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Phenylhydrazine

    • Product Name Phenylhydrazine
    • Alias Hydrazinobenzene
    • Einecs 202-373-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    209956

    CAS_Number 100-63-0
    Molecular_Formula C6H8N2
    Molecular_Weight 108.14 g/mol
    Appearance Colorless to pale yellow oily liquid
    Odor Aromatic, fishy odor
    Melting_Point 19°C
    Boiling_Point 243°C
    Density 1.097 g/cm³ at 20°C
    Solubility_in_Water Miscible
    Flash_Point 111°C
    Refractive_Index 1.619
    Vapor_Pressure 0.14 mmHg at 25°C

    As an accredited Phenylhydrazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Phenylhydrazine is supplied in a 500 mL amber glass bottle, featuring a secure screw cap and hazardous material labeling for safety.
    Shipping Phenylhydrazine should be shipped in tightly sealed, corrosion-resistant containers, protected from light, heat, and moisture. It must be labeled as a toxic and hazardous material, in compliance with local and international regulations. Appropriate cushioning and secondary containment are essential to prevent leaks or spills during transit. Handle according to UN 2572 guidelines.
    Storage Phenylhydrazine should be stored in a tightly closed container, under an inert atmosphere such as nitrogen or argon, in a cool, dry, well-ventilated area away from direct sunlight and sources of ignition. It must be kept segregated from oxidizing agents, acids, and bases. Safety precautions must be followed, as phenylhydrazine is toxic, combustible, and sensitive to light and air.
    Application of Phenylhydrazine

    Applications of Phenylhydrazine in Industrial Manufacturing

    As a direct manufacturer of phenylhydrazine, we serve a focused set of advanced chemical industries where this intermediate plays a distinctive role in core synthetic and formulation steps. Our material supports key downstream processes in pharmaceuticals, agrochemicals, dyes and pigments, and laboratory reagents. Below, we outline specific application scenarios that reflect real-world integrations of phenylhydrazine, with emphasis on compliance, process engineering, formulation, and end use.

    1. Pharmaceutical API Synthesis: Antipyretic and Antidiabetic Compounds

    Pharmaceutical producers rely on our phenylhydrazine to structure-safe hydrazone reactions essential for manufacturing APIs such as phenylbutazone, carbutamide, and isoniazid. Our technical support ensures integration each batch meets stringent pharmacopoeial quality for critical intermediates required in fever and diabetes treatments, where consistency in precursor quality translates directly to downstream product performance and regulatory acceptance.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredient Manufacture
    • USP-NF, Ph. Eur, and JP monograph requirements where relevant
    • FDA 21 CFR Parts 210/211 for finished dosage forms
    • EU Directive 2011/62/EU on falsified medicines supply chain

    Typical usage ratio

    • 0.8–1.2 molar equivalents relative to core aldehyde or ketone reactant in hydrazone-forming steps
    • Ratio adjusted based on impurity control and process residue specs

    Downstream process integration

    • Introduced during the condensation and derivatization step to yield target hydrazones and phenylhydrazones
    • Integrated in multi-step synthesis lines post-initial aryl/heterocyclic functionalization

    Final product types

    • Phenylbutazone tablets, carbutamide powders, hydrazone-based API intermediates, bulk API shipments

    2. Agrochemical Active Ingredient Manufacturing

    Agrochemical manufacturers apply phenylhydrazine when constructing nitrogen-containing heterocycles and for selective reduction processes central to a range of established herbicides and insecticides. Its controlled reactivity under anhydrous or acid-catalyzed conditions offers reliable pathways for triazole, pyrazole, and other bioactive scaffolds, where batch reproducibility and trace impurities can critically affect downstream crop protection efficacy and field regulatory auditability.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 for agrochemicals quality management
    • REACH Regulation (EC) No 1907/2006, Annex VII–X for substance registration
    • Local GHS (Globally Harmonized System) implementation requirements

    Typical usage ratio

    • 0.95–1.1 molar equivalents, dependent on the downstream heterocycle synthesis and impurity control needs
    • Normalized to ensure complete conversion with minimal unreacted precursor carryover

    Downstream process integration

    • Fed as a key starting material in cyclization or condensation reactors following initial halogenation or acylation of precursors
    • Monitored for hydrazine byproduct minimization at the work-up and extraction stage

    Final product types

    • Triazole herbicides, pyrazole fungicides, hydrazone-based plant growth regulators

    3. Synthetic Dyes and Pigments Manufacturing

    Dye and pigment facilities use phenylhydrazine as both a coupling agent and a reducing component during azo dye synthesis, crucially affecting color tone, fastness, and stability. Controlled dosing ensures consistent azo coupling for production of tartrazine, sunset yellow, and related colorants, where purity of isolable hydrazones matters for downstream blending in textile and ink applications subject to consumer safety certification.

    Industry compliance standards

    • EN 71-3:2019 Safety of Toys—Migration of Certain Elements (for colorant safety)
    • OEKO-TEX® Standard 100 (for textile dyes)
    • ISO 9001 Quality Management in pigment manufacturing
    • REACH Annex XVII restrictions on azo compounds

    Typical usage ratio

    • 1.05–1.2 equivalents per diazonium salt or coupling component, typically 3–10% weight/weight of pigment precursor
    • Process chemists optimize addition based on tone targets and batch volume

    Downstream process integration

    • Dosed during in-situ diazotization and azo coupling, post-purification of primary amine precursors
    • Controlled addition rates to tune the advance of the color-forming step

    Final product types

    • Food-grade azo dyes, industrial pigments for ink and plastics, water-based colorant formulations

    4. Laboratory Analytical Reagent Formulation

    Diagnostic and analytical reagent manufacturers specify phenylhydrazine for sensitive carbohydrate determination, notably in blood sugar and aldehyde/ketone quantification kits. Material quality must ensure minimal side impurities and consistent reactivity, as the compound forms characteristic hydrazones and osazones critical to reliable colorimetric or spectrophotometric assays used in clinical and research laboratories worldwide.

    Industry compliance standards

    • ISO 13485 for in vitro diagnostic medical devices
    • CLSI (Clinical and Laboratory Standards Institute) protocol EP05 for precision performance of chemistry analyzers
    • Good Laboratory Practice (GLP) guidelines
    • Sigma-Aldrich QC standards for analytical chemistry reagents (internally referenced by many labs)

    Typical usage ratio

    • 1 equivalent per target carbonyl group; typically 0.01–0.1% w/v in prepared reagent solutions
    • Formulation fine-tuned according to detection limit and sample matrix

    Downstream process integration

    • Dissolved in aqueous or mixed solvent as part of chromogenic reagent kits
    • Stabilized with buffer and antioxidant additives for shelf-stable test kit production

    Final product types

    • Blood sugar test kits, carbohydrate test reagents, aldehyde/ketone detection solutions, clinical diagnostic panels
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    Certification & Compliance
    More Introduction

    Phenylhydrazine: Experience, Practice, and the Value Behind a Classic Chemical

    Decades of Production Tell the Story

    As a chemical manufacturer focused on organic intermediates, we have decades of hands-on experience behind every drum of Phenylhydrazine. A molecule that may look simple, Phenylhydrazine offers more than just its chemical formula. Its role in dye synthesis and pharmaceutical research stretches back more than a century, and its steady demand comes from its ability to solve problems other materials cannot. Each batch reflects attention to consistency, purity, and safe handling, lessons learned through working side by side with chemists, quality managers, and production specialists worldwide.

    Understanding the Product: Core Attributes

    Phenylhydrazine—C6H8N2—has a distinct appearance. Workers in our plants recognize it by its pale yellow to light brown hue and recognizable, faintly aromatic odor. On the production floor, we focus on clear, sharp melting point ranges and meticulously control trace impurities. Our main model offers a purity of at least 99%, using both titrimetric and chromatographic verification, because stray off-spec batches can introduce unexpected reactivity in a customer’s process. Each drum, typically packed at a net weight of 200 kg, uses moisture- and UV-resistant steel, because improper packaging risks slow degradation and affects shelf life. We select containers and closures to resist phenylhydrazine’s reactivity and ensure safety from plant packing lines to customer storage rooms.

    With years in the business, we find customers most often specify water and non-volatile residue content below 0.2%. Batch-to-batch reproducibility takes more than just raw test data. Constant dialogue with customers led us to run stability checks before shipment rather than relying only on lab-scale sampling. Because this product plays an integral part in high-stakes synthesis, confidence matters as much as compliance.

    Real Uses: More Than a Building Block

    Discussion of phenylhydrazine often skips to hydrazone formation. From our view upstream, the process is more layered. Dye manufacturers have trusted phenylhydrazine as a staple for preparing azo dyes and pigments that still dominate textiles and plastics. It allows for the fine-tuning of colors not available through cheaper amines, and its hydrazone-forming power means it couples fast and doesn’t leave background colors that could weaken a brand’s textile finish.

    In pharmaceuticals, small-scale labs and commercial campaigns both rely on phenylhydrazine for assembling pyrazoles and indoles. We hear from customers who stress over trace byproducts, especially in their pilot batches. Our product responds well in sensitive reactions, because we minimize metal contaminants and color bodies during purification. This attention matters when producing active pharmaceutical ingredients, where quality mishaps delay months of scale-up work.

    Beyond classical organic synthesis, phenylhydrazine finds its way into specialty agrochemical projects. Teams innovating new seed treatments and growth regulators often employ it as a hydrazone precursor. Since these applications demand both consistent supply and traceability, we respond with full production records and standardized documentation, regular points of feedback across procurement and plant support teams.

    How We Stand Apart: Experience in Consistency

    Product purity doesn’t happen by chasing last-minute specs at the end of the line. Our operations grew from an early focus on in-process controls—sampling at multiple intervals and adjusting operating windows based on both current data and historical trends. Experience taught us that hydrazine derivatives like phenylhydrazine degrade faster with oxygen, heat, or the wrong pH. Plant teams receive continuous safety training, and process engineers work side by side with analytical chemists to catch deviations in real-time, not after the campaign wraps up.

    Some customers ask how our phenylhydrazine stands out from older products or those available from trading companies. Our factories operate with direct access to nitrobenzene and hydrazine hydrate, the two essential raw materials. This supply line avoids the inconsistencies of resold or blended batches. We control reagent ratios and process temperatures precisely, and waste management receives as much attention as product handling. By closing these loops, we prevent cross-contamination and keep the footprint of unwanted byproducts low, which customers notice both in the purity of supplied material and in the predictability of their own reactions.

    Differences from Other Suppliers: Direct Sourcing, Ongoing Partnership

    Trading houses often pursue the lowest-cost lots, but direct manufacturing offers a more reliable window into quality control. For us, the big difference is accountability. The chemists who drill into our process records or ask about minor off-spec readings find direct answers from teams who manufactured and tested the actual batch. We cover every adjustment in temperature, every anomaly in distillation, and every observation our technicians document. This transparency helps customers solve their production challenges before they become headaches downstream.

    Over the years, direct users of phenylhydrazine—from Basel to Mumbai—challenged us with outlier questions. Could we drop the metal content to the threshold needed for photographic chemicals? Could we minimize atmospheric exposure to cut trace peroxide formation? These customer requests rarely work with generic, third-party stock. We set up custom-grade manufacturing not by changing labels but by redesigning control points, recomputing yields, and, when needed, adjusting all the way back to the synthesis of hydrazine hydrate itself. This flexibility and willingness to experiment set us apart. Some requests take weeks or months, not days, but customers remember the effort.

    Product Safety Informed by Field Experience

    Decades of handling phenylhydrazine informed our approach to worker safety, product transport, and customer education. The risks—mainly toxicity, skin contact, and vapor inhalation—mean that short-term savings on containers or training lead to bigger problems later. Instead of focusing only on end-user packaging, we look upstream and downstream at every link. Cylinder inspection routines, pressure-relief devices, routine monitoring for leaks or corrosion—these seemingly small steps prevent bigger risks. Field experience taught us that regular, formal safety briefings make a bigger difference than any generic label warning or third-party data sheet.

    Customers, especially those scaling from lab to pilot, ask about peroxide buildup, oxidative discoloration, or shipment protocols. We answer straight from on-the-ground practice. Refrigeration helps, but without careful sealing the product won’t retain stability. Labels alone do not keep users safe—clear communication, concise technical guidance, and availability to troubleshoot make the difference when new safety or regulatory concerns surface.

    Built on Feedback and Long-Term Relationships

    Being a manufacturer connects us to users not just as suppliers, but as partners. Regular plant visits from customer QA teams aren’t just tolerated—they are actively encouraged. We look at their feedback to sharpen our sampling schedules and push the envelope on lower impurity profiles. Many improvements—reducing trace nitrobenzene, optimizing distillation, extending shelf life—came from joint meetings rather than inside our boardroom.

    We rely on close ties to keep improving. Once a customer pointed out variability in color between lots, and this highlighted a contamination risk in a specific valve on a reactor line. Simple process redesign fixed the issue, and subsequent shipments all fell within narrow color index readings. Small operational tweaks can impact end product quality in a major way, and keeping lines of communication open ensures these issues remain rare and quickly resolved.

    Responsible Manufacturing: More Than Compliance

    Targeting only legal compliance leaves room for error in a high-stakes field like chemical manufacturing. Our facilities not only follow local and international regulations, but also set up voluntary audits and sustainability pledges that push us beyond minimum requirements. Waste handling, air release, and effluent treatment receive constant attention, because phenylhydrazine’s production produces byproducts with environmental risks. We monitor and reduce discharge volumes, and double-filter runoff to capture trace nitrogen compounds.

    Responsible waste treatment protects not only our plant team but also logistics workers and the broader community. Old industry practices often allowed exhaust and stormwater “incidents” to slip by—experience and regulatory updates proved the risks of these shortcuts. After adapting, we now find that long-term cost savings and operational stability actually follow clean production and careful record-keeping.

    Mistakes and Improvements: Learning along the Way

    Not every batch of phenylhydrazine tells the story of perfect production. We learned the hard way that small temperature spikes during hydrazine addition can spiral into broader quality issues, contaminating entire tank batches. Early on, several storage tank mishaps led us to over-engineer safety margins: thicker valve housings, better heat exchangers, stricter entry protocols. Repairs, retraining, and, sometimes, expensive write-offs followed. These investments eventually paid off in fewer quality complaints and better on-time delivery rates.

    Customer-driven pilots and small-scale production campaigns sometimes surface unexpected challenges: rapid color change, minor drop in assay, or solubility limts that hinder intended coupling reactions. Instead of shifting blame or rejecting responsibility, we built a culture of digging into root causes, running joint lab studies with users, and changing process parameters when the science justified it.

    Documenting What Matters

    Product sheets and specifications matter, but our partners often mention the value of real-time answers to their technical questions: what happens if storage temperature climbs on a hot day, how a small increase in iron might change dye color, or which handling gear best fits a pilot plant’s new drum discharge line. Our teams review every shipping record and maintain transparent communication, closing the loop between our internal lab and external customers. We take pride in revisiting older batches, providing archived test results, and flagging possible outliers or concerns before they reach the customer.

    Our technical team delivers not just a checklist, but tailored insight and context, shaped by years of backing up phenylhydrazine-based projects worldwide. This dialogue is the element that keeps buyers returning decade after decade—it moves beyond paper and into true practical support.

    New Paths and Techniques in Phenylhydrazine Manufacturing

    Manufacturing phenylhydrazine cannot rely only on “legacy” techniques. Recent years brought tighter scrutiny over hydrazine emissions and nitrobenzene contamination. Continual investment in monitoring and control systems allowed us to run processes closer to target parameters without sacrificing safety or yield. By linking production data to shipment quality records, we identify drifts before they affect product performance.

    Innovation arrives in smaller steps: improved crystallization, internal closed-loop hydrazine recapture, and automation that flags nonideal filtration runs. Sometimes, customers request phenylhydrazine hydrochloride for specialized pharmaceutical applications; meeting this need requires close attention to pH, sampling, and extended stabilization routines. Integrating digital batch tracking means product traceability now stretches from starting material to the drum on the customer’s dock.

    Pressure from Environmental and Regulatory Shifts

    Global sustainability goals and stricter transport rules now shape both raw material sourcing and finished product export procedures. Phenylhydrazine sits on regulatory lists governing toxic chemicals, so our logistics partners receive safety briefings and compliance certificates custom-matched to each country’s shipment framework. Slow adoption of best practices in some regions can delay or complicate supply, and we respond by keeping a buffer inventory and actively coordinating with regulatory consultants.

    Local communities near plants expect—and often demand—visible evidence of safe waste handling and intervention plans for spills or accidents. Our experience shows that building local trust leads to smoother operating permits, a steadier workforce, and higher public tolerance for chemical operations. By inviting both regulators and independent auditors into our plants, we ensure phenylhydrazine manufacturing remains viable and respected rather than secretive or distrusted.

    Facing Industry Myths and Realities

    Some buyers feel wary about sourcing phenylhydrazine directly from manufacturers, fearing higher cost or reduced flexibility compared to brokers with larger portfolios. Experience suggests otherwise. By running extended plant campaigns and directly controlling all input flows, we offer both competitive pricing and more flexible production windows. Customers receive the exact grades needed for sensitive or high-throughput applications, not just what is sitting on a middleman’s shelf.

    We often respond to doubts regarding long-range storage, oxidative stability, and handling of returned drums. Product stewardship means more than taking credit for on-specification shipments—it means bearing responsibility for batch quality through the entire supply cycle and supporting customers as unexpected circumstances emerge.

    What Sets Our Phenylhydrazine Apart

    The practical difference comes down to long-term reliability and hands-on partnership. Onsite specialists adjust every production run in real time, not just in after-the-fact lab checks. Our commitment to open channels of communication means technical issues get resolved quickly. Batch documentation follows shipments, and customer concerns receive answers from the original manufacturing team—not a detached call center or distributor.

    Our capabilities grew as customers evolved. Whether the demand involves higher purity, better color, or traceability for regulated industries, we meet each challenge through practical engineering and grounded experience. Every plant operator, lab chemist, and technical support engineer knows how their role links to product reliability—and our customers see results in the materials they receive year after year.

    The Role of People: from Factory to Customer Site

    Beneath every container of phenylhydrazine stands a team invested in both the science and the practical business of chemistry. We invest in training, worker protection, and skill development to minimize risks and maximize product consistency. This commitment reflects in steady customer retention and problem-solving dialogue, not unexpected interruptions or headaches. Manufacturing success arises from predictable processes, seasoned staff, and a deep, ongoing engagement with real-world use cases.

    Customers who approach us with unusual challenges receive tailored support grounded in manufacturing reality, not generic promises or shifting international inventories. Our approach means that whether producing for a small-batch pharma customer or a major dye house, every drum reflects applied skill, real feedback, and an ongoing effort to surpass expectations in both quality and partnership.

    In Closing: Phenylhydrazine as Part of Ongoing Advancement

    Producing phenylhydrazine brings technical challenges and opportunities to refine our art and practice. Each shipment, and each customer interaction, drives us to improve. The value lies not only in compliance but also in reliability, transparency, and partnership. Our plant, people, and product all play a role. Those who depend on phenylhydrazine’s unique chemistry deserve a supplier invested in their ongoing success. Our experience proves that direct, experience-backed manufacturing leads to better results every step of the way.