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Methyl Isobutyrate

    • Product Name Methyl Isobutyrate
    • Alias methyl-isobutyrate
    • Einecs 202-597-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    353492

    Chemicalname Methyl Isobutyrate
    Casnumber 547-63-7
    Molecularformula C5H10O2
    Molarmass 102.13 g/mol
    Appearance Colorless liquid
    Odor Fruity, sweet odor
    Boilingpoint 92-93 °C
    Meltingpoint -95 °C
    Density 0.866 g/cm3 (20 °C)
    Solubilityinwater Slightly soluble
    Refractiveindex 1.376 (20 °C)
    Flashpoint 13 °C (closed cup)
    Vaporpressure 65 mmHg (20 °C)

    As an accredited Methyl Isobutyrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle, securely sealed, labeled "Methyl Isobutyrate," features hazard symbols and detailed handling instructions.
    Shipping Methyl Isobutyrate is typically shipped in tightly sealed drums or containers, clearly labeled with hazard information. It should be transported in accordance with local regulations for flammable liquids, kept away from heat and ignition sources. Adequate ventilation and spill containment measures are essential during shipping to ensure safety and compliance.
    Storage Methyl isobutyrate should be stored in a cool, dry, and well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep the container tightly closed and properly labeled. Store away from incompatible substances such as strong oxidizing agents and acids. Use approved containers made of compatible materials to prevent leaks or spills. Avoid prolonged exposure and keep out of reach of unauthorized personnel.
    Application of Methyl Isobutyrate

    Applications of Methyl Isobutyrate in Industrial Manufacturing

    As a direct manufacturer of Methyl Isobutyrate, we supply industrial users across a focused range of specialized downstream markets. Our material supports critical performance and regulatory needs in each application sector. Below, we detail actual industrial use cases, integrating technical parameters, regulated standards, production process roles, and finished product endpoints.

    1. Solvent Component in Industrial Coating Formulations

    In advanced coating manufacturing, formulators add Methyl Isobutyrate as a film-forming solvent and flow modifier for high-performance paints, inks, and lacquers. The material delivers a moderate evaporation rate, enhancing substrate leveling, gloss, and dry-time control, particularly in nitrocellulose and automotive coatings. Regulatory-driven VOC management often requires precise solvent selection to balance performance and compliance requirements.

    Industry compliance standards

    • EU REACH Regulation (EC) No 1907/2006
    • US EPA 40 CFR Part 59 (National Volatile Organic Compound Emission Standards for Consumer and Commercial Products)
    • China GB 24409—2020 (Limit of Harmful Substances in Industrial Protective Coatings)
    • JIS K 5663:2013 (Japanese Standards for Paints and Related Products)

    Typical usage ratio

    • 2–10% by weight in final coating formulations; formulators adjust within this range to target dry time and VOC content according to application (e.g., wood vs. metal substrates).

    Downstream process integration

    • Added during premix and let-down stages, together with resin and pigment dispersions; producers maintain controlled temperature and agitation to ensure homogeneous solution.

    Final product types

    • Nitrocellulose lacquer for furniture and musical instruments
    • Automotive refinishing basecoats and clearcoats
    • Industrial wood stains
    • High-gloss silk screen printing inks

    2. Extraction Solvent in Food and Flavor Ingredient Manufacturing

    Producers in the food and natural extract sector utilize Methyl Isobutyrate as a specialized extraction and carrier solvent. It plays a role in isolating flavors, fragrances, and food additives where mild polarity and low odor residues are paramount. Compliance with food safety regulations necessitates rigorous validation of residual solvent content and sourcing documentation.

    Industry compliance standards

    • US FDA 21 CFR 173.240 (Solvent Extraction Agents for Food Processing)
    • EU Directive 2009/32/EC (Extraction Solvents in the Production of Foodstuffs and Food Ingredients)
    • FAO JECFA Food Additives List
    • ISO 22000 (Food Safety Management Systems)

    Typical usage ratio

    • Solvent-to-feedstock ratios range from 1:1 to 5:1 by weight depending on target extract and process scale; after extraction, processors recover and recycle solvent to minimize residues and cost.

    Downstream process integration

    • Charged to extraction vessels during batch or continuous percolation; post-extraction, vacuum or atmospheric distillation removes most solvent prior to final concentration or formulation.

    Final product types

    • Natural flavor extracts (such as vanilla and citrus oil concentrates)
    • Food-grade fragrance bases
    • Oleoresins for seasoning blends
    • Specialty food additives (nature-identical flavor compounds)

    3. Fragrance Intermediate in Fine Fragrance Compounding

    Fragrance manufacturers rely on Methyl Isobutyrate as a fruity, ester-based note in perfume, personal care, and home care fragrances. The compound imparts a delicate apple and pineapple character, working as both a direct aroma material and as a blending diluent for oil-soluble phases. Consistent purity and traceability are crucial due to strict ingredient disclosure and allergen assessment regulations in international markets.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Guidelines
    • EU Cosmetics Regulation EC No 1223/2009
    • US EPA TSCA Inventory Listing and Disclosure
    • China GB/T 22731–2017 (National Standards for Perfume Raw Materials)

    Typical usage ratio

    • 0.05–0.5% in fine fragrance concentrates; use varies with desired olfactory intensity and target regulatory thresholds for volatile compounds.

    Downstream process integration

    • Metered into oil phase during premix with fixatives and top/middle notes; batch compounding occurs under inert environment to prevent oxidation and preserve scent profile.

    Final product types

    • Eau de toilette and eau de parfum for luxury markets
    • Personal care products (body mists, deodorants)
    • Home fragrance sprays and diffusers
    • Air freshener gels and liquid refills

    4. Synthesis Building Block for Pharmaceutical Intermediates

    In pharmaceutical chemical synthesis, Methyl Isobutyrate serves as a methylating and esterification intermediate, forming part of multi-step API production workflows. Process chemists employ it to introduce ester functionalities or as a reactant in Grignard and condensation reactions, especially for molecules that require controlled hydrolysis or transesterification steps. Strict quality management and EFSA or pharmacopeia-compliant documentation support batch release.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) purity criteria
    • USP–NF (United States Pharmacopeia–National Formulary)
    • Current Good Manufacturing Practice (cGMP) per ICH Q7
    • ICH Q3C Residual Solvents Guidelines

    Typical usage ratio

    • Acts as a stoichiometric reactant: 1.0–3.0 molar equivalents based on starting material; precise ratio determined by reaction pathway and yield optimization in synthesis route development.

    Downstream process integration

    • Charged to reactor at defined synthetic step (e.g., methylation or ester swap); after reaction sequence, excess is stripped under vacuum or aqueous wash to prepare crude API for purification.

    Final product types

    • Pharmaceutical intermediates for antihypertensive and anti-infective drug classes
    • Active pharmaceutical ingredient (API) precursor esters
    • Reference standards and analytical markers
    • Specialty pharma fine chemicals

    5. Chemical Intermediate for Agrochemical Synthesis

    Manufacturers in the agrochemical sector employ Methyl Isobutyrate as a precursor in the synthesis of pesticides and herbicides, where its ester structure allows selective functional group transformations. Its role as a feedstock in processes such as Claisen condensation or direct alkylation provides control over product selectivity and residue profiles. Compliance with raw material traceability and environmental containment is mandatory for export and regional usage.

    Industry compliance standards

    • FAO/WHO JMPR Pesticide Standards
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • ISO 9001:2015 (Quality Management for Agro Products)
    • China GB 20810—2019 (National Quality Standard for Pesticides)

    Typical usage ratio

    • 0.5–2.5 mole equivalent based on target synthetic route; downstream chemists balance reactant charge to maximize conversion efficiency and minimize unreacted ester.

    Downstream process integration

    • Fed into reaction train during base- or acid-catalyzed coupling stages; post-reaction, spent ester is separated by fractional distillation prior to isolation of active ingredient or formulation base.

    Final product types

    • Herbicide actives (e.g., isobutyric ester derivatives)
    • Insecticidal intermediates for synthesis of esters/ethers
    • Fungicide precursor compounds
    • Technical agrochemical concentrates for formulation
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    Certification & Compliance
    More Introduction

    Methyl Isobutyrate: Practical Insights from the Manufacturer’s Floor

    An Introduction Grounded in Daily Production

    Every day in our plant, Methyl Isobutyrate passes through the hands of technicians who know its every quirk and quality. From the faint, fruity scent that escapes during distillation to the clarity of its colorless liquid pouring from our reactors, we can trace its origins back to the rawest of materials—methanol and isobutyric acid—married by our catalysts under carefully monitored conditions. We do this work because Methyl Isobutyrate keeps industries running, whether it's a fragrance compound developer seeking its signature odorous punch or a coatings technician counting on a fast-evaporating solvent.

    Model and Purity: Delivered as Promised

    In our catalog, the core model is consistently the same, but every lot reveals small variations that matter to customers. Our standard offering comes in purity levels above 99.0%. Over the years, the process has settled into a rhythm: a robust batch process, stainless columns gleaming in the synthesis bay and GC testing at every stage. It’s not just about meeting the specs—it’s about anticipating what customers have seen before. By the end of each run, the liquid we fill into stainless drums holds true to the agreed figures, with water content below 0.1%, acidity kept in check, and a refractive index that signals the correct structural isomer. Technicians don’t just memorize the parameters; they trust in a sensory check—the right aroma profile, a precise boiling range around 96°C—that science and practice both endorse.

    Specifications Shaped by Use and Expectation

    Users in flavors and fragrances lean on the ester’s apple note, so we screen for off-odors, even those below the threshold of instrument detection. Solvent customers inspect haze, demanding a crystal-clear liquid that cuts through paint resins or cleaning agents. Researchers request custom grades, and for those, we tighten controls, dry down even further, and filter the product to sub-micron levels. All this plays out in a schedule that sees shipments leaving by drum, IBC, or tank truck, depending on demand, but the core remains: a volatile, fast-flashing ester that soaks into oily inks and dries quickly off paper or metal.

    Why Methyl Isobutyrate Matters on the Production Line

    Walking through our blending rooms, you see the value of a reliable ester at every turn. Fragrance technicians count on its consistency—batch to batch, year after year—because any drift shifts finished formulations unpredictably. In resins, it serves as a co-solvent, able to cut viscosity without compromising gloss or dry time. Lab teams send us questions about impurity profiles, and we open our books—we know the GC peaks, and we know how even minor byproducts affect outcomes. For clients making reactive resins, our low-water grade means no foaming or loss of activity during crosslinking. We’ve seen paint makers switch from ethyl to methyl esters, reporting faster flash-off times that boost productivity—one less bottleneck to eat into shift hours.

    Usage: Practical Applications from Real Manufacturing

    No two inquiries are identical, but most fall into familiar paths. Flavors professionals want purity and odor profile, looking for that sweet, ethereal note that gives fruit flavors lift without heaviness. They use our product within IFRA and FEMA guidelines, blending it into apple, pear, and pineapple profiles. Down the hall, paint chemists pump in Methyl Isobutyrate for its evaporation rate, which balances between methanol’s speed and butyl acetate’s slower pace. Coating lines benefit from the low residual odor, essential for flooring and automotive applications where scent is a concern. In printing, ink formulators hunt for solvents that dry fast without curling paper—a role Methyl Isobutyrate fills better than longer-chain esters.

    Some end users come from electronics, using our ester in precision cleaning formulations to strip oils and residues without leaving traces on sensitive surfaces. Agricultural researchers employ it as an intermediate in their pesticide actives. We’ve also seen growing interest in green chemistry projects—customers leverage Methyl Isobutyrate’s relatively easy biodegradability for eco-friendly solvent blends, often substituting it for chlorinated or glycol ether alternatives that face regulatory heat.

    What Sets This Ester Apart

    Plenty of esters exist. Each one brings its own volatility, solvency, and compatibility. Methyl Isobutyrate stands out because it strikes a balance rarely matched—fast evaporation, moderate polarity, tolerable odor strength, and low toxicity by the standards of solvent chemistry. Ethyl isobutyrate shares a similar aroma but leaves a heavier, stickier film. Isobutyl acetate flashes more slowly and lingers with that familiar banana-sweet undertone. In coatings work, the quick flash of Methyl Isobutyrate means two-part resins cure faster, and the shorter tail on its odor helps users comply with indoor air requirements. Our QC teams frequently test for hydrolysis and stability, since the lower molecular weight brings more volatility and, at the same time, more risk of water pickup—another reason we invest in robust drying lines and airtight packaging.

    Flavors experts appreciate that even tiny impurity spikes—acetates, isovalerates, or higher alcohols—muddy their blends, so our purification stages target those specifically. Solvent buyers, on the other hand, focus on evaporation rate data and solvency charts, which we’ve generated over countless pilot trials. We’ve even worked with automotive clients on low-VOC clear-coat projects, confirming that our Methyl Isobutyrate lowers system VOC totals without compromising flow and leveling. Developers rely on that reproducibility each time they vet a new batch for regulatory and technical fit.

    Trusted From Sourcing to Final Use

    Factories like ours don’t just ship drums; we answer calls when a new grade or spec is needed. Sometimes, a client needs lower water to avoid hydrolysis in a urethane blend, or tighter controls on acids to prevent trace corrosion in electronics. In our process, that means extra runs through the distillation tower, more frequent calibration of analytical equipment, or custom blending to meet a one-off project. Our technical team often invites clients to visit, so they see not just the end product but the care taken across QA labs, storage rooms, and the filling yard. Genuine transparency builds trust, and over years, that attention to detail sets relationships apart.

    Industry Challenges and Real-World Solutions

    Working with Methyl Isobutyrate, as with any solvent or flavor intermediate, isn’t free from problems. Seasonal variations in upstream raw materials show up as subtle shifts in esters’ purity or byproduct profile. Keeping impurity levels steady takes more than just a spec sheet: it calls for tight supplier relationships, frequent lab checks, and adjustments in catalyst composition or process temperature that only long-term plant staff know to make. Bottling success means honoring customer specifications—whether a batch needs ultralow odor or custom filtration.

    Handling the chemical safely comes up constantly in production meetings, too. Even with low toxicity, the rapid evaporation can present flammability risks, especially during warm, busy production cycles. Plant protocols keep loading bay risks low: dedicated transfer lines, explosion-proof pumps, and regular fire drills. We chose packaging strategies based on experience: nitrogen padding in drums to limit oxidation, heavy-gauge steel to minimize vapor loss, shrink wrap to stabilize pallets for freight. Supporting customers with safe, consistent material every time has a ripple effect on their own production safety and yield.

    Customers in flavors and food applications ask for assurances on food-contact status and migration data, so we’ve invested in tracing every step from raw materials to fill point, keeping records available for audits and certification. For customers outside the standard envelope—industrial cleaners, specialty resins, or custom fragrances—we offer technical service. Our experts troubleshoot real blending issues, from haze and phase separation to unexpected reactivity. This hands-on approach keeps us close to the application, not just the raw data.

    Environmental and Regulatory Realities

    Compliance shapes much of what we do. Solvent users watch regulatory lists closely; rules change, and suddenly a once-standard chemical lands on a restricted list. Methyl Isobutyrate’s lower hazard profile helps customers keep their formulas on the market, especially as VOC and HAP restrictions tighten in North America and Europe. Our own internal audits check emission loads, and we regularly review methods for solvent recovery and waste minimization. Where possible, we reclaim process solvents, distill side streams, and invest in improved vent scrubbing to cut plant emissions. The result is a more responsible operation, with benefits that carry downstream for anyone using our ester, whether it’s to lower VOC totals in architectural paint or to ease registration of a new flavor or fragrance compound.

    Notable Differences From Competing Esters

    Some makers chase higher yield or lower input cost, often tolerating broader impurity bands. In contrast, our focus keeps the product within a narrow, high-purity window, even at the expense of processing time. Where other manufacturers split their lines or batch multiple esters through shared columns, risking cross-contamination, we run Methyl Isobutyrate on dedicated lines to keep flavor and solvent grades distinct. Customers who’ve tried competing imports tell us they spot the difference in bottle-to-bottle consistency and in the finished product’s stability. Because many applications draw on its aroma, even tiny shifts in isomer ratios or acid content stand out. Our teams run comparative tests on every competitor sample we acquire—blind odor checks, solvent strength assays, residue-on-evaporation panels—so we know where our batches outperform, and what margin for improvement remains.

    Technical staff discuss with us how the purity and water content affect reaction yields or shelf life in sensitive end products. That’s why we fine-tune the dehydration steps and guard against cross-reactivity in storage. The real test comes not in the lab, but on your own production line, where a stray impurity can halt an entire shift or reset a months-long stability protocol. We take pride in feedback that highlights how Methyl Isobutyrate from our line cuts uncertainty in their processes, leading to fewer line shutdowns and less batch rework.

    Real Feedback From the End-user Chain

    At trade meetings and in technical service calls, we hear firsthand about what customers notice: strong solvency with manageable odor, minimal side products even after months in storage, and suitability for both high-end fragrance and large-scale industrial runs. Some describe moving from butyl esters and seeing improved drying in production-scale paint jobs; others highlight the absence of residual odor as a game-changer for consumer goods. Small specialty blenders appreciate access to low-minimum custom runs—something we can only offer thanks to efficient scheduling and excess distillation capacity. That agility matters when deadlines loom or specs shift suddenly.

    Support doesn't end on shipment day. Our technical service teams field questions on best handling, blending guidance, and even regulatory submission paperwork. We troubleshoot formulation snags and process hiccups as part of the ongoing relationship. That cooperation, rooted in decades of actual production experience, marks a difference that clients notice and value.

    Innovation and Continuous Improvement

    In the plant’s R&D wing, small teams keep pushing the chemistry and process controls forward. We experiment with new catalysts, energy-saving recovery systems, scale-up strategies to match customer demand, and on-site analytical improvements. Sometimes changes come from outside—in response to a client’s new regulatory requirement or a creative usage proposal. Other times, they're the product of operator insights, adjusting a process step to shave 0.1% off an impurity band or cut the cycle time by a few hours. That feedback loop, from operator to supervisor to technical manager, shapes a safer, cleaner, more consistent Methyl Isobutyrate and trims unnecessary waste. We share these improvements with customers, not just as a sales pitch, but because collaborative progress keeps the entire supply chain resilient to shifts in regulations or market needs.

    Looking Ahead: Trends and Adaptation

    Demand is climbing for more eco-friendly solvents and flavor ingredients. Regulatory bodies push for transparency and traceability, making real-time batch tracking and full documentation necessary. Our systems adapt with new IT and automation tools—traceability all the way from the raw acid shipment to finished drums. As downstream industries push toward biobased sourcing, we’re investing in methods to use renewable feedstock, even trialing pilot runs with plant-based methanol. Such transitions take time, and every pilot run is checked for consistency and compatibility with established customer applications.

    Final Thoughts on Reliable Manufacturing

    The true test of Methyl Isobutyrate comes not in data sheets or lab specs, but in how reliably it helps customers do their work. Whether keeping a flavor blend stable or ensuring a batch of coatings cures quickly and cleanly, the goal remains unchanged. A product that performs the same way, time after time, saves effort, supports regulatory compliance, and keeps production lines moving smoothly. From vetting every drum we fill to collaborating with customers on new uses, we remain committed to a transparent, hands-on approach, using knowledge built over years of daily experience on the manufacturing floor. That’s how we define the standard for Methyl Isobutyrate—by delivering each lot as if we were using it in our own formulas.