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Tetradecanoyl Chloride

    • Product Name Tetradecanoyl Chloride
    • Alias Myristoyl chloride
    • Einecs 203-942-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    196656

    Product Name Tetradecanoyl Chloride
    Cas Number 112-66-3
    Molecular Formula C14H27ClO
    Molar Mass 246.82 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 322.2 °C at 760 mmHg
    Melting Point 6-8 °C
    Density 0.950 g/cm³ at 25 °C
    Refractive Index 1.442-1.444 at 20 °C
    Solubility Reacts with water, soluble in organic solvents
    Flash Point 138.1 °C (closed cup)

    As an accredited Tetradecanoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Tetradecanoyl Chloride is typically packaged in 250 mL amber glass bottles with tamper-evident seals and hazardous material labeling.
    Shipping Tetradecanoyl Chloride should be shipped in tightly sealed containers under an inert atmosphere, protected from moisture and incompatible substances. It is classified as a corrosive chemical and should be labeled accordingly. Transportation must comply with local, national, and international regulations to ensure safe handling and prevent accidental leakage or exposure.
    Storage Tetradecanoyl chloride should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from moisture, heat sources, and incompatible substances such as water, alcohols, and strong bases. Keep away from direct sunlight and sources of ignition. Use corrosion-resistant storage materials and ensure proper secondary containment to prevent leaks or spills.
    Application of Tetradecanoyl Chloride

    Applications of Tetradecanoyl Chloride in Industrial Manufacturing

    Tetradecanoyl chloride acts as a key C14 acylating agent widely adopted by global manufacturers in selected specialty downstream industries. Due to its controlled reactivity and long-chain fatty acid structure, customers rely on this raw material for value-added derivatization processes where C14 functionality brings specific performance, regulatory, and physicochemical characteristics to end-use formulations. Below, we outline real-world B2B applications, corresponding compliance regimes, proven formulation ranges, points of process integration, and targeted end products.

    1. Synthesis of Specialty Surfactants for Cosmetic and Personal Care Applications

    As a controlled intermediate, this raw material is utilized in the preparation of cationic and non-ionic surfactants, contributing C14 acyl groups for tailored amphiphilic balances required in personal cleansing, hair conditioning, and emulsion systems. Mid- and large-scale formulators in the personal care segment incorporate this raw material during quaternization, esterification, or amidation stages, where the finished surfactants must meet strict purity profiles and geographic regulations on fatty acid chain structures and residual chlorides for leave-on and rinse-off use.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009 for ingredient traceability and purity
    • US FDA 21 CFR 720 for cosmetic ingredient labelling
    • IFRA Standards for allowable amounts in fragrance systems
    • ISO 22716 GMP for cosmetic production safety

    Typical usage ratio

    • For quaternary ammonium compound synthesis: 5–15% by molar basis relative to amine feedstock
    • Exact proportion scales with required alkyl chain distribution and surfactant performance grade

    Downstream process integration

    • Dosed directly into amine or alcohol functional reactants during the alkylation or acylation step, followed by controlled neutralization and purification
    • Used in closed system reactors for batch or semi-batch surfactant manufacturing

    Final product types

    • Cationic hair conditioning agents (e.g., behentrimonium chloride blends)
    • Non-ionic emulsifiers for skincare and cleansing products
    • Liquid and solid mild surfactant blends for shampoos and body washes
    • Conditioner bases and specialty textile softeners for personal care fabrics

    2. Production of Lubricant Additives for Metalworking Fluids

    Industrial lubricant additive manufacturers use this material in the acylation of polyamines or polyols, forming C14-functionalized esters and amides that impart tailored lubricity, dispersancy, and anti-wear properties. Compliance with heavy metal content requirements and performance testing is essential for downstream use in formulated fluids, especially under high-stress machining operations. Real-world dosing depends on base fluid compatibility, application temperature range, and final fluid classification.

    Industry compliance standards

    • REACH Annex XIV (EU) for acyl chloride handling and downstream risk management
    • ASTM D2625–15 (Standard Test Method for Evaluation of Rust-Preventive Additives in Lubricating Greases)
    • DIN 51517-3 for industrial lubricants (CLP classification)
    • ISO 12925-1 for industrial gear oils – performance and formulation safety

    Typical usage ratio

    • 3–9% w/w of metalworking lubricant additive concentrate; fine-tuned for base oil composition and performance targets
    • Higher percentages for high-temperature or heavy-duty lubricant classes

    Downstream process integration

    • Introduced during the esterification or amidation reaction of base polyols or amines, followed by phase separation and purification protocols
    • In-line blending possible for liquid additive concentrates

    Final product types

    • Anti-wear ester additives for cutting fluids
    • Lubricant dispersants in hydraulic and gear oils
    • Boundary lubrication enhancers used in drilling and stamping
    • High-stress machine tool lubrication additives

    3. Pharmaceutical Intermediate for Synthesis of Lipid-Based Drug Delivery Systems

    Drug manufacturers utilize this material to acylate glycerols or aminoalcohols, creating C14-chain lipid excipients for controlled-release or solubilization applications. Use as a registered starting material in cGMP synthesis demands strict batch traceability and conformance to pharmacopoeial limits for free acid, color, and heavy metals. Real-world implementation focuses on scaling chain length distribution and purity during excipient synthesis for lipid nanoparticles, emulsions, and oral delivery platforms.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF Monographs for excipients (e.g., glyceryl monomyristate)
    • European Pharmacopoeia lipid excipient standards (Ph. Eur.)
    • FDA Draft Guidance for Lipid Excipients in Drug Products

    Typical usage ratio

    • 2–8% by molarity during the controlled acylation of glycerol or aminoalcohols
    • Precision dependent on required drug loading efficiency and lipid nanoparticle size control

    Downstream process integration

    • Fed via high-shear mixer or jacketed reactor to conduct acylation with monitored temperature and inert atmosphere
    • Coupled to downstream crystallization and micronization if needed

    Final product types

    • Lipid-based drug delivery excipients (e.g., myristoylated glycerols)
    • Self-emulsifying drug delivery systems (SEDDS/SMEDDS)
    • Lipid nanoparticle carrier matrices for mRNA and therapeutic proteins
    • Oral and topical sustained-release formulations

    4. Advanced Polymer Modification: Functionalizing Specialty Polyamides and Polyurethanes

    Polymer producers incorporate this raw material as a chain modifier or end-group capping agent during the synthesis of high-performance polyamides and polyurethanes. C14 introduction tailors surface hydrophobicity, melt flow, and compatibility in specialty films, fibers, and foams. Usage must comply with sector-specific polymer standards, especially for regulated packaging resins or engineered components with direct/indirect food contact.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 for plastic materials intended to come into contact with food
    • FDA 21 CFR 177.1500 (Nylon resins for food contact)
    • UL 94 Flammability Standard for polymeric materials
    • ISO 9001 quality management for technical polymer manufacturing

    Typical usage ratio

    • 0.5–4% by weight relative to total monomer feed in step-growth or condensation reactions
    • Precise level selected to balance desired surface properties and thermal processing requirements

    Downstream process integration

    • Fed during the prepolymer chain extension or capping step of high-molecular-weight polyamide or polyurethane formation
    • May involve solution, melt, or interfacial polymerization techniques

    Final product types

    • Hydrophobic polyamide films for barrier packaging
    • Modified polyurethane coatings for moisture-resistant applications
    • Technical yarns and fibers with C14 functional chain ends
    • High-performance foams for automotive and electronics

    5. Synthesis of Quaternary Ammonium Compounds for Industrial Biocides

    Manufacturers in the biocidal sector depend on this material as a C14 acyl donor for the synthesis of quaternary ammonium surfactants, widely used as broad-spectrum disinfectants and antimicrobials. These compounds undergo strict regulatory scrutiny for purity, toxicity, and environmental impact in target markets where performance must be balanced with safe use concentration in commercial cleaning, food processing, and water treatment systems.

    Industry compliance standards

    • Biocidal Products Regulation (EU) 528/2012 (BPR) for active substance approval
    • US EPA FIFRA for antimicrobial chemical registration
    • AOAC Method 960.09 for germicidal and detergent sanitizers
    • ISO 11930 for microbiological quality of biocidal formulations

    Typical usage ratio

    • 6–14% by molar ratio for synthesis of quaternary amines
    • Dosing adjusted according to desired chain length distribution and target log reduction of test organisms

    Downstream process integration

    • Dosed into the alkylation reactor during the quaternarization of tertiary amines under controlled temperature and pressure
    • Subsequent neutralization, phase separation, and refinement before blending into final biocidal concentrates

    Final product types

    • Broad-spectrum disinfectants for institutional and medical use
    • Antimicrobial agents for hard surface cleaning
    • Sanitizing additives for industrial water treatment
    • Food-contact sanitizer concentrates
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    Certification & Compliance
    More Introduction

    Tetradecanoyl Chloride: Product Overview and Application Insight

    Direct from the Manufacturer: Why Tetradecanoyl Chloride Matters

    In our years handling specialty chemicals, Tetradecanoyl Chloride (model: industrial grade 98.5% min) stands out as a trusted fatty acid chloride. The demand comes straight from downstream industries—pharmaceuticals, agrochemicals, advanced materials, surfactant synthesis. We know because our team produces this compound, batch after batch, under controlled conditions. Compared to standard fatty acid chlorides, its medium-length chain (C14) brings balance in reactivity and processability. Each drum loaded off our line reflects a combination of know-how, monitored raw materials, real-world filtration, and chemical discipline.

    From Feedstock to Finished Product

    We receive natural vegetable oils and purified myristic acid as base materials. Consistency at this first step keeps the end product stable, with fewer impurities passing downstream. Our process uses a continuous chlorination system—hydrogen chloride reacts directly with the acid, followed by rapid phase separation. Every operator checks for residual acidity and color. Purity level 98.5% and above comes from this rigour—not just because of standards, but due to cumulative lessons from clients who reject any hint of byproduct. We notice that finer fractions—trace impurities, color changes—impact both their yields and downstream processing.

    Taking pride in our filtration and distillation routines, we manage chlorine residue and color before packaging. Cleaning cycles receive extra scrutiny. When dust or micro-residue builds in holding lines, both odor and shelf stability slip. Our approach comes from years of running both small and large batches; customers who synthesize custom intermediates give feedback that links any upstream shortcut to costly rework. In Tetradecanoyl Chloride, quality rides on these production realities.

    Physical Properties that Shape Performance

    Crystal-clear clarity and a pale straw tint mark a good drum. Tetradecanoyl Chloride flows as a liquid at room temperature in warm climates, but in winter can solidify at about 40°C. For shipment, we insulate drums and use inner liners that keep moisture out—no one wants HCl fumes on opening. Odor is sharp and matches the fatty acid backbone, but we test every batch for traces of over-chlorination. Measured density falls between 0.894-0.896 g/cm³ at 20°C, blending fluidly with common organic solvents such as dichloromethane, toluene, and non-polar hydrocarbons.

    From manufacturing lines, we see how moisture is always the enemy. Any trace of water triggers hydrolysis, generating free myristic acid and releasing corrosive hydrogen chloride. To avoid extra moisture content, our warehouse team deploys silica gel packs with every export. This isn’t just a QA checkbox—it comes from knowing that even a marginal contamination during transfer can ruin active batches for downstream users.

    Application Realities: Synthesis, Derivatives, and Unique Roles

    The heart of our business comes from buyers who use Tetradecanoyl Chloride as an acylation agent. We have worked with both large pharmaceutical intermediates manufacturers and custom molecule startups. Most seek this C14 chain for controlled reactivity—too short like lauroyl chloride and you lose hydrophobicity; too long, as in stearoyl chloride, and solubility in organic media diminishes. Our customers request this chain to build surfactants with specific melting points or to attach C14 moieties to drug intermediates, enhancing lipid solubility.

    We have seen this molecule perform in cosmetic intermediates—a field where batch-to-batch consistency impacts rheology, feel, and long-term emulsion stability. Tetradecanoyl Chloride finds its role in the custom synthesis of esters and amides, both important in specialty surfactants and fine chemicals. For agriculture, processors request our drums to manufacture adjuvant molecules that ease the penetration of active pesticides. Each of these uses shapes how we control specification—too high in free acid, and downstream color or odor drifts. Too volatile, and the desired acylation doesn’t proceed efficiently.

    The Difference: C14 Chain in Real Synthesis

    Talking with technical teams who order repeat lots, we understand the selection isn’t random. They have tried other fatty acid chlorides, but Tetradecanoyl Chloride gives predictable behavior—flow, melting, color, and reactivity. Shorter chains introduce volatility or too much reactivity, causing unwanted side-products in mild conditions. Longer chains struggle with solubility and downstream process compatibility. In the middle, C14 offers a sweet spot for both synthetic yield and material handling. We keep infrared and NMR verification on-site to reduce structure and purity doubts from buyers; direct questions about odd carbon counts or minor halide content can be addressed from in-house data, saving weeks of trial-and-error at customer plants.

    What Customers Ask for and Why We Listen

    We have received questions from researchers developing new surfactant heads. Tetradecanoyl Chloride allows flexible design: make C14 esters or amides, and the product will perform—neither too greasy nor too waxy. Its moderate chain length helps achieve low cloud points in nonionic surfactant blends or create medium-foaming emulsifiers. By working with actual customer processes—sometimes joining their technical meetings—we offer suggestions about solvent handling, local venting, and batch-size adjustments. Feedback on failed couplings or discoloration prompts our engineers to re-examine storage, transfer processes, or even drum materials.

    Safety, Handling, and Regulatory Considerations

    Clear procedures reduce hiccups. Our operators wear acid-block gloves, chemical goggles, and face shields at every production stage. Tetradecanoyl Chloride releases hydrogen chloride on exposure to air and water, so we supply it in lined steel drums with two-stage sealing. The difference this makes becomes clear during monsoon shipments—without liner upgrades, corrosion damages even steel drums and gives headaches on arrival at client warehouses.

    From experience, we find that early attention to these hazards sets everyone up for fewer surprises. Training new staff on careful transfer, neutralization protocols, and real-time pH checks happens before anyone touches the line. Our lab ensures every batch has up-to-date documentation on chain length and purity, as customs authorities or multinational clients require real-time compliance data. This attention protects downstream worker safety as well as our standing with large international users.

    Market Trends and Changing Requirements

    Demand for acyl chlorides follows the push toward more tailored surface-active agents, cleaner pesticide formulation, and specialty organic syntheses. Over years tracking requests, we’ve adjusted our lot sizes, packaging, and even labeling to meet emerging regulatory frameworks. More customers are asking about reach and global chemical inventory registration.

    Environmental and health standards keep rising, and buyers want direct assurance on residual contaminants—chlorine, acidity, impurities. Our ongoing audits with third-party labs and growing internal capabilities stem from these pressures. Customers want not just a COA, but also real-time temperature and humidity data for sea shipments. In the past, we underestimated the impact of storage temperature shifts; today, every export order comes with a data logger and shipment history accessible via QR code. Tallying shipment complaints now tells a better story: steady declines in off-spec returns.

    Process Improvements and Lessons Learned

    Experience drives incremental upgrades. Years back, our complaints came from handling lines that introduced trace iron, discoloring the product. Analysis tracked the cause to outdated transfer pumps—a fix that seemed small but drove up both shelf-life and buyer confidence. We invested in lined, non-reactive pumps despite the extra cost. Our records link fewer quality claims directly to such investments.

    Handling moisture contamination taught us another lesson. Replacing natural fiber drum seals with upgraded polymer liners cut down on hydrolysis incidents. After a run of negative customer feedback about drum “fuminess,” we revised both our winter storage and shipping protocols. By listening to incoming reports and prioritizing best practices, we cut spoilage risk and built longer customer partnerships.

    Comparisons: How Tetradecanoyl Chloride Stacks Up

    Few manufacturers have the facilities or patience to hit consistent, high-purity runs at the C14 chain. Standard lauroyl (C12) or palmitoyl (C16) chlorides dominate the market, primarily due to easier raw material access. Tetradecanoyl Chloride demands more process controls; chain-length uniformity affects both melting and handling. From the manufacturer’s line, you see the micro-differences: pourability at varying temperatures, handling difficulty as ambient shifts, distinct odor notes, and shelf-life when exposed to the elements. These are challenges that don’t emerge from a distributor’s warehouse, but they matter at every scale, from 25 kg carboys to 250 kg drums.

    We’ve run parallel batches on the same equipment using different chain lengths. The C14 drum clears a line faster than C16, owing to better flow at mild heat and lower wax content. Short-chained lauroyl chloride, for instance, evaporates faster and leaves more acidic vapor in air, creating a more aggressive workplace odor. These operator observations help explain why customers ask for precise chain lengths tied to their specific uses. Tetradecanoyl Chloride fits where both moderate melting and solubility matter.

    Continuous Feedback: Working with Partners in the Field

    Long-term reliability with this product comes from partnerships with direct users. Processors who blend in Tetradecanoyl Chloride target narrow functional ranges—emulsifier grades, active ingredient carriers, reaction intermediate pools. Regular direct feedback has led us to fine-tune packaging options and filter selections; sticky residue and micro-particles once caused measurable downtime at bigger custom plants. Lab-scale users need smaller packs and batch-level traceability. Our dedicated customer support specialists remain in direct contact with technical staff in pharma, agro, and materials companies. They flag new needs, guide us on evolving compliance requirements, and provide results of actual field tests, including observations on product behavior that don’t reach us through reports alone.

    Managing Scale: From Lab to Bulk

    Scaling up Tetradecanoyl Chloride requires discipline and adjustment. The product that works in a small lab flask behaves differently in a 5000-liter reactor; the difference lies in heat transfer, agitation, and off-gas management. We offer engineering advice drawn from our own scaling events—such as adjusting quench rates or venting systems to handle hydrogen chloride build-up. Clients value this transfer of hands-on knowledge more than any generic technical data sheet.

    Storage investments make a difference at both scales. Bulk buyers now insist on real tank-farm pump traceability and cleaning records after seeing cross-contamination with unrelated chlorides. Meanwhile, R&D departments ask for micro-scale verification; NMR spectra and chain-length guarantee batch-by-batch. We have embraced batch tracking and analytics drawn both from in-house and external labs, guided by the changing scale of our buyers.

    Supply Chain and Logistics from a Manufacturer’s Perspective

    Stable supply equals timely deliveries. Our experience with global shipments shows that delayed customs checks or missed labeling regulations can throw weeks off a project schedule. To prevent this, our team regularly updates documentation and aligns with the shipment protocols of new countries. Investing in better packaging and more reliable third-party warehouse partners translates into more secure, on-time delivery. We load our shipments into temperature-controlled containers only after confirming that shipping agents understand the handling precautions.

    Bulk shipments require careful drum placement and shipment pre-cooling. Containerized shipments that sat in tropical humidity used to result in deteriorated product or local regulatory interventions. By working upstream with both shipping companies and regulatory bodies, we reduce surprises. The paperwork, regulatory compliance, and physical inspection all stem from direct experience—failure in one link can set off a chain reaction. We spend every quarter reviewing this critical feedback loop; our improvements come not from abstract process-improvement programs but from firsthand logistics records over hundreds of batches.

    Building Trust: The Manufacturer's Responsibility

    As the producer of Tetradecanoyl Chloride, ongoing investment in both technical and human resources becomes part of the business. Markets for high-purity chemicals are built on trust—every decision on plant upgrades, QA equipment, and operator training reflects both lessons learned and the competitive realities of specialty chemical production. Upgrades to analytical instruments—GC, NMR, IR—stem from real customer audits, not marketing. We know auditors check both our spec conformity and our long-term capacity to meet contract volume and purity.

    By forging supply relationships based on reliability, quick technical support, and honest reporting of quality investigations, we maintain demand for Tetradecanoyl Chloride in an environment driven by both innovation and regulatory oversight. Our aim stays the same: deliver exactly what was promised, communicate risks if a deviation arises, and update both clients and staff on lessons from each mishap to prevent repeats. By staying close to those using the chemical every day, we contribute to better end products across multiple markets.