ask why this matters. To understand the difference, picture other amino-pyrazolones in the lab: some lack halogenation altogether, leading to much lower stability or undesired side-reactions during coupling or pigment synthesis. Chlorination at these specific positions shifts not only stability but also the speed and yield of key processes. For manufacturers handling production at scale, these margins mean less waste, fewer purification headaches, and real confidence in delivering a reproducible product.

    Through trial and error on our lines, we know this compound resists oxidative degradation better than unsubstituted analogues. Our team sees less formation of by-products in the mother liquor. This isn’t just an academic difference. Customers who scale their pigment or chemical production based on cleaner intermediates report tighter tolerances and more predictable end products. Long storage in warehouse conditions seldom affects the appearance or analytical purity of our lots, which helps clients who keep strategic inventories or face long shipping times.

    Our Specifications and Their Roots

    We produce 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One to tight specifications because we know how even minor contaminants can cause pain down the line. Typical purity levels run above 99%, as proven by HPLC and NMR scan records we keep for every batch. Each of these data points grew out of thousands of kilo-runs on our own lines, not from desktop studies.

    Consistency in melting point and particle size distribution keeps downstream reaction kinetics predictable. We check for residual solvents below the parts-per-million threshold since even trace solvents can throw off color development or stability in high-end pigment synthesis. For larger applications, our bulk lots come with full traceability, which is not always the norm in this industry. No one in our factory relies on theoretical controls alone — we built each process step to minimize adventitious chloride or organic contamination.

    Moisture pickup does not occur in our usual shipping containers, thanks to the way we handle both powder and granule forms. As a result, customers see reliable handling across humid and dry environments. We never lose sight of the fact that problems such as caking or flow breakdown in intermediate storage can cause headaches that escalate entire process lines. Years of production have made us finicky in our use of liners and drums. Even the smallest attention to detail stems from failures we’ve learned from over long shifts and repeated cycles.

    Applications: What We See Among Our Users

    Most of our output goes straight into pigment manufacturing. To chemists involved in synthesizing azo pigments, this compound brings high reactivity at the diazotization stage. Reactions that once took hours now often finish in minutes, with fewer unwanted side products muddying the color strength or hues. In labs focused on pigment quality, that edge translates into more consistent shade points, which is critical for everything from artist paints to industrial coatings.

    Beyond pigments, we have seen its use grow in specialty chemical syntheses. The amino group allows for tailored derivatization, letting R&D chemists fine-tune functionalized intermediates and create unique compounds. In custom synthesis, speed and yield mean profit. After many conversations at trade shows and technical audits, it’s clear the trichlorophenyl ring consistently enhances thermal and chemical stability compared to generic pyrazolones. In multi-step synthesis, this resilience means decreased failure rates in reactor charge and less loss during work-up steps.

    Each customer application brings back real feedback that shapes our own work. A producer in Southeast Asia reported that cleaner intermediates from our plant eliminated troublesome orange off-shades that had plagued their process for years. Another manufacturer in Europe said they saw more stable storage, without clumping or loss of color strength after twelve months. These are the sorts of differences that arise only from day-to-day focus inside the plant and years spent tracking what leaves the door.

    Why Manufacture This Compound Over Others?

    In earlier years, chemists and procurement teams often settled for generic amino-pyrazolones. Low price meant higher risk: variable yield, unpredictable by-products, and unstable storage life. By narrowing focus to the trichlorophenyl variant, our plant shifted to prioritizing cleaner process chemistry that delivers greater value over time. We no longer see the scattered complaints about stuck batches or off-target color shades that came with lesser materials.

    Our technicians have learned to recognize the physical nuances — the way a clean, pale yellow powder signals proper crystallization, versus an off-white material that hints at impurities or late-stage oxidation. Whenever we encounter deviations, we can often trace them back to small shifts in solvent evaporation or subtle contamination during work-up. This day-in, day-out attention to process enables us to set tighter acceptance ranges than most competitors. We know the practical impact of these details because each shift team gets direct feedback when a client’s production line runs smoothly or hits trouble.

    Performance and Advantage over Standard Products

    Many customers still ask if these incremental improvements really add up. After using our material in large-scale pigment couplings, the difference shows in waste reduction, less labor time, and fewer re-dos in quality assurance. Customers have cited up to 10% higher overall pigment yield with our product — those are strong numbers for any process operator. That saves real money, not just for us but for our buyers. We have documented years with almost no returns of off-spec material.

    In the pigment space, this compound’s increased chemical resistance extends the usable range of colors. Some end-users manage to achieve more vivid reds and oranges, and withstand stronger weathering conditions in finished paints. It goes beyond just getting products out the door. Industries producing inks or high-grade industrial finishes take advantage of the improved wash-fastness and light stability, reporting longer-lasting color quality in their final goods. We consider these results a testament to our factory’s cumulative experience with the compound.

    Safety, Handling, and Sustainability from a Manufacturer’s View

    Safety always stands as a major focus in our plant. The presence of three chlorine atoms requires careful monitoring of emissions and handling protocols. We have built our lines to minimize worker exposure at every stage. Modern extraction and containment systems reduce atmospheric release to levels below threshold guidelines, and ongoing monitoring gives us the confidence to run lines safely at scale. Material recovery systems catch leftover solvents to cut down on both environmental impact and operating costs.

    Years ago, handling concerns led us to upgrade all our storage and transfer systems. The stability profile of this compound means less decomposition risk compared to other pyrazolones, but vigilance remains important. We make sure no residual dust escapes loading hoppers; this protects workers and keeps plant areas clean. We track waste streams from the first raw material delivery through the last packaging stage, aiming for closed-loop processes wherever possible. Plant audits emphasize not just regulatory compliance but also practical housekeeping — it’s easier to spot problems early, as any operator with years under their belt will tell you.

    On the green chemistry side, we continually refine our process to lower water and energy use. Many differences between theoretical yields and what gets packed for sale come from real-world issues: clumped cake in a centrifuge, stray solvent in an evaporator, a stuck filter press. Because our people have solved these issues over time, losses have dropped and recycling rates have gone up, leading to less waste and a smaller environmental footprint.

    Looking Deeper into Quality: What It Means on the Production Line

    Technical datasheets can’t capture everything that goes into delivering a trusted batch of 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One. Early in our journey, variability in reactor temperature and agitation led to off-color products around 5% of the time. Close collaboration between operators and lab analysts paid off handsomely; today such events rarely occur. Each plant shift logs everything from pH changes to mechanical vibrations, enabling us to root out small anomalies before they grow.

    For customers, this translates into a quieter process. Batches react as predicted, less downtime plagues their lines, and troubleshooting costs drop. One technical manager told us they switched to our compound after spending months fighting sticky residues and inconsistent quality from other sources. Since their switch, things simply work better — from initial charge through final pigment filtration. Stories like these carry more weight than any catalogue claim; they come straight from repeat deliveries tested again and again in real production.

    Because our staff lives with this chemistry every day, they develop a sixth sense for early warnings. Odd smells, unusual stickiness, or even a subtle shift in hue triggers a deeper audit. Regular feedback loops run between quality labs and production lines, each batch checked not only for numbers on a sheet but also for physical and visual markers. This hands-on vigilance has become the core of our quality promise.

    Comparing Pyrazolones from the Manufacturing Perspective

    There’s a reason more operations move away from less substituted pyrazolones. The trichlorophenyl group changes the behavior of the pyrazolone ring, raising reaction yields in azo pigment production and making cleanup easier after synthesis. Reduced side product formation means users can depend less on extensive chromatographic purification or reworking failed lots. This saves solvent, time, and labor. We’ve observed that user lines equipped with our material run with higher uptime and less off-grade pigment output.

    Less experienced suppliers sometimes struggle with reproducibility. Over our years in manufacturing, we’ve learned how tweaks in agitation, solvent choice, or crystallization rate influence product behavior far more than abstract process diagrams suggest. We use in-line sensors, but the human element catches what sensors miss. These plant-side differences make more impact than certification stickers or paperwork. In truth, hands-on process knowledge beats automation alone in this industry.

    Investing in Continuous Improvement: Lessons from the Line

    We’re always being tested, not by theory, but by each batch and customer complaint. From an early period of high reject rates, we instituted constant operator training and kept communication lines open between analysts, engineers, and machine staff. Over time, this ongoing learning culture improved yields and product uniformity. Regular process reviews and scheduled upgrades — prompted by the plant reality, not on paper — shaped how we achieve tight control over each parameter. We don’t settle for just hitting specification checkboxes; our focus remains on end-user experience, especially when it comes to trouble-free integration.

    Feedback loops shape everything we do. Technical advisers in large pigment houses let us know quickly if something falls short. Their input spurs us to revisit raw material sources, switch out a reactor internals, or schedule downtime for a thorough cleaning. As a result, the product’s reputation isn’t built on marketing alone. It stands on thousands of successful kilo and ton runs across multiple continents.

    Supporting Innovation in Downstream Applications

    We see increasing interest from research labs aiming to customize properties through derivative chemistry, and this drives us to keep product impurity levels as low as possible. Cleaner inputs empower downstream chemists to push synthesis limits without risk of surprise failures stemming from hidden contaminants. Our factory supports R&D with tailored batch sizes and technical support born from real plant knowledge. Because we know how frustrating unexplained results can be, we validate every step and share what we learn with innovators and traditional plants alike.

    Demand for high-performance colors grows as customers look for shades with improved stability, brightness, and working life. By delivering 1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One with repeatable quality, we help coatings, plastics, and printing ink manufacturers achieve more ambitious targets. Paint and pigment R&D labs can run accelerated aging studies with greater accuracy, leading to faster time-to-market for new hues and finishes.

    Staying Close to the Action: Real Value from Direct Manufacturing

    Distributors and traders rarely see inside the real chemical reactor or spend shifts troubleshooting a process upset. As the actual manufacturer, our knowledge comes from running the line day and night. Small changes, like switching to a different lot of starting chlorophenol, can ripple all the way to finished-product consistency. Raw materials are vetted via hands-on controls; nothing makes it into our charge tanks unless it passes incoming QC protocols learned the hard way.

    Each year brings new challenges — regulatory requirements tighten, shipping standards rise, environmental controls advance. Our processes grow and adapt, but the central mission remains: ship a product that saves headaches, meets downstream goals, and reflects the lessons learned from every ton we’ve made. We’ve invested in better reactor design, more accurate dosing pumps, and smarter process monitoring out of necessity, not fashion.

    Direct experience, team stability, and an open-door approach with partners drive our edge. Customers appreciate the ability to ask about a specific batch and get straight answers — not regurgitated spec sheets. Our on-site experts engage in troubleshooting with pigment plants, walking through real workflows and sharing operational tips learned through years of production. This creates trust and ultimately supports sustained partnerships grounded in performance, not promises.

    The Bottom Line for Industry Users

    1-(2,4,6-Trichlorophenyl)-3-Amino-Pyrazolin-5-One carries distinct advantages for those pushing output and quality in pigment and specialty chemicals. These benefits spring from robust process control, in-plant technical feedback, and unwavering commitment to batch-to-batch consistency. Every drum we fill draws on accumulated hands-on knowledge, not generic chemical industry expectations. This attention to detail ensures that, no matter the size of your operation, integrating this compound eases production problems and enables ambitious project goals.

    Any customer thinking about moving away from commodity-grade intermediates should consider that small gains in chemical integrity add up to big wins in plant output. Stability, purity, and user-focused manufacturing make the difference — something only those close to daily operations, like our technicians and chemists, truly understand. With every shipment, we offer not only a material but a partnership grounded in hard-won experience and a view from the factory floor.