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(Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate

    • Product Name (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate
    • Alias Esbiothrin
    • Einecs 401-300-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    789372

    Iupac Name (Rs)-α-Cyano-3-phenoxybenzyl (Sr)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
    Common Name Cypermethrin
    Chemical Formula C22H19Cl2NO3
    Molar Mass 416.30 g/mol
    Appearance Colorless to yellowish viscous liquid or crystals
    Melting Point 60-80°C (depending on isomeric composition)
    Solubility In Water Very low (0.004 mg/L at 20°C)
    Density 1.21 g/cm³ (20°C)
    Logp 6.6 (octanol/water partition coefficient)
    Cas Number 52315-07-8
    Use Synthetic pyrethroid insecticide
    Stability Stable under normal conditions, sensitive to light
    Vapor Pressure 1.5 × 10⁻⁷ mmHg (20°C)

    As an accredited (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25g amber glass bottle, tightly sealed, labeled with chemical name, molecular formula, hazard symbols, and handled in protective secondary packaging.
    Shipping The chemical (Rs)-α-Cyano-3-phenoxybenzyl (Sr)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate will be shipped in secure, leak-proof containers, compliant with hazardous goods regulations. Packaging ensures protection from light, moisture, and temperature extremes. Accompanied by safety documentation and labeling, shipping follows all international and local transport guidelines for chemicals.
    Storage **Storage Description:** Store (Rs)-α-Cyano-3-phenoxybenzyl (Sr)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate tightly sealed in a cool, dry, and well-ventilated area, away from direct sunlight, heat, and incompatible substances such as strong oxidizers. Keep container tightly closed and store at room temperature. Protect from moisture and store in a clearly labeled container, following all regulatory and safety guidelines.
    Application of (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate

    Applications of (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate in Industrial Manufacturing

    This advanced pyrethroid ester intermediate plays a pivotal role in high-value-added downstream sectors where precise control of insecticidal properties, formulation stability, and regulatory compliance are paramount. Its functional characteristics and technical specifications have enabled its adoption in specialized agrochemical, veterinary, and public health routes.

    1. Agrochemical Formulation of Synthetic Pyrethroid Insecticides

    This raw material serves as a core building block in the synthesis of pyrethroid active ingredients, directly affecting the potency, photostability, and residual effect of formulated insecticides used on crops. Its incorporation must consider strict residue thresholds and the dispersion requirements of modern suspension concentrates and emulsifiable concentrates. Precision in the addition stage determines batch-to-batch consistency and the facility’s ability to scale production in accordance with international market demand while complying with export registration protocols.

    Industry compliance standards

    • FAO/WHO Specification for Agricultural Pesticides
    • EU Regulation (EC) No 1107/2009 and Regulation (EC) No 396/2005 (MRLs)
    • China GB 2763 Maximum Residue Limits for Pesticides in Food
    • US EPA Office of Pesticide Programs (OPP) Standards

    Typical usage ratio

    • 20-45% (w/w) as an intermediate for active ingredient synthesis; final formulation content in SCs or ECs typically 2.5–10% depending on target pest spectrum and regional MRL regulations

    Downstream process integration

    • Added as a key esterification or transesterification intermediate in the multi-step synthesis of common pyrethroids such as cypermethrin and cyfluthrin; handled in controlled reactors; incorporated either in final reaction or intermediate purification stages to ensure high-purity actives for downstream blending

    Final product types

    • Crop protection products: emulsifiable concentrates (ECs), suspension concentrates (SCs), capsule suspensions (CS), and granules (GR) for agricultural use targeting lepidopteran and sucking pests
    • Seed-treatment formulations

    2. Public Health Insecticide Manufacturing (Vector Control)

    Municipal and regional health authorities demand highly consistent vector-control actives for use in public facilities, urban environments, and disease prevention programs. Here, the intermediate must enable precise active molecule synthesis, batch traceability, and low impurity profiles critical for regulatory approval in indoor residual spraying and bed net treatments. Processing parameters at this manufacturing step directly impact both field longevity and safety for non-target organisms.

    Industry compliance standards

    • WHO Prequalification for Vector Control Products (PQ-VCP)
    • US EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) Section 18 oversight
    • ISO 9001 and ISO 14001 certification in production
    • National registration requirements in target markets (e.g., Brazil ANVISA, Indian CIB&RC)

    Typical usage ratio

    • 22-36% (w/w) for active ingredient intermediates; final products formulated at 1–5% technical grade for ready-to-use sprays, space sprays, and impregnated net applications based on end-user protocols

    Downstream process integration

    • Introduced during advance synthesis of target pyrethroid actives (such as deltamethrin or alpha-cypermethrin) with careful monitoring of reaction temperature and solvent purity to minimize by-products and ensure regulatory batch approval; blending into end-use DF (dispersion formulations) and CS stages follows active ingredient isolation

    Final product types

    • Indoor residual spray (IRS) concentrates
    • Long-lasting insecticidal nets (LLINs)
    • Aerosol and fogging formulations for public health

    3. Veterinary Ectoparasiticide Production

    Livestock and companion animal health sectors employ pyrethroid-based ectoparasiticides for tick and lice control, where the intermediate’s purity and controlled reactivity support safe, residue-compliant finished formulations for topical or pour-on use. During production, adherence to veterinary GMP guidelines and species-specific residue limitations is critical to align with food safety laws and ensure animal welfare requirements are met across global markets.

    Industry compliance standards

    • European Medicines Agency (EMA) Veterinary Good Manufacturing Practice (GMP) Guidelines
    • Ph. Eur. (European Pharmacopoeia) monographs for veterinary formulations
    • US FDA Center for Veterinary Medicine (CVM) requirements
    • Maximum Residue Limit (MRL) standards from Codex Alimentarius

    Typical usage ratio

    • 18-32% as pre-synthesis intermediate; final formulation typically 0.5–5% in pour-on, spot-on, or aerosol animal treatments, formulated based on target animal, weight, and level of infestation

    Downstream process integration

    • Enters the active synthesis procedure at the cyclopropanecarboxylation step; after final purification, the resulting actives are solubilized or dispersed with veterinary excipients; strict QC at each step to comply with animal safety regulations

    Final product types

    • Pour-on solutions and spot-on pipettes for cattle, sheep, and goats
    • Topical sprays for companion animals (cats, dogs)
    • Medicated dusts for mite and lice prevention

    4. Household and Structural Pest Management Insecticides

    Pest management manufacturers leverage this intermediate for synthesizing technical grade actives deployed in household aerosol sprays, indoor foggers, and residual surface applications that require fast action and minimized odor/fume by-products. The manufacturing focus here centers on achieving high purity profiles to limit non-target toxicity, combined with stringent chemical safety requirements for products intended for non-professional end users.

    Industry compliance standards

    • USEPA 40 CFR Part 158 guidelines for household pesticide products
    • European Chemicals Agency (ECHA) Biocidal Products Regulation (BPR) (EU) No 528/2012
    • Japan Household Product Quality Labeling Act (JIS Q 9001)
    • China GB/T 18457-2001 for household pesticide safety

    Typical usage ratio

    • 25–40% for active ingredient intermediate stages; 0.1–2% as converted technical in final domestic aerosol, coil, or mat formulations, adjusted according to room size and application exposure parameters

    Downstream process integration

    • Processed through condensation and final ester recovery prior to formulation blending; incorporated at the solvent blending or slurry preparation step in domestic product manufacturing facilities, with in-line purity and stability testing to conform to household regulatory criteria

    Final product types

    • Domestic aerosol sprays and pressurized cans
    • Insecticide-impregnated coils and mats
    • Ready-to-use surface sprays for home pest prevention

    5. Grain Storage and Post-Harvest Protection Formulations

    Downstream processors utilize this intermediate for development of pyrethroid actives targeting grain storage insect pests, with particular attention to compliance with strict food chain traceability, low odor threshold, and minimal residue properties. Production lines for these formulations require validated segregation and cleaning protocols to avoid cross-contamination, and accurate control of ingredient introduction to ensure safe, long-term storage of cereals and oilseeds.

    Industry compliance standards

    • Codex Alimentarius Maximum Residue Limits for Pesticides in Food
    • US FDA 21 CFR Part 573 (Food Additives Permitted in Feed and Grains)
    • Australia APVMA guidelines for grain protectants
    • Good Manufacturing Practice (GMP) for Agrochemical Facilities

    Typical usage ratio

    • 20–38% at intermediate active stage; final grain protectant formulations generally 0.1–1.5% technical content, calculated in relation to stored commodity tonnage and pest infestation risk analysis

    Downstream process integration

    • Entered into precursor ester batch reactors for the synthesis of cis- and trans-pyrethroid isomers; isolation and micronization of the active ingredient precede blending with dispersants and synergists in grain protectant systems; implemented as a critical step before final formulation packaging and labelling

    Final product types

    • Grain storage residual sprays
    • Ready-to-use fogging concentrates for silos
    • Dust concentrates for direct application to stored cereals
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    Certification & Compliance
    More Introduction

    (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate: From Our Factory Floor

    The Core of Precision in Pyrethroid Chemistry

    Our team has worked with pyrethroid esters for generations, and over the years, we have come to recognize the important place occupied by (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate in targeted insect control applications. Day in and day out, our chemists refine this compound in our own reactors, blending applied chemistry with hands-on observation to guarantee every batch maintains its distinct molecular profile. The people in our lab who synthesize and purify this ester do so with the clear understanding that agricultural reliability and public health solutions often start with molecular precision, not marketing language or generic commodity claims.

    Focus on Chirality: Why Stereochemistry Matters

    Manufacturing an insecticidal active ingredient looks like a routine chemical process from the outside. Under the microscope, the job demands far more than mere batch mixing. Our (Rs)-α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate stands out specifically because our crew controls the chirality at both the cyano-phenoxybenzyl site and the dichlorovinyl-cyclopropane carboxylate site. This focus on chiral form isn’t academic; field trials and published research continually show that certain stereoisomers promote knockdown speed and persistence in crop protection settings, while others might do less. In practical terms, handling stereochemistry right allows downstream formulators and applicators to achieve stronger biological performance with lower mass inputs.

    This stereochemical selectivity isn’t a point we chase for marketing punch, but a requirement shaped by regulatory demands and the practical needs of end use. Without tightly controlled chiral configuration, batch-to-batch variation increases, field effectiveness suffers, and the credibility of the pyrethroid sector deteriorates. That’s why every reactor operator in our building tracks optical isomer ratios, and we monitor those numbers long past internal process checks — stability doesn’t end at the shipping dock.

    Purity Driven by Manufacturing Discipline

    People reading technical sheets sometimes miss the toll that minor impurities or byproducts impose in real-world applications. For us, purity above 98.5%—measured specifically for this molecule—means more than a pass mark. Any trace compound, from process intermediates to solvent residues, can impact a formulator’s costs, odor profile, storage stability, and even legal compliance. By narrowing temperature curves, using upgraded condenser stacks, and applying batch fractionation, our production staff cuts through these risk factors daily. We do not depend on outsourced purification or synthetic intermediates beyond what our internal QA protocols certify. Looking at pages of analytical chromatography doesn’t ever replace hands-on assay and stability work when it comes to pyrethroid esters.

    Real Field Experience Shapes the Process

    Research teams often discuss the theoretical risks of using bulk-manufactured pyrethroids with uncertain provenance. Sitting across the table from upstream raw material vendors, we screen incoming chlorinated cyclopropane substrates using in-house GC-MS so that our process input looks the same every week, not just every quarter. Field officers who rely on consistent knockdown values or residue patterns on produce have traced erratic efficacy back to poor upstream control for years. By pinning our source checking and continuous lot sampling together, we manage to keep our performance levels where stakeholders expect — at least, as much as chemistry and scale permit.

    There is no overselling the impact of climate and batch scale on pyrethroid production, either. We work directly with temperature-controlled reactors and conduct constant sampling, especially because seasonality in feedstocks like phenoxybenzaldehyde can drive subtle changes in reaction kinetics. During the monsoon, our water management routines intensify, ensuring that residual moisture never increases hydrolysis byproducts. All of these small, practical steps help us prevent stories of late shipment or batch recall which, as many colleagues know, can haunt an operation for seasons to come.

    Differentiating Ourselves With Practice — Not Packaging

    People sometimes misunderstand “dropdown” chemicals as identical commodities, assuming selection lies mostly in the spreadsheet. Our (Rs)-(Sr) compound works as a measured answer to that line of thinking. Unlike basic technical-grade pyrethroids, ours offers more than a claimed purity or nominal weight; each lot reflects persistent bench-scale testing to verify its actual utility in defined end-use scenarios. We support partners in their registration efforts by supplying five-year stability data, photolysis data, and batch impurity spectra cross referenced with international standards.

    What separates this compound from closely related options, such as racemic or uncharacterized blends, is access to a well-documented pathway from raw substrate to purified finished product. In our facility, solvent residues, heavy metal levels, and organic trace compounds never rely solely on regulatory minimums. Thanks to our internal sample archive, which preserves vials for every monthly batch across five years, a downstream customer can trace quality at any point post-shipment.

    From Application Questions to Measurable Outcomes

    On every farm or in any household where this ester lands, users expect two things: high knockdown on target pests, and the least amount of off-target consequences. Practical deployment covers a spectrum, from low-volume, high-concentration crop sprays to more diluted public health applications. In all these cases, we supply the technical grade base needed by downstream formulators to incorporate custom wetting agents, controlled-release carriers, or specialized oil encapsulates. Unlike a product built purely for numbers on a datasheet, ours reflects continual adjustment for formulation stability, so partner companies can extend shelf life and adapt to variable climate distribution chains.

    In the field, the proof lands in efficacy data measured against key pests including Lepidoptera, Coleoptera, and certain Hemiptera. Regulatory studies in major agricultural economies consistently point to the importance of exact chiral compositions for effectiveness, as well as for time to pest knockdown and residual longevity on treated surfaces. Every year, input and feedback from field agronomists shape our crystallization endpoint protocols and help ask new questions of our separation stages. If batches drift, those reports inform our cycle reviews, which reduces waste and missed application windows for our partners.

    Specifications That Matter — Not Just Compliance

    We often talk shop with customers about what actually shows up on a shipping manifest versus what becomes a technical advantage. Yes, we meet regulatory targets for maximum allowable impurities, but our team always looks beyond those lines to anticipate where regulations may shift. Trends in food residue monitoring and cross-border harmonization mean that tolerances keep tightening: by continuously lowering chlorinated byproducts or unrelated ester content, we outpace these slow but relentless regulatory pivots. Our analytical lab runs daily batch checks, providing molecular fingerprinting of every outgoing shipment using both GC-HPLC and high-resolution mass spectrometry units.

    What builds trust over time, though, isn’t only paper records, but the ability to provide a repeatable solution cycle after cycle, harvest after harvest. In our experience, customers want product integrity during extreme storage or rapid distribution. Because certain intermediates degrade under UV or at elevated temperatures, our staff runs in-house photolytic and accelerated aging tests. This data doesn’t just satisfy compliance, but actually lets buyers design more robust secondary formulations—an aspect other generic suppliers tend to ignore. Problems like product settling or discoloration in secondary cans often begin at the technical grade stage, so our operators address those factors upfront, not as regrets after the fact.

    Addressing Market Challenges: Counterfeit and Off-Grade Material

    The wider pyrethroid market struggles with counterfeit and off-grade supply. We encounter direct requests for off-book specifications, and every operator here has fielded questions about lot re-labeling or illicit blending. For a manufacturer, these pressures do not represent trivial risks—once off-specification material seeps into the formal supply chain, the traceability unravels and legitimate brands suffer. Our plant gates remain closed to claims for shipment rectification when original batches deviate from certified compositions. Instead, our approach centers on robust lot serialization and third-party analytical reporting, so we stay ahead of misrepresentation and know exactly what leaves our site.

    Transparency also means opening our facility to external audits twice a year, both from downstream partners and third-party compliance bodies. These visits rarely turn up anything dramatic, but serve an important point: building long-term integrity through visibility beats marketing claims or post hoc apologies after a recall incident. Counterfeit material never starts with a single action, but rather a chain of weak controls—something hands-on manufacturing operations must watch for constantly. The pressure to cut corners never sleeps, especially when seasonal crops run late or demand spikes unpredictably, so we approve every order only after direct sample testing and full load traceability back to the reactor logbook.

    Sustainable Solutions Start With Responsible Sourcing

    Manufacturers have a responsibility to source inputs with the same scrutiny that regulators apply at the finished product level. We work closely with long-term partners in basic chemical synthesis and hold fixed contracts for all principal precursors, so the basic chemical profile remains stable year after year. Roadside procurement of base esters or recycled dichlorovinyl intermediates does not factor into our plans. Instead, we use vendor rating systems alongside regular audit checks, which support confident batch scaling and trace impurity reduction. This degree of oversight helps shield our partners from sudden residue spikes or “mystery lot” instability, which only gets worse as regulations tighten and customer knowledge grows.

    This insistence on upstream responsibility does not simply protect our own operations; it extends to the farmers and households who eventually benefit from cleaner, better-behaved pyrethroid actives. By cutting out the risk of upstream adulteration, we pass along lower cumulative impurity masses to our downstream partners, ensuring regulatory compliance not only in our core markets but across expanding regions as well.

    Custom Manufacturing — Adapting Process to Fit Advanced Formulation

    The shift toward more tailored syntheses didn’t come from our side; it came from repeated requests by formulators and regulatory managers for specific batch profiles. Our team now handles requests for non-standard chiral ratios or lower allowed impurity windows, adjusting process steps to fit the needs of high-performance biopesticide, household, and even veterinary solutions. Each custom synthesis run gets its own analytical roadmap, verified internally before any shipment is cleared. In practice, this means less back-and-forth at the registration stage and fewer reformulation headaches downstream.

    Whether it’s scaling up for an emergent pest outbreak or running a micro-batch for detailed residue analysis, the direct connection between the shop floor and the customer’s field solution means that we adapt, rather than forcing customers to choose from only what’s ready in the main tank. Making the effort to meet these requests means higher cost and tighter scheduling, but our crew understands that margins follow from consistent delivery, not from chasing the cheapest possible process.

    Support From Synthesis to Final Product

    Years of manufacturing experience highlight how important it is for product managers and formulators to connect directly with producers, not just salespeople. Queries about phase separation, pH-specific stability, or vitrification under cold-chain conditions frequently find answers onsite, either from the technical director or from process operators on the line. For every batch that ships from our lineup, our support continues through shipment, delivery, and even post-delivery shelf-life assessments. Our technical support team includes process chemists who handle practical questions about blending, end-use application, and even process troubleshooting against unusual weather or storage events.

    Technical documentation supports the regulatory and QA processes, but customers know they can call with nuanced questions specific to their process, from agitation steps to packaging responses. We have seen more cases where open communication solved an issue long before it threatened to impact product quality or distribution timelines. It is not a marketing push; it’s the lived experience of supplying material to global partners under varied and often changing conditions.

    The Road Ahead: Performance, Safety, and Collaborations

    Forward-thinking manufacturing involves anticipating shifts in public opinion, policy, and scientific understanding. As concerns around resistance in insects and environmental persistence attract more attention, we devote resources to tracking resistance gene markers and to forming partnerships with academic labs. Adjustments in our process occur not only for safety or compliance, but to deliver molecules that retain targeted effectiveness and degrade more predictably in field and household environments.

    Our collaborations with entomological institutes and field agronomists help us adapt run parameters and recalibrate reaction conditions when old assumptions break down. Resistance management and secondary ecological effects become real only when the people handling product in the field report changes to knockdown time or changes in pest spectrum. We revisit synthetic routes after hearing such feedback, and invest in new catalyst and base options to ensure consistently high stereo-selectivity with minimal byproduct production. In-house research personnel regularly present at industry events, sharing data but also gathering new ideas from active partners.

    Challenges and Solutions — Staying Ahead in a Fast-Moving Market

    Every year brings different regulatory paperwork, crop conditions, and sometimes even unexpected pests. Our approach to production revolves around direct control and immediate data, not back-end explanations. Instead of waiting for reported failures, our test plots and analytical labs assess batch stability and decomposition rates through simulated storage and transport cycles. Examples from recent years—delayed monsoons and jumps in input prices—demonstrate why having multiple, locally-based suppliers for all raw materials reduces the risk of a sudden stop. The chemical team also stays involved in field testing, adjusting process conditions to offset changes in expected climate patterns.

    Continuous improvement comes from listening as much as from laboratory work. We share anonymized performance outcomes and stability data with downstream partners to identify where process changes could benefit more than our own operations. By investing in better wastewater and emissions management, for instance, longevity and acceptance of this compound firsthand. Resource recovery and closed-cycle solvent reuse make economic sense, but also help ensure that regulatory changes do not stop production or shipment timelines.

    Comparisons With Related Esters: Science Over Marketing

    Customers occasionally ask why a technical grade with a specific chiral configuration commands a premium, or how performance compares with generic or racemic analogs. Our answer always falls back on observed data. Studies conducted at certified test plots, as well as independent regulatory field studies, report that the stereo-defined (Rs)-(Sr) configuration delivers greater persistency in environmental conditions including humidity and intense sun, leading to more consistent levels in the field at labeled application rates.

    Many widely available alternatives use less tightly controlled syntheses, relying on a racemic mixture. These materials frequently yield irregular field performance, uneven residue decay, and unpredictable side effects at higher application volumes—a situation that increases burden on farmers, pesticide formulators, and public health officials. Our team’s hands-on approach to chirality, stability, and batch integrity offers true value in predictable knockdown and re-entry interval, rather than just slightly higher technical specification percentages.

    Final Outlook: Building Better Chemistry, One Batch at a Time

    Manufacturing chemicals like (Rs)-Α-Cyano-3-Phenoxybenzyl (Sr)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate means showing up for both the science and the daily problem-solving that create trust across the industry. If there’s one thing experience has taught us, it’s that every specification—chiral content, purity, solubility, storage stability—only proves its value through years of reliable performance under variable, sometimes tough, application settings. Our facility centers on this principle, from each kilo synthesized to each analytical record archived. We keep this standard not out of obligation, but out of pride in a craft that delivers both value and safety for farmers, formulators, and end users. This compound represents not just a technical solution, but years of lessons learned at all points in the supply chain — and we remain committed to moving the benchmark forward, batch by batch.