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Styrene Oxide

    • Product Name Styrene Oxide
    • Alias Phenyl epoxide
    • Einecs 202-476-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    159349

    Chemical Name Styrene Oxide
    Cas Number 96-09-3
    Molecular Formula C8H8O
    Molar Mass 120.15 g/mol
    Appearance Colorless liquid
    Density 1.05 g/cm3
    Melting Point -58 °C
    Boiling Point 194 °C
    Solubility In Water 1.6 g/L at 20 °C
    Flash Point 68 °C (closed cup)
    Odor Sweet, aromatic
    Refractive Index 1.540
    Vapor Pressure 0.33 mmHg at 25 °C
    Logp Octanol Water 1.61

    As an accredited Styrene Oxide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Styrene Oxide, 500 mL, is packaged in an amber glass bottle with a tightly sealed cap and hazard labeling for safety compliance.
    Shipping Styrene Oxide should be shipped in tightly sealed, chemical-resistant containers, protected from sunlight and moisture. It is classified as a hazardous material (UN2436) and must be transported according to local and international regulations, including appropriate labeling and documentation. Ensure the container remains upright and is stored in a cool, ventilated area during transit.
    Storage Styrene oxide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from heat, sparks, open flames, and direct sunlight. It should be kept separate from acids, bases, oxidizing agents, and strong reducing agents. Proper chemical safety labeling and secondary containment are recommended to prevent leaks, spills, or unintended reactions.
    Application of Styrene Oxide

    Applications of Styrene Oxide in Industrial Manufacturing

    Styrene oxide serves as a critical chemical intermediate across multiple downstream sectors, supporting diverse synthesis pathways and functional material production. Below, we detail specific industrial applications, including compliance practices, formula guidance, integration methods, and the resulting commercial products.

    1. Epoxy Resin Modification for Electrical Laminates

    Manufacturers use styrene oxide to introduce reactive epoxy groups in specialty resin systems for electrical laminates. It increases network density, improves dielectric properties, and enhances mechanical strength for applications in printed circuit boards (PCBs). The additive is introduced during resin prepolymerization, controlling molecular weight distribution and crosslinking behavior. Sourcing purity and reactivity grade remain vital for process consistency and finished product reliability.

    Industry compliance standards

    • IEC 61249-2 for base materials for printed boards
    • UL 94 flammability rating compliance
    • RoHS directive 2011/65/EU (lead and hazardous substances)
    • ISO 9001:2015 for quality systems in electrical manufacturing

    Typical usage ratio

    • 0.5%–4.5% by mass in formulated epoxy resins; precise level adjusted for cure speed and desired glass transition temperature (Tg)

    Downstream process integration

    • Added during the blending of base resin and hardener
    • Dosed before lamination with glass fiber fabrics
    • Controlled temperature and mixing critical to prevent premature ring opening

    Final product types

    • FR-4 copper clad laminates
    • Multi-layer PCB substrates
    • Electronic insulation panels
    • Transformer spacers and slot wedges

    2. Synthesis of Pharmaceutical Intermediates

    Sterile-grade styrene oxide enters pharmaceutical API routes, notably as a building block for β-adrenergic blocking agents and certain antihypertensive drugs. Reaction specificity and impurity profile directly influence compliance and batch release. The epoxide ring enables regioselective nucleophilic addition, supporting chiral intermediate production under GMP conditions. Controlled handling minimizes exposure risk for operator safety and regulatory compliance.

    Industry compliance standards

    • ICH Q7A GMP for APIs
    • Ph. Eur. and USP monographs for raw material specifications
    • 21 CFR Part 211 (CGMP for finished pharmaceuticals)
    • REACH registration where applicable in the EU

    Typical usage ratio

    • Stoichiometric quantities based on targeted routes; commonly 1:1 or 1:2 molar equivalents relative to nucleophile for batch reactions

    Downstream process integration

    • Charged to reactor during stepwise synthesis of chiral alcohol or amine intermediates
    • Requires accurate addition under controlled temperature (10–30°C) and inert atmosphere
    • Careful monitoring for residual epoxide and byproducts

    Final product types

    • Metoprolol intermediate
    • Biaryl pharmaceutical precursors
    • Epoxide-derived active substances
    • Custom-synthesized fine chemical actives

    3. Nonionic Surfactant Synthesis for Detergents and Cleaners

    Styrene oxide supports laboratory and commercial production of nonionic surfactants via controlled ring-opening addition to fatty alcohols or phenols. The process achieves block or random copolymers, yielding distinct foaming, wetting, or emulsifying qualities. End formulation meets industrial hygiene and biodegradability requirements. Accurate dosing ensures consistent hydrophilic–lipophilic balance (HLB) for further downstream blending.

    Industry compliance standards

    • Regulation (EC) No 648/2004 on detergents
    • US EPA Safer Choice Standard (for surfactant SARA status)
    • OECD 301 test series for biodegradability
    • ISO 9001:2015 for quality in surfactant manufacturing

    Typical usage ratio

    • 0.8–2.5 molar equivalents relative to fatty alcohol; adjusted for desired surfactant chain length and HLB value

    Downstream process integration

    • Reacted in alkoxylation reactor after base activation of alcohol
    • Controlled addition rates to minimize side reactions and maximize conversion
    • pH and temperature tightly monitored for process safety

    Final product types

    • Styrene oxide-based nonionic surfactants
    • Concentrated detergent actives
    • Emulsifiers for agrochemical applications
    • Industrial cleaning formula ingredients

    4. Polyol Chain Extender in Polyurethane Elastomers

    Styrene oxide acts as a chain extender during polyurethane prepolymer reactions, yielding specialty elastomers with controlled flexibility and microphase separation. Its introduction modifies crosslinking density and mechanical tuning in high-performance PU foams or elastomeric coatings. Accurate batch control and analytical monitoring prevent excess ring-opening or residual reactivity in finished goods exposed to dynamic stress and heat aging.

    Industry compliance standards

    • EN ISO 16350 (polyurethane technical use)
    • REACH substance registration for downstream polymer use
    • ASTM D3574 for flexible polyurethane foam properties
    • ISO 14001 environmental management for PU manufacturing

    Typical usage ratio

    • 3%–12% by weight on total polyol; adjusted per target Shore hardness and rebound properties

    Downstream process integration

    • Dosed into polyol mixture prior to isocyanate addition
    • Employed in both batch and continuous PU systems
    • Real-time viscosity and NCO/OH balance monitoring

    Final product types

    • Microcellular PU gaskets
    • Automotive elastomeric parts
    • Industrial PU rollers
    • Resilient foam sheets

    5. Reactive Diluent in Adhesive and Sealant Formulation

    Styrene oxide functions as a reactive diluent to adjust viscosity and reactivity of industrial adhesives and sealants, including high-performance epoxy and acrylate systems. The compound enters as a co-monomer, regulating cure depth and speed, and improving adhesion on metal and composite surfaces. Integrated process and emissions controls ensure compliance with workplace exposure and permissible monomer content in the end use environment.

    Industry compliance standards

    • EN 923 for adhesive terminologies and test methods
    • ISO 10993-5 for cytotoxicity if used in medical device adhesives
    • Regulation (EC) No 1272/2008 on classification, labeling and packaging (CLP)
    • OHSAS 18001 for occupational health and safety

    Typical usage ratio

    • 1%–8% by weight depending on system viscosity and target working time

    Downstream process integration

    • Added to resin base pre-mix before hardener or initiator introduction
    • In-line adjustment for hot-melt or cold-cure technology
    • Maintains low free monomer content by end of cure cycle

    Final product types

    • Structural metal bonding adhesives
    • Electrical assembly sealants
    • Composite repair compounds
    • High-performance pressure-sensitive adhesives (PSA)

    6. Functional Monomer for Ion Exchange Resin Production

    Industrial polymerization units incorporate styrene oxide during the synthesis of ion exchange resins, especially for producing functionalized polystyrene-divinylbenzene beads. The epoxide group allows subsequent chemical grafting or crosslinking, imparting specificity to ion selectivity and improving thermal stability. Controlled reaction sequences, temperature, and radical initiation parameters secure final bead performance under continuous water treatment or process conditions.

    Industry compliance standards

    • NSF/ANSI 61 for drinking water system components
    • US EPA 40 CFR 141 for potable water treatment chemicals
    • ISO 9001:2015 in resin manufacturing QC
    • REACH compliance for polymer and monomer sourcing

    Typical usage ratio

    • 2%–7% by weight in monomer blend; adjusted on desired functional site density and bead mechanical strength

    Downstream process integration

    • Dosed during aqueous suspension polymerization
    • Reacts with crosslinker and styrene under controlled agitation
    • Post-polymerization chemical modification via epoxide group

    Final product types

    • Strong base anion exchange resins
    • Chelating resin beads
    • Water demineralization filter media
    • Industrial wastewater treatment resins
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    Certification & Compliance
    More Introduction

    Styrene Oxide: Manufacturer’s Perspective on Quality, Application, and Advantage

    Real-World Chemistry with Styrene Oxide

    Any chemical that leaves our plant carries not only a chemical formula, but a legacy of work, repetition, mistake, and improvement. Styrene oxide stands out as a molecule that’s earned respect from chemists and end-users across a range of industries. Every day, we see how even small changes to structure or purity can echo through a production line or research lab. That level of attention applies here: C8H8O, with its distinct oxirane ring joined to a phenyl group, is not just a line in a catalog. It’s a challenge to produce right, and a building block that reliably delivers results downstream.

    Production Realities: Batch, Purity, Handling

    Styrene oxide doesn’t allow for shortcuts. At temperatures above room temperature, it starts to shift, and its reactive nature means trace metal or acid contamination transforms yields and behavior. We’ve narrowed our batch and continuous processes over years, relying on precise temperature control and high-grade equipment. Typically, our product leaves the reactor at purities of 99% or greater, with color and water levels checked at every cycle. Not every manufacturer can say the same. Often, colleagues higher up the chain tell us how inconsistent supply—yellowing, off-odors, permanganate-positive impurities—has slowed their projects. Experience shows that managing headspace carefully, purging with inert gas, and thorough distillation are what guarantees a clear, colorless epoxide.

    Our technical team tracks each lot of styrene oxide until it reaches the consumer. Common practice demands GC-mass spectrometry analysis, along with regular checks for stabilizer content—usually less than 50 ppm. Storage tanks must be lined and regularly inspected, as styrene oxide attacks mild steel and some plastics. Even packaging is never an afterthought. We rely on fluoropolymer-lined drums or ISO-certified containers. These factors add cost, but they also reduce shutdowns and product loss at the customer site. Real reliability only comes from stubborn attention to these details, batch after batch.

    Practical Applications and Uses

    Styrene oxide finds its way into applications requiring both reactivity and subtlety. In reality, there’s no point in touting theoretical applications that never get past the lab bench. Most of our customers—coatings makers, agricultural chemical formulators, polymer manufacturers, and pharmaceutical companies—appreciate this compound for specific reactions. Epoxide ring-opening forms the backbone for a huge set of syntheses: starting from epoxy resin hardeners, surfactant intermediates, or as a precursor to phenylethanol, where purity and absence of side products dictate yields and safety.

    Take a resin formulator seeking better thermal stability. We’ve watched them test batches with 98% versus 99.5% pure styrene oxide, only to see foaming and crosslink breakage when lower-grade feeds are used. Pharmaceutical clients highlight the need for trace metals or aldehyde levels below industry norms, and we routinely engineer our process to their specifications. This isn’t academic; a minor impurity in the epoxide can cascade through the final product, affecting everything from shelf life to regulatory filings. We keep analytical data open, and we work alongside customers when tweaks are needed. Companies simply chasing a price point make compromises with imported blends, but we stick with what we know prevents recalls and customer complaints.

    Styrene Oxide versus Other Epoxides

    Industry veterans quickly recognize the practical differences between styrene oxide and seemingly similar epoxides. Anyone who has swapped out styrene oxide for ethylene oxide or propylene oxide on a cost basis in a plant setting runs into trouble. The oxirane ring on styrene oxide, linked directly to a benzene ring, changes both its reactivity and physical properties. Its boiling point stands higher than other simple epoxides, which means lower losses to evaporation and more straightforward storage, particularly where temperature swings are common.

    Beyond lab charts, the real divergence comes in downstream reactivity. Styrene oxide’s phenyl ring delocalizes charge during ring opening, setting it apart from the more basic, aliphatic epoxides. In polymerizations, this means more sophisticated branching or functional group introduction—without the aggressive, sometimes unpredictable side reactions common to methyl or ethyl-based oxiranes. One client, who once used glycidol in surfactant synthesis, described extra clean-up and off-odor with non-aromatic epoxides, compared to the phenyl-based route. We’ve run our own head-to-head trials, and it’s obvious how the aryl moiety brings not just better performance, but also greater versatility for post-reaction transformations.

    Regulatory classification gives another angle: styrene oxide is scrutinized more heavily due to its aromatic component, and as manufacturers, we feel the pressure to tighten controls and reports. Lower molecular weight analogs sail past some reporting thresholds, but true transparency around processing and environmental protection always helps in audits and long-term partnerships.

    Challenges: Handling, Shelf Stability, and Worker Safety

    Working hands-on, we know styrene oxide isn’t forgiving in sloppy environments. It acts as an alkylating agent, and skin exposure or inhalation produces effects that no lab manager tolerates. All production staff train regularly in respirator and glove technique, and our plant features redundant leak-detection. Far too many incidents happen at the drum transfer stage; strict purging and line-tracing prevent splash and vapor buildup. While some buyers ask about bulk tanker shipments, we insist on smaller, manageable units—not to drive up price, but because worker safety matters more than just metrics.

    Storage stability proves just as critical. We carry out accelerated aging trials for shelf life at several points: after distillation, after six months, and after one year in typical warehouse conditions. Even high-grade styrene oxide can degrade if exposed to trace acid, so we monitor pH and run headspace analyses for residual inhibitors. It makes no sense to ship a batch halfway around the world only to hear six months later about crystallization or loss of clarity. Our quality team spends as much time preventing post-production issues as manufacturing itself.

    Styrene Oxide in Research and Custom Synthesis

    Most research teams value repeatable, traceable sources of starting material. We’ve supplied universities and industrial labs for years, and they always ask about trace contaminants—peroxides, aldehydes, and even microgram levels of halogens. What started as strict electronic paperwork for compliance now shifts to technical assistance. We provide lot-resolved spectra, synthetic history, and real-time tech support for new reaction protocols. One principal investigator thanked our tech team for identifying an unexpected byproduct that only appeared in one year’s supply chain, which our lot-tracking helped trace back to an equipment changeover.

    We often discuss custom-scale runs with synthetic chemists aiming to produce gram to kilogram levels for medicinal chemistry or pilot-scale testing. Tailoring reactivity, color, or stabilizer content, teams rely on our adaptability and willingness to tweak process steps. It’s rare for catalog vendors to accommodate such requests, but at our scale, it’s simply part of long-term, trust-based relationships. As industrial synthesis trends toward more advanced, functionally dense molecules, the need for precise aryl epoxides continues to climb. We welcome every unusual request as a chance to improve the process for everyone.

    Environmental Controls and Industry Responsibility

    Years of environmental audits and tightened local and international regulation give a sober reminder—it’s not enough to make chemicals that work, they must also leave minimal mark on the planet. Styrene oxide escapes to air or water present a genuine risk, especially given its reactivity. Our emission reduction plan now stands as rigorous as our manufacturing SOPs. All condensers and vent lines run with real-time monitoring, and any spills trigger on-site containment protocols. Waste streams go to specialized incineration partners, not just for regulatory peace of mind, but because staff and customers both expect stewardship.

    This pressure for environmental responsibility trickles down to packaging and waste reclamation as well. We buy back used drums for cleaning or approved disposal, and encourage downstream clients to review their waste handling. In recent plant upgrades, we invested in solvent recovery for wash cycles and direct venting to activated carbon beds. Beyond compliance, we find persistent process optimization helps margins—less loss to the environment means more profit in every drum. As more buyers demand comprehensive hazard and lifecycle reports, we make openness and traceability a core part of our client relationships.

    Market Trends and Supply Chain Resilience

    Styrene oxide doesn’t ride the headline waves like some specialty chemicals, but its downstream demand tracks closely with coatings, agriculture, and pharmaceuticals. Pandemic disruptions made a lasting impression on global sourcing managers; lead times stretched out, and prioritization for high-specification product grew more intense. We’ve doubled down on regional material sourcing and on-site raw material holding to prevent the stockouts and delays that frustrated buyers in the past few years.

    Not every producer invests in vertical integration of phenyl and ethylene feedstock, but this strategy gave us more leeway to weather price shocks. We learned quickly that price alone means little if supply chokes at customs, so we worked to cut intermediaries and maintain open dialog with logistics partners. Communication up and down the chain, from laboratory staff through to shipping managers, prevents misunderstanding and late-stage hiccups. Many buyers sidestep distributor markups and come to us directly. That gives real room to discuss long-term requirements—not just next quarter’s price.

    Trust, Support, and Daily Challenges in Manufacturing

    Our chemists recall the decades when chemical companies opted for secrecy over support. Modern procurement teams want more: full traceability, rapid technical assistance, regulatory paperwork that withstands inspection. That feedback pushes us to open more of our process and safety data, provide 24-hour access to real technical staff, and respond quickly to incident reports. Once, a customer flagged an unexpected residue in a resin formulation. Within 48 hours, we linked it back to environmental fluctuations during a West Coast transit, and a revised packaging solution solved the recurrence. We never dismiss a call as “user error” without checking our own processes first.

    Operating at manufacturing scale means confronting real problems, from equipment failures to odd analytical blips to sudden raw material constraints. What matters isn’t pretending problems never happen, but responding with facts and fixes; sometimes, that means dispatching field staff for a plant visit, or hosting roundtable talks with partner companies. Our own experience says open communication and shared troubleshooting beat contract clauses and scripted responses. Each issue, solved in partnership, builds long-term reliability—and, in this industry, reputation matters as much as technical specifications.

    Looking Forward: Improvement, Innovation, and Partnership

    We invest as much in rethinking process chemistry and product documentation as in hardware or facilities. Our R&D team works directly with downstream research centers to test new applications—improving epoxide functionalization or designing greener catalysts that operate with less overhead and byproduct. Several joint trials now focus on using styrene oxide-derived intermediates for next-generation pharmaceuticals and advanced materials. We keep records open, engage in true feedback cycles, and see ourselves less as a silent supplier and more as a full partner in global progress.

    Our history with styrene oxide proves no product remains static. Regulations grow stricter, clients dream bigger, and production standards keep inching upward. We constantly analyze, refine, and challenge our internal benchmarks, knowing that our product’s reliability and safety underpin someone else’s innovation. Every drum that leaves our facility represents a chain of earnest work, testing, learning, and respect—for both the science, and the people downstream who trust in it.

    Chemistry connects unseen corners of the world, from the hands of lab techs to the end product in a customer’s plant. We recognize the responsibility that flows with each molecule and stay driven to meet the expectations set not by committees, but by every customer relying on styrene oxide to do its job, every day, without fail.