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n-Butylamine

    • Product Name n-Butylamine
    • Alias 1-Butanamine
    • Einecs 202-685-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    454704

    Chemical Name n-Butylamine
    Cas Number 109-73-9
    Molecular Formula C4H11N
    Molecular Weight 73.14 g/mol
    Appearance Colorless liquid
    Odor Ammonia-like
    Boiling Point 77-78 °C
    Melting Point -49 °C
    Density 0.740 g/cm³ at 20 °C
    Solubility In Water Miscible
    Flash Point 7 °C (closed cup)
    Refractive Index 1.399 at 20 °C
    Vapor Pressure 93 mmHg at 20 °C

    As an accredited n-Butylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing n-Butylamine is packaged in a 500 mL amber glass bottle with a secure screw cap, labeled with hazard and safety information.
    Shipping n-Butylamine is typically shipped in tightly sealed, corrosion-resistant containers, such as steel drums or IBCs, under cool, well-ventilated conditions. It is classified as a flammable and corrosive liquid (UN 1125), requiring labeling and handling in accordance with international transport regulations. Avoid sources of ignition and incompatible substances.
    Storage n-Butylamine should be stored in a cool, dry, well-ventilated area away from heat, open flames, and incompatible substances such as oxidizers and acids. Store in tightly sealed, clearly labeled containers made of compatible materials, such as glass or high-density polyethylene. Protect from physical damage and direct sunlight. Ensure spill containment and emergency eyewash/shower are nearby. Keep out of reach of unauthorized personnel.
    Application of n-Butylamine

    Applications of n-Butylamine in Industrial Manufacturing

    n-Butylamine serves as a pivotal intermediate in several industrial manufacturing sectors, supporting the synthesis of specialty chemicals, agrochemicals, pharmaceuticals, rubber processing additives, and water treatment agents. As an established manufacturer, we supply n-Butylamine to customers who demand consistency in purity, compliance, and performance for precise downstream integration within regulated environments.

    1. Crop Protection Synthesis (Herbicide and Pesticide Intermediates)

    Leading agrochemical producers use n-Butylamine as a fundamental building block in the production of active ingredients for selective and non-selective herbicides, including but not limited to 2,4-D and MCPA butylammonium salts. The compound enters condensation and salt formation reactions during the active ingredient synthesis phase, aligning with country-specific registration requirements for crop protection chemicals and Good Manufacturing Practice for technical-grade actives.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • European Plant Protection Product Regulation (EC) No 1107/2009
    • US EPA Pesticide Registration (FIFRA compliance)
    • China ICAMA Registration Guidelines

    Typical usage ratio

    • N-Butylamine use varies by formulation; typically 0.9–1.2 molar equivalents per carboxylic acid moiety in herbicide salt synthesis, based on stoichiometry and final product purity requirements.

    Downstream process integration

    • Direct amination or neutralization of carboxylic acid intermediates with controlled addition in closed-system reactors.
    • Salt formation under temperature-controlled, inert conditions to prevent oxidation and byproduct formation, followed by purification and crystallization of the herbicide salt.

    Final product types

    • 2,4-D butylamine salt formulations
    • MCPA butylamine salt herbicides (water-soluble concentrates)
    • Bipyridylium herbicides (pre-salt intermediates)
    • Custom selective herbicide technical materials

    2. Pharmaceutical Intermediate Synthesis

    n-Butylamine functions as a dedicated amine intermediate for the generation of active pharmaceutical ingredient precursors, including antihistamines, antihypertensives, and certain antidiabetic compounds. The material supports nucleophilic substitution, ring closure, and amidation reactions under strictly validated GMP environments to minimize impurity formation and ensure reproducible batch performance for downstream finished dosage forms.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF and Ph. Eur. monographs (as applicable for intermediates)
    • China Drug Master File (DMF) registration
    • ISO 9001:2015 Quality Management Systems for excipient-level supply

    Typical usage ratio

    • Standard addition ranges from 1.1–1.5 equivalents depending on the specific API synthesis route, with adjustments made for yield optimization and minimization of residual amine in the final intermediate.

    Downstream process integration

    • Included during intermediate synthesis via direct alkylation or acylation with control over pH and temperature.
    • Unit operations: batchwise or flow chemistry reactors, followed by phase separation, purification, and chromatographic removal of excess amine.

    Final product types

    • API building blocks for antihistamines (e.g., butylated amide intermediates)
    • Antihypertensive secondary amine intermediates
    • Pyrrole and piperazine pharmaceutical intermediates
    • Custom-made, registered pharmaceutical intermediates for contract synthesis

    3. Rubber Chemicals and Vulcanization Accelerators

    In the technical rubber sector, manufacturers use n-Butylamine to synthesize specialty accelerators such as N-butylthiourea and related compounds, which drive controlled sulfur vulcanization and crosslink density in both natural and synthetic rubber formulations. Its chemical contribution targets precise adjustment of cure time, tensile strength, and elongation profiles required for premium tire, hose, and industrial gasket applications—ensuring the additives meet major regional regulatory guidelines for process and final product safety.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 registration
    • ASTM D4678 specification for rubber chemicals
    • ISO 9001:2015 for specialty chemical supply chain management
    • Automotive industry quality management systems (IATF 16949, as required)

    Typical usage ratio

    • Usually introduced at 1.05–1.20 mole ratios with isothiocyanate or carbon disulfide feedstocks; final incorporation in rubber compounds at dosage levels of 0.1–1.0 phr based on end product application.

    Downstream process integration

    • Initial reaction in closed reactors to form the accelerator precursor, rigorous moisture and pH control, extraction, and drying before downstream integration into rubber compounding lines.
    • Final application in rubber mixing stages prior to shaping, curing, and post-treatment.

    Final product types

    • Butylated thiourea accelerators for tire tread and industrial hoses
    • Retarder and secondary accelerator blends
    • Heat-resistant gasket compounds
    • Rubber-coated fabric adhesives and sealants

    4. Corrosion Inhibitor and Water Treatment Formulations

    Process water system formulators utilize n-Butylamine for the synthesis of amine-based corrosion inhibitors, which protect industrial boilers, heat exchangers, and cooling circuits from scaling and oxidative damage. The compound participates in the formation of fatty amine derivatives or passes directly into neutralizing blends, guaranteeing system compatibility and compliance with operating permits in power generation, petrochemical, and municipal water sectors.

    Industry compliance standards

    • ANSI/AWWA B111 standards for water treatment chemicals
    • OECD EHS Series on Testing and Assessment (for aquatic toxicity data)
    • EN 1212:2017 for chemical additives in potable water treatment
    • EPA TSCA Inventory Listing (for US distribution)

    Typical usage ratio

    • Varies from 0.05–0.3% by weight in final formulated corrosion inhibitor solutions; precise dosing determined by equipment metallurgy, operating temperature, and water chemistry analysis.

    Downstream process integration

    • Reaction with fatty acid chlorides or phosphonates in closed kettle systems, followed by purification and blending with anti-scalants, sequestrants, or dispersants in automated mixing vessels.
    • Direct neutralization for on-site formulations when batch blending is employed by OEM partners.

    Final product types

    • Aqueous amine-based corrosion inhibitor concentrates
    • Multi-component boiler treatment products
    • Circuit protection formulations for industrial water cycles
    • Scale inhibitor and neutralizer mixtures for power plants and district heating systems

    5. Mining Flotation Reagents

    n-Butylamine finds consistent application in the mining industry as a primary or secondary collector reagent in the flotation process, especially for separation of non-ferrous minerals such as quartz, feldspar, and certain sulfide ores. The amine alters the surface chemistry of target minerals, enabling selective separation under controlled pH and ionic strength, and is formulated according to international safety regulations for both reagent manufacture and mine site use.

    Industry compliance standards

    • ISO 9001:2015 for specialty reagent manufacturing
    • EU REACH compliance for site delivery and use
    • MSHA and OSHA regulations (US mining sector)
    • UN GHS Safety Data Sheet format for global transport

    Typical usage ratio

    • Dosing ranges from 20–150 g/t (grams per ton of ore processed), with adjustments based on ore composition, commissioning pilot trials, and target selectivity.

    Downstream process integration

    • Inline addition as diluted reagent at the flotation cells.
    • Pre-mixing with aqueous phase and pH adjustment, typically in automated reagent dosing systems handling multi-stage flotation circuits.

    Final product types

    • Collector reagent formulations (in aqueous or emulsion concentrates)
    • On-site blended flotation additives for non-metallic and metallic ores
    • Composite flotation reagent packs (amine plus frother blends)
    • Recycling-compatible tailings treatment reagents
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    Certification & Compliance
    More Introduction

    n-Butylamine: Every Batch Starts with Experience

    Walking Through the Plant

    The door to the control room swings open at the start of every shift. The raw aroma of amines greets you, unmistakable. On the monitors, lines of chemical processes, pressure readings, and reactor temperatures play out in real time. For years, this is where we’ve built our understanding—living with these molecules, tracking each reaction step, and responding to every slight shift in feed quality or humidity. n-Butylamine, which leaves our distillation columns with a crisp amine scent and that signature colorless clarity, stands out by more than just its straightforward structure.

    How We Sustain Reliable Production

    It’s true—n-Butylamine would not tolerate shortcuts. Our production lines dedicate a lot of attention to operational discipline: tightly set reaction parameters, controlled pressure in the reactor, and real-time analytics for purity assurance. We have learned that fluctuating feed quality from primary amination can knock the whole plant out of specification if not adjusted for rapidly. Our senior technicians, many with over two decades of service, do not just push buttons. They watch for trends, tweak flows, and record notes from every shift that help tweak tomorrow’s output. That helps us ship product that meets its stated purity, batch after batch, with minimal drift.

    Specifications That Reflect Experience

    We produce n-Butylamine as a clear, low-water liquid, keeping water content to below 0.2%. This came after years of troubleshooting storage tank sweating and drum rusting in the early days of operation. Today, it’s routine to run gas chromatography and Karl Fischer titrations on every batch, but that habit was born out of real-world inconvenience and customer complaints that forced us to dig deep into root causes. Our standard batch targets free amine content above 99.5%. This is not just a number from a specification sheet. We got there after countless trials adjusting feed rates, column packings, and condenser designs, learning that shortcuts would result in downstream headaches during customer application.

    Packing and Handling—Realities from the Floor

    No one on our loading dock forgets the old days—when overfilled drums would arrive weeping to the customer or summer heat bulged containers. Now, filling lines run on calibrated scales, and vapor recovery sits front and center to limit product loss. Even so, the sharp, eye-watering smell pokes through if you press your face too close to an open drum. N-Butylamine demands respect in handling. Our own crew complaints about residual odors and drum reactivity led us to invest in lined steel containers, which proved superior to poly options during winter months. These little stories shape how we recommend and supply packaging options today.

    What Sets n-Butylamine Apart

    n-Butylamine walks its own line compared to methylamine, ethylamine, or even its longer cousin, hexylamine. Methyl and ethylamines reach a larger volume market, but their smaller molecular size means they stay highly volatile and tend to escape containment faster, even under good storage conditions. Customers working with these compounds relay headaches about evaporative losses and local environmental controls. Our own storage rooms favor n-Butylamine—it offers a balance of volatility and ease of capture that suits a steady drum operation without demanding an overbuilt venting system.

    Hexylamine and heavier aliphatic amines feel oily and build up with shorter shelf lives under humid conditions. We dislike having to pull product from the drum farm early because of adverse tank reactions or color formation. n-Butylamine, by virtue of its molecular weight and reactivity, offers none of the stickiness but plenty of cooperation in downstream chemistry. Whether used to build herbicides, pharmaceuticals, or rubber accelerants, the molecule reacts cleanly and leaves little room for byproduct carryover. This was especially noted by one of our long-term partners, who needed a pill-grade purity for an API intermediate. After repeated small-batch tests side-by-side with propylamine and pentylamine, the feedback was clear—n-Butylamine made downstream purification a practical step, not an ordeal.

    Main Uses Born of Technical Feedback

    Our main customers run n-Butylamine into synthesis of crop-protection products—mostly urea and carbamate herbicide intermediates. Over years of feedback, we’ve learned that a pure feed simplifies their reactor loadings and cuts side reactions, so we maintain the purity margin that lets their plant managers sleep better at night. Rubber chemical producers call us about foaming issues and polymerization artifacts they’ve encountered with certain amines. With n-Butylamine, most find it slips easily into vulcanization, activating the right chemical pathways without lingering in the final elastomer as a residual odor.

    In pharmaceutical intermediates, we’ve watched the landscape shift. Where smaller amines once ruled, n-Butylamine grew in importance due to its role in building key amide and urea structures for newer therapies. We talk directly to bench chemists on scaling up their processes, offering samples and sometimes visiting plants to troubleshoot foaming, sticking, or solvent layering challenges. The conversations are rarely abstract—yields increase or slip, based on the molecular quirks of the amine used. Having access to repeatable quality n-Butylamine, with characteristically low metal content and stable pH, seems to solve those problems without forcing entire new layers of purification.

    Downstream Impact Supports Careful Operations

    n-Butylamine makes a strong show in markets where consistent amine reactivity shapes the outcome—dyestuff manufacturing, corrosion inhibitors, and fuel additives. Many of our customers run legacy formulations, and they care a lot about lot-to-lot continuity. We put incoming raw materials under the same scrutiny as outgoing shipments. The facility never rushes—no one wants contaminated lines or unwanted cross-reactivity in nitration setups. We can’t afford batch failures, either. As a result, our teams record observations about batch idiosyncrasies and tweak procedures based on these small but meaningful process notes.

    Our quality pillars come from direct lessons learned—not from management mandates, but from operators catching a pump cavitation before it fouls a run, or lab techs flagging a spectral outlier before it ships in a customer drum. Each error, though hard-earned, tightens our procedures and builds trust between the lab and the floor. We see n-Butylamine not as a commodity, but as a responsive and dependable tool—the result of habit, consistency, and the slow march of operational learning.

    Safety and Real World Handling

    Many on our crew have stories about learning respect for n-Butylamine the hard way. A single misplaced seal, and the entire room fills with sharp, penetrating vapor that soaks into work clothes for the rest of the shift. Our response over the years has been to design containment and PPE programs that reflect lived experience, not just written regulation. Respirators, nitrile gloves, and splash guards represent standard gear. During transfer, air monitoring sends out a warning if vapor hits even half the occupational threshold. Tank farms stay ventilated and undergo preventive maintenance—replacing gaskets on a strict schedule shaped by documented near-misses. Personally, I fielded more than a few angry calls from loading crews about older transfer pumps that would leak by the shaft seal. Fixing these hardware issues soon paid off in reduced downtime, less lost product, and a happier team.

    Environment and Regulatory Compliance

    Local inspectors drop by unannounced. They check for updated logs and walk the tank yards. Years ago, n-Butylamine fell under tighter tracking for its VOC load and aquatic toxicity potential. Regulations shifted, and we had to bring in real-time monitoring for fugitive emissions while investing in training workshops—the old way of visual spot checks no longer met the letter or the spirit of compliance. We also improved our tank vent scrubbers. The ammonia-like odor makes escape impossible to ignore, but even sub-odor releases still drew fines in the past. With vapor containment tied to every transfer and real-time fenceline sensors reporting back, we now stay ahead instead of always chasing the paperwork.

    Field Feedback as Foundation for Improvement

    Any manufacturer who has delivered n-Butylamine for years will tell you: customer feedback doesn’t arrive as polite suggestions. It comes as urgent phone calls, plant stoppages, complaints of cloudy product, or even off-odors that threaten to halt a pharma process mid-campaign. Over time, we methodically recorded every concern and paired it with direct sampling. Seeing how drum liners interacted with certain cargoes forced us to switch suppliers. A cluster of viscosity complaints in cold months led us to heat-insulated storage. These direct lessons shape our day-to-day run sheets and show up in our batch logbooks.

    One of our largest customers in the rubber sector flagged minor amine discoloration. We traced it back to trace oxygen in the headspace of a storage tank during a rainy spell. Technicians tightened the nitrogen flows, quality rebounded, and similar issues vanished. The solution wasn’t a theoretical fix—it came from patient, granular teamwork and from placing enough trust in field operators to spot what analytic chemistry would have missed.

    Comparing n-Butylamine with Related Amines

    The market offers a roster of aliphatic amines, but our own run charts show where n-Butylamine outperforms cousins like iso-butylamine, di-n-butylamine, or propylamine. Isobutylamine, for instance, carries the same amine functionality, but its branched chain structure alters reactivity, increasing byproduct formation in key synthetic steps. Customers making herbicides have noted more side-reactions and lower yields when they ran comparative trials.

    Moving to di-n-butylamine, the extra butyl group adds bulk—and that can block certain reactions or introduce handling headaches with viscosity and solubility. By contrast, n-Butylamine maintains a good middle ground: sufficiently reactive, easy to meter, manageable volatility, and reliable downstream clean-up. Our repeated process audits confirm n-Butylamine’s tight purity ranges cause fewer surprises in extrusion or reactor loading.

    We sometimes field calls asking about scaling n-Butylamine against propylamine or pentylamine. Propylamine shares some storage ease, but offers less molecular reach for building out pharmaceuticals or specialty chemicals where carbon chain length is key. Pentylamine leans oily, and often gives us more trouble during plant transfer and tank cleaning; thicker films could fester into off-colors or odorous residues, so our team regards those lines as “high watch” during shutdown cleaning. n-Butylamine provides a chemical backbone that seems to bridge the gap between handling and output. Its straightforward molecular structure predictably builds up products tested over decades—this stability makes it a favorite for industrial chemistry where predictability wins over chasing small performance gains by swapping molecules.

    Quality Means Something Different in Practice

    In any chemical facility, watchdog terms like “specification” and “quality assurance” float through meetings. On the floor, these translate into tactile checks—visual inspection, scent, viscosity checks, and rapid titrations on inbound and outbound lots. Our team circles back batch by batch, never assuming next week’s drum looks or pours the same unless confirmed.

    Years ago, an off-spec complaint from an eastern customer forced us into root-and-branch process review. Only after shadowing the batch’s entire lifecycle—procurement, synthesis, distillation, loading, and transit—did we trace the culprit: a failed condenser gasket. Temperature climbed above target for an hour, damaging a portion of the batch before it was noticed. Since then, logging and alarms shift duty fatigue toward reliable oversight. These unseen changes—borne from the tough end of mistakes—drive our ongoing improvement.

    Price Pressures and Value Perception

    Commodities markets do not care for personal stories, but daily production gives perspective on why certain amines track a firm pricing premium. Raw material volatility bites everyone, but keeping step with transparency and consistent delivery sometimes costs more than paper-thin margins allow. We track energy costs, labor outlays, and raw amine procurement closely, knowing that cheaper substitutes bring extra handling or purification burdens not immediately clear to those removed from operations. A “cheaper” import, tarnished by inconsistent batch color or higher water, often burdens the buyer with higher downtime, rejects, or cleanup.

    Some buyers realize this only after a few cycles of “lowest bid wins”—calls return to our sales desk requesting quick-turn high-spec kilograms for a restart after past problems. This dance shapes real relationships, because technical evidence and direct operator-to-customer conversations clarify the hidden costs of supply chain pivots. Our aim remains not only to ship n-Butylamine at a spec, but to back up the usage cases with service, repeat feedback, and clear communication about what customers truly encounter on their production lines.

    Continuous Learning from the Ground Up

    We strive to keep lines open with our partners—sharing not just certificates, but observations about storage, handling, and minor formulation tweaks that may benefit their end use. Sharing shift logs and learning from their application-side troubleshooting, we collectively reduce guesswork. Plenty of facility changes came after field visits—updating transfer protocols, swapping seals, adapting to humidity swings, or recognizing small but meaningful shifts in local regulations. Direct feedback fuels these improvements as much as batch analytics or new instrumentation.

    n-Butylamine, for us, represents decades of trial and progression. Its profile offers a working mix of manageable handling, predictable reactivity, and application flexibility across major chemical sectors. This performance is built into every shipment we send. While our competitors might tout comparable specs, it’s the slow—but persistent—engraining of operator knowledge and feedback-driven improvement that makes our batches distinct. Through every filled drum and every loaded tanker, we move this inherited practice forward—keeping n-Butylamine not just on spec, but adaptable, reliable, and ready for what comes next in shaping tomorrow’s chemistry.