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1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate

    • Product Name 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate
    • Alias DTTFA Hydrate
    • Einecs 636-859-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    810261

    Chemical Name 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate
    Cas Number 460-19-5
    Molecular Formula C3H2Cl2F3O2
    Molecular Weight 200.95 g/mol
    Appearance White to off-white crystalline solid
    Density 1.675 g/cm³
    Melting Point 62-66 °C
    Boiling Point Decomposes before boiling
    Solubility In Water Soluble
    Storage Temperature 2-8 °C
    Purity Typically ≥97%
    Synonyms Hydrated 1,1-dichloro-3,3,3-trifluoroacetone
    Inchi Key KNBCYEXJZZEKGC-UHFFFAOYSA-N

    As an accredited 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle labeled with hazard symbols, containing 25g of 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate, tightly sealed for safety.
    Shipping 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate should be shipped in tightly sealed containers, protected from light and moisture. Handle with appropriate safety precautions, including secondary containment for leak prevention. Comply with relevant hazardous material regulations; label clearly. Store and transport at room temperature, away from incompatible substances like acids and alkalis. Consult SDS for detailed shipping guidance.
    Storage **1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate** should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong bases and oxidizers. Protect from moisture and direct sunlight. Use secondary containment to avoid leaks or spills, and ensure storage in compliance with all local, state, and federal chemical safety regulations.
    Application of 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate

    Applications of 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate in Industrial Manufacturing

    Our manufacturing expertise with 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate provides chemical producers and formulators with a high-purity intermediate designed for several advanced process applications. Below we highlight real-world, focused scenarios where this specialty compound delivers proven value in established industries. Each section provides practical formulation data, integration details, relevant standards, and lists authentic end use products derived from downstream operations.

    1. Pharmaceutical Active Ingredient Synthesis

    This hydrate functions as a key building block in the assembly of certain trifluoromethyl-containing pharmaceutical agents. Medicinal chemistry teams leverage its reactivity in carbonylation or halogenation steps to craft highly specific fluorinated intermediates used further down the API synthesis pipeline. During multi-step batch and flow syntheses, close control of the reaction environment—and strict adherence to international pharmacopoeial standards—are essential to ensure consistent output and regulatory acceptance of the end product.

    Industry compliance standards

    • United States Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • ICH Q7 Good Manufacturing Practices for Active Pharmaceutical Ingredients
    • 21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals

    Typical usage ratio

    • Applied at 0.5%–2% molar ratio relative to the core substrate in multi-step pharmaceutical synthesis, adjusted according to target molecule complexity and reaction pathway requirements.

    Downstream process integration

    • Added during intermediates’ construction in reactor vessels (glass-lined or stainless), entering after initial charge of co-reactant but prior to final cyclization or halogen exchange step; closely monitored for reaction completion and impurity profile control.

    Final product types

    • Trifluoromethylated heterocyclic intermediates
    • Potential precursors for kinase inhibitors and antiviral APIs
    • Patent-protected fluorinated building blocks

    2. Agrochemical Intermediate Formation

    Within crop protection chemical manufacturing, this compound serves as a fluorinated synthon used for constructing select herbicide and fungicide scaffolds. Its introduction at an intermediate stage imparts the desired electron-withdrawing effects, vital for compound stability and enhancing biological activity in the finished formulation. The synthesis takes place under controlled, closed-system conditions with all steps subject to global agrochemical and safety protocols ensuring environmental and product stewardship.

    Industry compliance standards

    • FAO/WHO JMPR Guidelines
    • OECD Principles of Good Laboratory Practice (GLP)
    • REACH Regulation (EC) No 1907/2006 (Substances in Plant Protection Product Manufacturing)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • Utilized at 1%–5% by weight within intermediate condensation reactions, ratio modified according to desired fluorine incorporation and yield optimization for each specific target compound.

    Downstream process integration

    • Charged during the key step of aryl or acyl substitution, upstream of final product crystallization and formulation, under inert atmosphere in pressure reactors designed for halogenated feedstocks.

    Final product types

    • Fluorinated herbicide intermediates
    • Precursor esters for modern broad-spectrum fungicides
    • Stabilized pesticide raw materials

    3. Specialty Polymerization Catalysts

    This material features in the preparation of fluorine-containing ligand sets for downstream catalytic applications in controlled polymerization of specialty plastics. Catalyst designers introduce the hydrate as a precursor during ligand formation, where its precise chlorine and trifluoromethyl groups enable modulation of key electronic properties. Strict adherence to high-purity polymer standards guarantees that the resulting catalysts deliver reproducible polymer properties demanded by advanced electronics and membrane manufacturers.

    Industry compliance standards

    • ASTM D5630: Standard Test Method for Ash Content in Plastics
    • ISO 9001:2015 Quality Systems for Polymer Production
    • RoHS Directive (2011/65/EU) for Electronic-Grade Materials
    • REACH Regulation (EC) No 1907/2006

    Typical usage ratio

    • It is introduced at 0.1%–1.5% (w/w) relative to total ligand mass, with the final ratio determined by targeted catalyst loading and molecular weight requirements in the polymerization process.

    Downstream process integration

    • Undergoes ligand exchange or coordination with transition metals in batch synthesis reactors, after which the tailored ligand systems enter downstream polymerization reactors for controlled radical, anionic, or coordination polymerizations.

    Final product types

    • High-purity membrane resins for filtration
    • Specialty fluoropolymer masterbatches for electronics encapsulation
    • Performance plastics for chemical process equipment lining

    4. Analytical Derivatization Reagents

    Analytical chemistry laboratories employ this compound to develop derivatization reagents for advanced GC/MS and LC/MS workflows, especially those requiring tailored electron-capture detection. Chemists optimize its use to form volatile, high-sensitivity analyte derivatives for trace-level quantitation in environmental and pharmaceutical matrices. Preparation and application operate under strict laboratory quality and safety controls to maintain reproducibility and contaminant-free results.

    Industry compliance standards

    • ISO/IEC 17025: General Requirements for the Competence of Testing and Calibration Laboratories
    • EPA Method 551.1: Determination of Chlorination Byproducts
    • FDA 21 CFR Part 58: Good Laboratory Practice for Nonclinical Laboratory Studies
    • GLP standards (OECD Principles)

    Typical usage ratio

    • Applied at 0.01–0.1 mg per mL sample, dosage tailored to analyte concentration and matrix complexity to ensure complete conversion with no excess reagent remaining post-derivatization.

    Downstream process integration

    • Used in derivatization step prior to automated sample injection for chromatographic analysis, with reaction mixing performed at controlled temperature and pH to maximize formation of targeted analyte derivatives without cross-contamination.

    Final product types

    • Stabilized derivatized sample kits for GC/MS quality control
    • Pre-prepared environmental analysis standard solutions
    • Certified pharmaceutical impurity reference materials

    5. Fluorinated Fine Chemical Synthesis

    Producers of high-value specialty and fine chemicals incorporate the hydrate into steps where direct introduction of trifluoromethyl and dichloro functional groups is required for downstream product stability or enhanced chemical reactivity. These processes, often run in multipurpose synthesis reactors, strictly regulate reagent purity, dosing, and reaction time to maximize selectivity while conforming to international quality and handling standards relevant to the target fine chemical application.

    Industry compliance standards

    • ISO 9001:2015 Certified Process Controls
    • Responsible Care® Management System Requirements
    • REACH (EC) No 1907/2006 (Industrial Fine Chemicals)
    • Chemical Facility Anti-Terrorism Standards (CFATS, 6 CFR Part 27)

    Typical usage ratio

    • Typically 0.3%–3.0% by batch total feed, calculated based on desired fluorine loading and substrate reactivity in custom synthesis for specialty fine chemicals.

    Downstream process integration

    • Fed into sequential halogenation or acylation stages in closed systems, timed precisely after completion of initial substrate activation to favor selective formation of high-purity target molecules.

    Final product types

    • Stable fluorinated coupling partners
    • Reagents for organic synthesis scale-up
    • Lab-scale specialty chemicals for R&D and pilot production
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    Certification & Compliance
    More Introduction

    1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate — Direct from the Manufacturer

    Making Reliable Chemistry from the Source

    Manufacturing 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate comes with its own set of challenges and rewards. Over the decades, we’ve refined methods to produce this compound with tight control and consistent results. Every batch reflects careful monitoring of purity, moisture levels, and handling protocols to keep standards high for both routine and specialized customers.

    We supply the hydrate for its stability and workspace safety. Unlike the anhydrous form, the hydrate keeps volatility in check and stores without sudden shifts that can catch a chemist off guard. This single property cuts headaches for formulation labs, pilot plants, and end-use integration since it limits risk during both storage and transfer.

    Product Model and Specifications Gained in Production

    There’s no shortcut to purity with this material. Controlled processes reduce the inclusion of extraneous halogenated impurities so reactions do not go sideways. Our model for production focuses on tuning crystalline quality — a crucial detail that separates hydrates with good reactivity from those prone to caking or slow dissolution. Every kilogram packed gets tested to make sure the hydrate form is complete, with water content kept within strict bounds to avoid deviations in stoichiometry during reactions.

    We typically see the hydrate as a white to off-white crystalline solid. Particle size stays tight for smooth weighing and dispersing, which matters in precision applications. Moisture content sits in a defined window for predictable performance; we avoid both excessive wetness and dryness, as both can raise difficulties with blending or downstream reaction yields. Years in technical manufacturing teach us to never overlook these details. Regular feedback from field users spurs ongoing adjustments in packing, shipping, and lot documentation.

    Practical Uses: From Laboratory to Industrial Scale

    Real projects have shown us the wide reach of 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate. Chemists come to us when they want to introduce both chlorine and fluorine moieties into advanced structures. The compound plays a role in pharmaceutical synthesis — especially where trifluoromethyl and gem-dichloride patterns are required for target molecules or intermediates. Custom synthesis projects often favor the hydrate for safety and consistency, since it manages the volatility better compared to related ketone forms.

    Labs preparing ligands, catalysts, and agrochemical building blocks often pull our hydrate into their toolkit. The reactivity centers on the carbonyl next to strong electron-withdrawing atoms, offering a unique way to build carbon skeletons with exacting control. Choices made during scale-up reflect not only chemical utility, but dependability across multiple batches. Nothing is worse for a project than shifting purity profiles or erratic melting behavior; we hear these stories often from customers who tried less controlled sources.

    In spray applications, particularly those used for surface treatments or specialty coatings, the hydrate’s predictable evaporation curve stands out. Control over hydrate content ensures repeatable application outcomes, sparing users from surprises in film properties or chemical residue. This feedback cycle helps us target our crystallization steps with every production run.

    Clear Differences: Hydrate Versus Other Options

    Direct experience with chlorinated trifluoroacetones shows the hydrate variant reduces exposure risks that come with anhydrous or more reactive analogs. Anyone handling the free ketone form knows the volatility — the hydrate’s extra water brings immediate, tangible benefits: chemical stability, restrained vapor pressure, and a pronounced drop in irritant fumes during use. These properties add up where safety officers and environmental managers push for safer workplaces.

    Comparing the hydrate to the anhydrous material, customers point out storage and weighing simplicity. The hydrated ketone keeps well in high-humidity climates, without sudden deliquescence or clumping. Compared to lower-chlorinated or non-fluorinated ketones, our product introduces both functional groups in a single step. This dual-halogen approach streamlines synthesis routes that otherwise demand consecutive, less selective halogenations; it saves time, waste, and energy by combining reactivity in one process step.

    Since we produce in large volumes under full traceability, customers steering away from imported intermediates or third-party blends have remarked on improved documentation and clear chain of custody. Problems tied to off-brand stocks — contamination or deviation in hydrate level — fall off the radar. Our specialty has always been to back every drum and every kilo with batch analytics, quality assurance, and open feedback channels with our users.

    User Feedback Shapes Every Batch

    Staying rooted in the manufacturing floor has taught us that even minor changes in water of crystallization or impurity content quickly snowball in downstream synthesis. Clients working in scale-up projects for fluorinated pharmaceuticals keep the requirements tight. If a batch strays from set specifications, the knock-on effects ripple through the process, impacting not just the yield, but also the profile of desired and undesired byproducts.

    We work closely with chemists, both in research and production, who bring direct observations from their benches and plants. For example, one facility reported greater batch-to-batch uniformity from our hydrate compared to a composite product sourced from overseas. Their clean-room process encountered fewer stoppages, since our product’s consistent water content matched their automated dosing requirements.

    Another key user in the agricultural synthesis sector pointed out how the hydrate’s manageable shelf life — even across long shipping routes in humid climates — fit their procurement cycles without last-minute ordering stress. That lesson shaped how we design our secondary containment and shipment handling protocols.

    Addressing Challenges in Production and Use

    No manufacturer can ignore the issues that come with halogenated ketones available as hydrates. One persistent challenge for large-batch users is managing the release of water during heating or reaction. If a process fails to accommodate the inherent water, the chemistry can drift; reaction conditions may require tweaks to reactant ratios or purification steps.

    On our end, we tackle this by providing full water-of-crystallization data up front. End users can adjust small pilot runs, using our batch certification to fine-tune their recipes. We offer practical guidance from real-world cases: for instance, adjusting base or acid equivalents to account for hydrate water. Open technical support — not just a data sheet — makes the difference between recipe failure and repeatable synthesis.

    Environmental and regulatory expectations drive ongoing improvements. Stricter controls mean that even low-level byproducts or trace solvents from manufacture cannot slip through the cracks. Our commitment to routine upgrades in filtering, drying, and finishing technology closes these gaps, helping customers satisfy quality and compliance audits without extra layers of paperwork.

    Quality is More Than a Certificate

    Instead of chasing certificates for their own sake, we run quality as a living system. Inspections do not end at finished product; they trace upstream, covering raw material sourcing, solvent reclaim, water purification, and every stage of handling. Technicians document and address quirks as they crop up — for example, a shift in the crystalline habit caused by a subtle change in cooling profile. Buyer feedback leads us to investigate and resolve even rare lot-to-lot fluctuations. It keeps the learning cycle alive, and results flow straight into process improvement routines.

    As direct manufacturers, we never delegate key steps to third parties. Each production run receives full in-house analytics, including melting point, infrared spectroscopy, and halogen ratios. Our technical staff often visits user sites to observe handling practices, providing real-world solutions to day-to-day obstacles.

    Even after delivery, we offer troubleshooting. A key aspect of serving demanding users is supplying not just product, but in-depth support. Recurrent field issues — things like clumping in humid warehouses, or uneven dosing in automated systems — get traced back and resolved in future lots. Production partners appreciate this loop: it closes the gap between what a material can do on paper and how it acts on the line.

    Why Direct Sourcing Matters

    From years of feedback and on-site collaboration, we understand the value of direct purchase from a chemical factory. Traders and distributors cannot explain every nuance or guarantee process details. When customers face issues mid-campaign, they rely on manufacturers like us to supply historical data, root cause analysis, and remedial options.

    We provide more than a label — we explain every variable, from minor shifts in crystallization water to trace element limits tied to our machinery and solvents. This level of traceability builds confidence with both regulatory inspectors and front-line synthetic chemists. Supply continuity has emerged as a critical concern across world markets; direct manufacturer links mean fewer surprises and faster problem-solving.

    Filtering out noise from the supply chain saves time and ensures better outcomes, especially for scale-up projects or new process launches. Our technical team helps interpret analytical findings, augments process chemists’ troubleshooting, and, where necessary, supports rapid development of material for pilot or full-scale operation. Having seen failures caused by indirect sourcing — from simple mislabeling to costly deviations in expected purity or hydrate level — we built our supply model to close these gaps.

    Improvements Driven by Applied Experience

    Working hands-on at every step, we encounter and solve problems that textbooks do not cover. For example, the risk of hydrate clumping in transit led us to invest in controlled-atmosphere packaging. Consistent handling and labeling suit automation in modern labs, supporting data-driven approaches across QC and production lines alike.

    We collect regular feedback through post-delivery surveys and factory visits, tracking both major and minor points: ease of opening containers, longevity after partial use, interaction with process wastes, and more. This keeps us tuned into reality, not theoretical best practices. Our improvements have grown from these inputs to include sustainability options, such as reduced-waste containers and reprocessing of used solvents.

    Downstream users often share details of yield improvements or process reliability jumps after switching to our hydrate variant. Analytical chemists value the lack of extraneous peaks in their spectra; process engineers mention smoother batch records, less downtime, and easier compliance review. These direct voices shape our ongoing development planning.

    Forward Looking: Anticipating Industry Change

    As competitive pressure and regulatory demands increase, chemical manufacturers must adapt. We respond by refining controls on even the smallest impurity, investing in upgrading purification trains, and applying automation to batch monitoring for faster intervention. New applications for 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate continue emerging in specialist chemical synthesis, prompting us to partner with research labs and entrepreneurs from the start-up phase.

    Where the market moves toward greener synthesis and energy-efficient technologies, we are reimagining both the compound’s production and its application. Optimizing the hydrate form reduces not only chemical hazards but also plant energy loads — minimizing the need for aggressive containment or specialized cold storage. Improving our system means shared progress for both supplier and customer.

    Through careful record keeping and root cause investigation, we tackle problems before they grow. By staying embedded in daily manufacturing — not just management oversight — our technical staff spots early trends and brings solutions to market quickly. This approach adapts us to shifts in global sourcing, shortage risks, and the tightening specification demands for high-stakes industries.

    Supporting Customers Beyond the Sale

    We see our role running past just getting material out the gate. True partnership with users involves troubleshooting process hiccups, supporting scale-up with more flexible lot sizes, and sharing process data for regulatory submissions. Feedback from industry partners often brings fresh technical challenges, keeping us alert and pushing our methods toward better reliability.

    When new uses for the hydrate pop up — from advanced electronic materials to selective fluorination tasks — we listen closely and offer advice on optimal handling. Direct experience with formulation changes, test run failures, or regulatory submissions spreads through our channels, helping the community of users advance together.

    Open communication channels with users facilitate a continuous flow of improvement ideas, real-world testing, and collaborative solutions for both routine and unique issues. This approach grounds our manufacturing culture, making every new lot a step forward in meeting customer needs with both quality and practicality.

    A Manufacturer’s Perspective on Long-Term Value

    Manufacturing 1,1-Dichloro-3,3,3-Trifluoroacetone Hydrate builds a reservoir of experience spanning lab-scale evaluation to multi-ton shipping. Over time, value grows not from a slick brochure but from daily adherence to process rigor, rapid technical support, and early intervention on supplier and customer side bottlenecks. We deepen knowledge through years of user dialogue and onsite trials, allowing us to recommend improvements even outside our own plant walls.

    Our sustained focus on technical quality, open support, and adaptability sets our hydrate apart from what traders or resellers send overseas. We see the product as more than a chemical — it’s a tool that when produced and supported correctly, elevates projects, improves safety, and simplifies compliance. Every container that leaves our facility bears the mark of manufacturing know-how, shaped not just by specifications but by lived experience serving the real needs of chemists, engineers, and quality managers worldwide.