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O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate

    • Product Name O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate
    • Alias parathion
    • Einecs 205-499-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    273798

    Chemical_Name O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate
    Molecular_Formula C10H14NO5PS
    Molecular_Weight 307.26 g/mol
    CAS_Number 311-45-5
    Appearance Yellow crystalline solid
    Melting_Point 42-45 °C
    Boiling_Point 332 °C (decomposes)
    Solubility_in_Water Slightly soluble
    Density 1.36 g/cm³
    Refractive_Index 1.563
    Storage_Conditions Store in a cool, dry place, tightly closed
    Common_Use Insecticide (parathion)
    Flash_Point 210 °C
    Odor Faint, characteristic
    Stability Decomposes on heating

    As an accredited O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100 grams; tightly sealed cap, hazard labels for toxic and environmental risk; chemical name and CAS clearly printed.
    Shipping O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate is shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. It is classified as a hazardous chemical and must comply with all relevant transport regulations, including labeling and documentation. Handling requires proper protective equipment. Shipping by air, sea, or road may be restricted or require special permits.
    Storage O,O-Diethyl-S-(p-Nitrophenyl) phosphorothioate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect from moisture, direct sunlight, and sources of ignition. Proper labeling and access restrictions are essential. Use secondary containment to prevent spills and ensure compliant hazardous chemical storage protocols.
    Application of O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate

    Applications of O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate in Industrial Manufacturing

    O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate serves as a highly specialized intermediate in industrial chemical synthesis, especially within advanced crop protection, veterinary, and public health sectors. As the original producer, we strictly align with process control and compliance requirements, delivering consistent quality for downstream users who demand performance traceability from raw material introduction through to the final product release. Below, we detail the principal application scenarios adopted by manufacturers worldwide.

    1. Synthesis of Organophosphate Insecticides for Crop Protection

    This material acts as a critical organophosphorus donor in the multi-step synthesis of commercial insecticides targeting sap-sucking pests and lepidopteran larvae in high-acreage grain, cotton, and fruit crops. Agrochemical formulation plants use controlled transesterification and sulfonation techniques under closed-system reactors to ensure precise conversion rates and strict residue management. Depending on the country, the downstream process must provide batch traceability and documented impurity profiles, particularly for export market destinations where permissible active ingredient content undergoes stringent post-manufacturing QA/QC inspection.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (Active Ingredient and Technical Requirements)
    • European Union Regulation (EC) No 1107/2009 on Plant Protection Products
    • US EPA Pesticide Registration Guidelines (40 CFR Part 158)
    • ISO 9001:2015 for agrochemical manufacturing

    Typical usage ratio

    • Initial active precursor charge: 96–99% purity input at 0.5–1.2 molar equivalents per batch, with adjustment based on targeted active content and recovery process yield.

    Downstream process integration

    • Material introduction at the esterification stage after the organophosphorus core assembly.
    • Input in reactor prior to sulfoxidation or amidation, controlled via metered dosing and real-time HPLC monitoring.

    Final product types

    • Technical grade chlorpyrifos, parathion, and related formulated insecticide concentrates
    • Water-dispersible granules, emulsifiable concentrates for direct field tank mixing
    • Ready-to-use agricultural spray formulations

    2. Intermediate for Veterinary Ectoparasiticide Formulations

    In veterinary pharmaceutical manufacturing, the material is used to produce organothiophosphate-based ectoparasiticide actives for topical and dip application in livestock and companion animals. Specialized process trains manage synthesis and isolation, with subsequent refining to veterinary pharmacopoeia grade. Downstream integrators are obliged to document all raw material procurement and process activities to support batch recall, pharmacovigilance, and GMP traceability audits, particularly when exporting APIs or formulated drugs.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.), Monographs on Veterinary Antiparasitics
    • United States Pharmacopeia (USP) for animal drug substances
    • Good Manufacturing Practice (GMP) (21 CFR Parts 210 and 211)
    • VICH GL40 Good Manufacturing Practice: Finished Pharmaceuticals

    Typical usage ratio

    • Input precursor concentration: 0.8–1.5 mmol per unit mass of target antiparasitic active, determined by stoichiometry and impurity profile management in veterinary products.

    Downstream process integration

    • Charged post-premix blending, during base-catalyzed phosphorylation/thiolation in reactor cascades.
    • Monitored in-line to ensure full conversion, with pre-crystallization purification prior to API isolation.

    Final product types

    • Pour-on ectoparasiticides and spot-on applications for ruminant and equine markets
    • Compounded veterinary active pharmaceutical ingredients (APIs) for injectable/drench dosage forms
    • Oral drench and topical dip formulations suitable for licensed veterinary distribution

    3. Raw Material for Public Health Mosquitocide Agents

    Vector control manufacturers source this chemical as an upstream organophosphate source for producing indoor residual spray and larvicidal agents formulated to combat mosquito-borne disease vectors. Critical-use products require validated impurity controls, formal prequalification, and environmental risk assessments, especially for large-scale public health tenders in line with international donor and WHO procurement programs. Purification and in-process QA sampling use standardized analytical protocols to limit unwanted secondary byproducts.

    Industry compliance standards

    • World Health Organization (WHO) Prequalification of Vector Control Products (PQ-VCP)
    • UN FAO/WHO JMPR Pesticide Specifications for Mosquitocides
    • Local national registration (e.g., Brazil Anvisa Normative Instruction, India CIB&RC Guidelines)
    • ISO 14001:2015 (Environmental Management in pesticide manufacture)

    Typical usage ratio

    • 0.6–1.0 molar equivalent per kg of target mosquitocidal intermediate; optimized according to local registration and toxicology limits for active substance.

    Downstream process integration

    • Material dosing during base-catalyzed organophosphorus ring closure reaction in batch reactors.
    • Real-time GC monitoring for byproduct suppression during scale-up for public health product campaigns.

    Final product types

    • WHO PQ-listed indoor residual spray (IRS) formulations for malaria control
    • Larvicidal emulsions, slow-release tablets for municipal and donor-supplied anti-vector programs
    • Concentrates for dilution and spraying in institutional vector management

    4. Precursor for Synthesis of Analytical Reference Materials

    Contract research and reference standard producers rely on our material for fabricating traceable analytical standards used in regulatory laboratories to quantify residues during food safety monitoring and environmental analysis. Traceability from original batch synthesis and COA-backed lot release demonstrate input control necessary for reliable calibration substances submitted to food and environmental authorities. Processes employ micro-scale batch reactions under inert conditions, followed by purification and NMR/GC-MS confirmation of isomeric purity and quantitation accuracy.

    Industry compliance standards

    • ISO 17034:2016 (General requirements for reference material producers)
    • ISO/IEC 17025 Accredited Testing Laboratory Supply Chain
    • EU Regulation (EC) No 396/2005 on Maximum Residue Levels (MRLs)
    • US EPA Pesticide Analytical Method Protocols

    Typical usage ratio

    • 0.1–0.25 mmol for micro-batch scale synthesis, strictly adjusted to target reference standard concentration; input mass verified gravimetrically and via purity titration prior to analytical standardization.

    Downstream process integration

    • Directly charged to micro-reactors at the organophosphothioate coupling stage for standard preparation.
    • Purification by flash chromatography and freeze-drying preceding final vialing and certification.

    Final product types

    • Certified pesticide residue reference standards for laboratory quality control
    • Validation chemical standards for environmental monitoring under regulatory control
    • Custom analytical reagents for government-accredited food safety laboratories
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    Certification & Compliance
    More Introduction

    O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate: Direct from the Manufacturer’s Floor

    Understanding Our Commitment to Reliable Chemistry

    After decades on the manufacturing floor, we know O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate from the inside out. You might recognize it under several names, especially in agricultural chemistry and pesticide synthesis. This compound carries a reputation built on reliability, traced down to every batch and molecule leaving our facility. Operators, quality supervisors, and technicians stand behind consistency here—standing behind repeatable chemistry that drives many essential processes.

    Product Overview and Real-World Applications

    O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate, better known in some industries as parathion, stems from practical needs in both large-scale crop protection and research. Most of our requests come from those who do not want vague promises, just results—a product that works batch-to-batch with no surprises. Users often want to see minimum impurity levels, unclouded appearance in the raw material, and full assurance on delivery timelines. Our direct oversight of every kilogram provides this.

    You often find this organophosphate used as an intermediate in synthesizing other active agents. There is a long-standing need for intermediates with high purity to avoid cross-contamination in the final application, especially since downstream users may push tolerance limits on any off-grade residue. Customers who approach us looking for O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate expect us to deliver not just a product but a promise based on actual plant experience and technical back-up.

    Model and Specifications as Seen from the Process Line

    Our standard model draws from the lessons of hundreds of production runs. On the technical side, we produce O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate in two main grades. The industrial grade typically tests above 97% purity. Research institutions, or specialty formulators that reach out, turn to the analytical or high-purity specifications—where purity extends even higher and documentation deepens. Moisture limits hold steady with every lot, reducing hydrolysis or unplanned degradation.

    Batch sheets reflect real-world variability. Some users accept slightly off-white crystalline powder, while others want material nearly colorless. We measure melt points, inspect bulk density, check residue on ignition, and document every small impurity through robust chromatographic techniques. Our certificates match the actual batch, not an old spec sheet printed months ago.

    Usage: What Actually Matters on Site

    Most of our buyers in the agricultural supply chain use O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate for synthesis of finished organophosphate-based pesticides or for research on enzyme inhibition in labs investigating cholinesterase activity. These applications demand tight lot control. Drifting purity, even by a small degree, can throw off synthetic yield or generate waste streams that cost time and money in cleanup.

    Several downstream processors also modify the product for calibration standards or for research testing in environmental analysis labs. Each group comes to us directly for assurance that what they receive today matches what they ordered last quarter. This request only grows after seeing the difference between direct manufacturing and a trading chain, where material history can fade or become confused.

    How O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate from a Plant Manufacturer Differs

    Producing this compound is not a matter of simple mixing and packing. The manufacturing windows for temperature, solvent control, and reagent addition demand experience and process tuning. Every shift operator working here knows that reaction times and phase splits lead to real changes in purity and safety. Our plant setup builds in equipment dedicated to phosphorus chemistry, reducing any chance of cross-contamination. This differs from facilities built more for bulk multi-purpose organic synthesis, which tend to shuffle priorities between dozens of unrelated products.

    Because we oversee every step—from delivery of phosphorus oxychloride right through sulfuration and neutralization—traceability is absolute. We do not use brokers for raw material either, so there’s never a question about the origin of key reactants. This makes a clear difference for users subjected to ever-more intense audits, especially those pursuing ISO 9001 or similar certifications.

    There are vendors on the global scene who repackage, dilute, or cut corners on documentation. By relying only on in-house processes, we hold complete records from lot numbers on raw material baths to barcode tracking on finished pails. Inspection teams regularly request our audit trail for compliance or environmental reviews. No long phone calls chasing shipment details. No passing the buck between traders.

    Other suppliers sometimes rely on contract sites or shared equipment. That leads to varying process control and, too often, uncontrolled impurities. With everything under one roof, every specification for O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate gets verified before leaving our warehouse. And should customers need an adjustment—such as reduced packaging size, custom labeling, or advance retention samples—the team with direct process knowledge handles it without delay.

    Importance of Quality at Every Level

    Substantial regulatory focus lands on organophosphate chemicals. Our plant maintains full documentation, including batch records, emissions logs, and worker safety protocols. External audits by authorities become routine rather than disruptive because preparation never happens at the last minute. Since we build the process to anticipate changing compliance standards, unexpected inspections or shifting export documentation never risk stalling important programs.

    Health and environmental standards do not exist just for the paperwork drawer. We treat process safety and solvent recovery as ongoing programs, not compliance afterthoughts. Routine testing for air quality, ensuring solvent vapor containment, and scrubbing waste streams define our running costs and company reputation. Customers no longer need to speculate about whether their intermediate might surprise them with undisclosed by-products or off-spec performance.

    Responding to Evolving Industry Requirements

    Over years of delivering organophosphates, we have seen tightening residue limits on agricultural actives. Modern formulations demand cleaner intermediates because end-use regulators require detailed impurity profiles. O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate produced five years ago looks different now—not because the molecule has changed, but because standards have.

    Adjusting for these changes means investing in off-gas abatement, better purification stages, and higher standards in analytical testing. We see these changes up close on our process line: for example, swapping to specialty glass-lined reactors or introducing finer filtration rather than a broader reliance on activated carbon. No batch leaves the site until our lab clears a trace metals and solvent residue panel. These protocols do not just satisfy auditors—they save our customers from rework downstream.

    Product Differentiation Beyond Brochures

    From inside the plant, the differences between our O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate and that from a bulk trader or distributor become easy to spot. We do not repackage or re-bag third-party stocks. Our lot numbers tie directly to the day of synthesis, with real-time process logs available for technical review.

    Feedback from our customers tends to mention transport stability and batch homogeneity most. Shipments arrive sealed, with every drum or pail tamper-evident. Color and odor remain uniform; no off-notes drift from batch to batch. Should any performance question arise, process technical managers review logs with every analytical file open. With us, clients gain more than email responses—they connect directly with the team that saw the product through every step.

    It is common for process optimization—sometimes a tweak of temperature or solvent ratio—to be the result of a conversation between our technical pool and customers at the bench. Often, these changes arise to solve a pain point: perhaps persistent haze in a downstream concentration step or trace residual solvents impacting an analysis. Regular exchanges with buyers feed into better production runs, not just for one client but for every order that follows.

    Traceability and Transparency: Key to Industry Partnerships

    Raw material sourcing stays transparent at every stage. Every incoming drum or bulk tanker gets logged by material type, source, and handling date. These logs go into both digital and paper records, supporting batch verification requests from clients or regulators. In over twenty years operating phosphorus chemistry, we have never passed on a batch with ambiguous parentage.

    Some organizations have told us horror stories involving inconsistent quality or missing certificates of analysis. We counter this with a commitment to real traceability, transparency in process adjustments, and documented technical support that addresses not only chemical specifications but also practical needs at the end-use site, such as guidance on storage conditions or dilution parameters.

    Supporting Customers Facing Real Production Challenges

    Discussing application challenges over the years, the biggest headaches always revolve around compatibility and reproducibility. A process line that sees even a minor drift in organophosphate quality ends up spending time—not producing, but troubleshooting. This wastes labor, interrupts contracts, and burdens technical teams.

    As a manufacturer, we step in with advice based not on theoretical support, but on daily plant reality. For instance, questions on solvent compatibility during synthesis, stability under varying warehouse climates, or best practices in long-term storage for customs clearance. By working directly with the team that produced the compound—and not through trading intermediaries—our customers resolve these challenges quickly and with greater confidence.

    Environmental Responsibility Built into Operations

    With heightened attention on industrial waste, we maintain responsible disposal of mother liquors and spent solvents. We minimize emissions from production and invest heavily in solvent recovery, not simply to comply but because these improvements outlast regulatory fads. By using closed-system reactors and rigorous air filtration, we reduce both workforce exposure and plant footprint.

    Customers know the difference, since sustained performance and regulatory compliance benefit both parties. Long-term partners regularly audit our plant, confirming our environmental commitment through actual site inspections and operating records. This transparency shapes not only our reputation but also the marketplace options open to our clients downstream.

    Continuous Improvement the Old-Fashioned Way

    Chemistry at scale feels the impact of every margin: energy used per kilogram, waste volume, labor hours per run. These numbers shape our daily business and drive a search for practical improvements in catalyst selection, batch times, or water use. Our staff meets every quarter to review batches, root-cause rare performance variances, and pass corrective actions forward. This approach, built up slowly over years, generates incremental but durable gains for every future customer.

    We are frequently approached for customized solutions, such as alternative packaging sizes, finer screening, or unique impurity targets. The direct control over every process step allows us to say yes more often—from a plant operator’s tweak to improved procedures in drum filling.

    Pragmatic Perspectives on Regulatory Dynamics

    The world now tracks supply chains closer than ever. End users in heavily regulated jurisdictions steadily raise expectations for documentation, shipping labels, safety data, and environmental declarations. Having built protocols designed to match these rising needs, we share batch results, certificate details, and safety analysis without delay or red tape.

    We understand the stakes for customers whose finished products face export documentation, local registration, or sudden regulatory reevaluation. Having a partnership with a factory, not a trading desk, means real answers from people who understand each synthesis variable and every label on the drum.

    Manufacturing Know-How Supporting Reliable Supply

    We recognize that reliability starts with the same product, every day, every batch. By holding our own inventory, planning production six months ahead, and dealing directly with downstream users, we limit disruption from volatile global logistics or force majeures. This gives peace of mind both to the largest agricultural chemical programs and to niche biotech research groups, whose projects can rise or fall on the consistent supply of a single intermediate.

    Inventory tracking, shelf-life logs, and temperature records tie back to batch history—so if a customer calls months after delivery, detailed answers are ready. No searching for lost paperwork or unexplained gaps in the supply trail. Factory managers, technical team leads, and logistics coordinators all play a part in making sure nothing slips through the cracks.

    A Forward-Looking Approach Rooted in Real Manufacturing

    We see the future of O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate not only in agriculture but also in specialty applications, such as reference standards for analytical chemistry or in high-purity enzyme inhibitor production. Innovations in analytical demands challenge us to adapt, adjusting both our plant practice and internal test protocols.

    The conversation between manufacturer and customer builds every year, driven by shifts in market demand, regulator requirements, and process innovation. By continuing to refine our practices, review impurity standards, and push investments in plant technology, we meet the next generation of industry needs.

    Why Direct-from-Manufacturer Chemistry Matters

    Decades of manufacturing O,O-Diethyl-S-(P-Nitrophenyl) Phosphorothioate have shown us that the direct approach matters most. Customers value knowing that every question or requirement will be met by people who personally oversaw their product’s journey through the plant—from batch to bag to shipment. This hands-on experience gives us the perspective to anticipate needs, offer real solutions, and deliver what customers depend on, day after day.