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n-Propyl isobutyrate

    • Product Name n-Propyl isobutyrate
    • Alias Propyl 2-methylpropanoate
    • Einecs 203-686-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    614800

    Chemical Name n-Propyl isobutyrate
    Cas Number 621-66-7
    Molecular Formula C7H14O2
    Molecular Weight 130.19 g/mol
    Appearance Colorless liquid
    Odor Fruity
    Boiling Point 128-130°C
    Melting Point -85°C
    Density 0.867 g/cm³ at 20°C
    Refractive Index 1.398-1.400 at 20°C
    Flash Point 28°C (closed cup)
    Solubility In Water Insoluble
    Vapor Pressure 6 mmHg at 25°C

    As an accredited n-Propyl isobutyrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle with a secure screw cap, labeled "n-Propyl isobutyrate," including hazard symbols and handling instructions.
    Shipping n-Propyl isobutyrate should be shipped in tightly sealed containers under cool, dry conditions, away from heat sources and oxidizing agents. It is typically classed as a combustible liquid and may require labeling according to transport regulations. Comply with all local and international chemical transport and safety guidelines.
    Storage n-Propyl isobutyrate should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed and properly labeled. Use appropriate safety measures to avoid inhalation, ingestion, or skin contact. Store in approved containers, and protect from moisture and direct sunlight to ensure stability and safety.
    Application of n-Propyl isobutyrate

    Applications of n-Propyl isobutyrate in Industrial Manufacturing

    n-Propyl isobutyrate finds consistent use in specialized industrial sectors due to its performance as a flavor solvent, fragrance carrier, and chemical intermediate. As the original manufacturer, we track actual downstream usage and ensure supply chain transparency for regulated applications. Listed below are core application scenarios broken down by sector and process.

    1. Food Flavoring Solvent Systems

    Major food ingredient processors apply n-Propyl isobutyrate as an efficient carrier for formulating fruit and dairy flavors in beverages, baked products, and confectioneries. It integrates at the compounding stage to amplify volatile esters without disrupting organoleptic quality. Our food industry clients strictly monitor the raw material for batch purity and verify compliance with dietary and food safety regulations before flavor blending and emulsification. Adjustments in solvent concentration respond to flavor profile intensity targets, process scale, and regional food additive limits. The final food products undergo chemical and sensory quality checks aligned with end-market requirements.

    Industry compliance standards

    • US FDA 21 CFR §172.515 (Synthetic flavoring substances and adjuvants)
    • EU Regulation (EC) No 1334/2008 (Flavorings and certain food ingredients)
    • GB 2760-2024 (Chinese National Food Safety Standard for Use of Food Additives)
    • FSSC 22000 (Food Safety System Certification for ingredient supply)

    Typical usage ratio

    • 0.03–0.15% by weight in compound flavors, adjusted per volatility and sensory validation
    • Maximum allowable daily intake as outlined in local flavoring guidelines

    Downstream process integration

    • Incorporation at flavor mixing tank with temperature-controlled blending
    • Dissolving into hydroalcoholic bases or emulsions prior to addition to food matrix
    • Usage documented through SAP or manual batch records for each blending lot

    Final product types

    • Ready-to-drink fruit beverages and juice drinks
    • Candy and confectionery fillings
    • Instant dairy desserts
    • Bakery cream and fruit jam flavoring bases

    2. Fine Fragrance Compounding

    Commercial fragrance houses include n-Propyl isobutyrate in their compounding step for fresh and fruity note enhancement due to its rapid volatility and stable performance in both hydrous and anhydrous formulations. The material provides a top note character in complex perfumery, deodorant, and room spray blends. Strict quality assurance ensures all input meets global IFRA and regional ingredient disclosure norms. Clients determine dosage by trial compounding, scale pilot, and finished product stability requirements, maintaining traceability through QA release. Downstream, the fragrance system undergoes dilution, aging, and filtration prior to bottling.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association, batch level adherence)
    • EU Regulation (EC) No 1223/2009 (Cosmetics Regulation – Annex III, IV)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) disclosure as required
    • ISO 9001:2015 (Quality Management for manufacturing and supply)

    Typical usage ratio

    • 0.03–0.18% in fine fragrance concentrates
    • Higher ratios considered for room air care using compatibility and evaporation test results

    Downstream process integration

    • Direct addition to fragrance compound during formulation batch blending
    • QC monitoring by gas chromatography and olfactory panels prior to approval
    • Final dilution into ethanol or other solvents according to end-use application

    Final product types

    • Alcohol-based perfumes and eau de toilette
    • Room sprays and air fresheners
    • Personal care deodorant sprays
    • Scented household products

    3. Solvent for Agrochemical Formulation

    Agricultural input manufacturers use n-Propyl isobutyrate to enhance solubility and dispersibility of active compounds in crop protection emulsifiable concentrates and microemulsions. The raw material enables clean solvation of aromatic and ester-based actives without compromising pesticide performance during large-scale blending. Compliance with hazardous chemical control, residue limits, and export material specifications is verified throughout storage and process transfer. The solvent proportion depends on the active ingredient’s solubility, regional formulation guidelines, and delivery system being produced, as documented in the product master formula. Rigorous in-process controls and trial spray testing verify active delivery performance before bulk packaging.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EPA 40 CFR Part 180 (Tolerance limits for residues)
    • Regulation (EC) No 1107/2009 (EU Plant Protection Products)
    • China GB 2763-2023 (MRL standards for pesticides in food)

    Typical usage ratio

    • 2–10% by weight in EC (emulsifiable concentrate) or ME (microemulsion) formulations
    • Adjustable by solubility curve of specific actives and target product viscosity

    Downstream process integration

    • Blending into solvent tank prior to addition of agrochemical actives
    • Homogenization using high-shear mixing for uniformity
    • Sampling for HPLC residue control and phase separation check

    Final product types

    • Herbicide and insecticide ECs and microemulsions for farm application
    • Seed treatment chemical carriers
    • Pesticide tank-mix adjuvants

    4. Intermediate for Pharmaceutical Synthesis

    Pharmaceutical API and intermediate plants use n-Propyl isobutyrate as a cost-effective esterification reagent and phase-transfer agent under controlled GMP manufacturing. It enters at the organic synthesis stage for building ester functionalities in prodrugs and supporting active ingredient solubility. The formula ratio is tightly managed under validated process methods, considering reaction yield, raw material purity, and subsequent downstream purification. All handling and batch dispensation follow current Good Manufacturing Practice and pharmacopoeial compendia for traceability, stability, and toxicological safety. The intermediate undergoes full structural confirmation before use or conversion in subsequent API steps.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP / EP / JP Pharmacopoeial monographs for starting materials, where relevant
    • FDA 21 CFR Part 211 (cGMP for finished pharmaceuticals)
    • China GMP for Pharmaceutical Products 2020

    Typical usage ratio

    • Based on stoichiometric excess, typically 10–30% surplus over limiting reactant in esterification
    • Adjusted according to target conversion and ease of isolation in downstream steps

    Downstream process integration

    • Dosed into reactor system together with alcohol and acid under controlled temperature and pH
    • Enters purification sequence via extraction or distillation following reaction completion
    • Full traceability and waste stream control for cGMP documentation

    Final product types

    • Pharmaceutical esters and related prodrugs
    • Bulk intermediates for oral or topical APIs
    • Precursors for further chemical modifications

    5. Specialty Coatings and Ink Production

    Formulators in specialty coatings and ink industries use n-Propyl isobutyrate as a low-odor, medium-evaporation solvent for high-gloss printing inks, specialty lacquers, and decorative coatings. It allows dispersion of pigment and binder resins without affecting rheology or substrate adhesion. Manufacturers select the solvent volume based on application method—such as flexographic or gravure printing—and the volatile organic compound (VOC) restrictions of the target market. We ensure lot-specific purity and residual moisture analysis to protect final film quality and ink shelf stability. Monitoring at compounding, blending, and final QC assures compliance with health and safety directives and product labeling rules.

    Industry compliance standards

    • EU 2004/42/EC (VOC Directive for paints, varnishes, and vehicle refinishing products)
    • ASTM D4302-18 (Standard Specification for Print Ink Solvents)
    • REACH (CLP Regulation, labeling and exposure documentation)
    • ISO 9001:2015 Quality Management for production sites

    Typical usage ratio

    • 5–25% by weight depending on ink formulation type and required evaporation rate
    • Adjusted during trial runs for drying speed and print sharpness consistency

    Downstream process integration

    • Added to pigment grinding or letdown batch stage, in closed-temperature mix tanks
    • Continuous monitoring for viscosity and diluent ratio prior to filtration and canning
    • Final solvent level determined by gravimetric analysis

    Final product types

    • Flexographic and gravure printing inks
    • Custom lacquer coatings for industrial packaging
    • High-gloss decorative overprint varnishes

    6. Extraction Solvent for Botanical Extracts

    Botanical extraction operators use n-Propyl isobutyrate to extract delicate flavors and bioactives from plant material in applications limited to non-ingestible, technical use, or further purification. The solvent’s ester character supports clean separation of essential oil and flavor fractions without antinutritional residue risk when downstream processes fully recover and remove solvent traces. Facilities closely monitor solvent usage per extraction batch, aligning with occupational exposure limits and closed-loop system requirements. The extract goes through sequential distillation and purity analysis before supply, and documentation certifies compliance with technical-grade application restrictions.

    Industry compliance standards

    • EU Regulation (EC) No 1907/2006 (REACH) for chemical solvents in technical extraction
    • OSHA 29 CFR 1910.1000 (Occupational Exposure Limits for Solvents)
    • ISO 22000 (when extracts are designed for further food or pharma conversion)

    Typical usage ratio

    • Liquid to solid ratio: 5–12 parts solvent to 1 part botanical mass by weight
    • Solvent selection and batch volume determined by extraction efficiency, temperature, and removal capability

    Downstream process integration

    • Direct addition to botanical maceration tanks or pressurized extraction units
    • Solvent recovery via distillation following target extraction time
    • Testing for residual solvent content using GC-MS during final QC

    Final product types

    • Technical-grade botanical oil extracts for fragrance bases
    • Plant-derived flavor concentrates for further synthesis
    • Non-food essential oil intermediates for aromas and air care
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    Certification & Compliance
    More Introduction

    Introducing n-Propyl Isobutyrate: Chemistry with Character

    Our Experience in Crafting n-Propyl Isobutyrate

    We’ve spent decades making fine chemicals for industries that value both precision and consistency. n-Propyl isobutyrate stands out in our lineup as a testament to the feedback we’ve received from our partners in flavors, fragrances, and specialty synthesis. Every batch we prepare reflects not only raw materials and expertise, but the relationships we’ve built with real users over time. With consistent process control and hands-on testing, we’ve come to appreciate the unique profile that n-Propyl isobutyrate delivers. Our chemists don’t just monitor for purity—they care about lot-to-lot aroma and performance, listening to what distillers, perfumers, and formulation specialists actually need in practice.

    Technical Approach and Reliable Manufacturing

    Let’s talk about what goes into our process. n-Propyl isobutyrate isn’t a byproduct or a sideline. We dedicate reactor time and resources specifically to its production, avoiding cross-contamination with other esters. Our plant runs modern continuous units with vacuum stripping, allowing for careful separation from side products. Experienced hands conduct the fractionation, minimizing impurities and keeping aldehydes, alcohols, and water at levels well below industry limits.

    Specifically, purity levels routinely test above 99%. We never rely on a single test; every drum runs through both GC and wet chemical assays. These protocols reduce the variability that end users worry about when they build scale recipes. We’ve built relationships with analytical suppliers and regularly requalify our standards, ensuring confidence for buyers who need full supply chain transparency.

    Defining Characteristics of n-Propyl Isobutyrate

    Many customers come to us wanting esters that don’t get lost among similar alternatives. n-Propyl isobutyrate carves its own path with a rich, fruity aroma that’s hard to mimic using generic butyrates or propionates. Our product usually carries a sweet, pear-like note, with a slightly creamy undertone that perfumers describe as smoother than most lower alkyl isobutyrates. This difference comes from the way we manage both the reaction temperature and the order of addition in synthesis. It isn’t a process anyone can rush; one careless hour of reflux can dull the delicacy that makes this ester worth choosing.

    Its volatility, Boiling at approximately 137°C, makes n-Propyl isobutyrate a favorite for creating layered flavors and top notes that linger longer than ethyl or methyl counterparts. Our sample performance tests highlight improved headspace profiles in product formulations, leading beverage creators and flavorists to return with higher volume orders when switching from less pure, off-the-shelf grades.

    Rational Selection: Why Not Just Use a Common Alternative?

    Decision-makers sometimes wonder why they should invest in n-Propyl isobutyrate when esters like ethyl isobutyrate or isobutyl butyrate are widely available. Our direct experience with formulation gives us a clear answer. Different esters may share backbone chemistry, but once you run side-by-side testing in beverage, e-liquid, or perfume applications, the contrasts become obvious. n-Propyl isobutyrate offers a less aggressive, but more persistent profile. In practice, its flavor stability through shelf life studies repeatedly beats that of isobutyl butyrate, especially in acidic or high-alcohol environments. Flavor architects know this—one small change from ethyl to propyl often means fewer reformulations downstream and less risk of costly recalls for off-flavor development.

    Another difference appears in volatility curves. Ethyl and methyl esters often evaporate quickly under normal use, leading to a burst of aroma that doesn’t linger. n-Propyl isobutyrate persists longer, making it ideal for products designed for extended enjoyment or multi-layered sensory effects. When a client wants a “pear drop” candy note that doesn’t vanish in the first whiff, our n-Propyl isobutyrate delivers that enduring impression.

    Direct Applications: What Our Customers Actually Make

    Our largest volume goes to the flavor industry, where developers of beverages, candies, chewing gums, and baked goods demand reliable quality. In the lab, we see our product blended into pear, apricot, and banana imitations, where too much sharpness or chemical harshness would ruin a delicate flavor profile. Commercial flavorists continue to value n-Propyl isobutyrate for its stability, especially when their formulation base includes acids, sweeteners, or alcohol. In comparison to alternatives, we’ve watched formulators cut their masking agents by nearly half with the right ester choice—savings that matter for both scale-up and the finished consumer experience.

    Fragrance manufacturers put our product to work in both fine fragrance and personal care. Our pure grade yields better solvency for oils and achieves a nuanced “freshness” that companies struggle to match using generic blends. Clients in the perfume industry often mention the seamless overlay over citrus or melon notes. For soaps and bath products, the mild and sweet aroma lifts the blend, setting it apart from harsher, more pungent choices. We’ve even supported candle and air-care producers looking for esters that won’t overpower or fade out too quickly during burn tests.

    Some of our technical customers use n-Propyl isobutyrate as a specialty intermediate in organic synthesis. Its reactivity, compared to bulkier esters, enables selective alkylations and esterifications. Chemists in research labs report that our material holds up well under laboratory scale-ups, especially where competing byproducts could create color or purity issues.

    Packaging Choices Built for Real-World Handling

    We know firsthand the headaches from leaky drums, degraded seals, or contamination complaints. Our product leaves our site in lined steel drums or ISO tanks, not just standard plastic pails. We examine every lot for water content and order-of-filling errors. Bulk buyers can opt for nitrogen-blanketed shipments, reducing oxidation risk during transit. Our team in quality control insists on batch records that track each shipment all the way back to synthesis. These details might sound obvious, but they make the difference between a disruption-prone supplier and a partner who keeps production lines moving. We never treat packaging as an afterthought.

    Quality Control: Accountability in Every Batch

    Factories rely on consistent chemicals to keep their end products meeting spec. Our technical managers stand behind QC data, making sure certificates reflect actual in-vessel performance rather than averages across unrelated shipments. Field failures rarely stem from the ester itself—instead, they usually trace back to storage issues or incompatibility with coatings. Our regular stability studies show that n-Propyl isobutyrate packaged and stored correctly maintains nearly all its sensory and performance characteristics for more than one year in sealed drums.

    Several global partners conduct blind performance comparisons. We’ve learned from these reports, modifying purification and storage protocols in ways that allow our product to consistently outperform factory-packed generic imports. If a customer ever faces supply interruption or a question about lot history, our staff can trace every filling to its reactor batch, giving the market supply chain transparency few competitors match.

    Sustainability, Safety, and Regulatory Attention

    Being a responsible manufacturer carries increasing importance today. Our plant invests in closed-loop solvent recovery for the main synthesis steps, lowering waste output and reducing volatile emissions. Some customers ask about compliance with evolving safety and purity standards. We go beyond flavor and fragrance regulations—every run meets the food-grade impurity limits for the markets that matter most. We publish full compositional breakdowns and maintain allergen statements with every order. Our safety officer monitors evolving guidelines and initiates process adjustments whenever authorities revise residue limits or environmental restrictions.

    Handling any ester requires basic worker protections. Our operators wear full PPE, but the low toxicity and mild volatility of n-Propyl isobutyrate make it far less hazardous than many bulk solvents or starting alcohols. We’ve adapted our facilities to contain and neutralize spills rapidly, avoiding downtime and ensuring site safety. Transport safety isn’t an afterthought—road and rail shipments comply with all applicable shipping codes, and we audit logistics partners to uphold both safety and chain-of-custody integrity at every stage.

    Addressing Market and Logistic Challenges

    Recent years have tested every chemical manufacturer’s ability to deliver on time and at expected quality. Supply chain snags for starting materials or unexpected demand swings occasionally affect scheduling. Having a vertically integrated facility means we aren’t dependent on single-source suppliers. Our procurement group maintains inventory buffers, letting us continue fulfilling orders during high-volume demand or temporary supplier disruptions.

    We’ve also invested in logistics partnerships that favor specialty chemical distribution over bulk commodity freight. Every case of quality deviation or late shipment triggers a root cause review, not just a replacement of the shipment. We treat feedback, both positive and negative, as data for continuous improvement. End users count on us knowing that any learning from a failure becomes part of our manufacturing and shipping process for future batches. We believe trust builds with transparency and demonstrated reliability.

    Research, Collaboration, and Future Trends

    Much of our innovation comes from collaborative research with customers in application labs. Flavors and fragrances remain the strongest drivers for improved ester production, but specialty synthesis applications continue to grow. Organic researchers and chemical engineers from universities and industrial consortia test our n-Propyl isobutyrate in new reaction types and product classes. Their findings often prompt us to tweak reaction conditions or offer experimental samples for pilot-scale tests.

    Trends in food and consumer goods prompt new demands: cleaner labeling, vegan or non-GMO certification, and even reduced-odor variants for ultra-sensitive applications. We’ve responded by validating isolation steps that minimize trace byproducts, as well as introducing documentation packages with every shipment that go beyond regulatory minimums. Product development doesn’t end at shipping; ongoing support and shared technical reports help customers refine their formulations for changing consumer preferences.

    Comparison in Real-World Use: n-Propyl Isobutyrate Versus Related Esters

    Clients often seek side-by-side comparisons to confidently justify process updates. Our experience aligns with published sensory data: n-Propyl isobutyrate lands mid-range in terms of volatility—less fleeting than methyl or ethyl versions, but lighter than butyl or amyl isobutyrate. This unique evaporative signature proves valuable for manufacturers balancing fast-release and persistent aroma effects. Side-by-side panel testing consistently shows that formulations with our product maintain flavor and aroma integrity longer in finished consumer goods. In commercial-scale beverages, switching from ethyl to n-propyl yields a fruit note that remains noticeable after three months of storage, particularly under stress conditions.

    From a chemical compatibility perspective, n-Propyl isobutyrate’s solubility across alcohols, glycols, and oils enables broader use than the more lipophilic higher esters. Its relatively low viscosity also pays off when blending into spray-dried flavors, emulsions, or alcohol-based perfumes. End users appreciate fewer surprises in blending trials and less tendency toward phase separation in finished products. Years of practical feedback confirm that these differences move beyond the theoretical and translate into tangible advantages on the factory floor.

    Packing the Experience into Every Shipment

    At the end of the day, manufacturing excellence starts with teams who care about what goes out the door. We rely on skilled technicians and chemists who know that an odd smell, off-color sample, or questionable GC peak matters as much as a production timeline. Every shipment reflects not only ISO process checks, but also a culture of real accountability—where someone experienced inspects and signs off, not just a computer ticking a box.

    We maintain open communication with partners about every step, whether it’s a protocol revision prompted by an audit, or the direct experience of a client who wants a specialized cut better suited to their product. If a customer needs help troubleshooting odor fade, or a subtle shift in flavor, we bring actual formulation experience and chemistry know-how to the discussion—bridging the gap between synthetic benchwork and finished item results.

    A Commitment to Our Customers

    n-Propyl isobutyrate serves industries looking for more than just a chemical that meets a spec sheet. Our manufacturing experience gives partners an edge—consistency, purity, and performance well above basic requirements. Years of practical success in beverages, fragrances, confections, and synthesis back up every promise we make about this product. For us, delivering n-Propyl isobutyrate isn’t a sideline or a minor specialty—it’s a core part of our daily craft, built on knowledge, transparency, and a real investment in quality from start to finish.