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Nitroethene

    • Product Name Nitroethene
    • Alias Nitroethylene
    • Einecs 209-371-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    102799

    Name Nitroethene
    Iupac Name Nitroethene
    Molecular Formula C2H3NO2
    Molar Mass 73.05 g/mol
    Appearance Yellowish liquid
    Density 1.167 g/cm3
    Boiling Point 97 °C
    Melting Point -11 °C
    Cas Number 563-80-4
    Pubchem Cid 12452
    Structure CH2=CHNO2
    Solubility In Water Slightly soluble
    Flash Point 37 °C
    Refractive Index 1.445 (20 °C)
    Canonical Smiles C=CN(=O)=O

    As an accredited Nitroethene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Nitroethene is packaged in a 250 mL amber glass bottle with a secure cap, labeled with hazard warnings and handling instructions.
    Shipping Shipping of **Nitroethene** must comply with hazardous materials regulations due to its flammability and potential instability. It should be packed in tightly sealed, inert gas-filled containers, transported at low temperatures, and kept away from heat, flames, and incompatible substances. Appropriate labeling, documentation, and emergency procedures are essential during transport.
    Storage Nitroethene should be stored in a cool, dry, and well-ventilated area, away from heat sources, open flames, and direct sunlight. Keep it in tightly sealed, appropriately labeled containers made of compatible materials. Avoid storing near strong acids, bases, or reducing agents. Ensure proper grounding and bonding during handling to prevent static discharge, and follow all local regulations for explosive or sensitive chemicals.
    Application of Nitroethene

    Applications of Nitroethene in Industrial Manufacturing

    Nitroethene, manufactured in strict adherence to global industrial standards, has established a solid presence as a key intermediate in specialty chemicals. Here we outline documented, real-world application scenarios across major downstream sectors, highlighting compliance, formulation dosage, process entry points, and typical end products.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers use nitroethene primarily as a versatile building block in the synthesis of nitroalkane derivatives and heterocyclic scaffolds, especially in the preparation of active pharmaceutical ingredients (APIs) for antimicrobials and antihypertensives. Its controlled reactivity supports clean conversion in condensations and Michael addition steps, where precise dosage and purity directly influence yield and regulatory compliance.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP), ICH Q7
    • Quality standards as per USP, EP, and JP monographs for intermediates
    • REACH (EC No 1907/2006) registration for chemical handling
    • Environmental Protection Agency (EPA) discharge regulations

    Typical usage ratio

    • Applied at 0.14–0.32 molar equivalents relative to core API skeleton; adjusted based on substrate reactivity and desired selectivity in multistep syntheses

    Downstream process integration

    • Fed into the initial condensation or nitro-Michael reaction stage, followed by hydrogenation and purification steps for pharmaceutical-grade intermediates

    Final product types

    • Intermediates for nitroalkane-based antibiotics (e.g., chloramphenicol synthesis)
    • Precursors to ACE inhibitors and antihypertensive APIs
    • Building blocks in anti-infective drug synthesis pipelines

    2. Agrochemical Synthesis and Crop Protection Formulations

    Within the agrochemical sector, nitroethene serves as an essential intermediate in the preparation of nitroalkene motifs for herbicides, fungicides, and insecticides. Manufacturers value its predictable reactivity for sequential reactions, leading to efficient incorporation in crop protection compound synthesis via alkylation and cycloaddition transformations, where product selectivity and regulatory mandates drive precise formulation.

    Industry compliance standards

    • FAO pesticide specifications
    • ISO 9001:2015 and ISO 14001:2015 systems
    • Globally Harmonized System (GHS) for labeling and SDS requirements
    • REACH substance authorization for agricultural inputs

    Typical usage ratio

    • Utilized at 0.10–0.27 mole fractions per batch formulation, selection based on target pesticide structure and desired reaction efficiency

    Downstream process integration

    • Introduced at the alkylation or conjugate addition step during synthesis of pyrazole and nitro-phenol herbicide intermediates, prior to final formulation blending

    Final product types

    • Intermediates for phenylpyrazole insecticides
    • Nitroalkene-derived triazole fungicides
    • Base materials for nitrated herbicidal actives

    3. Polymer and Specialty Resin Monomer Manufacturing

    The polymer industry employs nitroethene as a critical monomer precursor during the synthesis of specialty resins and copolymers containing nitrovinyl substructures. Its use enables tailored molecular design, influencing polymer reactivity, adhesion, and dielectric properties, while requiring adherence to specific chemical processing standards to ensure consistent batch quality and downstream performance.

    Industry compliance standards

    • ISO 9001:2015 quality management (specialty chemicals)
    • Restriction of Hazardous Substances (RoHS) for electronics applications
    • REACH registration and SVHC exclusion for safe manufacturing
    • OSHA process safety standards (where applicable)

    Typical usage ratio

    • Incorporated at 0.85–8 wt% monomer concentration, flexibility determined by copolymerization ratio, molecular weight endpoint, and product property specification

    Downstream process integration

    • Charged directly to bulk or emulsion polymerization reactors as a comonomer or chain extender, followed by post-polymerization purification and prepolymer modification for resin applications

    Final product types

    • Specialty adhesives for electronic assembly
    • High-performance coatings with controlled dielectric properties
    • Nitrovinyl-modified polyurethane intermediates

    4. Dye and Pigment Intermediate Production

    The colorant manufacturing sector uses nitroethene as a precursor for synthesizing azo and nitroaromatic dye intermediates. Its addition in specific steps supports the formation of chromophoric systems and intensifies shade durability. Compliance with ecological and heavy metal restrictions is critical for colorant applications in textiles, plastics, and printing inks, where batch consistency and product safety remain top priorities.

    Industry compliance standards

    • OEKO-TEX Standard 100 (for colorant safety in textiles)
    • EN 71-3 (European colorant safety for toys and plastics)
    • REACH Annex XVII restriction of hazardous aromatic amines
    • Chemical control regulations under the US Toxic Substances Control Act (TSCA)

    Typical usage ratio

    • Mixed at 0.23–1.6 molar equivalents per dye intermediate synthesis; ratio dependent on color depth and chromophore substitution patterns required by the end-user specifications

    Downstream process integration

    • Added during the aromatic nitration or diazo coupling stage, followed by purification and subsequent dye formulation blending for application-specific performance

    Final product types

    • Nitroaromatic dye intermediates for textile dyeing
    • Pigment precursors for inkjet and offset printing inks
    • Colorant components for plastics and polymer masterbatches
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    Certification & Compliance
    More Introduction

    Nitroethene: A Manufacturer’s Perspective on Pure Performance in Advanced Syntheses

    Introduction to Nitroethene

    Every chemist searching for reliable building blocks in synthesis circles back to the value of individual purity and performance. Nitroethene has carried its weight across a range of applications for good reason. Working as a chemical manufacturer, we have learned to appreciate this material’s particular strengths—not just because it fills a role, but because of how effectively it drives desired reactions. In our facility, we produce Nitroethene in tightly controlled environments, monitoring parameters batch by batch to hold contaminant levels at bay. The result reflects a focus on structure, reactivity, and robust yield in every gram.

    Model and Specifications

    Our Nitroethene appears as a pale yellow liquid, with a consistently measured purity above 98% confirmed by GC-MS. Customers have long relied on this product range, trusting our batch homogeneity and rigorous documentation. Flashpoint measurements show a strong safety margin for shipping and handling, while the boiling range (114–116°C under atmospheric pressure) keeps process controls reliable in large-scale operations.

    Moisture incursions or trace byproducts pose problems to sensitive downstream processes. Drying and filtration occurs in a sealed system, deterring atmospheric contamination. Every batch receives routine NMR scans and Karl Fischer titration reports before it ever leaves our floor. We also offer verified impurity profiles, so you know exactly what enters your reaction vessels.

    Unlike traders or repackagers, we run original synthesis and purification in-house. This gives us direct oversight on raw materials, allows for real-time problem solving with every run, and enables custom modification of process parameters if a client requires special characteristics—like tighter limits on nitrite or aldehyde residues beyond industrial baselines.

    Applications: Where Nitroethene Delivers Performance

    Chemists who’ve worked with Nitroethene use it primarily in condensation and cycloaddition reactions. It acts as a highly reactive Michael acceptor, and its straightforward structure makes it invaluable for quick, predictable C–C bond formation. Over years of production, many customers in pharmaceutical intermediates and agricultural chemical synthesis have requested our Nitroethene for these specific steps. The product streamlines crosslinking of enzyme substrates and helps generate heterocycles with strong pharmaceutical interest.

    Academic groups studying reactive intermediates constantly return for our Nitroethene because of its reproducible behavior in model reactions. Its profile serves as a standard for comparison, and knowing the reactivity window means less guesswork and reduced waste. Researchers synthesizing nitro derivatives and evaluating their energetic profiles stress that purity influences not only reactivity but also safety—contaminated samples fuel unpredictable byproducts and, in worst cases, runaway polymerization.

    A few experienced process engineers in the explosives industry—where fine-tuned energy density and sensitivity matter—find Nitroethene particularly useful during bench-top energetics studies. The same dialogue emerges when battery and advanced materials researchers ring our technical team: even trace organic impurities can disrupt the delicate interplay of charge carriers and lattice formation. Solutions-hardened Nitroethene has found a home in almost every application where reactivity outpaces bulk availability.

    What Nitroethene Offers That Analogues Do Not

    Comparing Nitroethene to other nitroalkenes or aliphatic nitro compounds underscores a few critical points. Unlike nitropropene, which incorporates a further methyl group and introduces additional steric hindrance, Nitroethene stays minimal yet highly activated. Stereochemical simplicity makes purification and analysis straightforward—GC and NMR spectra don’t fill with extraneous peaks, so assessment of downstream functionalization is direct. Even at modest scales, users notice cleaner, sharper isolations following product work-up.

    In Michael addition reactions, for instance, many chemists prefer Nitroethene over nitroolefins with longer chain lengths or branching. Yields jump several percentage points and separation of products gets easier. Polymers derived from Nitroethene (for those exploring novel conductive or piezoelectric materials) benefit from this straightforward molecular backbone; it allows direct access to short-chain prepolymers and building blocks without extensive deprotection or chain truncation.

    In regulatory reviews—especially with novel APIs—Nitroethene’s simple structure assists with compliance documentation. Analysts can quickly map reaction pathways and confirm a single mechanistic origin during impurity profiling, eliminating drawn-out correspondence with review agencies.

    Working in manufacturing, we understand customer frustrations over “commodity” chemicals sourced from unknown suppliers. Nitroethene often gets lumped in with low-quality alternatives. Persistent solvent residues, water traces, and redistilled fractions create variability that ripples into project delays and reactor fouling. By keeping our syntheses vertical, we regularly side-step these pitfalls, and have records on hand for every intervention undertaken—establishing an audit trail trusted by critical industries.

    Manufacturing Considerations: Scale, Safety, and Waste

    Bringing Nitroethene to scale is more complex than blending off-the-shelf precursors. The critical step involves condensation of chloroacetaldehyde with nitromethane. Controlling local exotherm and selectivity through closed-loop cooling and pressure regulation reduces the chance of dimerization or resinous byproducts. Vent scrubbers and vapor-phase neutralization help us capture and abate volatiles before venting, protecting the work environment and downstream air.

    Our plant’s design reflects years of continuous improvements, including sis monitoring and in-line spectral feedback during distillation. A quick spike in monochloro impurities triggers immediate adjustment—avoiding product loss and off-spec shipments. We keep batch records for traceability and offer clients direct access to anonymized process data for their own regulatory tuning.

    Waste handling and solvent recovery stand as ongoing priorities. Nitroethene’s reaction pathway yields aqueous byproducts and some low-boiling organic residues. These are collected, neutralized, and, where possible, reprocessed into less hazardous waste streams or raw material. Collaborating with local waste management firms and regional regulatory bodies, we’ve refined our protocols to minimize environmental load and drive down waste haulage costs. We don’t treat this as a greenwashing afterthought: every reduction in offcuts and emissions raises quality and lowers cost.

    Lessons from the Lab and Factory Floor

    Over countless production runs, some lessons always repeat themselves. A small uptick in water content can throw off sensitive downstream couplings, forcing extensive rework. That’s why our team tests not only for basic purity but for micro-level titer shifts and functional reactivity with common nucleophiles. This proactivity has saved multiple client campaigns from stalling weeks before scale-up checkpoints.

    Another real-world consideration: shipping and storage often induce molecular changes in energetic materials. Nitroethene, due to its unsaturated structure and tendency for self-polymerization under light or heat, demands cooled storage and amber glass containment. Moving batches rapidly from synthesis to processing helps limit degradation. Re-laboratory testing or track-and-trace data can identify bottlenecks that might otherwise cascade into supply hiccups for major clients.

    Production line teams remain the most important factor in safe, effective supply. Rotating staff between process control, QA, and logistics helps spot quality slips before product release, and aggressive feedback cycles inform ongoing training. Machine downtime or tank contamination can present as minor tics in GC profiles; previously, these signals caused recurring discards, but today they prompt quick, solution-oriented maintenance.

    Clients sometimes request special grades, seeking NOx content below a single part per million, or screening out specific aldehyde impurities for advanced catalysis. Offering this means running extra purifications, often under tighter inerting or microdistillation. What sets direct manufacturers apart from resellers is the ability to modify live processes rather than simply sorting options in a stock catalog.

    Safety Concerns: Handling, Storage, and Use

    Handling Nitroethene calls for vigilance, from bulk tank lines to benchtop flasks. As an unsaturated nitro compound, it reacts readily with a range of nucleophiles and oxidants. Experienced operators minimize incident risk by following established PPE routines, venting excess pressure, and never mixing batches without tracer and titer confirmation.

    Storage remains a common point of failure for less careful operations. Nitroethene oxidizes and polymerizes under sunlight or heat; we use temperature-controlled, light-shielded containers. This extends shelf life and product reliability long past typical distributor standards. Supervisors check inventory monthly, spot test for retained purity, and refresh expired stock before it ever enters outgoing logistics.

    As the manufacturer, we field technical queries from customer labs about dose thresholds and reactivity triggers. Some materials sold through brokers reach clients with incomplete hazard documentation; we advise partners directly and can provide process-specific risk assessments. On the rare occasion of workplace exposure, our facility’s emergency response drills have prepared every crew member to manage fire or contamination events. Insurance audits sometimes lead to extra mitigation steps, such as redundant venting and suction, or expanded fume handling systems.

    Supply Chain: Traceability and Market Realities

    Many industries learned to distrust the generic chemical supply chain after shipment of off-spec or adulterated materials. We took early steps toward vertical integration and digital traceability, linking each production lot with raw material batches. If a client in pharmaceuticals or advanced materials flags an issue, we can resolve the entire supply chain—no finger-pointing, no third-party delays.

    Our digital records integrate with client portals, supporting both compliance and internal process optimization. We can flip records, reprocess outliers, or run total impurity breakdowns in hours instead of days. Trusted supplier relationships allow forward purchasing for seasonal spike periods, so lead times stay tight and customers receive the same high-purity Nitroethene year in and year out.

    We keep direct lines open not just to customers but to regulators and professional groups tracking quality incidents worldwide. Early detection of synthetic pathway outliers or new regulatory risks benefits everyone downstream, and maintaining a reputation as a source, not a middleman, helps with cross-market trust.

    Development Partnerships and R&D Feedback

    A fair number of new reactions in organic synthesis never make it past small-scale proof of concept because of error bars from inconsistent starting materials. Our R&D collaboration with universities and private labs puts ultra-pure Nitroethene into the hands of top scientists. Reports of new reactivity, stability studies, and kinetic data flow back to production, closing a feedback loop that sharpens both academic and industrial output.

    Start-ups working on synthetic methods for fine chemicals can request direct technical support, bringing our chemists into joint troubleshooting and scale-up planning. On several occasions, this has uncovered practical alternatives to high-cost purification or improved atom economy by subtle process shifts, all based on actual, quantified lab results—not marketing claims.

    Nitroethene keeps finding new uses in energy storage, specialty coatings, and even green propellants. Quality requirements for each field keep ratcheting up. Our technical teams use previous application data to adapt processes proactively, maintaining a supply chain built for changing technical needs, not just volume.

    Sustainability, Environmental, and Social Responsibility

    Chemicals with energetic or high-reactivity profiles often come under scrutiny for environmental and human health risk. Our response is neither to minimize these concerns nor to offload responsibility to others in the supply chain. Every unit of Nitroethene leaves our facility with a full record of waste minimization, neutralized residuals, and emissions control.

    Recent years brought new scrutiny, demanding lower VOC emissions and minimized carbon footprint per kilogram produced. In response, process adjustments moved toward higher-efficiency condensation reactors and solvent reclaim loops. These cut emissions and dropped utility use, which not only satisfies regulators but aligns with growing end-user demand for traceable, lower-impact materials.

    Recent dialogue within the industry aims to phase out legacy byproduct disposal routes that historically placed a burden on surrounding communities. We contribute to this progress through on-site waste neutralization and cooperation with specialty recyclers for solvents and organics. These changes aren’t just for compliance—the local teams assembling, moving, and supporting Nitroethene production live nearby, and our responsibility stays personal.

    Conclusion: Why Direct Manufacturing Matters with Nitroethene

    Anyone who’s sat through a failed set of reactions or stalled product launch knows the real frustration of poor-quality starting materials. Across hundreds of production batches and thousands of kilograms shipped, our facility’s focus on Nitroethene performance, traceability, and reliability stands as the real value-add. Each improvement in storage, testing, or documentation saves headaches for both producers and users. Collaborating with regulators, end-users, and industry groups ensures every canister that moves out our doors maintains the standard that drove chemists to choose it in the first place.

    Nitroethene remains more than an off-the-shelf chemical. With the right manufacturing care, its role as a precision tool for building next-generation molecules—whether for synthesis, materials, or research—comes to the forefront. As technical barriers and requirements climb, working directly with those who know the material inside and out makes the difference. Production knowledge, continuous feedback, and process innovation guarantee the reliable performance researchers and industrial chemists depend on—today and tomorrow.