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Thiophosphoryl Chloride

    • Product Name Thiophosphoryl Chloride
    • Alias Phosphoryl chloride, thiophosphoryl chloride
    • Einecs 208-686-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    815044

    Chemical Name Thiophosphoryl chloride
    Chemical Formula PSCl3
    Molar Mass 169.41 g/mol
    Appearance Colorless to yellow fuming liquid
    Melting Point -46 °C
    Boiling Point 125 °C
    Density 1.576 g/cm3
    Solubility In Water Reacts violently
    Vapor Pressure 18 mmHg (20 °C)
    Cas Number 3982-91-0
    Odor Pungent, suffocating
    Refractive Index 1.547
    Flash Point 42 °C (closed cup)
    Un Number 1817

    As an accredited Thiophosphoryl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Thiophosphoryl Chloride is typically supplied in a 500 mL amber glass bottle with a secure cap, labeled for hazardous chemicals.
    Shipping Thiophosphoryl chloride must be shipped in tightly sealed, corrosion-resistant containers, clearly labeled as a toxic, corrosive, and moisture-sensitive substance. Transport is subject to strict regulatory requirements, typically under UN number 1818. Packages should be protected from physical damage and stored in a cool, dry, and well-ventilated environment during transit.
    Storage Thiophosphoryl chloride should be stored in a cool, dry, and well-ventilated area, away from moisture, water, and incompatible substances such as strong bases and oxidizing agents. It must be kept in tightly sealed containers made of compatible materials, typically glass or certain plastics, clearly labeled, and placed in dedicated corrosive chemical cabinets to prevent leaks, spills, and accidental contact.
    Application of Thiophosphoryl Chloride

    Applications of Thiophosphoryl Chloride in Industrial Manufacturing

    As the manufacturer specializing in high-purity Thiophosphoryl Chloride, we serve leading corporations across globally regulated value chains. The following sections detail how our material integrates into diverse production processes, optimizing specific chemical transformations crucial to the synthesis of advanced industrial compounds. Each scenario reflects real-world usage observed in scale manufacturing under stringent quality systems.

    1. Synthesis of Organophosphorus Pesticides

    Leading agrochemical producers use our material as a phosphorylation and chlorinating agent in the synthesis of organophosphorus active ingredients, such as chlorpyrifos and parathion. This compound enables direct chlorination and formation of phosphorus ester bonds during intermediate production. Its controlled reactivity allows precise batch or continuous manufacturing, reducing byproducts and supporting high conversion yields demanded by commodity and specialty pesticide markets.

    Industry compliance standards

    • ISO 9001:2015 for quality management in chemical processing
    • REACH Regulation (EC) No 1907/2006 for imported/exported chemicals in EU
    • FAO/WHO specifications for active ingredients in pesticides
    • Globally Harmonized System (GHS) for hazard labeling

    Typical usage ratio

    • Used at 0.8–1.4 molar equivalents per mole of phosphorus precursor; exact ratio adjusted according to active ingredient synthesis pathway and target purity.

    Downstream process integration

    • Enters the process after initial precursor charging, during phosphorus halide conversion stage.
    • Used in closed, inerted reactors to prevent environmental or operator exposure; automated dosing systems for scale consistency.
    • Followed by controlled hydrolysis or secondary substitution.

    Final product types

    • Technical-grade and formulated organophosphorus insecticides (e.g., chlorpyrifos, parathion)
    • Emulsifiable concentrates, suspension concentrates, and granules for crop protection

    2. Manufacturing of Plasticizer Intermediates (e.g., Trialkyl Phosphates)

    Producers of flame retardants and plasticizer additives apply our material in the stepwise phosphorylation of alcohols to manufacture trialkyl phosphate esters, notably tributyl phosphate (TBP) and trioctyl phosphate (TOP). This process, essential for polymers and specialty plastic markets, requires tight control of the chlorination environment and neutralization steps to assure minimal contamination and uniform molecular weight distribution in the resulting plasticizer.

    Industry compliance standards

    • ISO 14001:2015 for environmental management systems in chemical plants
    • ASTM D1045 for plasticizer analytical testing
    • UL 94 recognition for flame retardant applications
    • Chinese GB/T 4610-2016 specifications for phosphate esters

    Typical usage ratio

    • Applied at 1.1–1.25 molar equivalents per mole of alcohol feed, depending on chain length and process temperature.

    Downstream process integration

    • Introduced in jacketed reactors post alcohol charge, in the phosphorylation/reactive esterification step.
    • Careful control of reaction temperature, agitation, and acid scavenger addition for high-purity intermediates.
    • Subsequent aqueous workup and purification to achieve required performance metrics

    Final product types

    • Phosphate ester plasticizers for PVC, cellulose derivatives, and engineering plastics
    • Flame retardant packages for electrical and construction sectors

    3. Production of Pharmaceutical Organophosphorus Intermediates

    Leading pharmaceutical companies incorporate our material in the chlorination or phosphorylation stages when synthesizing organophosphorus compounds—intermediate APIs and process catalysts. Applications include manufacturing of nerve agent antidotes, certain lipid-modifying drugs, and nucleoside analogues. Process engineers require stable supply and lot-to-lot consistency to meet highly regulated impurity profiles mandated for pharmaceutical synthesis.

    Industry compliance standards

    • ICH Q7: GMP for active pharmaceutical ingredients
    • 21 CFR Part 211 (FDA) for cGMP in drug manufacturing
    • European Pharmacopoeia monographs for organophosphate materials
    • USP <467> for control of residual solvents

    Typical usage ratio

    • Ranges from 1.0–1.5 molar equivalents per substrate; tuned to balance conversion and minimize process impurities, batch-specific per validated synthesis route.

    Downstream process integration

    • Added during the phosphorylation step, frequently under anhydrous and oxygen-excluded conditions.
    • Reacts with organic bases in multi-step synthesis to isolate sensitive phosphonium or phosphonate intermediates
    • Integration into automated or continuous reactors for consistency

    Final product types

    • Key organophosphorus pharmaceutical intermediates
    • Drug substances, reactive intermediates, and specialty catalysts used in GMP-compliant production

    4. Synthesis of Fire-Resistant Hydraulic Fluids

    Industrial lubricant manufacturers employ our material in controlled phosphorylation of polyols, yielding phosphate ester-based hydraulic fluids. These formulations prioritize fire resistance for applications in mining, metal casting, and aviation sectors. It enables batch reproducibility, precise viscosity targeting, and robust stability against hydrolysis, while aligning with globally recognized performance and safety standards.

    Industry compliance standards

    • ISO 12922 for hydraulic fluids
    • FM Global fire-resistant fluid approvals
    • DIN 51502 specification for lubricants
    • SAE AS1241 for aircraft hydraulic fluids

    Typical usage ratio

    • Dosages at 1.0–1.2 mole per polyol reactant, adjusted for molecular weight and targeted fire resistance ratings.

    Downstream process integration

    • Charged into reactors following thorough dehydration of all organic feedstocks, enters during phosphorylation of polyol backbone.
    • Vacuum distillation post reaction to remove HCl byproduct and achieve clarity
    • Blending of finished base with proprietary additive packages before final QC

    Final product types

    • Phosphate ester fire-resistant hydraulic fluids (HFD-R, HFD-T)
    • Hydraulic system lubricants for industrial, mining, and aviation use

    5. Specialty Application: Halogenated Flame Retardants for Textiles

    Manufacturers of textile treatment chemicals incorporate our material in the phosphorylation-chlorination step to produce halogenated phosphorus flame retardants. This process generates high-performance coatings and finishes capable of meeting strict flame spread and smoke emission standards in protective clothing and contract furnishing fabrics. Controlled process parameters ensure compatibility with downstream binder systems and minimize residual phosphorus odor in fabrics.

    Industry compliance standards

    • Oeko-Tex Standard 100 for hazardous substances in textiles
    • NFPA 701 for textile flame propagation
    • EN ISO 11612 for protective clothing
    • REACH Annex XVII for restricted chemicals in consumer textiles

    Typical usage ratio

    • Typically at 0.9–1.3 mole equivalents per organic precursor, ratio based on desired halogen content and textile application thickness.

    Downstream process integration

    • Combined with polyol or amine feedstock in stirred-tank reactors under precise temperature and HCl control.
    • Post-reaction neutralization and emulsification for aqueous or solvent-based textile finishing
    • Finish applied by padding, spraying, or exhaustion onto fabrics

    Final product types

    • Halogenated flame retardant finishes for technical and decorative textiles
    • Industrial uniforms, protective curtains, upholstery and bedding
    Free Quote

    Competitive Thiophosphoryl Chloride prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing Our Thiophosphoryl Chloride: Trusted Performance from a Dedicated Manufacturer

    Thiophosphoryl Chloride: Decades of Proven Quality

    Manufacturing thiophosphoryl chloride isn’t just a matter of mixing ingredients according to a recipe, handing it off, and calling it a day. We know this because for years, our team has guided every batch from raw material sourcing through to finished product. We don’t leave details to chance, especially not with a chemical where purity, handling, and trace contaminants can shape entire downstream outcomes for our clients. In making thiophosphoryl chloride—chemical formula PSCl3—we rely on seasoned staff and monitored processing, not just automation, to turn out product that meets exacting standards batch after batch.

    What Sets Our Thiophosphoryl Chloride Apart

    Many in the field recognize thiophosphoryl chloride by its clear, light yellow liquid appearance and its sharp, penetrating odor. We focus on tight purity control. When we talk about technical grade, it means we’ve held impurities to defined upper limits, routinely below 0.5% total nonvolatile matter and with minimal organochloride residues. Our own proprietary process, refined through years of customer feedback and internal testing, actively minimizes disulfide byproducts and ensures tight composition.

    Other suppliers sometimes ship thiophosphoryl chloride with a greenish tint or release with a higher water content. Our in-house dehydration and distillation protocol brings that moisture content reliably below 0.05%. This matters for anyone using the product as a chlorinating agent or as a raw material for phosphorus-based intermediates, where unwanted hydrolysis spoils the efficiency. We’ve learned the hard way that seemingly tiny shifts in water or organic impurity content can lead to off-color finished products for the end user.

    Tested Uses Across Industries

    Our customers have told us that they rely on thiophosphoryl chloride as a workhorse in pesticide synthesis—particularly for producing organothiophosphate compounds. We’ve supplied the active ingredient base material for several major international agrochemical brands. Each of them demands zero deviation from purity, not just for regulatory compliance, but to keep catalyst poisoning from ruining their high-value reactions. We’ve built our purification steps with this feedback in mind.

    Beyond the agricultural sector, some clients draw on thiophosphoryl chloride for flame-retardant intermediates, dye-manufacturing reagents, and specialty plasticizers. Chemical researchers aiming to substitute baseline phosphoryl chloride in specific syntheses now opt for our product when sulfur introduction calls for precision.

    Direct-from-Plant Difference

    There are clear differences between sourcing from a dedicated, experienced manufacturer and buying through layers of intermediaries. For one, our plant runs at full traceability—right down to each drum number traced back through production records. If a customer faces an issue in their downstream application, we pull sample retains to get real answers. No distributor in the chain can replicate this level of accountability because they don’t see the raw process.

    Our deep involvement with thiophosphoryl chloride means we can respond to customer questions about reactivity or contamination with practical solutions, not guesswork. We regularly host visiting chemists from clients’ plants who see our glass-lined reactor systems, our in-line GC analysis, and our drum-filling rigs operating in real-time. No repackaging, untraceable relabeling, or guesswork about original source ever enters the equation.

    Model, Packaging, and Handling Approach

    We ship our product from the factory either in high-integrity steel drums, lined internally to prevent iron chloride formation, or in isotank containers for large-scale buyers. The standard concentration sits reliably above 99.0% as confirmed by our in-house GC method, but we routinely supply analytical reports not just by percentage, but by actual quantification of residual sulfides and volatiles. For specialty syntheses needing sub-batch customization—such as reduced acidic chloride byproduct—we maintain a quality assurance team able to adjust at the order level.

    Safe handling instructions and compliance guidance draw not from generic warning labels but from our years of logistical experience. We’re familiar with the real hazards—distinct from hypothetical regulatory scenarios—so our packaging reflects lessons learned from transport to humid climates, drum stacking in bulk warehouses, and the genuine risks of container breaches. For bulk volumes, we provide technical consultation to ensure your site receives not just the material, but support for local plant adaptation, scrubbing system recommendations, and prevention of accidental phosphine release.

    Comparisons with Other Related Chemicals

    Thiophosphoryl chloride often gets lined up against phosphoryl chloride (POCl3) or thionyl chloride (SOCl2) as if they are interchangeable. Our clients in pesticide and flame-retardant production know otherwise. Thiophosphoryl chloride’s unique sulfur double bond grants reactivity that just isn’t mirrored by its oxygen analog. Thionyl chloride serves as a better chlorinating agent for acyl chlorides but falls short where direct sulfur incorporation is required.

    What we’ve found—especially in scale-up stages of new syntheses—is that switching between these reagents without a full appreciation of their distinct physical and chemical behaviors leads to costly batch failures. Thiophosphoryl chloride hydrolyzes under moist conditions, producing hydrogen chloride and volatile phosphorus compounds, but it also creates side reactions in glass vessels not seen with other halides. This particular characteristic has shaped the way we store and transport the product, ensuring the use of steel or PTFE-lining wherever extended contact occurs.

    Our customers appreciate that we don’t just sell raw product; we offer hard-won knowledge about material compatibility, lab-scale testing, and full-traceability on supply. We help troubleshoot when new formulations switch from phosphoryl chloride to thiophosphoryl chloride, addressing bottlenecks ranging from reaction kinetics to product isolation.

    Why Our Manufacturing Approach Matters

    Across the market, not every factory goes to the same lengths in quality assurance. Quality in thiophosphoryl chloride does not simply come down to a single purity number. We go beyond the spec sheet, conducting ICP-MS trace metal results, and we screen for halogenated volatile organics with GC-MS. We retain every batch for sample archiving and provide integrated shipment testing on every batch released. Our focus extends from production to final packaging, and these steps bring peace of mind to formulators working at the edge of product specifications or those dealing with regulatory audits.

    Our insistence on direct technical involvement also plays a role. We’ve supported clients resolving problems from unexpected polymer color shifts related to chloride contamination and have traced pesticide efficacy drop-offs to minute changes in batch stoichiometry. Our technical support specialists are all drawn from years on the plant floor—no outsourcing, no automated operators. This makes a difference when you rely on someone to talk solutions instead of reading from a scripted response.

    Handling Difficult Supply Chain Questions

    Markets for specialty phosphorus chemicals, including thiophosphoryl chloride, swing due to regulations, global phosphorus supply, and shifts in end-user demand. Our facility sources raw phosphorus directly and processes on-site, reducing exposure to the price volatility that hits plants relying on imported intermediates. We carry inventory that buffers clients requiring a steady supply even across unstable market cycles.

    Regulatory delivery has tightened in recent years, driven by stricter export licensing, dangerous goods declarations, and advanced compliance frameworks. As a direct manufacturer, we maintain up-to-date compliance documents, from detailed SDS sheets to full transport declarations, crafted by process engineers who understand every technical detail about this chemical. All batch files remain available for auditing, not just to satisfy an inspector, but to ensure client operations never pause for paperwork.

    Seeing the End User’s Requirements

    Most downstream issues clients run into involve variations in dosing, suddenty in reactivity, or downstream byproduct formation. By working alongside our clients, we’ve tailored part of our production to offer custom modifications where it makes sense. As an example, some customers developing flame retardants may face stricter halogen content limits, demanding ultra-low impurities. Adjusting to these needs, we’ve invested in pilot-scale purification rigs and batch-blending to provide material that supports their evolving standards.

    Over the years, we’ve seen plenty of problems when firms source bulk commodity chemicals through resellers or traders who can’t provide batch traceability, real-time issue resolution, or proper technical information. Every batch leaves our plant with a full history available. This isn’t just paperwork; it’s the outcome of a committed manufacturing team that’s handled queries ranging from sudden process corrosion to full-scale batch recalls. Our goal is reliability—for your formulations, your finished goods, and your peace of mind when things don’t go as planned.

    Supporting Responsible Application

    With experience comes responsibility. We’ve witnessed the evolving scrutiny over environmental handling, emissions, and end-of-life issues tied to thiophosphoryl chloride. Our investment in closed-loop filling and dedicated vapor scrubbing has helped reduce local emissions by over 80% compared to typical local market practice. As new restrictions roll out regarding hazardous air pollutants, we’ve proactively adjusted our procedures, helping clients anticipate and avoid operational headaches before they arise.

    We don’t act on theoretical models or outsource audits. Through constant process review, targeted emission control, and practical support to user sites, we keep environmental and regulatory boxes ticked with substance, not just for local compliance, but as partners to global firms facing pressure from buyers and authorities alike.

    Lasting Partnerships through Real Manufacturing

    Supplying thiophosphoryl chloride for years, our experience tells us that trust grows from real technical engagement and consistently delivered product, not from overpromises or untraceable shipments from brokers. From the earliest orders for bulk pesticide synthesis, through to today’s advanced requirements in specialty plastics and flame retardants, our focus has remained fixed on detailed knowledge, unbroken batch traceability, and open communication. We believe direct-from-plant sourcing, backed by teams who live and breathe thiophosphoryl chloride chemistry, offers more than chemicals—it delivers a foundation for lasting growth, innovation, and compliance in a challenging industrial landscape.