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Nitroethene

    • Product Name Nitroethene
    • Alias Nitroethylene
    • Einecs 209-371-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    102799

    name Nitroethene
    iupac_name Nitroethene
    molecular_formula C2H3NO2
    molar_mass 73.05 g/mol
    appearance Yellowish liquid
    density 1.167 g/cm3
    boiling_point 97 °C
    melting_point -11 °C
    cas_number 563-80-4
    pubchem_cid 12452
    structure CH2=CHNO2
    solubility_in_water Slightly soluble
    flash_point 37 °C
    refractive_index 1.445 (20 °C)
    canonical_smiles C=CN(=O)=O

    As an accredited Nitroethene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Nitroethene is packaged in a 250 mL amber glass bottle with a secure cap, labeled with hazard warnings and handling instructions.
    Shipping Shipping of **Nitroethene** must comply with hazardous materials regulations due to its flammability and potential instability. It should be packed in tightly sealed, inert gas-filled containers, transported at low temperatures, and kept away from heat, flames, and incompatible substances. Appropriate labeling, documentation, and emergency procedures are essential during transport.
    Storage Nitroethene should be stored in a cool, dry, and well-ventilated area, away from heat sources, open flames, and direct sunlight. Keep it in tightly sealed, appropriately labeled containers made of compatible materials. Avoid storing near strong acids, bases, or reducing agents. Ensure proper grounding and bonding during handling to prevent static discharge, and follow all local regulations for explosive or sensitive chemicals.
    Application of Nitroethene

    Applications of Nitroethene in Industrial Manufacturing

    Nitroethene serves as a key reactive intermediate for multiple specialized chemical industries. Its role centers on controlled addition reactions for fine and bulk chemical synthesis. Our manufacturing expertise ensures consistent purity and particle size for industrial production requirements.

    1. Synthesis of Pyrrole Derivatives in Pharmaceutical Intermediates

    Pharmaceutical manufacturers rely on nitroethene for constructing nitrogen-containing heterocycles, especially pyrrole and substituted pyrrole scaffolds. Nitroethene reacts as a Michael acceptor, supporting multi-step routes under controlled pH and temperature. GMP-compliant facilities adjust reactant concentrations to balance yield and selectivity, meeting specification for low residual solvents and byproducts. The process calls for in-process analytical checks for intermediate verification before downstream purification and salt formation, ensuring suitability for regulated API synthesis.

    Industry compliance standards

    • ICH Q7 GMP Guideline for Active Pharmaceutical Ingredients
    • USP <1225> for Analytical Method Validation
    • 21 CFR Part 211 Good Manufacturing Practice for Finished Pharmaceuticals
    • EU EudraLex Volume 4 - GMP Guidelines

    Typical usage ratio

    • 10–30 mol% relative to target pyrrole framework, adjusted according to substitution pattern and desired batch volume

    Downstream process integration

    • Initial Michael addition in multi-step synthesis
    • Intermediate formation, followed by reduction, cyclization, and salt formation
    • Inline monitoring and solvent exchange for continuity

    Final product types

    • Pyrrole-based pharmaceutical intermediates
    • Substituted pyrrole building blocks for small molecule API synthesis
    • Pyrrole carboxylates and salts for later-stage drug product

    2. Polymer Additives: Crosslinking Agents for Specialty Polymers

    Polymer compounders incorporate nitroethene during crosslinking and functionalization stages for specialty materials. Use as a monomer or comonomer precursor enables post-polymerization modifications, increasing compatibility and enhancing end-use properties like flexibility or chemical resistance. Reactors operate under nitrogen atmosphere to maintain monomer integrity and control exotherms. Quality assurance validates nitro content and confirms crosslinked network formation by FTIR and DSC methods before masterbatch compounding for film, fiber, or adhesive production.

    Industry compliance standards

    • ISO 9001:2015 Quality Management
    • REACH Regulation (EC) No 1907/2006 for chemical safety
    • ASTM D7015 for polymer composition
    • ISO 11357 thermal analysis guidelines

    Typical usage ratio

    • 0.5–2.5% by weight in polyester or polyamide precursor mixtures; specific loading determined by targeted network density and reactivity

    Downstream process integration

    • Added in pre-polymer blending stage
    • Introduced during batch or continuous reactor feed
    • Crosslinking initiated by controlled heating or catalytic activation

    Final product types

    • Modified polyester and polyamide resins
    • Specialty adhesive formulations
    • Flexible films and fibers with custom functional group content

    3. Fine Chemical Synthesis: Preparation of Beta-Nitro Alcohols

    Fine chemical manufacturers utilize nitroethene for the synthesis of β-nitro alcohols through direct nucleophilic addition with aldehydes. The process operates in polar aprotic solvents with basic catalysts, producing intermediates for agrochemical and pharmaceutical uses. Continuous flow reactors often implement in-line pH and temperature controls to ensure batch uniformity. Downstream purification involves selective crystallization and vacuum drying, meeting customer purity and moisture thresholds for further processing.

    Industry compliance standards

    • ISO 14001 Environmental Management (for process control and emissions)
    • Chemical Weapons Convention Schedules (to avoid diversion)
    • GHS Classification and Labeling
    • REACH preregistration and reporting

    Typical usage ratio

    • 1:1 to 1:1.1 molar ratio with carbonyl reactant, modifiable for solubility and target conversion rate

    Downstream process integration

    • Direct addition to aldehyde or ketone in cooled reactor vessels
    • Batch or semi-continuous operation with intermediate sampling
    • Pilot and plant-scale crystallization tailored for downstream handling

    Final product types

    • β-nitro alcohols for further chemical transformation
    • Hydroxylamine or amine intermediates (after reduction)
    • Agrochemical active ingredient precursors

    4. Synthesis of Nitroalkene Additives for Lubricant Formulations

    Lube oil blenders use nitroethene to prepare value-added nitroalkene additives by regioselective alkylation. Controlled batch reactors operate at moderate temperatures with tailored catalysts to maximize nitrate functionality without undesired side-products. QC technicians confirm additive content via HPLC before downstream blending. These compounds enhance oxidative stability and wear protection in formulated lubricants, with careful adjustment of dose rate according to viscosity grade.

    Industry compliance standards

    • API 1509 Engine Oil Licensing and Certification System (EOLCS)
    • ISO 21469 for lubricants used in incidental food contact
    • ASTM D4485 for automotive engine oils
    • OECD chemical safety guidance for occupational use

    Typical usage ratio

    • 0.2–1.0% in finished oil blends, optimized through bench wear and oxidation tests

    Downstream process integration

    • Reacted with alkenes or alkynes in stirred reactor
    • Crude additive separated and refined before tank blending
    • Inline blending or post-additive top treat depending on lube grade

    Final product types

    • Engine lubricants with enhanced oxidation stability
    • Industrial gear oils with improved anti-wear features
    • Hydraulic fluids requiring advanced additive chemistry
    Free Quote

    Competitive Nitroethene prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Nitroethene: A Manufacturer’s Perspective on Pure Performance in Advanced Syntheses

    Introduction to Nitroethene

    Every chemist searching for reliable building blocks in synthesis circles back to the value of individual purity and performance. Nitroethene has carried its weight across a range of applications for good reason. Working as a chemical manufacturer, we have learned to appreciate this material’s particular strengths—not just because it fills a role, but because of how effectively it drives desired reactions. In our facility, we produce Nitroethene in tightly controlled environments, monitoring parameters batch by batch to hold contaminant levels at bay. The result reflects a focus on structure, reactivity, and robust yield in every gram.

    Model and Specifications

    Our Nitroethene appears as a pale yellow liquid, with a consistently measured purity above 98% confirmed by GC-MS. Customers have long relied on this product range, trusting our batch homogeneity and rigorous documentation. Flashpoint measurements show a strong safety margin for shipping and handling, while the boiling range (114–116°C under atmospheric pressure) keeps process controls reliable in large-scale operations.

    Moisture incursions or trace byproducts pose problems to sensitive downstream processes. Drying and filtration occurs in a sealed system, deterring atmospheric contamination. Every batch receives routine NMR scans and Karl Fischer titration reports before it ever leaves our floor. We also offer verified impurity profiles, so you know exactly what enters your reaction vessels.

    Unlike traders or repackagers, we run original synthesis and purification in-house. This gives us direct oversight on raw materials, allows for real-time problem solving with every run, and enables custom modification of process parameters if a client requires special characteristics—like tighter limits on nitrite or aldehyde residues beyond industrial baselines.

    Applications: Where Nitroethene Delivers Performance

    Chemists who’ve worked with Nitroethene use it primarily in condensation and cycloaddition reactions. It acts as a highly reactive Michael acceptor, and its straightforward structure makes it invaluable for quick, predictable C–C bond formation. Over years of production, many customers in pharmaceutical intermediates and agricultural chemical synthesis have requested our Nitroethene for these specific steps. The product streamlines crosslinking of enzyme substrates and helps generate heterocycles with strong pharmaceutical interest.

    Academic groups studying reactive intermediates constantly return for our Nitroethene because of its reproducible behavior in model reactions. Its profile serves as a standard for comparison, and knowing the reactivity window means less guesswork and reduced waste. Researchers synthesizing nitro derivatives and evaluating their energetic profiles stress that purity influences not only reactivity but also safety—contaminated samples fuel unpredictable byproducts and, in worst cases, runaway polymerization.

    A few experienced process engineers in the explosives industry—where fine-tuned energy density and sensitivity matter—find Nitroethene particularly useful during bench-top energetics studies. The same dialogue emerges when battery and advanced materials researchers ring our technical team: even trace organic impurities can disrupt the delicate interplay of charge carriers and lattice formation. Solutions-hardened Nitroethene has found a home in almost every application where reactivity outpaces bulk availability.

    What Nitroethene Offers That Analogues Do Not

    Comparing Nitroethene to other nitroalkenes or aliphatic nitro compounds underscores a few critical points. Unlike nitropropene, which incorporates a further methyl group and introduces additional steric hindrance, Nitroethene stays minimal yet highly activated. Stereochemical simplicity makes purification and analysis straightforward—GC and NMR spectra don’t fill with extraneous peaks, so assessment of downstream functionalization is direct. Even at modest scales, users notice cleaner, sharper isolations following product work-up.

    In Michael addition reactions, for instance, many chemists prefer Nitroethene over nitroolefins with longer chain lengths or branching. Yields jump several percentage points and separation of products gets easier. Polymers derived from Nitroethene (for those exploring novel conductive or piezoelectric materials) benefit from this straightforward molecular backbone; it allows direct access to short-chain prepolymers and building blocks without extensive deprotection or chain truncation.

    In regulatory reviews—especially with novel APIs—Nitroethene’s simple structure assists with compliance documentation. Analysts can quickly map reaction pathways and confirm a single mechanistic origin during impurity profiling, eliminating drawn-out correspondence with review agencies.

    Working in manufacturing, we understand customer frustrations over “commodity” chemicals sourced from unknown suppliers. Nitroethene often gets lumped in with low-quality alternatives. Persistent solvent residues, water traces, and redistilled fractions create variability that ripples into project delays and reactor fouling. By keeping our syntheses vertical, we regularly side-step these pitfalls, and have records on hand for every intervention undertaken—establishing an audit trail trusted by critical industries.

    Manufacturing Considerations: Scale, Safety, and Waste

    Bringing Nitroethene to scale is more complex than blending off-the-shelf precursors. The critical step involves condensation of chloroacetaldehyde with nitromethane. Controlling local exotherm and selectivity through closed-loop cooling and pressure regulation reduces the chance of dimerization or resinous byproducts. Vent scrubbers and vapor-phase neutralization help us capture and abate volatiles before venting, protecting the work environment and downstream air.

    Our plant’s design reflects years of continuous improvements, including sis monitoring and in-line spectral feedback during distillation. A quick spike in monochloro impurities triggers immediate adjustment—avoiding product loss and off-spec shipments. We keep batch records for traceability and offer clients direct access to anonymized process data for their own regulatory tuning.

    Waste handling and solvent recovery stand as ongoing priorities. Nitroethene’s reaction pathway yields aqueous byproducts and some low-boiling organic residues. These are collected, neutralized, and, where possible, reprocessed into less hazardous waste streams or raw material. Collaborating with local waste management firms and regional regulatory bodies, we’ve refined our protocols to minimize environmental load and drive down waste haulage costs. We don’t treat this as a greenwashing afterthought: every reduction in offcuts and emissions raises quality and lowers cost.

    Lessons from the Lab and Factory Floor

    Over countless production runs, some lessons always repeat themselves. A small uptick in water content can throw off sensitive downstream couplings, forcing extensive rework. That’s why our team tests not only for basic purity but for micro-level titer shifts and functional reactivity with common nucleophiles. This proactivity has saved multiple client campaigns from stalling weeks before scale-up checkpoints.

    Another real-world consideration: shipping and storage often induce molecular changes in energetic materials. Nitroethene, due to its unsaturated structure and tendency for self-polymerization under light or heat, demands cooled storage and amber glass containment. Moving batches rapidly from synthesis to processing helps limit degradation. Re-laboratory testing or track-and-trace data can identify bottlenecks that might otherwise cascade into supply hiccups for major clients.

    Production line teams remain the most important factor in safe, effective supply. Rotating staff between process control, QA, and logistics helps spot quality slips before product release, and aggressive feedback cycles inform ongoing training. Machine downtime or tank contamination can present as minor tics in GC profiles; previously, these signals caused recurring discards, but today they prompt quick, solution-oriented maintenance.

    Clients sometimes request special grades, seeking NOx content below a single part per million, or screening out specific aldehyde impurities for advanced catalysis. Offering this means running extra purifications, often under tighter inerting or microdistillation. What sets direct manufacturers apart from resellers is the ability to modify live processes rather than simply sorting options in a stock catalog.

    Safety Concerns: Handling, Storage, and Use

    Handling Nitroethene calls for vigilance, from bulk tank lines to benchtop flasks. As an unsaturated nitro compound, it reacts readily with a range of nucleophiles and oxidants. Experienced operators minimize incident risk by following established PPE routines, venting excess pressure, and never mixing batches without tracer and titer confirmation.

    Storage remains a common point of failure for less careful operations. Nitroethene oxidizes and polymerizes under sunlight or heat; we use temperature-controlled, light-shielded containers. This extends shelf life and product reliability long past typical distributor standards. Supervisors check inventory monthly, spot test for retained purity, and refresh expired stock before it ever enters outgoing logistics.

    As the manufacturer, we field technical queries from customer labs about dose thresholds and reactivity triggers. Some materials sold through brokers reach clients with incomplete hazard documentation; we advise partners directly and can provide process-specific risk assessments. On the rare occasion of workplace exposure, our facility’s emergency response drills have prepared every crew member to manage fire or contamination events. Insurance audits sometimes lead to extra mitigation steps, such as redundant venting and suction, or expanded fume handling systems.

    Supply Chain: Traceability and Market Realities

    Many industries learned to distrust the generic chemical supply chain after shipment of off-spec or adulterated materials. We took early steps toward vertical integration and digital traceability, linking each production lot with raw material batches. If a client in pharmaceuticals or advanced materials flags an issue, we can resolve the entire supply chain—no finger-pointing, no third-party delays.

    Our digital records integrate with client portals, supporting both compliance and internal process optimization. We can flip records, reprocess outliers, or run total impurity breakdowns in hours instead of days. Trusted supplier relationships allow forward purchasing for seasonal spike periods, so lead times stay tight and customers receive the same high-purity Nitroethene year in and year out.

    We keep direct lines open not just to customers but to regulators and professional groups tracking quality incidents worldwide. Early detection of synthetic pathway outliers or new regulatory risks benefits everyone downstream, and maintaining a reputation as a source, not a middleman, helps with cross-market trust.

    Development Partnerships and R&D Feedback

    A fair number of new reactions in organic synthesis never make it past small-scale proof of concept because of error bars from inconsistent starting materials. Our R&D collaboration with universities and private labs puts ultra-pure Nitroethene into the hands of top scientists. Reports of new reactivity, stability studies, and kinetic data flow back to production, closing a feedback loop that sharpens both academic and industrial output.

    Start-ups working on synthetic methods for fine chemicals can request direct technical support, bringing our chemists into joint troubleshooting and scale-up planning. On several occasions, this has uncovered practical alternatives to high-cost purification or improved atom economy by subtle process shifts, all based on actual, quantified lab results—not marketing claims.

    Nitroethene keeps finding new uses in energy storage, specialty coatings, and even green propellants. Quality requirements for each field keep ratcheting up. Our technical teams use previous application data to adapt processes proactively, maintaining a supply chain built for changing technical needs, not just volume.

    Sustainability, Environmental, and Social Responsibility

    Chemicals with energetic or high-reactivity profiles often come under scrutiny for environmental and human health risk. Our response is neither to minimize these concerns nor to offload responsibility to others in the supply chain. Every unit of Nitroethene leaves our facility with a full record of waste minimization, neutralized residuals, and emissions control.

    Recent years brought new scrutiny, demanding lower VOC emissions and minimized carbon footprint per kilogram produced. In response, process adjustments moved toward higher-efficiency condensation reactors and solvent reclaim loops. These cut emissions and dropped utility use, which not only satisfies regulators but aligns with growing end-user demand for traceable, lower-impact materials.

    Recent dialogue within the industry aims to phase out legacy byproduct disposal routes that historically placed a burden on surrounding communities. We contribute to this progress through on-site waste neutralization and cooperation with specialty recyclers for solvents and organics. These changes aren’t just for compliance—the local teams assembling, moving, and supporting Nitroethene production live nearby, and our responsibility stays personal.

    Conclusion: Why Direct Manufacturing Matters with Nitroethene

    Anyone who’s sat through a failed set of reactions or stalled product launch knows the real frustration of poor-quality starting materials. Across hundreds of production batches and thousands of kilograms shipped, our facility’s focus on Nitroethene performance, traceability, and reliability stands as the real value-add. Each improvement in storage, testing, or documentation saves headaches for both producers and users. Collaborating with regulators, end-users, and industry groups ensures every canister that moves out our doors maintains the standard that drove chemists to choose it in the first place.

    Nitroethene remains more than an off-the-shelf chemical. With the right manufacturing care, its role as a precision tool for building next-generation molecules—whether for synthesis, materials, or research—comes to the forefront. As technical barriers and requirements climb, working directly with those who know the material inside and out makes the difference. Production knowledge, continuous feedback, and process innovation guarantee the reliable performance researchers and industrial chemists depend on—today and tomorrow.