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Methyl 2,2-Dimethylpropionate

    • Product Name Methyl 2,2-Dimethylpropionate
    • Alias methyl-pivalate
    • Einecs 226-535-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    707357

    Chemical Name Methyl 2,2-Dimethylpropionate
    CAS Number 595-41-5
    Molecular Formula C6H12O2
    Molecular Weight 116.16 g/mol
    Appearance Colorless liquid
    Boiling Point 106-108 °C
    Melting Point -65 °C
    Density 0.878 g/cm3 at 25 °C
    Refractive Index 1.394
    Purity Typically ≥ 98%
    Flash Point 16 °C (closed cup)
    Solubility in Water Insoluble
    Odor Fruity
    Storage Temperature Store at room temperature
    SMILES CC(C)(C)C(=O)OC

    As an accredited Methyl 2,2-Dimethylpropionate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 500 mL of Methyl 2,2-Dimethylpropionate, tightly sealed, labeled with hazard warnings and product information.
    Shipping **Shipping Description for Methyl 2,2-Dimethylpropionate:** Methyl 2,2-Dimethylpropionate should be shipped in tightly sealed containers, protected from heat, moisture, and direct sunlight. Transport in accordance with local regulations for flammable liquids, using appropriate labeling and safety documentation. Ensure containers are upright and secure to prevent leakage or accidental release during transit. Handle with care.
    Storage Methyl 2,2-dimethylpropionate should be stored in a cool, dry, well-ventilated area away from heat, open flames, and direct sunlight. Keep the container tightly closed and clearly labeled. Store away from strong oxidizing agents, acids, and bases. Use appropriate chemical storage cabinets and ensure proper secondary containment to prevent spills. Handle with appropriate personal protective equipment (PPE).
    Application of Methyl 2,2-Dimethylpropionate

    Applications of Methyl 2,2-Dimethylpropionate in Industrial Manufacturing

    As a specialized producer, we supply Methyl 2,2-Dimethylpropionate to a select set of chemical manufacturing industries requiring reliable ester intermediates. Each downstream application follows rigorous operational and regulatory frameworks to ensure product safety, quality, and process consistency.

    1. Pharmaceutical Intermediate for Synthesis of Active Pharmaceutical Ingredients (API)

    Pharmaceutical manufacturers use this ester intermediate for constructing specific side chains in non-steroidal anti-inflammatory drugs and certain anti-infective APIs. Its high purity and controlled reactivity support multi-step synthesis, including alkylation and condensation reactions where low water content and precise dosing are essential. It enables chemists to introduce branched structures more efficiently compared to other propionates in scale-up environments.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP <823> Chemical Purity Requirements
    • EMA Guideline on the chemistry of APIs
    • 21 CFR Part 211 (US FDA cGMP)

    Typical usage ratio

    • Applied at 0.3-1.5 molar equivalents per batch, adjusted according to the synthesis route and yield optimization results
    • Dosing adjusted based on crude purity by in-process HPLC analysis

    Downstream process integration

    • Charged after base catalyst addition in esterification step
    • Reactive intermediate isolated before pharmaceutical final coupling reaction

    Final product types

    • Anti-inflammatory tablet actives
    • Broad-spectrum antibiotic intermediates
    • API precursors for hospital injectables

    2. Resin Modifier in High-Performance Coatings

    Coatings manufacturers blend methyl 2,2-dimethylpropionate into alkyd and acrylic resin formulations to adjust molecular weight distribution and boost final film flexibility. The ester’s unique steric profile promotes faster cross-linking and improved weather resistance, essential for exterior structural coatings and marine paints. Precise integration helps deliver consistent gloss levels and controlled curing rates under variable humidity.

    Industry compliance standards

    • ASTM D16 Standard Terminology for Paints and Related Coatings, Materials, and Applications
    • ISO 12944-6:2018 for Paints and Varnishes—Protection of Steel Structures
    • REACH Regulation (EC) No 1907/2006—Substance Registration
    • RoHS Directive 2011/65/EU for restricted substances

    Typical usage ratio

    • Added at 2–7% weight by total resin solids, depending on required flexibility and solvent evaporation rates
    • Adjustments based on viscosity development and film hardness test results

    Downstream process integration

    • Blended into resin pre-polymer stage under controlled temperature to achieve uniformity at molecular level
    • Monitored via GPC molecular weight analysis after polymerization

    Final product types

    • Marine protective coatings
    • Automotive OEM clearcoats
    • Industrial metal primers

    3. Synthesis Agent in Agrochemical Formulations

    Crop protection and agrochemical manufacturers employ methyl 2,2-dimethylpropionate as a significant intermediate for constructing ester-linked pesticide scaffolds. Extreme purity is vital, as byproducts can affect downstream biological activity and field stability. Chemical process engineers use real-time GC tracking to tailor input levels, reducing unreacted residues and ensuring consistent batch-to-batch application performance.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EPA FIFRA guidelines on inert ingredients
    • ISO 1750:2015 Pesticides and other agrochemicals—Common names
    • Good Laboratory Practice (GLP) as per OECD

    Typical usage ratio

    • Used at 0.2–0.8 eq in target molecule synthesis
    • Levels determined by conversion rates measured after reaction completion (HPLC test)

    Downstream process integration

    • Combined with amine or acid function in condensation reactor
    • Phase separation and purification before formulation into wettable powders or ECs

    Final product types

    • Herbicide esters
    • Pyridine-based fungicides
    • Selective insecticide intermediates

    4. Monomer Precursor for Polymeric Additives

    Producers of specialty polymers integrate this ester in the monomer synthesis phase to impart branched chain architecture, enhancing thermal and hydrolytic resistance of additives. Its predictable reactivity minimizes undesired side-products and enables narrow polydispersity profiles in block copolymers. Quality control tracks each batch using SEC and FTIR to assure consistent incorporation.

    Industry compliance standards

    • ISO 9001:2015 for Quality Management Systems in polymer production
    • ISO 11357 for polymeric material thermophysical properties
    • REACH compliance for new chemical substances
    • DOE Good Manufacturing Practices for chemical intermediates

    Typical usage ratio

    • Feeds at 1–4 mol% relative to total monomer content; specific loading varies with targeted MW and additive function
    • Monitored using batch analysis during continuous or batch polymerization

    Downstream process integration

    • Added during pre-polymer mixing before radical initiator introduction
    • Polymerized in nitrogen-purged vessels under temperature control to avoid degradation

    Final product types

    • Antistatic masterbatch additives
    • Viscosity index improvers for oil formulations
    • Impact modifiers for engineering plastics

    5. Chemical Intermediate in Fragrance Ester Manufacturing

    Fragrance compound manufacturers rely on methyl 2,2-dimethylpropionate to build branched esters that serve as key aroma notes in fine fragrance and air care systems. The compound supports high-yield transesterification processes, enabling consistent olfactory profile delivery. Critical process controls maintain low impurity levels, as even trace contaminants can impact scent fidelity in the end-use environment.

    Industry compliance standards

    • IFRA Code of Practice for fragrance ingredient safety
    • EU Regulation (EC) No 1223/2009 on cosmetic products
    • ISO 9001 for fragrance chemical manufacturing
    • SAFETY DATA SHEET (SDS) conformance

    Typical usage ratio

    • Used at 5–15% of total ester feedstock in reaction batch, adjusted per desired scent volatility and structural properties
    • Process optimization via GC-MS profile matching

    Downstream process integration

    • Mixed with target alcohol under acid catalysis in batch reactors
    • Isolated by vacuum distillation before formulation to bulk concentrate

    Final product types

    • Fine fragrance bases
    • Room air freshener esters
    • Specialty flavor and aroma ingredients for beverages
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    Certification & Compliance
    More Introduction

    Methyl 2,2-Dimethylpropionate—Precision from Manufacturer’s Bench

    Direct From the Source: A Product We Know Inside Out

    Years of hands-on production and continuous improvement have shaped our expertise with Methyl 2,2-dimethylpropionate. Every batch reflects deliberate choices, tight control, and a clear understanding of what chemists, engineers, and formulators want. Unlike traders or resellers, our perspective grows from thousands of production hours and direct feedback from those shaping industries. We hold ourselves accountable for quality at every level.

    Getting the Details Right—Model, Specification, and Real-World Handling

    You’ll find our standard material supplied as a transparent, colorless ester, produced at high consistency for applications demanding reliable performance. Typical specifications target high purity—with GC analysis confirming levels above 99%—and water content kept below strict limits. We keep acid value low to avoid unwanted side reactions when our product enters your process. Boiling range and refractive index are measured and recorded for batch traceability. Our production uses stainless-steel reactors to keep out iron contamination, and dried nitrogen for transfer to prevent moisture pickup. These steps matter, especially for formulations sensitive to trace impurities.

    Technically, this compound answers to the chemical formula C6H12O2. Our line usually supplies it by model code MDP-001 or equivalent, though tailored grades with tighter impurity profiles stand ready if the situation demands. We focus efforts on making sure what comes out of the reactor will face the real demands of your reaction kettle, pilot plant, or formulation workshop with no surprises.

    How Customers See Real Benefit—Where It Delivers in Industry

    Methyl 2,2-dimethylpropionate slots into several specialty and intermediate roles. Most commonly it appears as a starter, intermediate, or blocking group in organic synthesis pathways—its structure opens options for introducing tert-butyl branches or protecting groups. We’ve seen customers choose it where they need ester groups that don’t easily hydrolyze, or where the bulkier tert-butyl side chains influence the sterics in downstream products. Several pharmaceutical and agricultural chemical developers rely on this trait for creative molecule design. Custom polymer chemistries sometimes use our product as a building block, adding control to the backbone microstructure. Solvent and carrier applications surface now and then—its volatility and low odor prove useful in controlled-release or fast-evaporation formulations.

    Lab projects and pilot plants often need lots trimmed to exactly fit a synthetic campaign, and our custom container options—from kilogram buckets to packed drums—have kept those teams on schedule. Consistency over multiple deliveries determines their trust; we back that by holding retention samples and sharing full lot COAs on demand. When projects move from bench scale to full plant run, we’ve supported scale-ups with adjusted viscosity, tailored bulk density, or even reworked handling protocols so everything keeps running safely and efficiently.

    What Sets It Apart—Choosing This Over Other Esters

    Direct experience tells us Methyl 2,2-dimethylpropionate earns its spot not by being the cheapest ester, but by offering something extra in reactivity and control. Compared to methyl acetate or methyl propionate, this material stays robust against hydrolysis under moderate conditions. It has allowed some customers to skip tedious purification steps they would otherwise face. Its steric hindrance distinguishes it from straight-chain methyl esters—this effect brings out selectivity in some syntheses where unwanted rearrangements or transesterifications would cut into yield.

    Technologists running pilot studies have described how the extra bulk around the ester group gave superior blocking properties in multifaceted molecule construction, especially under acid or base exposure. That’s not something you get from simpler linear esters, and for some fine chemical pathways, this small difference has a big financial and practical impact. Also, differing volatility means this ester will persist where methyl acetate flashes off—an advantage in controlled applications needing slower evaporation or targeted delivery.

    Real Challenges—From Production to Final Use

    Manufacturing and supplying this ester taught us about real-world hurdles. Its sensitivity to moisture and air during synthesis means we fine-tune all steps—otherwise, you risk methyl isobutyrate by-products or water traces. Logistics play a role, especially with the need for clean, sealed drums; no one wants garbage data from a formulation ruined by airborne particles or leached plasticizers. We faced early problems with drum liners affecting product stability, which led us to switch suppliers and test compatibility with aggressive solvents.

    Customer QC teams sometimes highlight issues only apparent after weeks in storage or following export transit at high temperatures. Our technical support works with those labs directly—a conversation between those who make it and those who use it, not a chain of go-betweens repeating the same generic instructions. That’s led us to implement short-cycle feedback and put more sampling and retention protocols in place, slashing the risk of stray impurities escaping notice.

    A handful of users flagged occasional trace isobutyric acid as a concern for sensitive reactions. Fine-tuning temperature gradients, checking catalyst selection, and stepping in with advanced purification has brought those levels to well below one part-per-thousand. This is the work traders and distributors can’t replicate—the heart of specialty chemical production comes down to personal accountability for every drum, every label, every lot ticket.

    Environmental and Safety Considerations

    No modern operation ignores environmental controls. Our synthesis routes optimize yield to squeeze out as much value from feedstock as possible. We operate under local environmental guidelines and achieve emissions that stand below regulatory thresholds. By recycling process solvents and handling waste on-site, we lessen exposure risks for our team and limit the load sent out for disposal.

    Safe handling is built on long shifts in the plant room, where our technicians deal with the low, understated odor of the ester and respect its mild flammability. Safety sheets and real training matter—ventilated transfer, proper PPE, ground-tight drum handling, and thorough clean-out of all process lines. Storage at controlled temperatures keeps the product’s strengths sharp and avoids slow, undetected degradation. These details build trust with users, because they don’t have to second-guess the risks built into their upstream materials.

    Ongoing Innovation and Listening to the Customer

    Product development never stops. While the chemistry of Methyl 2,2-dimethylpropionate looks simple on paper, the needs of real customers change with new process demands. We’ve invested in smaller-scale pilot plants to experiment with alternative catalysts and greener solvents, always watching out for batch-to-batch reproducibility. Some partners ask about scaling from small drums to ISO-tanks, which brings new challenges—shipping environment, agitation on ocean freight, and compounded quality control with bulk volumes. We’ve adapted by keeping a technical team on-call, ready to troubleshoot both in-house and at the receiving site.

    Feedback from experienced chemists out in the field spurs improvements. Some synthetic routes now require even tighter controls on acid number or color index. We respond by revising purification and filtration routines, bringing in new analytical equipment when needed. Training our teams on evolving hazards and compliance standards forms part of our routine, passing that confidence on to our customers.

    Supply chain reliability has crept up as a theme in recent years, especially among buyers frustrated by missed shipments or variable purity from third parties. Our direct manufacturing means traceability never gets lost. We offer clear documentation—lot histories, signed-off release data, and real-time support—so you’re not left wondering where your critical intermediate came from or whether it matches this month’s batch to the last.

    Shaping Standards by Listening to Practice

    Being a manufacturer means learning from hands-on realities, not just synthesis journals or sales literature. Customer process failures occasionally trace back to minute differences in starting materials, so we work with partners running pilot plant trials, scale-ups, or new product registration projects. They tell us about solubility quirks, downstream odor liability, and late-process stability in their formulations. We update our technical files to capture these outcomes, which points right back to batch reviews and production tweaks.

    Real trust in specialty chemicals comes from accountable, knowledgeable suppliers. Our direct involvement lets us blend production experience with on-the-ground feedback, helping to define what “good enough” means for Methyl 2,2-dimethylpropionate in different industries. That keeps technical teams agile and allows creative process improvement from both ends—lab and plant floor.

    Key Lessons—Why It Matters to Work with the Manufacturer

    Our story speaks to the heart of specialty chemical manufacturing. A trader might quote lots or offer a data sheet, but only years of making, handling, and troubleshooting build the kind of expertise our customers value. From raw materials right through synthesis, purification, drumming, and customer handoff, knowledge grows with every production run.

    Having a direct line between user and producer cuts time troubleshooting, ensures variability gets contained quickly, and means feedback drives real change. When end users care about product stability, impurity profiles, or tweak their reaction conditions for new markets, having a direct relationship saves money, energy, and lost time.

    Cheaper, more bulk-available esters exist, but the difference seen in process yield, waste profiles, or formulation reliability builds up over time. Our pride lies not in hitting the lowest price but in keeping promises—know your source, know your product, and know that every drum or tote reflects what our team has learned, often in sweat, about what makes Methyl 2,2-dimethylpropionate valuable for you.

    Choices and Outlook—Sustaining Value through Deep Practice

    Those choosing Methyl 2,2-dimethylpropionate know there’s no one-size-fits-all option in modern chemical manufacturing. We respect that, matching our production flexibility to a diversity of applications. Projects in pharmaceuticals, polymers, agrochem, and emerging materials demand not just purity but reliable supply and technical nuance. As chemistry projects push further—demanding greener processes, lower emissions, or new formulation performance—we see our experience as an advantage, not an afterthought.

    The future asks for more than a product listing. It asks for a partner able to respond to new process needs, quickly adapt handling or quality routines, and communicate openly when the unexpected happens. Our strength lives in walking that line—open to new insight, strict with process, focused entirely on what keeps our users turning new ideas into working products.