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HS Code |
296501 |
| Chemicalname | Hyaluronan |
| Alternativename | Hyaluronic Acid |
| Molecularformula | C14H21NO11n |
| Molecularweight | Variable (depending on polymer length) |
| Casnumber | 9004-61-9 |
| Physicalappearance | White to off-white powder or fibrous material |
| Solubility | Highly soluble in water |
| Phrange | 5.0 - 8.0 (in solution) |
| Biologicalsource | Produced naturally in connective, epithelial, and neural tissues |
| Mainuses | Cosmetics, pharmaceuticals, wound healing, ophthalmology |
| Stability | Stable under normal conditions, but susceptible to enzymatic degradation |
| Viscosity | Forms highly viscous solutions |
| Charge | Anionic (negatively charged) |
| Odor | Odorless |
| Origin | Biosynthesized or extracted from animal and microbial sources |
As an accredited Hyaluronan factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 10g white HDPE screw-cap bottle labeled "Hyaluronan, 10g, USP grade, store at 2-8°C, for laboratory use only." |
| Shipping | Hyaluronan is shipped in sealed, airtight containers to protect it from moisture and contamination. It is typically transported at room temperature unless otherwise specified, and labeled according to regulatory requirements. Care is taken to avoid exposure to extreme temperatures or direct sunlight during transit to maintain product integrity. |
| Storage | Hyaluronan should be stored in a tightly sealed container, protected from light and moisture. It is best kept at 2–8°C (refrigerated) to maintain stability and prevent degradation. Avoid repeated freeze-thaw cycles if stored as a solution. For long-term storage, keep hyaluronan as a dry powder at -20°C. Always follow the manufacturer's recommendations for optimal storage conditions. |
Applications of Hyaluronan in Industrial ManufacturingAs a chemical raw material manufacturer with established expertise in hyaluronan production, we supply high-purity grades adapted for a range of precisely regulated industrial sectors. Each application below reflects direct, large-scale manufacturing uses adopted by commercial producers across targeted downstream fields. 1. Injectable Medical Devices for Osteoarthritis and Ophthalmic SurgeryMedical device manufacturers rely on our hyaluronan for formulating intra-articular joint injections and ophthalmic viscoelastic devices. The stringent purity and biocompatibility profile enables direct integration into device filling under aseptic conditions. Hyaluronan is hydrated and filtered, then compounded into finished solutions in ISO 5 cleanrooms. Our teams directly support OEM production with documentation and validated COAs for batch release, conforming to global device quality regimes. Industry compliance standards
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2. Topical Dermal and Cosmetic FormulationsMajor skincare and beauty manufacturers incorporate our hyaluronan as a moisture-binding agent for premium creams, serums, and masks. Its high molecular weight enhances long-lasting surface hydration, while low molecular weight grades penetrate deeper skin layers. Our production batches meet cosmetic GMP, with precise molecular weight profiles to support desired product characteristics and stability through heated emulsification, homogenization, and cold compounding. Industry compliance standards
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3. Oral Dietary Supplements and Functional FoodsHyaluronan features in chewable tablets, capsules, and liquid drinks developed by nutraceutical and functional food processors. Bioavailability and purity are critical Industry compliance standards
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4. Veterinary Pharmaceuticals and Animal Health ProductsVeterinary product manufacturers integrate our hyaluronan in injectable and oral preparations for companion and livestock animals. The primary application involves intra-articular injections for equine and canine osteoarthritis, and oral solutions for joint and skin health in cats, dogs, and horses. Regulatory documentation, veterinary GMP batch histories, and endotoxin validation accompany all animal-grade shipments for straightforward QP release and downstream compounding. Industry compliance standards
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5. Advanced Wound Care and Hydrogel DressingsSpecialty medical dressing manufacturers utilize our medical-grade hyaluronan to construct hydrogel matrices for moist wound therapies. Its biocompatibility and hydration capacity support chronic and acute wound recovery in diabetic foot ulcers, burns, and trauma cases. The raw material enters at various points, such as hydrogel solution formation, film casting, or during freeze-drying protocols, and must demonstrate trace endotoxin, consistent viscosity, and proven sterility. Industry compliance standards
Typical usage ratio
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Competitive Hyaluronan prices that fit your budget—flexible terms and customized quotes for every order.
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Hyaluronan, more widely known as hyaluronic acid, has come a long way since early days of extraction from animal sources. Our manufacturing team knows what it takes to raise quality and purity beyond the bulk supplies found in most markets. Each batch starts with pharmaceutical-grade fermentation processes, not leftovers from animal by-products. Our team manages every step, choosing only the cleanest, traceable raw materials. This approach doesn’t just cut down on the risk of allergies and contamination—it also means the hyaluronan we ship comes certified for the strictest cosmetic and medical standards.
Over the last decade, customers have come to expect consistent, reliable viscosity and molecular weights. Our SERIXA™ HA-10 (molecular weight 1.0–1.5 MDa), SERIXA™ HA-300 (300 kDa), and SERIXA™ HA-2000 (2.0–2.5 MDa) models were developed in partnership with research groups testing stability, solubility, and performance in demanding applications. Higher molecular weight versions like HA-2000 create longer-lasting, more elastic hydration films for premium skincare and injectable formulations. The mid-weight (HA-10 and HA-300) provides better absorption for serums and eye drops. We focus on this range for a reason: customers in medical, cosmetic, and veterinary fields want proven options—not just fancy branding.
Seeing everything from poor solubility to trace proteins slip through in cheaper brands, we set up routine third-party mass spectrometry checks and our own internal HPLC tests. Pharmaceutical and injectable customers insist on precise, ultra-low endotoxin levels. Our purification eliminates pyrogens and residual proteins with high-pressure membrane filtration. This not only keeps the product safe, but it delivers a neutral odor and clarity in solution that pleases even the strictest quality heads in multinational pharma labs.
On top of ultra-pure powder, we also offer sodium hyaluronate in solution, designed to dissolve immediately with minimal shearing—even in challenging cold-mix or low-salt conditions. Many of our clients switched to our hyaluronan after struggling to get their finished product viscosity within spec using generic supplies. The difference shows up in every real-world test: less clumping, less loss during transfer, more predictable shelf life. We have direct data from pilot-scale skin patch and ophthalmic production lines that show lower batch-to-batch variation than EU pharmacopoeia minimums.
From the start, our plant built out its cleanroom manufacturing and sterile packaging lines to reach the standards needed for regulated export. Our hyaluronan powders and solutions carry documentation for European and Japanese pharmacopoeia, and both USP and EP monographs. Clean fill-finish work, redundant filtration, and tamper-resistant packaging come from high-stakes experience—our management team started in the injectable antibiotics sector, where contamination and recalls can destroy a business overnight.
Real GMP experience teaches what’s critical for global customers. For instance, every shipment destined for intra-articular injection or eye surgery goes through lot-specific endotoxin and protein content validation. Production files also archive full traceability back to premix fermentation tanks—a deep dive lets us spot any deviation fast and recall if something ever slips, a safeguard most brokers or relabelers simply cannot offer.
A huge part of our production volume now goes to R&D labs and high-value consumer products. Thanks to our engineering group’s close ties with academic researchers, we’ve adapted our processes for both classic and custom-modified hyaluronan. Cross-linkable grades, thiolated and methacrylated variants, as well as pharmaceutical sodium hyaluronate for ophthalmic and orthopedic applications, can all be shipped from the same plant where basic food or cosmetic grade starts. Technical staff from our plant often work with customers to adjust molecular weight or optimize for special cross-linking chemistries. One recent project involved reformulating a medical wound dressing to keep viscosity stable despite extreme pH swings. In these cases, it’s more than just shipping powder; it’s troubleshooting, sampling, and documentation at every step.
Every member of our support team has worked hands-on with actual production lines. Advice isn’t pulled from a marketing script—it comes from real-world troubleshooting, batch failures, and hundreds of small improvements over years of process optimization. When a skin care startup could not compound a stable serum, we visited, diagnosed the filtration setup, and suggested a blending schedule to prevent localized clumping. Their product line launched on time. This hands-on approach gives us repeat business and trustworthy relationships.
Supply chains for ingredients like hyaluronan can look similar on paper, but the differences start at fermentation. Many commercial hyaluronic acids come from animal tissues, then refined using basic alcohol precipitation and single pass filtration. Protein, nucleic acid, or impurity content often runs higher than what regulated applications allow. Those cuts end up in cheaper skin creams or pet gels. Once we invested in plant-based fermentation, our input costs increased, but the trade-off for purity and bio-safety pays off when customers rely on ingredients to meet strict standards.
Hyaluronan’s science has exploded in the last few years, especially as injectable and nano-formulated products reach the market. Demand for precise molecular weights, tight size distributions, and impurity controls has outstripped legacy supplier capabilities. Unlike companies relying on old animal-based extraction lines, we invested early in high-throughput chromatography and multi-stage membrane purification. Our main reactor trains feature dynamic, real-time process feedback, which means we adjust pH, feed rates, and agitation based directly on in-process analytics. Downstream, our integrated purification skips the older, more wasteful chemical precipitation that tends to strip away high-molecular-weight fractions.
In the finished product, the difference shows up quickly. One international pharmaceutical client tested solution clarity and found our lots scored 20% lower in absorbance than competitors, a strong sign of lower residual peptide and nucleic acid content. Consistency in molecular weight distribution delivers predictable thickening for medical gels and zero irritation for sensitive personal care lines. Every major step in our plant—from raw material intake to final fill—follows protocols more stringent than basic food-grade systems. These upgrades translated into fewer customer complaints and near-zero regulatory warnings.
The journey from animal-based hyaluronan to precision-fermented, pharmaceutical-grade material has become a necessity, not a luxury. Our customers continue to push into newer fields: subcutaneous fillers, tissue engineering, sustained-release implants, and advanced wound healing dressings. Their work requires predictable rheological behavior and purity at the parts-per-million level. We’ve adapted by introducing onsite molecular weight fractionation and deep purification with virus-removal capability.
Our role doesn’t stop at the production gates. We gather field feedback from researchers and manufacturers who use the product on real assembly lines and in clinical trials. This feedback loop feeds directly back into continuous process improvements. In one case, clients from a European biotech firm struggled with unexplained gelation during the formulation of a drug-eluting stent. Our process engineers reviewed their formulation steps, supplied a custom molecular weight cut, and helped adapt their blending order. The stents cleared clinical hurdles thanks in part to this collaboration.
Medical device makers have adopted our pre-sterilized, injectable syringes filled with hyaluronan solutions for viscoelastic eye surgery and arthritis injections. Each lot comes with depth-tested certificates covering all relevant pharmacopeia standards. A dedicated cleanroom line handles only injectable grades to eliminate cross-contamination risks with lower-purity runs.
Many in the industry treat hyaluronan as a simple commodity, focusing purely on price. Our experience says otherwise. Time and again, new clients send us competitor samples that fail to dissolve or smell “off.” Each failed batch tells a story. Bad batches aren’t just a supplier headache—they cost real dollars for companies that lose production time and must discard valuable ingredients. We use in-process quality checks rather than end-stage testing alone. Our team prefers to solve problems at the source, not when products are already loaded onto a truck.
The industry’s best practices develop from both failure and success. Our facility has dealt with microbial contamination events in years past, leading us to overhaul air filtration and raw material quarantine procedures. We upgraded fermentation tanks to self-cleaning, fully enclosed vessels and added UV sterilization to water feeds, steps that paid dividends during later surges in demand. This level of vigilance results in a safer end product but also in firm schedules that our customers can depend on.
A core part of our reputation comes from willingness to share technical data and address tough questions from customers and regulators. Over dozens of audits from industry partners and health authorities, we demonstrate our process openness. Visitors see real-time production logs, validated cleanroom procedures, and documentation mapping every ingredient lot to its finished batch. This transparency sets expectations and reassures clients—from major pharmaceutical companies to boutique skincare labs—that the material they receive has been made with safety top of mind.
Problems can and do arise in the world of manufacturing. Raw material shortages, unforeseen equipment downtime, or staff turnover all impact output. Our plant keeps safety stock and maintains cross-trained staff to limit disruption, and we keep an open feedback channel to inform customers about shipping timelines or production updates. Suppliers who dance around delays or quality issues rarely keep repeat business for long.
Every hyaluronan model we ship carries a story—a set of process milestones, audits, and real-world applications. We use each setback as an improvement opportunity. One key change last year: dialing in more sensitive in-line molecular weight sensors to detect process shifts even earlier. These improvements may not show up on data sheets, but they drive fewer customer headaches and greater long-term loyalty.
As customer needs shift, our manufacturing evolves with them. The growing interplay between hyaluronan and emerging technologies such as 3D-printed scaffolds, nano-formulated carriers, and even targeted drug-delivery platforms brings higher expectations. The challenge is not just to keep up, but to lead in technical development and reliability. Our close relationships with customer R&D teams position us to respond quickly to experimental requests, offer honest technical advice, and share application notes gleaned from multiple markets.
Long partnerships come from shared problem-solving. That means providing not only consistent hyaluronan but also process recommendations, data transparency, and responsive logistics. It’s this face-to-face, hands-on approach that turns a base material into a critical enabler of medical progress and consumer safety. Hyaluronan is more than a trend—it’s a platform for innovation and trust, built by people who know manufacturing from the ground up.
