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1,2,3-1H-Triazole

    • Product Name 1,2,3-1H-Triazole
    • Alias Vinyl azide
    • Einecs 208-765-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    531476

    Iupac Name 1H-1,2,3-Triazole
    Molecular Formula C2H3N3
    Molecular Weight 69.07 g/mol
    Cas Number 288-36-8
    Appearance White to off-white crystalline solid
    Melting Point 120-122 °C
    Boiling Point 203 °C
    Density 1.31 g/cm3
    Solubility In Water Miscible
    Pka 1.17 (1H position)
    Flash Point 104 °C
    Refractive Index 1.542

    As an accredited 1,2,3-1H-Triazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, tightly sealed bottle labeled “1,2,3-1H-Triazole, 100g,” with hazard symbols, lot number, and safety instructions clearly visible.
    Shipping **1,2,3-1H-Triazole** is shipped in tightly sealed containers to prevent moisture entry and contamination. The chemical should be transported under cool, dry conditions, following standard hazardous material regulations. Packaging must comply with local and international DOT and IATA requirements, clearly labeled, and accompanied by appropriate safety documentation and handling instructions.
    Storage **1,2,3-1H-Triazole** should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition or heat. Keep away from incompatible materials such as strong oxidizers. Store in a chemical storage cabinet designed for flammable liquids. Ensure proper labeling and follow all relevant safety guidelines for handling and storage.
    Application of 1,2,3-1H-Triazole

    Applications of 1,2,3-1H-Triazole in Industrial Manufacturing

    1,2,3-1H-Triazole serves as a core intermediate in multiple sectors, supporting the synthesis and performance of end-use materials through its efficient reactivity and well-documented compatibility. Below, we provide a detailed breakdown of its industrial applications, emphasizing compliance benchmarks, recommendable incorporation ratios, integration points, and manufactured end products for each sector.

    1. Agrochemical Synthesis: Fungicides and Crop Protection Agents

    As a nitrogen-rich heterocycle, 1,2,3-1H-Triazole forms the structural foundation for a series of systemic and contact fungicides in the agrochemical industry. Its role extends from serving as a core building block for triazole-based active ingredients—such as tebuconazole, propiconazole, and difenoconazole—to enabling selectivity in formulation processes. Manufacturers rely on its reproducible reactivity and strict adherence to international crop protection quality protocols when scaling production for agricultural deployment.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EPA 40 CFR Part 158 – Data Requirements for Pesticides
    • EU Regulation (EC) No 1107/2009 – Placing of Plant Protection Products on the Market
    • ISO 9001:2015 for Quality Management Systems in Chemical Synthesis

    Typical usage ratio

    • Integrated at 2–6 mol% relative to the core agrochemical batch size; actual addition varies with the molecular target and reaction pathway, adjusted according to the desired active ingredient potency and downstream formulation requirements.

    Downstream process integration

    • Introduced during multi-step heterocyclic synthesis; specifically, it enters during cyclization or condensation steps to generate triazole-substituted intermediates, followed by purification and in situ conversion into active fungicidal moieties as part of continuous or batch mode reactors.

    Final product types

    • Systemic fungicides (tebuconazole, propiconazole, epoxiconazole)
    • Seed treatment agents
    • Protective and curative crop sprays

    2. Pharmaceutical API Manufacturing: Antifungal and Anticancer Compounds

    In pharmaceutical manufacturing, 1,2,3-1H-Triazole acts as a pivotal intermediate in the preparation of active pharmaceutical ingredients, particularly in antifungal agents (including fluconazole and itraconazole) and those targeting cancer pathways. Its reliable synthetic profile and compliance with pharmacopeial purity standards make it the preferred scaffold for introducing triazole rings under GMP conditions, guaranteeing batch reproducibility and pharmacological safety for downstream formulation.

    Industry compliance standards

    • ICH Q7A GMP for Active Pharmaceutical Ingredients
    • USP-NF Monographs and Reference Standards
    • European Pharmacopoeia (Ph. Eur.) 10.0
    • FDA cGMP 21 CFR Parts 210/211

    Typical usage ratio

    • Usually charged at 3–8 mol% as a reaction intermediate, adjusted by synthetic route and API yield demands; refinement based on target impurity profile and downstream regulatory requirements for residuals.

    Downstream process integration

    • Enters the process during N-alkylation, cyclization, or functional group interconversion steps in API synthesis, after which the triazole core is elaborated through additional functionalization, followed by isolation, purification, and final form conversion (salt formation/tableting/excipient blending) under validated cleanroom environments.

    Final product types

    • Oral and parenteral antifungal medications (fluconazole, itraconazole)
    • Anticancer therapies (investigational or generic drugs with triazole scaffolds)
    • Bulk pharmaceutical intermediates for licensed drug manufacturers

    3. Corrosion Inhibitor Additives for Water Treatment and Oilfield Applications

    Downstream formulators use 1,2,3-1H-Triazole in corrosion inhibitor blends designed for industrial water treatment, power plant circulation, and oil & gas pipelines. Its electronic properties and chelation capability enable the development of triazole-containing inhibitors that reliably adsorb onto metal surfaces, forming protective films in challenging environments, including systems handling high-pressure steam or acidified flows.

    Industry compliance standards

    • ASTM D2688 – Standard Test Method for Corrosivity of Water-in-Oil Emulsions
    • API RP 682 – Pump and Piping System Corrosion Control
    • REACH Regulation EC 1907/2006
    • ISO 14001:2015 Environmental Management Systems

    Typical usage ratio

    • Concentration typically ranges from 100–500 ppm (parts per million) in finished inhibitor formulation; dosage calibrated using electrochemical test results, with site-by-site modification based on water quality variables and required protection duration.

    Downstream process integration

    • Blended during the post-synthesis homogenization stage for inhibitor package compounding; introduced as a solution or direct addition to the main aqueous or solvent phase, followed by filtration, drum-filling, and shipment to water treatment or oilfield operators.

    Final product types

    • Industrial water circulation inhibitors
    • Closed-loop boiler and chiller corrosion control packages
    • Oil & gas pipeline corrosion inhibitor fluids and concentrates

    4. High-Performance Polymer Synthesis: Crosslinkers and Modifiers

    Major polymer and material science companies rely on 1,2,3-1H-Triazole as a modular core to craft crosslinkers and functional monomers in advanced polymer systems, especially those manufactured for electronics encapsulation, adhesive systems, and specialty coatings. The triazole ring introduces thermal stability and chemical resistance, while offering numerous derivatization possibilities for customizing crosslink density or surface properties during polymer network formation.

    Industry compliance standards

    • RoHS 2015/863/EU for Prohibited Substances in Electronic Materials
    • UL 94 Flammability Test for Plastics
    • ISO 9001:2015 for Quality Management in Chemical Production
    • IEC 61249-2-21 Halogen-Free Materials Standards

    Typical usage ratio

    • Utilized at 0.5–3.0 wt% in epoxy or acrylic resin blends; dosing determined by target crosslinking density, mechanical strength, and thermal performance of the final polymer matrix.

    Downstream process integration

    • Charged during the resin blending or prepolymer preparation stage; undergoes coupling or click chemistry reactions with terminal groups of base resins, followed by molding, curing, or extrusion according to the required part geometry and end-use specifications.

    Final product types

    • Electronic encapsulants and adhesives
    • High-durability protective coatings
    • Specialty plastics for electrical and fiber optic applications

    5. Heterocyclic Intermediate for Dye and Pigment Manufacture

    The dye and pigment sector incorporates 1,2,3-1H-Triazole in chromophore synthesis, yielding stable colorants with improved lightfastness and processability for textiles, plastics, and industrial coatings. Its functionality aids in constructing extended conjugated systems through azo coupling or cross-conjugation, supporting the evolution of next-generation dyes that meet stringent global performance and toxicity criteria.

    Industry compliance standards

    • REACH (EC) 1907/2006 for Regulatory Compliance of Chemical Substances
    • OEKO-TEX Eco Passport for Textile Chemicals
    • ISO 105-B02 for Color Fastness Testing
    • GHS Hazard Communication Standards

    Typical usage ratio

    • Applied at 1–5 mol% in the dye synthesis batch; variance depends on target chromophore intensity, substitution pattern, and downstream application (textile vs. industrial pigment grade).

    Downstream process integration

    • Added during the coupling or diazo condensation step, enabling regioselective ring formation or functional group insertion; the resulting intermediate undergoes purification, stabilization, and subsequent blending into dispersions or dry pigment preparations.

    Final product types

    • Pigment-grade dyes for plastics and inks
    • Textile dyes requiring high wash and light fastness
    • Industrial colorants for automobile and appliance coatings
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    Certification & Compliance
    More Introduction

    Understanding 1,2,3-1H-Triazole from the Manufacturer’s Perspective

    The Heart of Triazole Production

    Working directly with 1,2,3-1H-Triazole each day allows a deep view into what shapes a quality chemical, and what sets ours apart. In our facility, raw materials don’t just become finished product by chance. Trained hands, strict environment, integrity in process—these traits build the foundation behind each kilogram. Nobody here waits for someone else’s standard. We measure every batch, check purity, tally yields, catch trace moisture, and examine color long before customers ever uncork a drum.

    For those less familiar, 1,2,3-1H-Triazole belongs to that class of nitrogen-rich five-membered rings, and it’s been core to various chemical syntheses for decades. Its basic formula, C2H3N3, packs three nitrogen atoms together—a recipe for versatility in industrial and research labs. But there’s far more behind the scenes than a molecular diagram lets on.

    Model, Specifications, and Our Processing Practices

    Our standard 1,2,3-1H-Triazole model presents itself as a white to off-white crystalline powder, running with a minimum purity of 99% by HPLC. This comes not out of accident or tradition, but because reliable chemical reactions and reproducible experiment results require more than paperwork—each bag must match the expectations not only on paper but in the field.

    Chemists don’t like unknowns. Residual solvents, heavy metals, or inconsistent melting points all spell trouble. Our regular program runs each product through a combination of gas chromatography, near-infrared moisture checks, and repeated melting point assessments. Failure to meet specifications means disposal, not compromise. We’ve learned through repeats and reruns that even minute by-products born from incomplete cyclizations end up haunting reaction steps down-stream, especially for end users in pharmaceuticals or specialty coatings.

    Packing methods matter, too. Moisture is the hidden enemy for triazoles. Desiccation steps take time but skipping them brings clumped, partially decomposed solids. Welded aluminum drums or moisture-barrier pouches, each chosen to fit logistics and batch size, keep stability up across transit zones and climates.

    From Lab Bench Curiosity to Industrial Workhorse

    A steady demand line traces back to the compound’s unique behavior in synthetic routes. In-house, the clean, dry nature of our 1,2,3-1H-Triazole removes complications during nucleophilic substitution, click chemistry, and cycloaddition reactions. Muddled, off-spec material stalls those steps or triggers incomplete conversion, producing headaches for scale-up teams and waste for all. Long experience has taught us that no shortcut on purification, no skipped test, ever escapes notice further down the chain.

    What makes 1,2,3-1H-Triazole memorable is not only the large range of uses—from intermediates for active ingredients in crop science and pharmaceutical compounds, to corrosion inhibitors and specialty dyes—but how many customers rely on batch-to-batch consistency. For example, research scientists screening reaction conditions need to trust that impurities or excess moisture from one drum won’t differ from the next and affect their results. Manufacturers using it as a building block in high-value synthesis—with stringent downstream purification—see every small impurity multiplied, impacting both quality and process costs.

    Practical Uses: From the Factory Floor Outward

    Synthetic chemists will recognize 1,2,3-1H-Triazole as a staple for the copper-catalyzed azide-alkyne cycloaddition. This reaction—a paradigm shift ever since it was popularized—built the foundation for everything from polymeric materials to advanced pharmaceutical candidates. Ask those in the field and they’ll tell you how variables like purity, water content, even trace metal contaminants, decide whether the reaction closes within minutes or trails off, leaving hard-to-separate impurities.

    Our experience working alongside users in scale-up chemistry shows a harsh reality: Not every triazole is equal under factory or pilot-plant conditions. Downsides from a less stringent process pop up as more tarry residues in reactors, higher solvent costs, more time spent in purification. Labs making use of our triazole get the benefit of fewer side reactions, lower batch-to-batch variation, and less troubleshooting. In a pharmaceutical context this isn’t just convenience, it protects regulatory submissions and keeps production timelines on track.

    In corrosion inhibitor development, 1,2,3-1H-Triazole’s electron-donating framework blocks oxidation at a critical point, making it valuable in pipeline maintenance and specialty lubricants. Materials scientists look for steady performance over many cycles. By delivering product where melt point and spectral data meet target with little drift, we help suppliers reduce unexpected downtime caused by out-of-spec products. We see the calls and requests for follow-up support from process engineers most often when some aspect of raw triazole supply veers from these basics.

    Development teams in pigment and dye manufacturing prize the stable, conjugated triazole as a precursor. Variations in crystal size or trace contaminants affect color strength or shelf-life, and those teams are quick to spot batches that don’t meet their needs. Over years of shipments, we’ve learned which traits matter most—consistency, controlled particle size, and full traceability from final product back to every flask and lot of precursor.

    How Our Product Differs from Others

    Differences begin with the raw materials and extend through every step. In our setup, small touches—matched reactor linings, filtered vacuum systems, and seed crystal selection—matter just as much as the headline specifications. These controls find their value once downstream users discover that their process scales up smoothly and waste streams remain steady. Most mass-market triazoles might bring an attractive price at first glance, but troubles become clear in the final application: unpredictable yield, more off-product, extra purification, sometimes even regulatory complications if the impurities are not fully identified.

    We’ve made a conscious decision not to cut cycles, change purification solvents with fluctuating market prices, or drop below our QC thresholds for the sake of volume. Yes, this sometimes puts pressure on lead times or production schedules. But from extensive chemical engineering experience, we know which corners left uncut lead to a chemical that outperforms a generic blend every time. Producers who once tried cheaper alternatives frequently return after a cycle or two, sharing stories about lost time, equipment cleaning, and wasted raw materials. These lessons aren’t printed in datasheets—they’re learned by living through the aftermath of failed production runs.

    Laboratory confirmation alone doesn’t replace process reliability on the shop floor. We verify not just by analytical purity but also through practical pilot-scale reaction trials. If a batch doesn’t perform up to benchmark demands, we scrap and retool. Seeing the entire chain from nucleus formation to drum loading, the team appreciates subtle cues—an odor, a hint of color, an atypical cake on filtration—that generic manufacturers won’t always catch or correct.

    Triazole manufacture isn’t simply about hitting published chemical specs. For example, a 99% purity batch by HPLC may still hide concealed impurities that interfere with downstream reactions, especially where copper catalysts or moisture minimization matters. Years spent talking to researchers and production chemists spotlight this: adjust one variable and entire product lines are at risk. By overbuilding checks and consulting with partners directly, we keep the losses minimal and the feedback loop direct.

    Facing Genuine Production Challenges

    Working as a direct producer brings responsibility to shape not just the chemical but the system delivering it. Global supply chains fail every year for want of traceability or tolerances that go unchecked. The triazole customer base gets split—those seeking the cheapest tons, and those looking to reinforce mission-critical production lines for months or years. We align ourselves with the latter, because every lost batch, every recall for off-quality triazole, costs exponentially more than the premium paid up front for clean, steady delivery.

    In the real world, unexpected problems challenge even the most careful operations. Moisture incursion during storage, cross-contamination after line changes, or shifts in feedstock consistency—only early detection and preemptive mitigation keep product reliable shipment after shipment. We’ve gained ground using in-line sensors, advanced filtration, and carefully sequenced reaction stops, each improvement rising out of equipment failures or near-misses from years past. There’s no finish line for these practices. Maintaining customer trust means continuous upgrades and absolute transparency when a hiccup slips through.

    The environment for chemical supply brings shifting pressures, from evolving regulatory regimes to wider calls for sustainability. Full traceability—from basic raw materials to finished product—remains a must. We chart every shipment, supporting documentation with analytical data, GHS-compliant labeling, and storage advice grounded in practical handling experience. That record doesn’t just serve our needs; it’s critical for customers asked to justify every link in their material chain, especially those navigating strict pharmaceutical, electronics, or agricultural markets.

    Built on Real Feedback, Focused on Improvement

    Companies depending on our triazole look beyond the powder itself. Support in troubleshooting, open communication during urgency or market swings, flexibility for custom requests—these shape reputations in the small world of specialty chemistry. Many of the improvements to our process came from sharp observations or direct complaints. Out-of-tune drying once caused agglomerates; now we maintain strict monitor stations and train staff not to cut corners even at shift’s end. Color drift flagged by a pigment maker prompted process changes to quench certain by-products earlier. Result: more predictable hue performance down the stream.

    Accidents haven’t vanished, but the culture here runs on solving problems before they repeat. The shop floor never forgets which supplier brings ease—the steady product, the fast document delivery, technical backstops on tricky synthesis work. From junior analysts in the QC lab to veteran operators handling finished product drums, the group shares pride in sending out not “a generic chemical,” but a specialty product that rarely sees itself returned for rework.

    Solutions for End Users Facing Challenges

    Those confronted with recurring technical issues—batch failures, new impurity profiles, or unstable storage—are often working with less tightly controlled triazoles. The solution always starts with dialogue. Beyond checking COA or MSDS sheets, real solutions come from discussing end-use goals, process details, and points where difficulties first arise. Installation of third-party sensors detecting water or trace heavy metals in their process shed light on the problem—uncovered after full testing runs with our triazole as the swapped variable.

    We do not leave customers to “trial and error” once a shipment arrives. Site visits, walk-through audits, or simple shipment matching use actual test samples in end-user conditions—discovering not just what the chemical “should” do but what it really does after shipping, storage, and handling. Ancillary services, like repackaging at reduced scales or sourcing inerted drums for sensitive work, spring up from direct conversation, not template offerings.

    Our focus stretches to fine-tuning protocols alongside customers, minimizing sampling errors, and updating protocols to match the latest compliance frameworks. The chemistry world does not rest, and for those pursuing next-generation synthetic targets, triazoles remain building blocks. Modern research sometimes demands tighter impurity specs, lower trace metals, or alternate physical forms like micronized or granulated triazole. Instead of waiting for a broad industry “move,” we add these lines on request, fold them into existing manufacturing cycles, and check that altered process parameters still yield intended results.

    Trust Comes from Proven Performance

    After years supplying 1,2,3-1H-Triazole across industries and markets, the core belief here hasn’t wavered: substance matters more than claims. Every batch reflects the commitment of seasoned production staff, choice in raw material sources, twin tracks of analytics and customer feedback. Not every drum leaves here perfect—but chasing perfection, and owning the process up to how the product performs in real-world conditions, moves results closer each cycle.

    Speaking plainly, customers who come to us rarely seek triazole just to tick a box on a formulation sheet. They want a partner, not just a product—a source who walks the process together, diagnostics in hand when needed, ready for honest dialogue if issues arise. Delivering this consistently forms the backbone of long supplier relationships, and puts tangible support behind each kilogram shipped out the door.