Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Vinyl Chloroacetate

    • Product Name Vinyl Chloroacetate
    • Alias Chloroacetic acid vinyl ester
    • Einecs 214-093-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    762498

    Cas Number 542-87-0
    Molecular Formula C4H5ClO2
    Molecular Weight 120.54 g/mol
    Iupac Name vinyl 2-chloroacetate
    Appearance colorless liquid
    Boiling Point 132-134 °C
    Density 1.168 g/cm3 at 20°C
    Flash Point 30 °C (closed cup)
    Refractive Index 1.427 at 20°C
    Solubility In Water Hydrolyzes; immiscible
    Odor Characteristically sweet
    Melting Point -42 °C
    Vapor Pressure 8 mmHg at 25°C

    As an accredited Vinyl Chloroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Vinyl Chloroacetate is packaged in a 500 mL amber glass bottle with tamper-evident seal and labeled with hazard information.
    Shipping Vinyl Chloroacetate should be shipped in tightly sealed containers, protected from moisture and sunlight, and kept at a cool temperature. It must be labeled as a hazardous material and handled according to relevant regulations, including UN number 1302. Ensure proper ventilation and segregation from incompatible substances during transport.
    Storage Vinyl chloroacetate should be stored in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong bases and oxidizers. Keep the container tightly closed and properly labeled. Use under a chemical fume hood and store in a flammable liquids cabinet. Avoid contact with moisture, and ensure all storage procedures comply with relevant safety regulations.
    Application of Vinyl Chloroacetate

    Applications of Vinyl Chloroacetate in Industrial Manufacturing

    Vinyl chloroacetate is a specialty chemical used in targeted segments of fine chemical, agrochemical, and pharmaceutical production. Our direct synthesis and quality management ensure strict traceability from raw material to downstream use. Below, we outline industrial application fields, highlighting compliance, formulation ratios, integration points, and main finished products.

    1. Synthesis of Pharmaceutical Intermediates

    Pharmaceutical manufacturers incorporate this material as a key alkylating agent during multi-stage preparation of certain active pharmaceutical ingredients (APIs), particularly for small-molecule drugs featuring chloroacetyl or vinyl functionalities. It enables controlled introduction of functional groups in heterocyclic or aromatic compounds, with precise molar ratios tailored to intermediate chain length or yield targets specified in the synthesis protocol. Handling requires validated closed-system transfers and in-process impurity controls, with batch records aligned to cGMP or ICH criteria.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • US FDA 21 CFR Part 211 (Manufacturing, Processing, Packing, or Holding of Drugs)
    • EU EudraLex Volume 4 (EudraGMDP for APIs)
    • USP-NF Monographs for intermediates where applicable

    Typical usage ratio

    • 0.6–1.1 molar equivalents per target intermediate, adjusted by step yield and residual chloroacetyl content
    • Adjusted based on desired purity and chain-length of the intermediate

    Downstream process integration

    • Charged to alkylation or acylation reactors upstream of isolation or chromatography purification steps
    • Monitored by in-line NMR or HPLC for endpoint detection

    Final product types

    • Active pharmaceutical intermediates for antiviral, anticancer, or antifungal drugs
    • Protected amine derivatives
    • Modified glycoside skeletons for niche APIs

    2. Production of Agrochemical Active Ingredients

    Agrochemical producers use vinyl chloroacetate as a synthetic building block for select herbicide and insecticide actives containing chloroacetate moieties. Controlled dosing ensures compliance with maximum impurity limits set by crop protection regulations, and correct stoichiometric ratios reduce unreacted by-products in downstream condensation or cyclization reactions. Our customers scale this process in glass-lined reactors under nitrogen to minimize hydrolysis and manage exothermic load.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • EPA 40 CFR Part 180 (Tolerances and Exemptions for Pesticide Chemical Residues)
    • REACH Annex II (Safety Data Sheet requirements)

    Typical usage ratio

    • 21–26% by mass relative to other reactants in condensation reactions
    • Adjusted according to target active ingredient concentration and batch size

    Downstream process integration

    • Added after initial base or amine input for controlled substitution
    • Processed under constant agitation and controlled temperature profile

    Final product types

    • Chloroacetate-based herbicide technical concentrates
    • Precursor intermediates for organophosphorus insecticides
    • Crop protection active ingredients for cereals and vegetables

    3. Fine Chemical Synthesis for Specialty Monomers

    Manufacturers of high-value specialty monomers and polymer intermediates introduce vinyl chloroacetate as a reactive monomer or comonomer for downstream copolymerization. Its reactive vinyl and chloroacetyl groups support formation of tailored copolymers for advanced resins, adhesives, and crosslinkers. Quality control requires pre-polymerization purity checks and monitoring of conversion rates to maintain performance specifications in final polymer batches. Integration involves both batch and continuous production, depending on resin end-use.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems for Chemical Production
    • EU REACH Substance Registration, Evaluation, Authorization requirements
    • ASTM D2567 (Standard Practice for Laboratory Preparation of VCM-based Polymers)

    Typical usage ratio

    • 9–16% by weight of total monomer feed for copolymer runs
    • Variable based on molecular weight targets and crosslink density requirements

    Downstream process integration

    • Metered into monomer kettle as last component before initiator addition
    • Monitored for vinyl group conversion and residual acetyl group content

    Final product types

    • Adhesive resins for electronics assembly
    • Crosslinked specialty coatings for automotive and aerospace components
    • Monomer-terminated macromolecules for high-performance materials

    4. Manufacturing of Dyes and Pigment Intermediates

    Producers specializing in organic pigment dispersions and synthetic dyes employ vinyl chloroacetate as an electrophilic building block during the assembly of complex chromophores. The compound introduces acetyl and chloro groups into aromatic structures, impacting pigment shade and solubility. Strict batch control and compliance with heavy metal and impurity limits are essential according to downstream textile or ink applications. The material enters condensation or coupling step after azo or heterocycle framework assembly, with ratio fine-tuned for target hue intensity and stability.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for textiles (limit values for unwanted substances)
    • EN 71-3 (Safety of Toy Materials, migration of certain elements)
    • REACH Annex XVII (Restrictions on the manufacturing and placing on the market of certain dangerous substances)

    Typical usage ratio

    • 3–7% relative to pigment or dye intermediate mass, modified for desired intensity
    • Calculated by target chromophore yield and reaction efficiency

    Downstream process integration

    • Added post main chromophore formation before final coupling or end-capping
    • Mixing and heating under controlled pH to reach desired acetylation level

    Final product types

    • Color-fast textile dyes for natural and synthetic fibers
    • Pigment intermediates used in offset and digital printing inks
    • Azo dye precursors for leather and plastics applications
    Free Quote

    Competitive Vinyl Chloroacetate prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Understanding Vinyl Chloroacetate: Production Insights and Practical Uses

    What Drives Our Approach to Vinyl Chloroacetate Manufacturing

    Working directly in the synthesis of vinyl chloroacetate brings a particular sort of clarity about what performs well in the real world. In the production plant, every kilogram of this specialty chemical represents the outcome of calibrated process control, thoughtful material selection, and consistent refinement. Vinyl chloroacetate is an organochlorine compound, and over years of manufacturing, valuable lessons have emerged about what truly separates a quality product from a generic alternative. These insights shape our drive for purity and predictability that customers want for their downstream transformations.

    Product Model: Our Standard and Custom Offerings

    Through years of orders for both routine and highly specialized batches, we've established our model range to match lab requirements with plant economies of scale. In our main production route for vinyl chloroacetate, we use a carefully controlled addition of chloroacetic acid derivatives to vinyl acetate under catalytic conditions. In this synthesis, consistent batch purity hinges on both the integrity of the starting materials and the fine-tuning of temperature and catalyst ratios. The model most requested by polymer clients matches assay values above 99% and maintains residual solvent under strict limits—especially important since slight variations show up unpredictably in polymerization or acylation processes.

    What Sets Vinyl Chloroacetate Apart

    We look at the market and see competing esters and vinyl monomers—vinyl acetate, methyl chloroacetate, and numerous specialty derivatives. But vinyl chloroacetate stands apart due to its reactive functional groups and the balance it strikes in volatility and reactivity. The molecule features both a vinyl and a chloroacetyl group, which opens a broader set of transformations compared to the simpler vinyl esters. Chemists value this because it allows both addition and substitution chemistries, enabling advanced syntheses not possible with vinyl acetate. Compared to methyl chloroacetate, the vinyl analog increases the molecule’s versatility for both polymer chain extension and custom functionalizations.

    From a processor’s viewpoint, the boiling point—hovering near 150°C—lets operators avoid some of the runaway volatility concerns of low-boiling monomers. In practical terms, these handling advantages reduce loss and risk during transfer, particularly in summer heat, without crossing into excessive viscosity that complicates pumping or dosing.

    Purity, Isomer Control, and Batch Consistency

    Purity control runs deeper than headline assay numbers. Every batch draws scrutiny for trace chlorides, residual acids, and non-vinyl byproducts. In years past, uncontrolled residual acid swung downstream yields wildly or triggered unwanted polymerization. After investing in closed-loop distillation and real-time monitoring, our output remains tight on both GC and NMR analyses, with major byproduct signals driven to undetectable levels. Analysts check not just the total organochlorine content but also the E/Z isomer ratio where applicable—since this subtly shapes reactivity for certain pharmaceutical and agrochemical syntheses.

    Strict batch traceability ensures each drum matches well with records on precursors, processing conditions, and quality test points. With regulatory eyes shifting to risk-based inspection models and tighter tolerances for impurities, our operation documents every deviation and adjustment, allowing rapid root cause analysis and transparent answers for client audits.

    Applications—How End-Users Deploy Vinyl Chloroacetate

    Decades of feedback from synthesis teams and scale-up engineers have given us a practical sense of where vinyl chloroacetate finds its best fit. The chemical enters at the level of intermediate in fine chemical, agrochemical, and pharmaceutical production pipelines. One frequent use is as a starting reagent for the creation of complex ketones, carboxylic acids, or acetyl-protected amino acid derivatives. Its structure allows for both nucleophilic substitution at the chloroacetyl group and addition across the vinyl double bond, so versatility is its main draw.

    Polymer manufacturers often focus on the value provided by the vinyl group, which enables co-polymerization with a wide range of monomers. This broadens access to materials with bespoke mechanical or chemical resistance properties, often without the need to use more hazardous or tightly regulated raw materials. In agricultural chemistry, the molecule’s reactive sites are harnessed to build up more elaborate pesticide precursors, tying together efficacy with reduced purification waste when done skillfully.

    Where pharmaceutical developers need mild chemical handles or protecting groups that can later be removed without harsh conditions, vinyl chloroacetate’s leaving group profile fits well. The same properties that make this possible—a judicious mix of lability and stability—underscore the benefit of tight impurity control, since residue from side reactions complicates both purification and final bioactivity evaluations.

    Handling and Process Safety: Factory-Level Insights

    Years of direct experience in both batch and continuous operation show that vinyl chloroacetate needs strong stewardship in terms of temperature management and containment. The compound’s chloro group brings moderate toxicity; strict PPE, effective ventilation, and clear leak mitigation measures stay on top of our daily checklist. We’ve seen how even small lapses in containment can lead to not just product loss but health risks—so our team enforces written checklists and invests in staff retraining rather than assuming expertise is a one-time achievement.

    On the technical side, pressure controls and relief valves rated for moderate chloroester volumes anchor our fixed equipment design. Maintenance teams test gasket materials regularly, with preference for fluoroelastomers, since swelling or permeation with cheaper rubbers brings downtime and avoidable cleaning hazards. Mixed loading operations sometimes tempt short-cuts, but the downstream costs of even a trace cross-contamination incident far outweigh minor efficiency gains.

    Product Differentiation: Not Just About Purity

    Conversations about “quality” often focus on a single number, but we’ve learned that customers who scale up in actual production settings need predictable flash point behavior, low color bodies, and tight viscosity control. In one recent audit case, a customer reported erratic polymer performance traced to trace stabilizers present in an externally sourced lot. Out-of-spec color or haze can trigger whole batch discards or rework downstream. For this reason, we adopted double filtration steps at the final stage, using high-clarity glass media over granular charcoal to guarantee visual as well as instrumental cleanliness.

    We maintain full logs of stabilizer and antioxidant additions, rather than assuming residuals won’t matter. Some products with similar end groups tolerate more sloppiness, but at kilo or tonne scale, the costs multiply and hit product marketability. Our crew has identified that colorless appearance alone doesn’t guarantee the absence of oxidation or side products. Real-world outcomes for customers matter most—measured in batch yield, not technical trivia.

    Environmental Stewardship and Process Efficiency Lessons

    Every year, regulatory and environmental standards push us to operate leaner and greener without sacrificing product quality. Solvent recycling programs capture and purify more than 85% of cycle solvent, dramatically cutting both waste disposal costs and ambient release. Thermal balance in our vinyl chloroacetate reaction sequence makes a measurable difference—precise temperature modulations within a few degrees improve both yield and byproduct suppression.

    For the small fraction of chlorinated byproducts we can’t eliminate in-process, we run scrubbers and neutralization beds designed after systematic root-cause audits. These aren’t just checkboxes—each incremental improvement in pollutant catching nets measurable benefits in regulatory compliance, long-term liability, and good working relationships with neighbors and authorities. In a field where legacy practices often stifle innovation, the appetite to revisit processes after customer complaints or shifting legal frameworks makes a difference.

    Customer Feedback and End-User Requirements Shaping Product Direction

    Direct calls from technical teams handling process optimization have done more to refine our formulation than any in-house experiment. Polymer chemists highlight the value of unchanged reactivity in their pilot plants as the best validation of our process, more so than the formal certificate of analysis metrics. This trust isn’t built overnight; it’s the payoff from troubleshooting joint problems and keeping “off-spec” product to negligible levels across hundreds of batches.

    The fine chemical sector pushes for enhanced reactivity, while the polymer field demands absolute purity over reactiveness. By listening and adapting, we balance these at source. Pressure from European and North American partners for documentation and transparent impurity profiles drives our team to share more—not out of compliance fear, but because this rigorous interaction iteratively refines quality benchmarks.

    Supply Planning and Logistics: Realities Beyond the Lab

    Supplying vinyl chloroacetate to different continents means navigating both transport limitations and regulatory thresholds. The product ships best in stainless steel drums with welded seals and nitrogen blanketing; our team discovered early on that cheap transfer lines or oxygen ingress quickly degrade product reserves. In-transit tracking links back to our in-house quality database, letting both scheduling and receiving teams see any anomaly in transit impact, with a live view into storage temperature and seal integrity.

    Regional differences in storage standards mean our packaging team remains ready for both UN-certified barrels and smaller canisters depending on country-specific rules. We document every outer and inner container batch and train shipping staff on emergency response—not because rules demand it, but because we have seen firsthand the costs of mishaps, both financially and in professional credibility.

    Continuous Product Improvement: The Manufacturer’s Perspective

    Unlike resellers, manufacturing teams live with the impact of their own process tweaks, both good and bad. Real process improvement emerges through a data-driven mix of frontline operator feedback and post-sale customer commentary gathered over years. For vinyl chloroacetate, the latest optimizations reduced end-to-end reaction time by 9% and pushed energy use per unit output down measurably, without sacrificing the narrow impurity profiles or functional purity that pharmaceutical clients demand.

    Ever-tightening regulatory attention and rising customer expectations push us to update both raw material sources and critical equipment, aiming for shorter response times to both supply chain shocks and chemistry innovations. Rarely does a year pass without at least one minor overhaul—swapping a distillation tray, adjusting coreactant feeding methods, or investing in new test instruments for impurity mapping. As a result, maintaining consistency from specification to delivered product remains both a source of pride and a hard-won differentiator.

    Compliance, Cross-Discipline Collaboration, and Transparent Information Sharing

    This business doesn’t thrive on secrecy. Instead, upstream suppliers, downstream users, and even rival manufacturers end up advancing the field by cross-talking about pitfalls and advances. Our technical documentation borrows from user feedback and our own lessons—highlighting what actually creates trouble at scale. Regulatory environments are rarely static, and our plant management discusses changes candidly with partners rather than just issuing new paperwork.

    Testing teams collaborate with R&D and production regularly to validate both process drift and batch stability. Each time a customer points out an unexpected impurity or process hiccup, these findings channel directly into corrective cycles, marked both by new protocols and practical retraining. On rare occasions where a structural plant change becomes necessary, early notification and open dialogue with top customers halt cascading costs and build lasting trust.

    What the Future Holds for Vinyl Chloroacetate

    With specialty monomers growing in pharmaceutical and materials sectors, demand for vinyl chloroacetate climbs yearly, driven by the molecule’s utility in ever-more customized syntheses. Halogen management, green chemistry pressures, and the chase for higher reactivity at lower environmental costs all shape the ways we continue to refine the product. R&D investment directly into new catalysts and low-energy separation technologies targets further improvement in throughput, while minimizing waste and hands-on labor.

    New projects focus not only on bringing down contamination risk but on maximizing value extraction from spent batch residues—an area where traditional plants bled untold amounts in waste. During scale-up trials, plant operators team up with university consortia and customer process scientists to map new use cases that reduce bottlenecks, shorten purification steps, and expand the product’s applicability in both established and emerging markets.

    Why Hands-On Expertise Matters

    Day-to-day synthesis and quality assurance reveal that theory only gets a chemical manufacturer so far. Operators flag subtle color changes that often don’t appear on automated print-outs; maintenance engineers catch the faintest gasket degradation before it turns into a leak or contamination crisis. This hands-on care, backed by a resolve to follow through long after a contract signs, is what ultimately sustains both product standards and client confidence in high-spec chemicals such as vinyl chloroacetate.

    We don’t see ourselves as simple providers of a commodity. Decades of cumulative effort and constant review shape every shipment, every drum, and every technical data point we support. In this field, honest engagement and technical resilience matter just as much as the molecules themselves. Vinyl chloroacetate production, done right, isn’t just about output volume—it’s about dependability, responsibility, and the assurance that each customer can build their own chemistry on a reliable foundation.