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N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide

    • Product Name N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide
    • Alias Pronamide
    • Einecs 401-040-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    725841

    IUPAC_Name N-(2,6-diethylphenyl)-N-methoxymethyl-2-chloroacetamide
    CAS_Number 161050-58-4
    Molecular_Formula C13H18ClNO2
    Molecular_Weight 255.74
    Appearance White to off-white solid
    Solubility Soluble in organic solvents like dichloromethane, ethanol; low solubility in water
    Synonyms Chloroacetamide, N-(2,6-diethylphenyl)-N-(methoxymethyl)-
    Storage_Conditions Store tightly closed in a cool, dry place away from incompatible substances
    Purity Typically available at >97%
    Application Used as a chemical intermediate or research chemical

    As an accredited N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g quantity of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide is packaged in a sealed, amber glass bottle with tamper-evident cap.
    Shipping Shipping of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide requires secure, leak-proof packaging, typically in sealed glass or HDPE containers. The chemical should be labeled according to hazard regulations, shipped at ambient temperature unless specified otherwise, and transported in compliance with local and international chemical shipping guidelines (such as IATA or DOT).
    Storage N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight. Keep away from incompatible substances such as strong oxidizers and acids. Store at room temperature, and avoid moisture. Properly label the container and follow all applicable safety and regulatory guidelines for chemical storage.
    Application of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide

    Applications of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide in Industrial Manufacturing

    N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide serves as a precision intermediate in several specialty chemical sectors. Our dedicated production lines provide consistent quality and traceability for integration into advanced formulations. The following sections outline its key downstream industrial applications.

    1. Active Ingredient Intermediate for Selective Herbicide Synthesis

    Major agrochemical companies utilize this compound as a functional intermediate during the synthesis of certain pre-emergent selective herbicides. The chloroacetamide moiety allows selective acylation, facilitating catalytic coupling with crop protection actives. Our product supports production of high-purity actives, where strict process controls enable reproducible agrochemical performance in field application. Formulators often optimize the use of this intermediate to adjust the compound’s substitution pattern, which influences weed spectrum and soil persistence.

    Industry compliance standards

    • ISO 9001:2015 for quality management during agrochemical synthesis
    • Globally Harmonized System (GHS) for transport and labeling
    • REACH Annex XVII regulatory limits on aromatic amide intermediates
    • EPA 40 CFR Part 180 for tolerance regulations in pesticide production

    Typical usage ratio

    • 10–15% w/w relative to total precursor mass; adjustments depend on target substitution density and desired herbicide loading

    Downstream process integration

    • Direct introduction during N-acylation or alkylation steps in the synthesis reactor before purification phases
    • Monitored with online HPLC to ensure residual intermediate remains at controlled low levels

    Final product types

    • Pre-emergence herbicide technical concentrates (e.g. acetanilide-class herbicides)
    • Formulated herbicide granules for broad-acre crops
    • Non-selective weed control emulsifiable concentrate (EC) solutions

    2. Key Intermediate in Pharmaceutical API Development (Process Chemistry)

    Pharmaceutical manufacturers rely on this compound as a functional electrophilic building block to introduce specific aromatic N-alkoxyacetamide groups in novel active pharmaceutical ingredients. It offers controlled reactivity for stepwise formation of drug molecules requiring ortho-alkylated phenyl substitutions. Process chemists benefit from its high purity and stable shelf life, which help maintain replication across multi-batch syntheses. Use extends to both pilot-scale and cGMP-compliant commercial routes, especially for APIs evaluated under regulatory review.

    Industry compliance standards

    • ICH Q7 for API manufacturing control
    • USP-NF monograph reference (for related synthetic routes)
    • Good Manufacturing Practices (GMP) Part 211, FDA Title 21
    • European Pharmacopoeia (Ph. Eur.) requirements for process chemicals

    Typical usage ratio

    • Varies from 3–8 mol% per target API precursor, with the exact ratio determined by molar substitution demand and optimization of yield

    Downstream process integration

    • Charged in the late-stage synthetic vessel after primary scaffold assembly
    • Removed in final work-up, with traces monitored in the API’s impurity profile via validated methods

    Final product types

    • Small-molecule pharmaceutical intermediates
    • Experimental APIs containing N-alkoxyacetyl moieties
    • Regulated drug substances for clinical supply

    3. Building Block for High-Performance Polymer Additives

    Specialty plastics manufacturers select this compound as a tailored functionalizing agent for synthesis of polymer stabilizers and crosslinking additives, specifically those enhancing thermal and chemical resistance in polyolefin and engineering resin systems. Its controlled reactivity profiles help form molecular bridges or side chains, influencing polymer morphology and melt flow properties. Production lines precisely meter the compound to maintain batch uniformity and ensure downstream polymer performance for demanding applications.

    Industry compliance standards

    • ISO 14001 for environmental management in polymer manufacturing
    • ASTM D256 for testing polymer additive performance
    • RoHS Directive 2011/65/EU for additive content in electronic plastics
    • REACH compliance for additive registration and safe handling

    Typical usage ratio

    • 0.2–1.8% by polymer mass, determined by targeted stabilization effect and compatibility with primary polymer matrix

    Downstream process integration

    • Dosed into mixer during the compounding phase prior to extrusion or granulation
    • Monitored using infrared spectrometry to confirm additive incorporation in the polymer backbone

    Final product types

    • Polyethylene and polypropylene masterbatches with enhanced oxidation resistance
    • Specialty wire and cable insulation compounds
    • Resin-modified films for automotive interiors

    4. Intermediate for Synthesis of Fine Chemicals for Electronics

    Producers of high-purity fine chemicals for microelectronic etchants and specialty coatings specify this compound as a phase-selective alkylating intermediate. Its well-defined structure allows precise functional group transformations for tailored organics critical in photoresist manufacturing and etchant formulation. Technical teams closely monitor purity throughout processing, as microelectronics applications demand the strictest contaminant thresholds. This material plays a role in both batch and continuous flow chemistries for scalable production.

    Industry compliance standards

    • SEMI C93 for chemical purity in semiconductor processing
    • IEC 61249-2-21 for material standards in electronic circuit substrates
    • IATF 16949 for automotive electronics chemicals suppliers
    • RoHS Directive for electronics-related applications

    Typical usage ratio

    • 0.5–2.5% based on required functionality; loading varies with target end-group concentration and process scale

    Downstream process integration

    • Integrated at the functionalization stage in reactor or flow synthesis during preparation of specialty etchants
    • QC releases only lots with sub-ppm impurities suitable for microelectronics standards

    Final product types

    • Microelectronics-grade photoresist resins
    • Specialty etching solutions for fabricating semiconductor wafers
    • Conductive polymer coatings for electronic display devices
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    Certification & Compliance
    More Introduction

    N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide: An Inside Look from the Maker’s Bench

    Cornerstones of a Reliable Synthesis: What We See in N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide

    Ask anyone who has spent significant time in a chemical production environment: the real measure of a compound isn’t only bound up in its formula. Every batch of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide tells a story, written in raw materials, crystallization patterns, and hours logged at the reactor. This is a compound that demands vigilance from start to finish. Its profile stands out to any manufacturer used to handling substituted acetanilides, and as someone working daily with these substances, I’ve learned that the unique structure of this molecule brings both challenges and advantages in equal measure.

    The Making of a Distinctive Molecule: Where Practical Chemistry Matters

    Production always starts with the little things most chemists barely give a second thought—the noise of the stirrer, the faint odor of the amide, the way that methylation progresses as the hours tick by. N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide’s model sits squarely at the intersection of reactive elegance and sturdy design. For those unfamiliar, its chemical backbone features diethyl substitutions on the phenyl ring, a methoxymethyl side chain, and a chloroacetamide group. That combination shapes more than just the name: it decides how it handles heat, solvents, and other reactants.

    We know from experience that even a slight variation in temperature or reaction time can tip the entire batch from clean white solid to a stubborn off-color particulate. Getting the methoxymethylation just right requires both well-calibrated glassware and a practiced hand. This product doesn’t forgive careless metering or sketchy filtration. Across dozens of batches, we’ve developed a sixth sense for reading the crystals as they form—every time, it feels a bit like tending a sourdough starter. The human element looms large.

    Beyond the Spec Sheet: The Realities of Application

    End-users usually want consistency and clear performance. They don’t see the subtle differences that set this molecule apart from the crowd. But our team sees how the placement of those diethyl groups stabilizes the compound during storage; how the methoxymethyl chain adds a level of solubility and increases reactivity under certain conditions. In the world of fine chemicals and pharmaceutical intermediates, these differences generate real downstream impacts.

    Over the years, we’ve delivered this compound for several fields—each with its own priorities. Crop protection researchers have leaned on it for custom syntheses, especially as a building block for more complex actives. Fine chemical labs order it by the kilo for method development. Our own formulation chemists value the balance between its stability and willingness to take part in further alkylation or acylation. It doesn’t just slot into their processes; it opens up new ones.

    Specifications That Stand Up to Reality

    Lab results stay meaningful only when repeatable on the kilo scale. We’ve invested years in quality control, not just relying on equipment readouts but digging into root causes every time a result falls outside the norm. Our batches run at high purity, routinely exceeding industry benchmarks for analogous derivatives. Impurity tracks hover in the low single digits thanks to careful phase transfer and strictly controlled reagent purity.

    Our standard packaging uses moisture-tight drums with double-sealed liners, since minor humidity swings can foul the best product if left unchecked. We keep a close eye on melting point changes—drift by a degree and it signals the start of something going wrong upstream. Direct experience with recrystallization has taught us the limits of solvent choice. We’ve trialed acetonitrile, toluene, and acetone blends, eventually settling on a balance that preserves both efficiency and worker safety.

    The Quiet Differences: What Manufacturers Notice Every Day

    N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide separates itself from similar chemicals in unexpected ways. Colleagues outside our plant might overlook how it resists hydrolysis better than other chloroacetamides in open-air settings. Under standard lab lighting, it keeps a uniform appearance longer, where similar products tend to yellow or cake. Some customers have told us spills are easier to handle because clumping resists static—you rarely see that documented anywhere, but it saves headaches on a busy floor.

    Handling also matters. Workers don’t complain of the harsh chlorinated smell that other amides release during exposure. Some of our senior crew refer to it as a “quiet” compound, meaning you rarely hear of accidental irritation or smoky residues. That’s meaningful for anyone in PPE all day long.

    Why Reliability Means More Than Chemistry

    I’ve learned that even excellent purity doesn’t matter if delivery is unpredictable. Our process includes routine live checks: we pull working samples from the production line, not just the finished stock, to spot-check color, granule size, and scent. We insist on dual signoff before every lot leaves the site. If a batch doesn’t hit every parameter, it stays in-house until we can resolve the issue. The goal stays the same year after year—help customers avoid downtime and costly troubleshooting.

    It’s easy to talk about high-tech instruments, but what keeps the wheels turning are the ordinary checks: careful weighing, meticulous tare adjustments, handwritten reaction logs. Each person involved takes pride in keeping surprises to a minimum. In a market that’s grown crowded with intermediates and generic offers, that brand of consistency sets us apart.

    The Human Side of Process Improvement

    Optimizing for scale and safety rarely happens overnight. We have tried batch sizes both large and small, with smaller runs revealing problems faster but requiring more oversight per kilogram. Through trial and error, we have landed on a middle ground that balances throughput with the focused attention each run deserves.

    Worker safety occupies as much attention as product neatness. We rotate staff through active hazard drills, maintain generous buffer times between maintenance cycles, and build in regular downtime for cleaning. Years of experience have taught us that shortcuts quickly show up as recalls or out-of-spec complaints. It’s a lesson we learned the hard way with other products, and which we vowed to never repeat here.

    What Sets This Compound Apart in Demand and Field Performance

    Throughout regular dialogue with clients, we’ve seen how the specific profile of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide directly affects process yields in multi-step synthesis. Reaction engineers have commented that its clean cut and predictable melting profile facilitate downstream processing—a practical benefit in continuous-flow setups. It resists degradation in mixed organic and aqueous phases, something that similar molecules often struggle with. We hear these real-world impacts more often than theoretical complaints, which isn’t always true for niche amides.

    Testing in various formulations, especially in agricultural chemistry, has called for lots of repeated purification. Across these repeated cycles, our product has maintained low impurity buildup, avoiding the need for constant batch repurification. That’s not just a savings in solvent or time; it plays out in better yields, less waste, and a smoother handoff through the supply chain.

    Solving Challenges on the Production Floor: Practical Notes

    At the manufacturing level, small variances in raw material quality show up quickly—off-spec 2,6-diethylaniline delays the entire cycle and increases reject rates. We’ve invested in direct sourcing relationships with trusted partners to lock down quality at the source. This simple, hard-won step did more for batch consistency than any slick process control software.

    We all know that maintaining isolation of intermediates means more than technical proficiency; it requires a team that treats housekeeping as an extension of chemistry. Cross-contamination remains a constant lurking risk, so we’ve adopted clear lines of demarcation for every stage, reinforced with dedicated vessels. That decision came from a run-in with anomalous byproducts a few years back, reminding us that on-spec chemistry depends on rigor from receipt dock to shipping room.

    Daily Realities: Storage, Handling, and Shelf-life in the Real World

    A shelf-stable product only matters if users can count on that stability. Over our years producing N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide, we have developed a conservative approach to storage. Warehouse staff log temperature and humidity more often than most competitors, because even slight moisture ingress can change a good solid into an unusable lump. Our inner liners come from suppliers we’ve visited and vetted ourselves, and we cycle out all stock past two years even though test samples remain stable beyond that mark.

    Shipping brings its own headaches. Summer holds risks of caking; winter, of condensation. To address these, we time major shipments to avoid high-risk periods wherever possible, and pack with desiccant for cross-continental orders. No shortcuts or bold promises—just repeated, careful adjustments based on what has failed before.

    How Real-World Feedback Guides Our Operation

    We encourage feedback from labs and formulation teams, often adapting our process based on collective insights from years of field trials. Some clients have suggested changes to granule size or flow behavior, and after hands-on evaluation, we’ve retooled our sieving process to better align with user preferences. Direct dialogue with chemical engineers has led us to tweak drying cycles and reaction pH for optimum performance, often resulting in a better product for everyone on the chain.

    A recent round of case studies in scale-up projects highlighted gains in reproducibility when using our batch over a competitor’s. One formulation group reported smoother incorporation during late-stage alkylation, with less need for rework. Not every review is glowing, but every criticism acts as a lesson; the process never gets easier, only more refined.

    The Wider Industry View: Navigating Regulations and Global Demand

    Any producer dealing with synthetic intermediates like N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide recognizes that regulation casts a wide shadow. Compliance isn’t just a matter of ticking boxes—it touches every aspect, from choice of solvent to effluent management. Over the years, we’ve adjusted our offerings to meet or exceed evolving safety and environmental standards, driven not just by rules but by the desire to pass audits with confidence.

    Expanding into global markets means learning each country’s unique demands. North American clients value extensive traceability, European partners focus on green chemistry footprints, and Asian customers care about rapid fulfillment. We engage in ongoing audits and welcome visits from regulatory teams, knowing that a strong compliance record grows trust as much as any technical breakthrough.

    Meeting Specific Customer Needs: Where Customization Happens

    Customization rarely means dramatic changes. It’s often a matter of targeting finer mesh sizes, tighter purity grades, or solvent-free handling. Clients in pharmaceuticals sometimes need a product with absolute traceability, while agricultural researchers request larger, easier-to-blend granules. We accommodate the needs that align with our quality commitments. Over time, those client partnerships have prompted us to upgrade both our analytical equipment and operator training, seeing real dividends in reduced complaints and improved workflow.

    On more than one occasion, a client request has triggered a fresh round of in-house trials, leading to incremental improvements that ripple through the rest of our catalog. We take pride that these tweaks stem from real-world feedback and close listening—not just abstract theorizing. Each improvement grows from daily stories at the bench.

    Building for Tomorrow: Challenges and Opportunities Ahead

    The journey of N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide stretches well beyond constant process tweaks. We keep a close eye on new greener synthetic routes, given the pressure to cut waste and lower environmental impact. Some teams inside our shop run pilot tests for alternative solvents and recyclable reagents, balancing scalability against risk. Upgrading reactor infrastructure features on our roadmap, as does partnering with university labs on process research. We know new synthesis pathways can bring both cost savings and regulatory advantages, though they need careful validation before scaling up.

    We don’t claim to have solved every issue or reached a plateau—chemical production never truly stands still. Each year throws new logistical snags, market bumps, and technical puzzles our way. The key is using experience as both a shield and a compass, not hiding mistakes but learning from them alongside colleagues up and down the supply chain.

    From Our Shop Floor to Your Project: The Value of Transparency

    Transparency grows from staying honest about what the product can and can’t do. We take time to walk partners through the reasons behind each protocol, and we keep records open for scrutiny. That honesty builds a thicker layer of trust with labs, blenders, and downstream processors relying on this compound as a starting point. We refuse to take shortcuts in documentation, because integrity in reporting creates a culture strong enough to support years of success.

    Staying close to the ground, our team’s commitment to quality, safety, and performance doesn’t come from a list of buzzwords or templated claims. It has been forged batch by batch, growing sharper as both demand and regulatory orders become more complex. As a manufacturer, we see the full lifecycle of this and every chemical; every improvement sinks roots in the details of day-to-day work, meaningful both in the lab and in the final application.

    The Difference on the Ground: Why N-(2,6-Diethylphenyl)-N-Methoxymethyl-Chloroacetamide Continues to Matter

    This compound isn’t new, nor is it a miracle material, but its value keeps growing in our eyes the deeper we understand its quirks and strengths. The edge it offers comes not solely from its structure but from the accumulated know-how wrapped around each shipment. For labs seeking both reliability and flexibility, or formulations that need a stable, clean-reacting intermediate, it holds its ground year after year. Every day we produce it, we’re reminded that the core value of our work lies in the steady, honest effort behind each kilogram sent out to the world.