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1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether

    • Product Name 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether
    • Alias Sevoflurane
    • Einecs 401-680-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    563664

    Chemical Name 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether
    Cas Number 375-19-1
    Molecular Formula C4H2ClF7O
    Molecular Weight 246.50 g/mol
    Appearance Colorless liquid
    Boiling Point 42-44°C
    Density 1.573 g/cm³ at 25°C
    Refractive Index 1.282
    Solubility Insoluble in water
    Odor Ethereal
    Purity Typically ≥ 98%
    Vapor Pressure 540 mmHg at 20°C
    Storage Temperature Store at 2-8°C
    Synonyms Ethanol, 2-chloro-1,1,1,3,3,3-hexafluoro-2-(trifluoromethoxy)-

    As an accredited 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether is packaged in a 100g amber glass bottle with a secure, airtight cap.
    Shipping 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether must be shipped as a hazardous material in compliance with international regulations. It should be packed in tightly sealed, chemical-resistant containers, clearly labeled with proper hazard warnings, and transported by authorized carriers to minimize environmental and health risks during transit. Handle with appropriate safety precautions.
    Storage 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from heat, sparks, and open flames. Keep separate from strong acids, bases, and oxidizers. Store in a chemical fume hood and use secondary containment to prevent leaks or spills. Label containers clearly and protect from physical damage.
    Application of 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether

    Applications of 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether in Industrial Manufacturing

    1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether plays a specialized role in several advanced manufacturing sectors. Drawing from our production experience and supply chain partnerships, we supply this material primarily for downstream processes requiring high-performance fluorinated intermediates. The following sections outline verified application fields, backed by industrial standards, precise formulation ratios, integration process points, and actual end products relying on this raw material.

    1. Fluorinated Pharmaceutical Intermediate Synthesis

    Major pharmaceutical producers apply our hexafluorinated ether during the manufacture of targeted fluorine-containing pharmaceutical intermediates, especially for next-generation antiviral and anticancer active compounds. Stringent regulatory control governs the inclusion of such specialty building blocks to ensure purity, traceability, and functional group retention throughout multi-step organic synthesis. Formulation teams measure addition levels to balance reaction conversion and downstream purification demands.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP General Chapter <1092>: Pharmaceutical Impurities
    • EU EudraLex Vol 4: GMP Guidelines Parts I, II for APIs
    • China Pharmacopoeia current edition for fluorinated intermediates

    Typical usage ratio

    • Generally 0.8–2.0 molar equivalents relative to key substrate, fine-tuned in route scouting to manage nucleophilic substitution and prevent byproduct formation

    Downstream process integration

    • Introduced at early- or mid-stage step of multi-step API intermediate synthesis, frequently in solvent-mediated batch reactors with controlled temperature and inert atmosphere

    Final product types

    • Fluorinated intermediates used for synthesis of active pharmaceutical ingredients (APIs)
    • Small-molecule drugs with enhanced metabolic stability
    • Specialty antiviral compounds featuring fluoroalkyl moieties

    2. Precision Electronic Chemicals Manufacturing

    Producers of specialty electronic chemicals utilize this compound for critical cleaning, etching, or dielectric precursor blends in advanced semiconductor and display manufacturing. Its high volatility and chemical inertness enable effective removal of particle and ionic contaminants and act as a component in CVD precursor cocktails engineered to deposit fluorinated thin films.

    Industry compliance standards

    • SEMI C93: Specification for Electronic Grade Organic Solvents
    • JEITA ET-7304: Guidelines for Chemicals Used in Semiconductor Manufacturing
    • IPC-5704: Cleanliness Requirements for Unpopulated Printed Boards
    • RoHS Directive 2011/65/EU for material safety and environmental impact

    Typical usage ratio

    • Ranges from 0.5–5% by volume for cleaning/etching, 2–10% as a functional additive in chemical vapor deposition (CVD) blends, according to film thickness and substrate chemical resistance needs

    Downstream process integration

    • Added directly in wet bench cleaning or advanced photoresist strip processes; in CVD steps, included in precursor formulations delivered by bubbler or direct liquid injection

    Final product types

    • High-k gate dielectrics
    • TFT-LCD and OLED display panels
    • Advanced node logic/memory ICs
    • Photomask blanks and cleaning chemicals

    3. Performance Fluoropolymer Synthesis

    Leading fluoropolymer manufacturers adopt this ether as a chain transfer agent or co-monomer modifier in emulsion or solution polymerization, improving the chemical resistance and processing flexibility of advanced fluoroelastomers and fluoroacrylics. Consistent addition supports narrow molecular weight distribution and surface property control for end-use in automotive and aerospace environments.

    Industry compliance standards

    • ASTM D2116: Standard Specification for Fluoropolymer Resins
    • ISO 9001:2015 Quality Management (for product batch traceability)
    • REACH Regulation (EC) No 1907/2006 on chemical safety and registration
    • ISO 14001: Environmental Management for hazardous process control

    Typical usage ratio

    • Typically 0.1–2.5 wt% of total monomer feed; tuning based on polymer architecture targeting molecular weight and end-group incorporation

    Downstream process integration

    • Dosed with initiators at the onset of polymerization (batch or semi-continuous) in pressure reactors; can also serve as a post-polymerization surface modifier

    Final product types

    • FEP (fluorinated ethylene propylene) and modified PTFE grades
    • Fluoroacrylic textile finishes
    • High-performance fluoroelastomer gaskets and hoses

    4. Specialty Refrigerant and Heat Transfer Fluid Design

    Refrigerant and cooling fluid producers formulate certain next-generation, low-global-warming-potential (GWP) fluids by incorporating this raw material as a backbone intermediate or stabilization agent. Its unique electronegative structure optimizes thermal stability and reduces flammability in formulated mixtures required by strict environmental protocols for use in HVAC, refrigeration, and mission-critical electronic cooling.

    Industry compliance standards

    • ASHRAE Standard 34: Designation and Safety Classification of Refrigerants
    • EU F-Gas Regulation (EU) No 517/2014 limiting high-GWP substances
    • ISO 5149: Safety and Environmental Requirements for Refrigerating Systems
    • UL 60335-2-40: Electrical heat pump, air-conditioner and dehumidifier systems safety

    Typical usage ratio

    • Composes 1–7% by mass of the total blend, with adjustment based on volatility, miscibility and tox profile to comply with environmental and toxicity guidelines

    Downstream process integration

    • Blended in closed-system reactors during base refrigerant synthesis or as a final-stage additive in heat transfer fluid blending operations, followed by filtration and charge filling

    Final product types

    • Low-GWP specialty refrigerants for commercial HVAC
    • Precision dielectric coolants for server and data center immersion cooling
    • High-performance automotive air-conditioning fluids

    5. Advanced Laboratory Reagent and Research Chemicals

    Chemical research and analytical labs rely on this ether as a reference standard or as a reactant for synthesizing rare fluorinated compounds, enabling the development of experimental materials and facilitating testing of new fluoro-organic transformations in academic and industrial innovation projects.

    Industry compliance standards

    • ISO/IEC 17025:2017 General Requirements for Testing and Calibration Laboratories
    • OECD GLP principles for laboratory chemical management
    • European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR)
    • UN Model Regulations on Transport of Dangerous Goods

    Typical usage ratio

    • Applied in quantities from micrograms to tens of grams per run, scaled to experimental design and synthesis pathway requirements

    Downstream process integration

    • Introduced manually or via automated liquid handling equipment at designated step for fluorine incorporation in small-scale synthesis, analytical reaction mechanism studies, or standard solution preparation

    Final product types

    • Analytical reference standards
    • Rare custom fluorinated molecules
    • Research-grade reagents for structure-activity relationship studies
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    Competitive 1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    1,1,2,3,3,3-Hexafluoropropyl Chlorofluoromethyl Ether: Real-World Value from the Source

    Why We Still Trust Fluorinated Ethers—And What Sets This One Apart

    In the chemical sector, few substances match the profile of 1,1,2,3,3,3-Hexafluoropropyl chlorofluoromethyl ether. We have produced and handled this specialized ether for over a decade, and experience tells us how much it matters to work with a product manufactured with consistency. R&D technicians and production chemists come to us looking for purity they can count on, solvent performance they can model, and stability that won't backfire in storage. In our hands, this ether holds up through months in the drum or glass bottle—even after repeated opening. We take our process from synthesis to packing seriously, because even micro-level impurities can throw off advanced material workflows.

    Our team makes this compound for advanced electronics, high-performance coatings, and the synthesis of specialty monomers. We see consistent demand from customers who push the boundaries in polymers, photoresist manufacturing, and fluorochemical research. The chemical’s formula C4H2ClF7O is more than a string of letters—it translates to very real advantages in solubility and reactivity. Materials development depends on solvents and reagents that don't introduce mystery curveballs. Our clients often share stories about switching from less controlled products—imported batches with clouded clarity, or inconsistent results—and immediately getting better lab reproducibility with our batches. That's not just luck; it comes from our decision to control every part of the manufacturing process, right down to the design of our reactors and the way each drum is sealed.

    Performance Details: Not All Ethers Are the Same

    Customers frequently ask about model variants and specifications. In our experience, the unique hexafluoropropyl backbone, capped with a chlorofluoromethyl ether group, defines the chemical's behavior in both laboratory and industrial settings. That fluorine load—six fluorines on the propyl chain—is key. Compared with common linear or cyclic ethers, hexafluorinated structures like this one resist oxidation, hydrolysis, and thermal stress, even under demanding use. You will not find the same thermal or chemical inertness in low-fluorine, hydrocarbon, or plain perfluoropolyether solvents. The difference shows in everything from evaporation rate to shelf life: this ether keeps its integrity weeks after opening, even in less-than-ideal lab conditions. That’s not something every competitor can say.

    Specifications at the manufacturing site matter more than any paperwork. For each batch, we run GC-MS analysis to verify identity and check impurities to below 0.1%. Water and acid scavenging steps get us total water content consistently below 50 ppm. We set our in-house color standard to an APHA below 10, which gives a crystal clarity when poured. Many downstream applications—especially polymerizable coatings or photoresist resins—need this level of purity, because anything less produces haze or electronic defects. Our operators know the price of cutting corners. Sure, specs like purity percentage or acid value tell part of the story, but hands-on knowledge from decades of troubleshooting cleanup, recovery, or reaction failures rounds out the product quality in real terms.

    In the Field: Uses and Real-World Problem Solving

    We see 1,1,2,3,3,3-Hexafluoropropyl chlorofluoromethyl ether mostly requested by customers designing new types of fluoropolymers or surface coatings. In those circles, it offers solvation profiles that conventional ethers can't match. The high density and polarity shift results in better performance when dissolving high-molecular-weight or highly fluorinated resins. Some customers work on anti-graffiti or anti-smudge films, where only true fluoroethers allow even dispersion of fluorinated additives. Others build up microelectronics sensor platforms and need an ultra-low-conductivity solvent that won’t corrode sensitive metal traces—this ether fits that niche because its low reactivity and insulating properties safeguard prototypes from random shorts or chemical drift.

    Process reliability holds everything together. Clients sending us feedback have used other solvents that degraded during polymerization or left trace contaminants. We’ve documented cases where switching to our ether eliminated product yellowing or microflakes—problems that jeopardize product launches on tight timelines. In scale-up environments, the product’s low viscosity even at low temperatures means pumps stay happy and lines don't jam, reducing downtime and headaches for maintenance crews. This raises more than just output; it lowers the risk of unscheduled batch failures or contamination picks up later on the line.

    We also know some sectors—especially those working at the intersection of chemistry and electronics—have safety and environmental concerns about many chlorofluoro products. Our process design emphasizes both operator and environmental safety. We close exhaust points and condensation loops, run regular leak testing, and track every kilo of solvent from raw material to packed drum. This traceability didn’t come from market pressure alone—our own staff demanded it after a near-miss incident a few years ago. Transparency isn’t an afterthought; it’s a part of long-term manufacturing success that lets innovation happen at the customer’s site, not the factory waste bay.

    Comparisons with Other Chemistry—Why Customers Come Back

    The market offers lots of alternatives, but few match the combination of reactivity and stability provided by 1,1,2,3,3,3-Hexafluoropropyl chlorofluoromethyl ether. Standard diethyl ether, THF, or DME perform well for some lab work, but each picks up water, oxidizes, or decomposes faster under heat or light. Perfluorinated ethers like perfluoromethylcyclohexane or Fomblin types provide better resistance, but they rarely dissolve even lightly polar or large-molecule resins well. Customers save time with our ether by avoiding complex pre-conditioning steps or extensive drying, because our process cuts water ingress and chlorinated trace contamination right at the fill line.

    In our early years, we tried sourcing generic ether solvents to fill gaps between production runs, but frankly, the disappointment was real. Batch-to-batch variation—ranging from small haze formation to inconsistent boiling behavior—wasted time and money on prep work and damaged valuable end-products. Based on that hard-won lesson, we doubled down on sourcing top-grade raw materials, and locked in close partnerships with upstream fluorine chemistry suppliers, so nothing gets diluted or carelessly reformulated. Today, we only ship product that passes our in-house stress and compatibility tests—no awkward surprises, no bland excuses. Raw truth: cutting corners at the supplier puts too much pressure on the customer’s end, and anyone who’s had to run 24h rework cycles knows how that story ends.

    Handling, Storage, and Customer Support—Direct from the Factory Floor

    It isn’t enough to manufacture great product; it has to land in your storage safely and stay that way until it’s used up. We fill and seal every container under a dry nitrogen stream at positive pressure, not in ambient air, so there’s almost zero water or CO2 pickup inside the drum. Each drum and bottle carries a batch number that tracks right back to a date, crew, and instrument set. Our warehouse staff train on careful drum handling, no matter the order size, and treat every shipment as if it’s going on our own production line next week. We’ve even run in-house drop and vibration tests—because if the chemical leaks on a loading dock or in a customer’s store, nobody wins.

    For bulk buyers running continuous operations, we offer refillable vessel programs and on-site technical support. Many large-scale users have HW and environmental controls tuned to our specific ether. When process or application engineers call, they talk with technical staff who’ve actually run the reactions in our own pilot suites. That difference—factory-to-factory connection—makes post-sales support faster and more reliable. Our instructions don’t just come from books; they come from years wrestling tanks and valves ourselves. If a customer hits a snag—pipelines icing, filter plugging, or material incompatibility—we give direct advice, not runaround emails or buried specs. There’s pride in seeing a customer’s project hit spec for yield or clarity, especially if other solvents or suppliers have let them down before.

    The Real Differences: Science Backed by Experience

    While lab data matters, real-world performance shapes loyalty and reputation. We keep our reaction yields for 1,1,2,3,3,3-Hexafluoropropyl chlorofluoromethyl ether at high levels through careful impurity management and regular process optimization. Feedstock selection and low-moisture handling start the quality chain. We never take shortcuts by mixing reclaimed solvent into “new” batches or diluting to meet an average spec. Each run gets monitored for end-point conversion, so downstream customers see no random swings in acidity, color, or evaporative residue—problems that often plague lower-priority manufacturers. Our analytical lab runs not just quality control for product, but problem-solving checks for clients—if a new application needs tweaking, we can suggest process changes, not just say, “Sorry, can’t help.”

    Environmental responsibility is not just press-release material to us. The same staff who run batch reactors and distillation columns live near the site. Waste streams, process venting, and product containment get regular reviews with local environmental agencies. That means clients don't face unexplained regulatory questions or product shortages due to licensing shocks down the line. Years ago, site operators suggested recycling process solvents after seeing the waste tally spike; it cut costs, yes, but it also made for cleaner, more consistent production. The results travel with every shipment—not just because they meet regulated thresholds, but also because nobody wants surprises on audits or unneeded waste on their backs.

    Feedback, Failures, and Facing Real-World Challenges

    No manufacturer has a perfect record, and we’ve faced our own setbacks getting this ether to market. In an early production year, a condenser line fouled unexpectedly, causing a spike in hydrolysable impurities and several drums failed outgoing spec. We took those drums back at our own expense, worked overtime to troubleshoot, and implemented dual-stage condenser cleaning. That one error shaped our approach: every technician trains in failure management, not just volume production. Today, staff have open call-in privileges to report potential issues, from color drift in a day tank to minor label misprints. Old-school QA supervisors will tell you—the best troubleshooting starts before product goes out the door. That’s how we caught the “unfindable” leaks in anhydrous lines that sometimes plague new manufacturers of fluoroethers.

    End-user feedback matters. We have open channels for reporting unexpected results, and take each complaint on its own merits, not as a knock on stats. If a customer’s solution starts clouding or a reaction yield drops, we ask for real sample data and, if needed, pull retained samples for cross-checking. Collaboration with research customers led to our adopting new filtration and packaging upgrades—real tweaks, not box-ticking exercises. That attitude—proactive, skilled, and hands-on—spills over into our whole operation. Product stewardship isn’t a dusty compliance phrase; it’s an everyday practice that benefits everyone who uses, sells, or transports our ether products.

    Looking Forward—Continuous Improvement in Product and Practice

    The industry moves fast toward more demanding applications. Polymeric films, precision electronics coatings, and next-wave fluoromaterial syntheses all set the bar a little higher every year. Our investment in process analytics and in-house R&D reflects that pressure. Automated systems now track each reaction cycle, logging temperature, flow, and conversion dozens of times every hour. If we spot drifts in data, we don’t just “let it ride”; we halt, re-evaluate, and fix. Those adjustments mean process output isn’t left up to luck or best guesses—each lot lands with the consistency our end-users expect. Years ago, such process transparency was unheard of in fluorochemical ether production, but customer expectations for robust, documentable supply have changed the game.

    We’re also watching how global regulatory and supply dynamics impact this chemical class. Some regions clamp down on solvents containing both fluorine and chlorine, especially for emissions abatement or waste management. By investing in abatement and closed-loop handling, we keep our footprint low and avoid passing off compliance costs to our customers. Our technical staff regularly attend workshops and standards meetings to stay sharp—sharing findings, seeing what challenges others face, and learning what new process tweaks are emerging from across the industry. Staying current isn’t about watching trends from a distance; it’s about participating in the science and engineering communities that actually shape discipline standards and product requirements.

    Conclusion: Our Promise as Direct Manufacturers

    Supplying 1,1,2,3,3,3-Hexafluoropropyl chlorofluoromethyl ether isn’t just about drums and order forms for us. The product sits at the intersection of tough chemistry, safety expectations, and performance demands that customers can’t negotiate away. Each ton, each lab bottle carries evidence of choices we’ve made on raw material sourcing, processing, and technical support. Many clients started as skeptics—burned by third-party traders or underwhelming bulk producers. They stuck around because, batch after batch, the chemical works. It gets reactions started, carries coatings farther, and solves problems where less capable ethers fail.

    We know that in specialty chemicals, long-term trust comes not from catalogs or glossy branding, but from the day-to-day experience of users in lab coats, factory boots, and production control rooms. That’s who we answer to, every run, every order. From our side of the plant wall, our commitment is simple: keep raising the standard, keep learning, and never let down the professionals who trust us with their most demanding chemistry.