Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Chloroacetate

    • Product Name Chloroacetate
    • Alias Monochloroacetic acid
    • Einecs 203-475-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    388032

    chemical_name Chloroacetate
    molecular_formula C2H3ClO2
    molar_mass 94.49 g/mol
    appearance Colorless to pale yellow liquid or crystalline solid
    odor Pungent, irritating odor
    solubility_in_water Highly soluble
    boiling_point 189 °C (372 °F)
    melting_point −22 °C (−8 °F)
    density 1.266 g/cm³
    pKa 2.87
    flash_point 88 °C (190 °F)
    stability Stable under recommended storage conditions

    As an accredited Chloroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Chloroacetate is packaged in a 500g sealed, high-density polyethylene bottle with a tamper-evident cap and clear hazard labeling.
    Shipping Chloroacetate should be shipped in tightly sealed, chemically resistant containers, labeled according to hazardous material regulations. It must be protected from moisture, heat, and incompatible substances. During transport, use appropriate packaging with clear hazard labels, and follow all relevant legal and safety guidelines for shipping toxic and potentially corrosive chemicals.
    Storage Chloroacetate should be stored in a tightly sealed container in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Keep it separate from strong oxidizing agents, acids, and bases. Use corrosion-resistant shelving or cabinets, and clearly label the storage area. Ensure access to emergency spill and eyewash stations nearby for safety.
    Application of Chloroacetate

    Applications of Chloroacetate in Industrial Manufacturing

    Chloroacetate plays a critical role in producing specialized intermediates and performance chemicals within several established industrial sectors. As a producer, we supply chloroacetate for downstream applications where strict process control, regulatory adherence, and consistent quality are vital. The following scenarios illustrate its use in major chemical manufacturing segments.

    1. Synthesis of Carboxymethyl Cellulose (CMC) for Food and Industrial Use

    Carboxymethyl cellulose production relies on accurate chloroacetate dosing during etherification of alkaline cellulose. The reagent reacts under controlled temperature and agitation, leading to substitution of hydroxyl groups on the cellulose backbone. QCs monitor the degree of substitution, impacting functional properties for thickening or stabilizing applications. Food-grade CMC plants impose traceability and batch validation requirements, while industrial CMC production may adjust viscosity targets per customer order.

    Industry compliance standards

    • ISO 22000:2018 for food safety management systems
    • GB 1886.232-2016 China Food Additive Standard for CMC
    • FCC (Food Chemicals Codex) monograph on carboxymethyl cellulose
    • FDA 21 CFR 182.1745 for food additives in the United States

    Typical usage ratio

    • Chloroacetate is used at 0.57–0.62 mol per mol of anhydroglucose unit for medium DS (Degree of Substitution) CMC
    • Exact ratio is adjusted according to required viscosity and purity grade
    • Minor adjustments for process losses and byproduct formation
    • Batch-wise input checked by titration and mass balance

    Downstream process integration

    • Injected after alkali activation of cellulose pulp
    • Etherification in alkali-alcohol slurry, maintained at 60–75 °C
    • Post-reaction purification via washing and neutralization to remove residual reagents
    • Final milling and blending before packaging

    Final product types

    • Food-grade CMC as a rheology modifier in beverages and dairy
    • Industrial-grade CMC for paper coating and detergent thickening
    • CMC used in textile printing pastes
    • Exploration and oil drilling fluid thickeners

    2. Herbicide Intermediate Production (Monochloroacetic Acid Derivatives)

    The manufacture of novel plant protection compounds often requires intermediate steps involving chloroacetate esterification or amination, acting as a core building block for auxinic herbicides and phenoxyacetic acid derivatives. Technical teams optimize feed ratios and solvent systems to favor high conversion and selectivity, while residue controls are aligned with agrochemical registration needs. Dedicated reactors with in-line scrubbers handle chlorinated byproducts.

    Industry compliance standards

    • FAO/WHO specifications for active ingredients (e.g., 2,4-D, MCPA)
    • ISO 9001:2015 for quality management in agrochemical plants
    • REACH (EC No 1907/2006) for substances manufactured in or imported to the EU
    • China Pesticide Registration Requirements GB 4839

    Typical usage ratio

    • Chloroacetate charged at 1.0–1.1 mol per mol of phenolic or amine precursor
    • Variations based on desired intermediate purity and downstream synthetic route
    • Quantitative excess supports reaction completeness but increases byproduct handling
    • Continuous monitoring for unreacted acid or chloride content

    Downstream process integration

    • Incorporated at initial condensation or alkylation steps
    • Reactors equipped with pH-controlled addition systems
    • Post-reaction separation includes crystallization or distillation of intermediates
    • Finished intermediate supplied for further formulation or technical concentrate production

    Final product types

    • 2,4-D (2,4-dichlorophenoxyacetic acid) herbicide actives
    • MCPA (2-methyl-4-chlorophenoxyacetic acid) actives
    • Other halogenated herbicide intermediates
    • Agricultural technical material and pre-mix concentrates

    3. Manufacture of Glycine and Ethylene Diamine Tetraacetic Acid (EDTA)

    Chloroacetate is introduced in batch or continuous synthesis of glycine and EDTA, where it acts as a primary reactant for nucleophilic substitution with ammonia or polyamines. Reactor control, pH adjustment, and temperature profiles are critical to yield and minimize side reactions such as dichloro byproduct formation. Downstream processing includes neutralization and purification to meet food additive or industrial chelant specifications.

    Industry compliance standards

    • USP Food Additive Monograph for glycine
    • GB 25541-2010 China National Standard for glycine
    • ISO 9001:2015 documented process controls for chelating agents
    • EU Regulation No 231/2012 for food additives

    Typical usage ratio

    • For glycine: 1.0 mol chloroacetate per 1.0 mol ammonia
    • EDTA synthesis: 2.0 mol chloroacetate per 1.0 mol ethylenediamine, with buffer regulation
    • Process efficiency may require small excess to compensate for competing hydrolysis
    • Adjustment by titration based on precursor purity

    Downstream process integration

    • Introduced into ammoniation reactors or fed dropwise based on reaction exotherm
    • After neutralization, product is crystallized or spray-dried for free-flowing powders
    • Pilot and large-scale plants employ inline pH and conductivity feedback loops
    • Stepwise washing and filtration for food or pharma grade lots

    Final product types

    • Glycine food additive for flavoring, animal feed, and supplements
    • Industrial grades for metal complexants and cleaning agents
    • EDTA and its salts for application in water treatment and detergents
    • Disinfectant and pharmaceutical chelating formulations

    4. Production of Surfactant Intermediates (Alkyl Polycarboxylates and Ether Carboxylic Acids)

    Surfactant producers utilize chloroacetate in the carboxymethylation of alcohol ethoxylates or fatty amines, yielding ether carboxylic acids and alkyl polycarboxylate surfactant bases. Facilities implement closed transfer systems for safe handling and reactivity control. The precise input ratio and progressive feed dictate the final product’s solubility and performance. Analytical validation guarantees batch-to-batch consistency required for downstream household, I&I, or oilfield formulations.

    Industry compliance standards

    • Ecotoxicological evaluation to OECD 301 biodegradability test
    • ISO 14001:2015 for environmental management at chemical production sites
    • GB/T 6360 for surfactant quality testing
    • REACH registration for European market access

    Typical usage ratio

    • 0.90–1.03 mol chloroacetate per mol alcohol ethoxylate or amine substrate
    • Slight molar excess ensures full conversion in continuous reactors
    • Ratio is refined for targeted mono- or di-carboxymethylation
    • Process flow adjusted based on downstream application requirements

    Downstream process integration

    • Continuous metering feed directly into ethoxylate/alkali slurry
    • Reaction under inert atmosphere due to volatility and reactivity
    • Neutralization and solvent stripping before blending into surfactant concentrates
    • Final QC on active content and salt profile

    Final product types

    • Ether carboxylic acids for mild personal care surfactants
    • Alkyl polycarboxylate dispersants for laundry detergents
    • Surfactants in cement admixtures for construction chemicals
    • Speciality emulsifiers for agricultural or oilfield formulations

    5. Pharmaceutical Intermediate for Thiopental Sodium and Other Barbiturates

    Pharmaceutical manufacturers employ chloroacetate in the route to thiopental sodium and related barbiturates, requiring tight input controls and high-purity, GMP-compliant raw material. The reagent is introduced in esterification or alkylation stages, subject to multi-stage purification and robust documentation. Each lot is monitored for identity, residual solvents, and endotoxins to meet injectable-grade thresholds.

    Industry compliance standards

    • ICH Q7 GMP guidelines for active pharmaceutical ingredients
    • USP/Ph. Eur. monographs for barbiturates and intermediates
    • FDA CFR Title 21 for ingredient traceability and control
    • China ChP standards for injectable and oral pharmaceuticals

    Typical usage ratio

    • Chloroacetate at 1.0–1.05 mol per mol of urea or malonic acid in the initial condensation
    • Slight excess compensates for hydrolytic degradations during synthesis
    • Specification sheets define range based on target yield and residual impurity acceptance
    • Pre-batch calculations reviewed by QA for every GMP batch

    Downstream process integration

    • Charged during initial condensation or alkylation in jacketed reactors
    • Process includes real-time sampling and HPLC checks on intermediate formation
    • Purification by recrystallization, solvent extraction, and controlled drying
    • Strict documentation for material movement in GMP records

    Final product types

    • Thiopental sodium for anesthetic application
    • Other barbituric acid derivatives for sedative or anticonvulsant use
    • API intermediates for human and veterinary preparations
    • Sterile injectable and oral barbiturate medications
    Free Quote

    Competitive Chloroacetate prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Chloroacetate: Manufacturing Insight into a Versatile Chemical

    Understanding Our Approach to Chloroacetate Production

    Our journey with chloroacetate started decades ago in an environment where close attention to purity, reliability, and real-world usability defined our benchmarks. Over years of hands-on experience, we’ve optimized conditions across each batch, investing in continuous research for improved crystallization, color stability, and impurity control. Our line-up primarily features sodium chloroacetate and methyl chloroacetate as the main industrial variants, though we keep a limited range of customized modifications to support specialty applications. We’ve seen requests ranging from agriculture to pharmaceuticals, and from everyday surfactant blends to high-end polymers. This range demands more than a one-size-fits-all grade. After thousands of tons processed, a blend of robust protocol, chemical intuition, and relentless attention to details marks our production floor. Quality doesn’t rest on a certificate but the discipline of watching every raw material drum, operator notebook, and reaction tank.

    Model and Specifications

    Our chloroacetate grades follow a tight internal specification based on strict content and color benchmarks. We keep sodium chloroacetate with a concentration not less than 99.0 percent, and maintain volatile matter below established industry limits. The white powder—often requested in mesh 60 or finer—is packed against moisture and light exposure, which have been shown to affect stability over longer storage times. Methyl chloroacetate, available in clear, water-white liquid, shows a boiling point tailored for easy residue removal. Each lot ships with a full impurity profile assay run on modern chromatographs, not simply as a paper guarantee, but as a result checked against repeated reference standards. That’s the result after many years identifying subtle off-colors, unknown peaks, and the rare drift in pH, all of which have shaped our acceptance criteria over time.

    Practical Differences from Other Chemical Building Blocks

    Years of supplying chloroacetate taught us where it stands apart from neighboring products, especially in contrast with monochloroacetic acid, dichloroacetate, or simple acetates. Sodium chloroacetate offers higher solubility and storage stability than the acid, simplifying formulation for users who want to avoid pH swings or corrosive feeds. In several cases, buyers want to shift up from monochloroacetic acid to the neutral salt, and we’ve seen firsthand how this decision can cut down equipment corrosion, reduce handling risk, and enable in situ blends. Compared with acetate salts, the chloro-substitution brings a strong activation for downstream reactions. This property opens a much broader utility, especially in carboxymethylation, cellulose modification, and herbicidal intermediates. Some users have switched from other alkylating agents after running cost-benefit analysis on byproduct profiles; they saw lower unwanted chlorinated wastes and more straightforward separation steps.

    Our methyl chloroacetate differs sharply from ethyl or higher alkyl esters — both in terms of boiling range and reactivity under nucleophilic displacement. This distinction proves crucial for those seeking short-chain activation and limiting unwanted side reactions. Some literature offers a comparison on how longer alkyl chains in the ester group can cause sluggish conversion rates; we’ve found this observation matches with what our customers encounter on the plant floor. For those who work in pharmaceutical synthesis or advanced plasticizer formulation, that slight difference in volatility or leaving group capacity means higher yields and fewer clean-ups.

    Chloroacetate in the Field: User Insights and Applications

    Talking with downstream formulators week after week, our technical group follows how users deploy our chloroacetate varieties. Herbicide producers highlight the reliability of our sodium chloroacetate in manufacturing glyphosate and related products. They rely on consistency—one batch of impure material can throw off plant throughput and spike the cost of waste treatment. We’ve had customers call in, relieved by a steady process after shifting their supply to our product line, saying their reactors run cleaner and finishing times improve.

    Cellulose ether factories make extensive use of methyl chloroacetate, where proper degree of substitution relies on a tailored profile of reactivity and minimal impurities. Skipping steps in neutralization or washing costs time and money at scale. Our feedback loop includes lab-scale simulating real-world preparation, helping many small and mid-size users ramp up without trial-and-error pitfalls. As a manufacturer, whenever we source raw chloroacetic acid for conversion, strict input selection shields downstream equipment from lifetime stress. Years of faulty product analyses from markets short on quality have proven that this detail galvanizes user trust.

    Some of the more specialized applications—in polymers, dyes, and pharmaceutical intermediates—draw on aspects of chloroacetate chemistry that a generic supplier may overlook. For instance, producing certain glycine derivatives means controlling trace organic halides and keeping water out of critical steps; our product design responds directly to those needs. One pharmaceutical client, after collaborating with our team, hit a new target on purity, surpassing their own older benchmarks. They documented lower side product formation and improved their scalability. Even minor technical nuances, like trace iron-managed with stainless reactors and careful maintenance—quietly improve real yield on industrial scale reactions.

    Sourcing Raw Materials: What Matters Downstream

    True reliability starts with raw material control, and our purchasing team knows every supplier—verifying quality at the dock before it hits our tanks. Chloroacetic acid, as the base for all our chloroacetate derivatives, varies from batch to batch, even among reputable global sources. Running wet chemical checks and frequent LC-MS spots issues before they escalate. Over years, skipping shortcuts in filtration or temperature control helped us prevent issues ranging from off-odors to runaway reactions.

    Transport and handling, too, shape what arrives on your floor. Packing chloroacetate—particularly the sodium salt—demands humidity control, high-integrity liners, and strong tight drums. Moisture pick-up can create lumps or degrade performance, so we engineered upgrades that dramatically lowered complaint rates. Only after direct feedback and plant visits did we understand how carrier timing and storage conditions shaped user experience more than spec sheets suggest. We saw that even minor tweaks at source—adding extra barrier layers, altering drum fill speeds—reduced returned lots and helped operators unload with confidence and less waste.

    Purity and Analysis as the Manufacturer Sees It

    Lab-to-lab differences can spell trouble in specialty chemicals. Instead of relying solely on paper specs, we routinely cross-check against customer-provided working standards, catching fine contamination that standard methods miss. Analytical upgrades—gas and liquid chromatography, mass spectrometry, and trace metal analysis—quickly flag changes in reaction byproducts or elemental residues. Over the years, even small variance in carbonate or sulfate got our attention, because their buildup in customer processes showed up in reactor fouling and variable final yields.

    Our plant floor workers know how to spot early signs of shifting output—slight color changes, differences in powder free-flow, or a new odor. Each parameter ties back to what chemists downstream need to minimize plant downtime and sidestep tank cleaning. We pick sampling plans carefully: early, mid, and late tank draws, not just a single scoop for a report. It’s math and experience, made richer by years of pharmacy and agrochemical maker feedback, pointing out trends a spreadsheet doesn’t catch.

    Traceable documentation holds it all together. Internal logs connect batch data, raw material lots, operator names, and analytical charts in a single archive. These are not just for regulatory compliance, but to build a bridge of technical trust: plant managers and formulators know the source, process, and controls behind every bag or drum. Reproducibility springs not only from controlled variables but from a culture of respect for the unseen factors—a rainy day, a new shift, a minor reactor fix.

    Solving Tough Problems from the Factory Floor

    Production rarely runs without challenges. Warm summers introduced byproduct spikes that a standard cooler couldn’t solve; we installed new chillers and re-trained staff to monitor the whole process curve. Regulatory shifts—especially in allowable trace impurities—pushed us toward ever-tighter controls and documentation chains. Our process engineers invested in automatically sampled titration, catching slight deviations in neutralization before they compromise final product. One difficult period—supplier interruption on a key raw—forced us to refine alternative sourcing protocols; backup plans smoothed production switchover without missing orders.

    From time to time, customers brought lab data showing spots missed in our own assays. Instead of deflecting, we reproduced their tests, reviewed their process flow, and adjusted our own controls until both sides met agreement. Honest, data-driven conversation led to several process overhauls: removing a sludge build-up step, increasing our air scour before drying, and re-training our QC team to recognize new impurity peaks on the chromatogram. Site audits uncovered bottlenecks we hadn’t noticed—packing errors during rush season, avoidable transfer losses from old pipelines. Fixing these lowered customer batch variability and kept confidence high.

    A practical solution often comes down to training and equipment reliability, not just chemistry. Regular team sessions explain the why behind SOPs, and we empower operators to report small changes before they snowball. Fielding technical calls—ranging from how to dissolve our product efficiently to troubleshooting downstream batch failures—builds a feedback loop we depend on. Information from end-users enters our protocols and informs our next round of process improvements.

    Safety and Environmental Responsibility in Manufacturing Chlorinated Compounds

    Safe handling of chloroacetate rests on more than following MSDS paperwork. Chlorinated organics, if not managed properly, present health, fire, and environmental concerns. We engineered multiple containment systems, install real-time leak monitors, and limit worker exposure by automating loading in high-throughput zones. Staff training doesn’t stop at annual recertification: supervisors demonstrate stepwise handling, reaction safety drills, and unannounced emergency shutdowns.

    Waste stream control became a hard lesson too. Years ago, we saw build-up in local effluents push us to re-engineer neutralization systems and install activated carbon beds. Government agencies set the pace, but internal standards reach beyond them. We monitor for both raw chloroacetate and side-product trace organics, knowing that waste variability can affect aquatic life and nearby farmland. After several upgrades, water discharges consistently exceed public safety thresholds, and neighbors appreciate the clean record.

    Responsible manufacturing means keeping a line of communication open with the community. We support site tours for regulatory officials and schools, review our practices against industry-wide benchmarks, and bring each new generation of engineers onto the floor for hands-on training. The discipline for safe, compliant chemical management now lives as a normal part of daily operations, not just a regulatory checkbox.

    Supporting Our Customers Beyond the Sale

    A core belief at our factory holds that supporting a product like chloroacetate doesn’t end at shipment. Technical representatives take calls daily from formulators, process engineers, and plant managers—troubleshooting dissolution time, pH control, crystallization, or waste handling. Sometimes customers call about an unexpected lab result, a slower reaction, or a blocked feedline. Our teams respond by sharing real-world solutions: adjusting pre-mix stages, switching agitation speeds, or simply walking through best practices gleaned from our own experiences.

    The feedback loop enriches both sides. Customers spark new ideas on process tweaks; in turn, they gain reliability and troubleshooting skills from our experience. Periodic customer visits and lab sample exchanges allow both parties to test alternative blends, tweak storage guidelines, and plan the next campaign with confidence. Lasting partnership means responding promptly to challenges and sharing knowledge, not just shipping boxes and closing tickets.

    Documentation and training materials—built from countless production runs—travel with every shipment; newcomers avoid old mistakes, and plant veterans find answers to uncommon problems. That database, annotated and revised by both fieldwork and factory insight, forms an ongoing resource for the industry. Our support doesn’t wrap up with a delivery note. It stretches through the project lifecycle, ready to troubleshoot, suggest process changes, and inform on regulatory shifts as needed.

    Choosing a Reliable Chloroacetate Manufacturer: Lessons from Decades in the Field

    Anyone sourcing chloroacetate looks past the lowest offer. Price matters, but only with a steady stream of reliable material, traceability, and technical support. Sourcing from a direct manufacturer brings confidence rooted in transparent batch records, face-to-face technical guidance, and a production culture that can spot and address changes before they impact your process.

    We’ve learned that true partnership grows not from transaction but from sustained effort, mutual respect, and shared technical progress. Chloroacetate—while a staple in many manufacturing sectors—carries both hidden risks and unique opportunities. As a chemical producer, we see it less as an isolated drum of white powder or liquid, and more as a crucial building block linking upstream diligence with downstream success.

    Our production lines keep learning from every ton shipped, and every question asked. Feedback doesn’t collect dust; it informs our next process refinement, safety drill, or quality assurance tweak. Users trust us because they know we stand behind each batch—not from a distance, but as active partners in their everyday operations.

    Choosing your supplier shapes your entire process. The most reliable chloroacetate comes not from faceless intermediaries but from those who’ve lived the production detail, sweated the reaction parameters, solved the unexpected plant issues, and embraced both the science and craft of chemical manufacturing.