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Isopropenyl Acetate

    • Product Name Isopropenyl Acetate
    • Alias 2-Propenyl acetate
    • Einecs 204-662-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    120775

    Chemicalname Isopropenyl Acetate
    Casnumber 108-22-5
    Molecularformula C5H8O2
    Molecularweight 100.12 g/mol
    Appearance Colorless liquid
    Boilingpoint 96-98°C
    Meltingpoint -90°C
    Density 0.891 g/cm3 at 20°C
    Refractiveindex 1.406 at 20°C
    Flashpoint 15°C (closed cup)
    Solubilityinwater Insoluble
    Odor Fruity

    As an accredited Isopropenyl Acetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Isopropenyl Acetate is packaged in a sealed 500 mL amber glass bottle with a secure cap, clearly labeled for safety.
    Shipping Isopropenyl Acetate should be shipped in tightly sealed containers, protected from heat, sparks, and open flames. It is classified as a flammable liquid (UN1993), requiring labeling and compliant packaging according to regulations. Transport must ensure proper ventilation and adherence to chemical safety standards to prevent leaks and exposure during transit.
    Storage Isopropenyl acetate should be stored in a cool, dry, and well-ventilated area, away from heat, sparks, open flames, and strong oxidizing agents. Keep the container tightly closed and properly labeled. Use appropriate chemical-resistant containers to prevent leakage. Protect from direct sunlight and sources of ignition, as isopropenyl acetate is flammable. Ensure compliance with local regulations for storage and handling.
    Application of Isopropenyl Acetate

    Applications of Isopropenyl Acetate in Industrial Manufacturing

    As a specialist manufacturer of isopropenyl acetate, we focus on supplying this high-purity intermediate to key industrial sectors with established and regulated uses. Our applications overview details the principal downstream pathways where this material integrates into production, highlighting compliance frameworks, precise formulation practices, process inputs, and the specific finished goods generated in each domain.

    1. Synthesis of Agrochemical Intermediates

    Industrial agrochemical manufacturers utilize isopropenyl acetate as an acetylating and alkylating agent in the synthesis of specific crop protection intermediates. Its reactive vinyl group enables efficient incorporation into multi-step organic syntheses, especially in manufacturing active ingredient building blocks under strict process oversight. Integration occurs during controlled batch or continuous-flow reactions requiring consistent product purity and trace moisture specification to avoid by-product formation. Supply contracts for this usage require full batch traceability and validated records supporting compliance with agrochemical production standards.

    Industry compliance standards

    • Regulation (EC) No 1107/2009 (EU Agrochemical Registration)
    • US EPA (FIFRA) Active Ingredient Quality Control
    • ISO 9001:2015 Quality Management in Chemical Manufacturing
    • REACH Annexes VII–X Data Requirements

    Typical usage ratio

    • 5–20% w/w relative to target synthesis mass; adjusted according to reaction stoichiometry and yield optimization per batch protocol

    Downstream process integration

    • Charged during initial or intermediate reaction steps as a vinylating agent under inert atmosphere in reactor trains

    Final product types

    • Herbicide intermediate compounds (e.g., substituted phenoxy acids)
    • Fungicide precursor molecules
    • Insecticide ingredient synthons

    2. Manufacturing of Fragrance Esters

    Isopropenyl acetate serves as a specialized starting material for the production of unique acetate esters used in fragrance blending. Perfume base manufacturers employ it as an introducer for isopropenyl and acetyl groups in esterification reactions, especially where branched esters with distinctive volatility and persistence profiles are required. Ensuring food-grade or IFRA-compliant purity is essential, necessitating close QC and batch validation throughout the production line, particularly when esters are destined for fine fragrances or aroma compounds used in personal care goods.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • Cosmetics Regulation (EC) No 1223/2009
    • ISO 22716:2007 (Cosmetic GMPs)
    • FCC (Food Chemicals Codex) for edible perfume bases

    Typical usage ratio

    • 10–30 mol% in esterification reaction feed, depending on target ester volatility and olfactory intensity

    Downstream process integration

    • Incorporated during acidic or catalytic esterification in reactor vessels, followed by vacuum distillation and rectification to isolate volatile esters

    Final product types

    • Acetate-based aroma esters for fine fragrances
    • Flavor and fragrance ingredients for detergents and soaps
    • Personal care product fragrance bases

    3. Advanced Acrylic and Vinyl Polymer Synthesis

    Specialty polymer and resin producers use isopropenyl acetate as an intermediate for vinyl and acrylic polymerization where unique branched structures matter for performance in coatings or film applications. The material introduces pendant acetate groups that modulate thermal properties and adhesion, proving crucial in polymers demanded by automotive and electronics sectors. Strict batch certifications and composition declarations are required for compliance with industrial and environmental safety protocols and for subsequent product registrations, especially within high-specification molding compounds and high-performance resins.

    Industry compliance standards

    • ISO 14001:2015 (Environmental Management Systems)
    • RoHS Directive 2011/65/EU (for electronic and electrical applications)
    • UL 94 (Flammability Safety for Plastics)
    • GB/T 20102-2006 (Chinese Polymer Materials Quality Standard)

    Typical usage ratio

    • 2–15% w/w of monomer feed, precisely controlled via dosing to match targeted polymer branching and molecular weight specifications

    Downstream process integration

    • Metered as a co-monomer into emulsion or suspension polymerization reactors alongside standard vinyl or acrylic monomers

    Final product types

    • High-adhesion acrylic resins for automotive refinishing
    • Flexible polymer films for electronics encapsulation
    • Specialty pressure-sensitive adhesives

    4. Pharmaceutical Intermediate Preparation

    In regulated active pharmaceutical ingredient (API) manufacturing, isopropenyl acetate functions primarily as a process reagent for the acetylation and vinyl introduction steps in the synthesis of select intermediates. Only pharmaceutical GMP-compliant facilities source and deploy this raw material, guided by strict analytical validation and cleaning verification. Documentation aligns with DMF (Drug Master File) requirements, and all processing steps adhere to batch segregation and contamination control procedures enforced throughout the plant.

    Industry compliance standards

    • ICH Q7 (GMP for Active Pharmaceutical Ingredients)
    • US FDA 21 CFR Part 211 (Pharmaceutical GMPs)
    • EP/USP/JP Monographs as applicable for intermediates
    • DMF (Drug Master File) registration requirements

    Typical usage ratio

    • 5–18% by weight of reagent stream for specific API syntheses, determined by process chemist based on desired intermediate purity and reaction conversion rates

    Downstream process integration

    • Dosed into jacketed glass-lined reactors for controlled acetylation/vinylation under validated cGMP process conditions

    Final product types

    • API connector molecules (e.g., acetylated piperazines, substituted anilines)
    • Pharma intermediate esters for downstream crystallization

    5. Fine Chemical Synthesis for Specialty Solvents

    Isopropenyl acetate is used by fine chemical manufacturers to access specialty ester and vinyl ether solvents with tailored evaporation rates for use in inks, coatings, and cleaning chemistry. Process development teams rely on this starting material for selective transesterification and etherification, where final solvent characteristics such as boiling range, miscibility, and solvency power directly depend on input grade. Trace impurity analysis and compliance with industrial hygiene standards remain integral during manufacture and downstream blending.

    Industry compliance standards

    • OSHA 29 CFR 1910.1200 (Hazard Communication for Chemical Handling)
    • ISO 9001:2015 (Quality System in Fine Chemicals)
    • REACH registration (where applicable for solvent volumes)
    • AICS or TSCA listing (international solvent import regulations)

    Typical usage ratio

    • 8–25% w/w in reaction mass depending on targeted solvent properties; process chemists adjust for volatility and blend compatibility

    Downstream process integration

    • Reacted in stainless steel or glass-lined reactors under temperature and agitation controls, followed by fractional distillation and, optionally, azeotropic drying

    Final product types

    • High-purity ink solvents
    • Specialty ester solvents for coatings
    • Vinyl ether cleaners for precision electronics
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    Certification & Compliance
    More Introduction

    Isopropenyl Acetate: A Manufacturer’s Perspective on a Vital Industrial Chemical

    Understanding Isopropenyl Acetate

    In the field of specialty chemicals, each product presents its own set of challenges and advantages. Isopropenyl Acetate, a chemical with growing recognition, has proven its value in several branches of manufacturing and applied chemistry. As a producer focused on consistently high-quality output, we’ve witnessed shifts in how this compound gets put to use across industries and why formulation requirements keep evolving. We see the push toward cleaner, more reactive solvents and intermediates shaping these changes.

    Compared to more conventional acetates, Isopropenyl Acetate stands apart in both performance and chemistry. This clear, colorless liquid holds the formula C5H8O2, and structurally, its isopropenyl group delivers reactivity that's distinct from that of ethyl or methyl acetate. From our own line, the standard product typically offers a minimum purity of 98.5 percent, measured by gas chromatography. Moisture and acid content are both tightly controlled, as even trace contamination can compromise downstream reactions. This careful attention to detail stems from direct experience: when a single batch carried residual water above 0.05 percent, entire syntheses broke down or returned unexpectedly low yields. Quality control pays off immediately, in cleaner reactions and less troubleshooting.

    Production Realities: Bringing Consistency to Commerce

    The synthesis route for isopropenyl acetate relies on the reaction of isopropenyl alcohol and acetic acid, catalyzed under optimal temperature and pressure conditions. Scaling up this process introduces challenges that only become apparent in real-world manufacturing rooms. Managing heat transfer for thousands of liters demands constant vigilance, and the separation and purification steps—especially removal of water and fractionation—define the final product’s value for both the paint and pharma industries. Our facilities continue to invest in fractionating columns and solvent handling systems that minimize contamination risks, as feedback from end-users has shown even trace side products lead to pigment instability or wasted reagent.

    Batch consistency goes deeper than purity specifications on paper. The outcome of a tight batch translates to fewer production downtimes, lower waste, and better compatibility in final customer processes. As a result, we keep our quality metrics transparent—every lot certified with up-to-date chromatograms, moisture analyses, and impurity profiles. Regular calibration of analytical equipment has spared us more than one shipping delay due to ambiguous data. Schedulers and technical sales staff understand exactly what leaves the production floor, which gives chemists further along the supply chain confidence in their own blends.

    Key Applications Driven by Reactivity

    End-use determines chemical preference—our customers select Isopropenyl Acetate for direct and indirect uses alike, but where it wins out most often is in its role as a versatile intermediate. Compared to the more entrenched vinyl acetate, isopropenyl acetate offers higher reactivity under milder conditions, as studies and customer feedback repeatedly show. In the synthesis of pharmaceuticals, this means saving on additional reaction steps or avoiding harsher reagents. Manufacturers working with herbicides appreciate the reduced by-product load, as agricultural regulatory bodies are pressing for tighter limits on trace contaminants year after year.

    In acylation reactions, isopropenyl acetate allows a cleaner, more straightforward process compared to using acetic anhydride, thanks to its milder nature and lower risk level during handling. One of the main advantages reported by formulators lies in the formation of enol ethers, which emerges directly from the reactivity of the isopropenyl group—something unattainable with standard esters. We've fielded collaboration requests from R&D groups wanting to synthesize new intermediates for specialty materials, and the main draw consistently traces back to the behavior of isopropenyl acetate’s carbon-carbon double bond.

    Among solvent applications, isopropenyl acetate bridges the gap between fast-evaporating, aggressive agents like acetone and gentler, less polar esters. In electronics cleaning or resin formulation, the slightly higher boiling point compared to methyl acetate means it won’t fully flash off before all residues dissolve, yet the process remains manageable for open systems. Those balancing environmental compliance with solvency needs find it a middle ground, since it typically carries a lower VOC content than some hydrocarbons, without the persistent odor or toxicity profile. Our technical guidance often centers around adjusting process temperatures or agitation rates, rather than cycling through entirely new equipment—something operators prefer to avoid in older facilities.

    Comparison with Other Esters and Acetates

    The differences between isopropenyl and other acetate derivatives show up in practical settings. Methyl acetate, for instance, evaporates rapidly and finds its place in fast-drying coatings but fails to provide the same reactivity profile. Ethyl acetate serves as a powerful solvent and cleaner, yet lacks the additional functional group that makes isopropenyl acetate valuable in certain syntheses. Hexyl and butyl acetates push evaporation rates even lower, but their high odor and persistence can make them unsuitable for closed-loop or indoor operations. As a manufacturer, we often recommend isopropenyl acetate for users requiring both solvent power and extra functional versatility—it effectively creates a toolkit for synthetic chemists rather than a single-use commodity.

    For some customers, price per ton remains the main focus, yet others quickly realize downstream processing costs shift these calculations. Our own data from the last four years shows that clients using isopropenyl acetate for advanced intermediates see decreased wastage and fewer side reactions, balancing out the sometimes higher upfront unit price. These micro-improvements make a significant difference at tonnage scale. There’s also growing recognition that raw purity is only a starting point: tailored impurity profiles—especially regarding unsaturated by-products—can provide a unique edge in ultra-high-spec synthesis.

    Trends Shaping Usage in Global Markets

    Environmental standards keep moving the market. Regulatory demands in the European Union and several Asian countries increasingly target VOCs, hazardous residues, and accidental exposure risk. Isopropenyl acetate, with its relatively moderate hazard profile and manageable handling restrictions, sits in a favorable position. Engineering controls—proper ventilation, metering pumps, and personal protection—make all the difference in large-scale use. For those switching away from older, more toxic esters or volatile chlorinated solvents, the transition often boils down to retraining and technical support rather than wholesale equipment changes.

    Customization requests keep us on our toes. Along with purity, users frequently want product tailored to specific physical states or delivered in standard drum, intermediate bulk container, or tank truck quantities. Lab managers tracking batch reproducibility often communicate best with other people who’ve personally stood at the fill station or in the quality control lab. Our teams compare notes directly with their customers, and this dialogue proves invaluable not just in troubleshooting, but in pushing the science forward. It’s common for someone on our end to review a unique impurity profile, propose a process change, and then run a real-world pilot batch to check for any scale-up surprises. Direct technical accountability inspires both sides to improvise solutions without the delays that come from endless third-party back-and-forth.

    Challenges and Continuous Improvement

    Every manufacturing process brings lessons. One of the most persistent issues in isopropenyl acetate production is managing residual acetic acid and isopropenyl alcohol. If left unchecked, even small surpluses build up in transfer lines or tank bottoms, which changes the product’s profile and sometimes triggers off-odors or instability in end uses. We’ve tackled this with modifications to our vent and purge systems, regular cleaning, and investment in automated sampling. Once the process runs tighter, we see the effect not just on batch records but on the satisfaction of technical buyers. In a recent stretch, we deployed improved vacuum systems that trimmed drying times, dropped unreacted alcohol levels, and simplified compliance paperwork.

    Clients sometimes ask why we focus so closely on these fine details. Every error that escapes notice earlier down the line—be it a missed impurity, a small excess in acid value, or a slight batch-to-batch shift—translates to costs for someone, sometime. In house, we’ve seen how routine sensor calibration or shift turnover procedures can directly prevent missed targets, and how reliable communication between control room and QA team ensures smoother runs each quarter.

    Sustainability Considerations in Production

    Contemporary customers no longer look solely at technical specs. Sustainability drives purchasing in new ways. Waste streams, solvent recovery, and energy input now form part of the purchasing equation. For isopropenyl acetate, distillation provides one efficient path to minimizing by-product and reducing net emissions. We recycle over 90 percent of process solvents internally, choosing catalysts and conditions that produce minimal effluent. Trends point toward greater regulatory tracking of not only finished product content but also life cycle emissions, and those who fail to upgrade their systems risk losing shelf space in competitive markets.

    Onsite handling procedures matter as much as feedstock choices. Continuous monitoring of emissions, scheduled maintenance, and comprehensive record-keeping all play a part. As manufacturers, we take direct responsibility for what leaves our site, sending regular emissions reports to third-party verifiers and offering documentation to customers completing their own audits. This accountability isn’t just a box-ticking exercise—individual operators and supervisors know their decisions affect the entire chain, upstream and downstream. Over time, small investments in process refinement multiply as fewer complaints arrive and long-haul partnerships expand.

    Real-World Feedback: Case Histories from the Plant Floor

    The truest test of a specialty chemical lies in feedback from users and workers. In the early days, isopropenyl acetate often gained a reputation as “difficult” due to its tendency for polymerization during hot weather storage, especially in unlined or exposed tanks. Our engineering teams met this by revising inhibitor packages and ensuring drums and containers are manufactured from compatible, UV-stabilized materials. Issues of shelf life and storage stability became recurring topics at annual review meetings; with data-driven tweaks and proactive batch analysis, product returns nosedived. Stories like these demonstrate that a manufacturer’s job rarely ends at shipment—real satisfaction comes from months or years of stable performance in customers’ hands.

    We also pay close attention to feedback when users attempt process modifications, such as using isopropenyl acetate in untested reactions or pilot runs for new pharmaceutical intermediates. On several occasions, open dialogue has led to the discovery of advantageous new uses based on direct field results. In one scenario, a manufacturer of specialty adhesives reported improved bond strength and clarity after swapping in isopropenyl acetate as a replacement for phenolic solvents, with additional gains in reduced off-gassing and better regulatory compliance. These are not always linear processes; there are failures as well as wins, but the collaborative spirit yields a level of insight that results rarely come from isolated lab work or speculative third-party reports.

    Looking Ahead: How We Continue to Adapt

    Markets never stop shifting. New end-uses arise each year, along with increasing demands on documentation, transparency, and service. As a direct producer of isopropenyl acetate, we learn to adapt from each project and relationship. Our future plans include updating reactor designs for more efficient heat management, introducing traceability measures through digital batch logging, and continued investment in process safety. These measures aren’t just industry talk—they come from years of fielding customer calls and addressing their toughest issues head-on.

    Working directly with other manufacturers, blending facilities, and R&D teams, our aim stays fixed on timely delivery, technical reliability, and honest trouble-shooting. We take pride in knowing where every drum of isopropenyl acetate originates and how it performs over months of use, well beyond the dockside handover. This brand of accountability, built from long experience, underpins each decision we make and each improvement we put in place.

    For anyone seeking insight into why isopropenyl acetate continues to find new relevance in specialty chemical markets, the key lies in its genuine versatility, real-world reliability, and the experience-backed commitment to steady improvement. Our work reflects both the realities of today’s industry and the ways in which attention to detail—at scale—still makes a genuine difference.