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N-Ethyl-1-Naphthylamine

    • Product Name N-Ethyl-1-Naphthylamine
    • Alias N-Ethyl-1-naphthalenamine
    • Einecs 202-273-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    245966

    Chemical Name N-Ethyl-1-Naphthylamine
    Cas Number 86-15-5
    Molecular Formula C12H13N
    Molecular Weight 171.24 g/mol
    Appearance Yellow to brown crystalline solid
    Melting Point 56-60°C
    Boiling Point 324-326°C
    Density 1.06 g/cm³
    Solubility In Water Insoluble
    Flash Point 156°C
    Synonyms N-Ethyl-1-aminonaphthalene
    Pubchem Cid 6742

    As an accredited N-Ethyl-1-Naphthylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g amber glass bottle with a tightly sealed cap, labeled "N-Ethyl-1-Naphthylamine" and detailed hazard, handling, and manufacturer information.
    Shipping N-Ethyl-1-Naphthylamine should be shipped in tightly sealed containers, away from direct sunlight, heat, and incompatible substances. It must be labeled according to relevant regulations, and transported by approved carriers. Protective packaging is required to prevent leaks or spills. Ensure all safety data and emergency handling instructions accompany the shipment.
    Storage N-Ethyl-1-Naphthylamine should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as oxidizing agents and acids. Protect from moisture, heat, and direct sunlight. Label the container clearly, and store at room temperature or as specified by the manufacturer. Always follow proper chemical storage protocols.
    Application of N-Ethyl-1-Naphthylamine

    Applications of N-Ethyl-1-Naphthylamine in Industrial Manufacturing

    N-Ethyl-1-naphthylamine supports a range of downstream industrial processes, contributing as an intermediate or functional additive in applications demanding strict material performance and traceable compliance standards. Our production aligns with end-user requirements from colorant synthesis to advanced electronics, addressing high-precision sector needs and regulatory parameters.

    1. Dyes and Pigments Synthesis

    Manufacturers utilize this compound as an intermediate in azo dye and pigment production, especially for both textile and ink applications. It provides targeted reactivity in diazotization-coupling reactions, enabling chromophores with high fastness and specific shade control. Operators adjust input ratios based on desired hue intensity and compatibility with fiber or print binders, integrating the amine in the early coupling step and managing residues throughout the process. This route yields colorants for cotton, synthetic fibers, and printing inks where resistance to light and washing is imperative and impurities must meet strict QC standards.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for handling aromatic amines
    • OEKO-TEX® Standard 100 for eco-friendly textile chemicals
    • EN 71-3 Safety of Toys (Specific Migration Limits for aromatic amines in colored articles)
    • ISO 9001:2015 for documented quality management in all batches

    Typical usage ratio

    • 5-15% by mole in coupling stages, adjusted based on target shade and yield requirement
    • Ratios fine-tuned depending on coupling partners and final dye structure

    Downstream process integration

    • Added during diazotization-reactive stage, following precise pH and temperature control
    • CQC sampling at the coupling point to monitor by-products and color density
    • Residue removal via filtration before finishing

    Final product types

    • Direct dyes for cellulose textiles
    • Azo pigments for solvent-based printing inks
    • Water-dispersible pigments used in industrial coatings
    • Permanent textiles colorants for apparel and upholstery

    2. Rubber Chemical Synthesis (Antioxidants and Accelerators)

    Producers integrate this aromatic intermediate in the synthesis of specific secondary amine antioxidants and accelerator compounds for rubber compounding. It participates in condensation with quinone or oxidative reactants to generate molecules that inhibit vulcanization degradation or catalyze cross-linking. Blending ratios must address final polymer application and residual amine limits, incorporating this raw material at the emulsion mixing or pre-polymer preparation phases. The proper execution reduces premature aging in tires, seals, and technical rubber articles, consistent with environmental and safety auditing.

    Industry compliance standards

    • ASTM D4676 Standard Classification for Rubber Compounding Materials
    • EU Regulation EC 1223/2009 Annex II (restrictions on hazardous aromatic amines)
    • ISO 14001 for environmental management in chemical synthesis
    • ETRMA (European Tyre & Rubber Manufacturers’ Association) guidelines for chemical inputs

    Typical usage ratio

    • 2-8% by mass for antioxidative compounds, based on base polymer and performance target
    • Levels adjusted for balance between stabilization efficiency and processing safety

    Downstream process integration

    • Charged into pre-polymer blending tanks under inert atmosphere
    • Combined with other accelerators/antioxidants before mixing with raw rubber
    • Monitored for amine residue using HPLC before extrusion or molding

    Final product types

    • Anti-aging rubber additives
    • Accelerators for tire vulcanization
    • Sealing gaskets resistant to ozone and heat
    • Rubber technical goods for automotive and industrial applications

    3. Analytical Chemistry Reagents

    Laboratories and diagnostic reagent firms deploy this amine compound in colorimetric analytical indicator systems, especially as a coupling component for determining trace nitrite and nitrate in water matrices. It reacts under defined conditions to yield quantifiable color changes. Batch purity and traceability are paramount as per analytical supplier protocols, and formulating teams adjust reagent concentration to balance detection limits with background stability. This substance enters the process at the premix phase and under cleanroom packaging conditions to prevent cross-contamination, directly supporting quality control kits for municipal and environmental water analysis.

    Industry compliance standards

    • ISO 17025 laboratory management and test method validation
    • EPA Method 353.2 for Colorimetric Determination of Nitrite/Nitrate in Water
    • EU Drinking Water Directive 2020/2184 Annex I: parametric values for analytical reagents
    • GLP (Good Laboratory Practice) for in-process and batch control

    Typical usage ratio

    • 0.01-0.1% by mass in indicator reagent solutions; adjusted as per detection sensitivity requirements
    • Concentration specified by method protocol for calibration accuracy

    Downstream process integration

    • Dissolved and stabilized in aqueous reagent premixes
    • Charged during batch filling of analytical kits under laminar airflow
    • Batches released after blank and performance verification

    Final product types

    • Environmental test kits for nitrite/nitrate analysis
    • Water quality monitor reagents
    • Diagnostic strips for laboratories
    • Automated analyzer calibration solutions

    4. Organic Synthesis Intermediate for Pharmaceutical API Development

    API and pharmaceutical intermediate manufacturers apply this building block for synthesizing structurally specific amine-containing molecules, especially in heteroaromatic ring functionalization and active intermediate generation. Material input ratios and impurity profiles must maintain compliance with ICH Q7 for API synthesis, incorporating the amine at the nucleophilic substitution stage under monitored reaction conditions. Operators oversee conversion rates and employ in-line QC for residual amine, securing precursors for antihypertensive, antimicrobial, or diagnostic contrast agent syntheses. Downstream formulations use strict isolation and purification, protecting the integrity of the pharmaceutical chain.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP/NF pharmacopeial standards for raw material quality
    • 21 CFR Part 211 for pharmaceutical manufacturing controls
    • EMA guidelines for synthesis traceability in APIs

    Typical usage ratio

    • 10-20% by mole as starting material in stepwise synthesis; precise dosage optimized per route yield and impurity control
    • Entry amount defined by target intermediate molecular structure

    Downstream process integration

    • Introduced to closed reactor systems in nucleophilic substitution or coupling stages
    • Strict batch record and material reconciliation per GMP rules
    • In-line sampling for impurity and residual detection via HPLC or GC

    Final product types

    • Pharmaceutical intermediates for antihypertensives
    • Contrast agent precursors for imaging applications
    • Intermediates for antimicrobial APIs
    • Heterocyclic building blocks for drug discovery programs
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    Certification & Compliance
    More Introduction

    N-Ethyl-1-Naphthylamine: Direct from Our Synthesis Facility

    Our Commitment to Consistent Quality in N-Ethyl-1-Naphthylamine Production

    On the shop floor and inside the process control room, producing N-Ethyl-1-Naphthylamine (NENA) is a hands-on journey that goes beyond technical data sheets. Our team starts with high-purity precursors, maintaining strict attention to every stage that bridges raw naphthalene derivatives to the finished amine. The most experienced operators track color, crystallinity, and odor from the first drop of ethylamine. They rely on observation and reliable instrumentation, never cutting corners on primary amine purity. We produce NENA as dense, off-white to amber crystals, minimizing byproduct contamination that can compromise downstream reactions in dyes, pesticides, or analytical reagents.

    Day in and day out, our reactors run controlled temperatures and careful agitation. The safety team always steps up with real-time pH monitoring and solvent recovery. Each batch sees documented analysis—GC, HPLC, melting point tests—standing behind its certificate of analysis rather than chasing typical claims found in generic brochures. The lot history travels openly with the product because we track every batch, so users from textile research labs to organic synthesis units can pinpoint the outcome right back to the day it was made.

    Why Chemists Still Seek N-Ethyl-1-Naphthylamine

    N-Ethyl-1-Naphthylamine has earned its place as a classic aromatic amine. Over decades, organic and analytical chemists repeatedly turn back to this compound for diazotization and azo coupling reactions. The N-ethyl group tunes the amine’s reactivity for specialty intermediates not easily reproduced by related naphthylamines. For those developing dye precursors, the structure of this molecule allows reproducible color development with precise tone adjustments.

    Wastewater analysts use NENA for the Griess reaction, where selectivity and signal clarity in nitrite detection matter. This isn't a catch-all amine. Other common analogues—such as N-methyl-1-naphthylamine or the unsubstituted 1-naphthylamine—behave differently under analytical conditions. Tried-and-true NENA resists unwanted side reactions that complicate azo dye formation, enabling users to control endpoint chromogenic response and minimize workup headaches.

    Purity: Why Our Users Value Our In-House Methods

    The most common questions we hear focus on specification. We typically ship material at purity not less than 98%, confirmed by gas chromatography and checked for moisture as well as residual solvents. Melting point ranges hover in the 68–71°C window, a number each technician learns to match by hard-won experience. We keep iron and heavy metals below the tolerances set by pigment and dye manufacturers, knowing that only trace contaminants can spoil color fidelity.

    Because these factors are built by years on the same production line, our specifications come from hands-on learning with each new batch. If odd-shaped crystals show up or a slight color shift appears, someone from QA physically investigates. It saves laboratory customers the effort of extra purification and lets pharmaceutical researchers trust their calibration standards. We store samples in controlled rooms, protecting against ambient humidity that can trigger hydrolysis or discoloration over the long term.

    How N-Ethyl-1-Naphthylamine Fits into Industrial Synthesis

    Our N-Ethyl-1-Naphthylamine supports pigment and dye houses chasing specialty shades in textiles and plastics. The ethyl group creates new branching paths for couplers, helping achieve hues not possible from less-substituted naphthylamines. Dispersion remains predictable and solubility falls in line with what experienced formulators expect. Instead of running small-scale purification every time, large operations rely on our consistent lots to cut day-to-day troubleshooting.

    Some herbicide intermediates cannot form without the right naphthylamine scaffold. We often see procurement teams drawing up requests for synthetic standards with tight tolerance, especially in agrochemical labs screening for selectivity and biodegradability. These users care about trace metals, secondary amines, and any tail ends from the nitration step. Because our operation closes that loop in-house, we keep impurity levels where sensitive downstream synthesis remains viable, rather than clogging up columns or requiring excessive rework.

    What Makes N-Ethyl-1-Naphthylamine Different from Related Aromatic Amines

    Many users ask why they shouldn’t just swap in N-methyl-1-naphthylamine, 2-naphthylamine, or basic aniline. While substitutions sometimes work on paper, small changes alter electron density and reactivity, shifting coupling rates or leaving unwanted byproducts. Our lab found the ethyl substituent on the one position creates a balance: strong enough electron donation to promote clean diazotization, but not so activating that it attracts background oxidation or tars. Compared to N-methyl homologues, the slightly longer chain produces a softer, more refined solubility and cleaner precipitation in dye trials.

    Substituting with 2-naphthylamine always leads to challenges in spectroscopic analysis and creates isomers when left unchecked. Aniline’s smaller structure misses the aromatic breadth needed for color development and produces less stable diazonium intermediates. Even custom intermediates with bulky side chains can't walk the tightrope between reactivity and stability that NENA offers. Synthetic chemists with years of bench work can attest to the difference, since batch-to-batch reproducibility rarely holds up with substituted analogues made by less-experienced teams or from brokers.

    Supporting Analytical Chemistry in Monitoring and Standardization

    Analytical labs circle back to N-Ethyl-1-Naphthylamine for colorimetric assays, especially those using diazotization. Public water supplies and food safety teams rely on its specificity when tracking nitrite in environmental and health samples. Any switch to lower-purity or substitute amines leads to inconsistent color gradients and forces method re-validation. We shipped specialty grades to metrology institutes and state water agencies, building trust one bottle at a time.

    Direct conversations with chemists reveal concern about background fluorescence, false positives, or ghost peaks when using kitchen-sink amines sourced from secondary resins or repackagers. By focusing production on reproducibility and clear answers to questions about batch differences, we help users hold to regulatory standards. Our support team speaks in direct terms about lot-to-lot differences, not marketing jargon, letting customers make informed choices before scaling up assays or method validation.

    Safety and Handling: Perspective from Those Who Make It

    Handling N-Ethyl-1-Naphthylamine in a reactor suite is a daily reality that colors our approach to safety. Breathing or direct skin contact with the crystalline dust creates risks that our safety managers never downplay. Our plant uses local exhaust hoods and runs closed transfer lines wherever practical. Operators wear gloves and fitted goggles, keeping product containers sealed after sampling. Extended contact over long shifts prompted us to switch to engineered controls and train new workers in hazard recognition.

    Unlike smaller aromatic amines, NENA produces a characteristic odor and can cause mild irritation at low airborne concentrations. Maintenance crews regularly monitor for leaks and spills, especially since cleanup costs rise fast if small residues oxidize or polymerize in drains. We answer customer questions about MSDS precautions in clear language, translating experiences from our shop floor to any lab or warehouse where NENA travels. Sharing real outcomes helps younger chemists avoid mishaps, and sets expectations realistically for every shipment.

    Responding to Supply Chain Challenges

    Our plant weathered raw material shortages and transport disruptions over the decades. Fresh naphthalene supplies often take priority in the broader market, leaving secondary amines in tight spots. Because we maintain direct relationships with upstream chemical suppliers, we keep control over incoming purity and reservoir inventory. Stockpiling essential intermediates and refining in-house logistics avoids the pinch felt by many downstream customers who rely on spot buying or third-party brokers.

    Moving beyond just finished product, our team inspects packaging integrity each step from drier to drum. Many times, older containers or rough handling lead to product deterioration. We revamped pallets, increased package linings, and moved to double-sealed bags for long-distance transit—saving unnecessary rework on arrival and improving shelf stability in user facilities. Chemists coordinating multi-step syntheses, especially for scale-up batches, tell us these changes made a direct difference when delivery timelines run tight and there’s no room for guesswork.

    Transparency and Technical Support: Lessons from the Factory Floor

    Having walked through every room in the factory, our technical experts know the quirks and potential issues that only experience reveals. Sometimes a new customer receives a drum and worries about crystal size or slight color variations between lots. We treat each complaint as a learning opportunity, revisiting process logs and pulling reserve samples to get answers fast. Our willingness to send lab samples ahead of main shipments reflects a commitment to open, fact-based partnership.

    Consulting on reaction setup, storage, or blending, our engineers sidestep complicated scientific language and focus on what works on the bench. Exchange with end users, no matter the size of the purchase, sharpens awareness of common pitfalls and helps prevent costly errors. Over the years we fielded everything from formulation sticking to multi-kg scale-up quirks, reinforcing the fact that real chemical manufacturing means supporting users before and after sales—not just shipping containers down the road.

    Regulatory Confidence: Built on Experience Instead of Paperwork

    In a landscape shaped by regulatory inspections and evolving standards, we focus not just on minimum compliance but long-term trust. N-Ethyl-1-Naphthylamine synthesis produces intermediates that flagged regulators for toxicity and process emissions decades ago. Our plant responds with in-system scrubbers, batch-level production logs, and staff training that keeps our operation above changing requirements.

    Documented audits allow any customer or inspector to trace product genealogy—from raw material to finished inventory—without gaps or missing links. Our team tracks every recall and corrective action, feeding lessons into system updates for real-world relevance, not just paperwork. Users facing new international bans or shifting environmental requirements find value in our commitment to honest, traceable standards. We address those changes up front, engaging regulators or buyers as soon as possible to align goals and build resilience on both sides of the supply agreement.

    Opportunities and Challenges in Application Development

    Growth in specialty dyes and emerging analytical methods push N-Ethyl-1-Naphthylamine into new territory. Innovators in areas like smart textiles, advanced sensors, and pharmaceutical intermediates value performance more than broad claims or generic lots. They share the raw, direct feedback that shapes our process refinements and inspires new test protocols. Sometimes we collaborate on development runs matching tighter impurity gradients—far outside standard commercial needs—positioning our plant as more than just a bulk supplier.

    That same push for innovation creates new demands on our manufacturing staff. Packing, sampling, and documentation all adapt to specialty market requests, demanding versatility from people and machinery alike. Our project management team tracks each pilot run closely, logging each variable shift and outcome. This continuous learning feeds back into core production, paving the way for improvements in reliability, safety, and performance.

    Conclusion: A Manufacturer’s Reflection

    Producing N-Ethyl-1-Naphthylamine is a multi-faceted mission for our facility. It pulls together rigorous chemistry, on-the-ground process control, responsive support, and honest transparency. Each drum and bottle shipped stands as a report card on our hands-on experience and attention to what matters in complex synthesis or sensitive analysis. We uphold our commitment to knowledge-sharing and no-nonsense support, making sure users can trace and trust every lot, from the first reaction flask to the final application.

    The best outcomes come not from generic claims, but from real engagement and hard-won lessons passed forward. By staying connected to both industry trends and practical bench realities, we aim to keep raising the bar for quality, reliability, and partnership in N-Ethyl-1-Naphthylamine production—for chemists who know the difference that experience makes.