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Isobutyric acid

    • Product Name Isobutyric acid
    • Alias isobutanoic acid
    • Einecs 201-148-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    285091

    Chemical Name Isobutyric acid
    Iupac Name 2-methylpropanoic acid
    Cas Number 79-31-2
    Molecular Formula C4H8O2
    Molar Mass 88.11 g/mol
    Appearance Colorless liquid
    Odor Unpleasant, rancid-like odor
    Boiling Point 155 °C (311 °F)
    Melting Point -47 °C (-53 °F)
    Density 0.962 g/cm³ at 20 °C
    Solubility In Water Soluble
    Pka 4.86
    Flash Point 56 °C (133 °F)
    Vapor Pressure 6 mmHg at 20 °C
    Refractive Index 1.387 at 20 °C

    As an accredited Isobutyric acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Isobutyric acid is packaged in a 2.5-liter amber glass bottle, tightly sealed, with hazard labeling and safety instructions printed clearly.
    Shipping Isobutyric acid should be shipped in tightly sealed containers made of compatible materials, such as glass or specific plastics, to prevent leaks and contamination. It must be labeled as a flammable and corrosive substance and transported according to applicable hazardous materials regulations, away from sources of ignition, heat, and incompatible substances.
    Storage Isobutyric acid should be stored in a cool, well-ventilated area away from sources of ignition, heat, and incompatible substances such as strong oxidizers and bases. Containers must be tightly closed and made of compatible materials like glass or specific plastics. Avoid direct sunlight, moisture, and excessive temperatures to prevent degradation or pressure build-up. Properly label and segregate from food and feedstuffs.
    Application of Isobutyric acid

    Applications of Isobutyric Acid in Industrial Manufacturing

    Our technical-grade isobutyric acid is manufactured with strict process and quality oversight to support demanding industrial standards. Below are major application scenarios across specialty chemicals and advanced manufacturing sectors, highlighting compliance requirements, formulation practices, integration points, and common end products.

    1. Food Flavor and Fragrance Esters Production

    Isobutyric acid serves as a primary precursor for synthesizing esters used in food flavors and fragrances, favored for its contribution to natural fruit notes. Production facilities integrate it in continuous esterification setups, ensuring adherence to food safety and purity standards. Specification consistency is crucial, given that these esters enter regulated consumer ingredients.

    Industry compliance standards

    • FCC (Food Chemicals Codex)
    • 21 CFR §172 FDA Food Additive Permitted Standards
    • EU Regulation (EC) No 1334/2008 on flavorings
    • ISO 9235:2013 for aroma chemicals

    Typical usage ratio

    • 10–30% by mass relative to the total esterification charge, adjusted for alcohol type and targeted flavor volatility

    Downstream process integration

    • Direct addition into the acid/alcohol reaction vessel during batch or continuous esterification, followed by catalyst introduction and fractional distillation of the ester product

    Final product types

    • Isobutyl isobutyrate and methyl isobutyrate used in confectionery, beverage, and bakery flavors
    • Specialty fragrance bases for perfumery and personal care formulations

    2. Pharmaceutical Active Ingredient Synthesis

    Many pharmaceutical manufacturers employ isobutyric acid as an intermediate in the synthesis of active pharmaceutical ingredients (APIs), especially for certain local anesthetics and beta-blocker derivatives. Strict quality controls and validated processing conditions are required, including impurity profiling and GMP documentation, due to the critical downstream medical use.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) Monographs
    • USP-NF (United States Pharmacopeia–National Formulary)
    • FDA 21 CFR Part 210/211 for drug substances

    Typical usage ratio

    • Varies between 0.5–2.5 molar equivalents relative to amino group-containing reactants, optimized by targeted yield and impurity profile

    Downstream process integration

    • Input during amide bond formation with amines or alcohols in multi-step synthesis, either before or after protective group manipulations in API manufacturing

    Final product types

    • Chloroprocaine hydrochloride and other local anesthetic drug AIs
    • Intermediate for certain antihypertensive and anti-arrhythmic APIs

    3. Animal Feed Additives

    Downstream nutrition ingredient makers use isobutyric acid in the formulation of specific feed additives, notably as a preservative and growth-promoting compound in ruminant diets. High-purity material aligns with veterinary and feed hygiene directives, with rationalized dosing for efficacy and cost control at industrial scale.

    Industry compliance standards

    • EU Regulation 1831/2003 on additives for use in animal nutrition
    • Directive 2002/32/EC (contaminants in animal feed)
    • AFCO Feed Ingredient Definition Guide (U.S.)
    • ISO 22000 Food Safety Management for feed production

    Typical usage ratio

    • 0.1–0.5% by weight in compound feed premixes, variable by species and target nutritional effect

    Downstream process integration

    • Blended in liquid or powder premix stage prior to final homogenous mixing and pelletizing or extrusion of finished feed formulations

    Final product types

    • Antimicrobial compound feed for cattle, sheep, and goats
    • Preservative-enhanced silage and forage additives

    4. Solvent Ingredient for Resin Manufacturing

    Advanced resin manufacturers in coatings and adhesives sectors leverage isobutyric acid as a co-monomer modifier, enhancing flexibility and adhesion of cured resins. Controlled incorporation during polymerization ensures desired physical properties, while sector-specific environmental and workplace safety requirements apply.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • ISO 9001 Quality Management Systems
    • OSHA 29 CFR 1910.1200 (U.S. Hazard Communication Standard)
    • China GB/T 22327-2016 (Chemicals safety use in coatings)

    Typical usage ratio

    • Typically 2–7% by weight in resin polymerization reactions, depending on molecular weight and application type

    Downstream process integration

    • Dosed during initial monomer blending in solution or emulsion polymerization reactors for alkyd or acrylic resin production

    Final product types

    • Thermoplastic and thermoset alkyd or polyester resins
    • Waterborne and solventborne adhesives for industrial and specialty coatings

    5. Herbicide Intermediate for Agrochemical Synthesis

    Isobutyric acid is a precursor in the synthesis of select herbicidal active substances, where it enters as an acylation agent alongside complex heterocyclic precursors. Agrochemical plants implement traceability and residue management in accordance with crop and environmental regulations, customizing input ratios to achieve target specificity and minimal residue profiles.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EU Regulation (EC) No 1107/2009 (plant protection products authorization)
    • Good Laboratory Practice (GLP) OECD Principles
    • China GB 2763 National Food Safety Standard for Maximum Pesticide Residue Limits

    Typical usage ratio

    • Ranges from 1–4 molar equivalents based on the synthetic route, with final selection calibrated to maximize conversion and actives content

    Downstream process integration

    • Added in initial or intermediate stages of multi-step herbicide synthesis, particularly for herbicidal esters and amides

    Final product types

    • Pre-emergence and post-emergence herbicides for row crop and orchard protection
    • Active ingredient intermediates for modern low-residue pesticide formulations

    6. Specialty Plasticizer Production for Polymers

    Chemical processers utilize isobutyric acid as a building block in manufacturing specialty plasticizers, particularly for modifying PVC and certain engineering plastics. The controlled esterification step occurs under monitored temperature and catalyst regimes, ensuring product compatibility with safety and environmental standards required for downstream markets such as packaging and medical tubing.

    Industry compliance standards

    • RoHS Directive 2011/65/EU
    • US EPA TSCA (Toxic Substances Control Act)
    • EN ISO 10993 for medical device polymers
    • ISO 14001 Environmental Management (processing)

    Typical usage ratio

    • 7–15% by mass of total plasticizer charge, adjusted for target migration and flexibility profiles

    Downstream process integration

    • Introduced during the esterification phase with alcohols in the batch or continuous reactor, followed by filtration and neutralization for polymer blending

    Final product types

    • PVC film plasticizers for food-grade and industrial sheeting
    • Plasticized compounds for flexible tubing and wire coatings
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    Certification & Compliance
    More Introduction

    Isobutyric Acid: Behind the Scenes at the Production Line

    What It Means to Make the Real Stuff

    Isobutyric acid, known in the trade as 2-methylpropanoic acid, turns up in a surprising range of manufacturing projects. From where I stand on the plant floor, the importance of consistency and clarity in every drum or bulk container couldn’t be clearer. In our operation, each ton of this material leaves our gates after passing through multiple hands and eyes. Most customers notice the sharp, pungent smell—it's a marker of purity—but behind the scenes, there’s much more to the story than just the odor.

    Model and Specifications: What Matters Most

    Our standard product line focuses on the technical grade, with purity running above 99.5%. That number isn’t just a marketing claim; it reflects our reactor conditions, fractional distillation setup, and lab verifications. Water, heavy metals, and structural isomers cause trouble in downstream usage, so we control them down to trace levels. Final specifications often include moisture below 0.1%, iron content below 1 ppm, and residue on evaporation negligible enough not to throw off anyone’s analytical balance.

    What actually matters on the production side isn’t only the numbers. Fluctuating feedstock, subtle changes in temperature or pressure, even the choice of gaskets—these choices affect quality. Each batch’s certificate comes from hands-on sampling; we never push claims without a real, documented sample analysis. If you see cloudiness or smell notes that veer far from the sharp tang of isobutyric, something’s gone wrong, and we work it out before it ever leaves our yard.

    Production Insights: From the Reactor to the Drum

    On the reactor floor, handling is straightforward on the surface, but it takes awareness all day long. Isobutyric acid’s volatility means that transfer pumps, line joints, and storage tanks need robust gaskets and seals. At 155 degrees Celsius boiling point, it’s not going to evaporate in seconds, but ventilation is still a basic part of the plant environment. Fumes linger if engineers don’t run things carefully. Our storage tanks use special vent filters to keep pressure steady without letting vapors drift where they’re not wanted. Any sign of corrosion or gasket wear gets flagged fast—good equipment maintenance saves headaches down the line.

    Behind those standard operations, the feedstock matters too. Some operators use isobutyraldehyde as the starting point; in our case, we use a carboxylation route. Reaction monitoring drives schedules: temperature, pressure, and catalyst loads control both efficiency and by-product formation. No batch gets released on schedule until it meets all microbial and chemical purity checks. We keep the documentation as tight as the product itself.

    Applications: Where Isobutyric Acid Works Best

    The largest buyers we see are those in esters production—perfume and flavor manufacturers trust isobutyric acid for its short-chain structure, which delivers sharp, fruity esters and flavor notes. On a practical level, its low toxicity and manageable odor threshold let operators use it safely in open systems with basic precautions. It works well in agriculture: as a building block for synthetic herbicides and insecticides. Many industrial partners come back year after year because their processes—especially flavor and fragrance compounding—demand not just the acid itself, but also tight spec control so unwanted side reactions don’t interfere.

    A few other uses crop up: plasticizers, pharmaceuticals, and as solvents in specific polymer manufacturing niches. Isobutyric acid’s basic structure allows it to slot into reaction schemes where simple carboxylic acids wouldn’t fit. Our teams have worked with engineers tuning reaction baths for custom polymer resins; they value a steady, reliable supply more than any price cut.

    What Sets Isobutyric Acid Apart from Others

    Our team often fields questions about isobutyric acid versus n-butyric acid or valeric acid. The chemistry looks close on a blackboard, but on the shop floor, the difference in odor and downstream reactivity is enormous. Isobutyric acid’s branched chain makes its esters sharper—lighter, almost sweet—whereas straight-chain butyric acid gives off a heavier, sometimes rancid note that fragrance chemists recognize instantly. Process engineers also spot how the two acids differ in solubility and volatility. In essence, they are not interchangeable in formulas, even if their boiling points line up.

    We don’t use the same reactors for both acids, either. n-Butyric and isobutyric differ in volatility and corrosion profiles, so cleaning protocols change batch by batch. Cross-contamination risks remain high if the same valves aren't swapped and cleaned out. Our plant’s choice of materials for piping and storage reflects years of experience with minute contamination risks: even small residues can spoil an entire lot of fragrance esters or pharmaceutical intermediates.

    Worker Safety and Environmental Commitment

    In daily plant life, worker protection always comes first. Isobutyric acid vapor lingers if ventilation gets neglected, and direct skin exposure can irritate. We use full coverage PPE and continuous air monitoring around the drum filling line. On summer days, the plant layout allows natural airflow to supplement forced extraction around the mixing stations—that keeps vapors down and aligns with our environmental controls.

    Waste acid and rinsate require careful handling. We avoid open drains at all points. Every bit of residual product goes to our in-house neutralization unit before anyone thinks of disposal. We track every waste load, and environmental audits confirm our system works. We’ve learned from early-morning visits by regulators that documentation—real, signed, and checked—speeds along inspections. Good records don’t just satisfy auditors; they build trust with clients who want proof of reliability.

    Reliability: The Manufacturer Mindset

    As the people who make what gets shipped, we feel the pressure to deliver on both quality and consistency every day. Unplanned shut-downs or process upsets cascade along the chain. Regular maintenance, tight process control, and training sessions for newer operators set our operation apart. Our perspective: a clean, safe, efficient plant leads to cleaner, more reliable product. Returning customers give the best testament to product reliability: they keep sending in new orders and seldom raise complaints.

    When our drums leave the plant, freight carriers appreciate the difference: leak-proof closures, accurate weights, and hours posted for efficient loading. Each operator knows the buyer counts on specifications that don’t change unexpectedly, so we avoid last-minute re-blends or corrections whenever possible. There’s pride in keeping returns minimal.

    Issues in Scale-Up and Transportation

    Handling isobutyric acid in the lab is not the same as handling thousands of kilos in a tank truck. We’ve found bulk transfer to be a real risk point. Leaking gaskets, temperature changes on the road, or driver errors all need actual experience to solve. Mechanics check seals and hoses regularly, and everyone from loader to supervisor stays in the loop at dispatch. Even after years of smooth operation, one error in loading protocol can mean a minor leak or odor drifting across the yard. Fast response and clear roles in spill management get drilled into every team member, not just those on the EH&S roster.

    Some of our distribution partners ask for custom packaging or extra-low moisture levels for their processes. Meeting these demands means more than swapping out tankers for drums; it can call for new filling stations, nitrogen blanketing systems, or even cold storage, depending on project needs. Every plant shift, we gather feedback and review if last month showed any trend in packaging or carriage concerns.

    Quality, Traceability, and Customers’ Real Needs

    Tracing every batch from raw material purchase through final shipment never falls off our checklist. We log the lot numbers, reactor settings, sampling times, and finished product specs in detail. Customers who work with tight regulatory controls demand full traceability. Pharmaceutical clients in particular expect origin and process documentation, and we keep those records locked, backed up, and accessible for years.

    As manufacturers, only repeated, demonstrated reliability earns trust. That means not hiding behind fine print when a shipment falls short. We manage any claims by going back through all process logs and sampling results—not just one random test. Often, good relationships with customers hinge on this openness. They've seen what happens with cut-rate or resold acids; spikes in side products or inconsistent performance send buyers looking for another supplier and make production lines stop and start.

    Supporting Emerging Uses and Customer Feedback

    Markets for isobutyric acid shift with the development of new flavors, fine chemicals, and even crop protection compounds. We keep an eye on research trends coming from the academic world and align with customer requests for tweaks to product purity, dryness, or packaging. A few times, we’ve participated in pilot runs for customers testing new esterification schemes. These require closer lab collaboration, custom purity gradients, and sometimes new analytical methods to verify results that wouldn’t show on a typical COA.

    The plant’s technical group watches for feedback on odd reactions or performance differences in our acid versus a competitor’s. In one study, a client observed persistent haze in a formulated fragrance oil, traced back to trace metals that slipped into a poorly-filtered batch from another vendor. Our filtration and sample retention processes remain in place not just for incident response, but as a way of preemptively tracking and reducing contaminants to undetectable levels.

    Long-Term Thinking in Manufacturing

    Decades in chemical manufacturing teach that a focus on bulk output quickly runs up against reality: equipment wears, production staff face turnover, and raw materials never stay perfectly the same. We keep spare parts on hand, retrain teams with each process tweak, and try to balance speed with safety. After repeated audits, customer visits, and even the occasional crisis drill, one thing becomes clear. Product quality relies on small decisions made well, batch after batch. Routine checks and stubborn attention to anomalies—even when metrics look fine—separate us from those just pushing drums onto the market.

    Some clients use our product in pharmaceutical synthesis where a single impurity, such as a higher aliphatic acid, can compromise safety and final bioactivity. Others might care about only the absence of significant odor or moisture for a plastics grade. Either way, we funnel their needs back into the process, not just sales claims. Openness to tweaking purification steps, installing improved sensors, or even changing suppliers for base chemicals all come from a deep respect for how a seemingly small change at the molecular level shapes the finished goods.

    Challenges: Supply Chain and Market Pressures

    The past few years tested our agility in sourcing. Raw material interruptions send ripples through the plant. We maintain relationships with multiple suppliers to spread risk. Sometimes, price spikes or transport delays push us to adjust production schedules late at night to make sure priority clients stay on track. In tough cycles, the reality is that no plant can buffer all the shocks, but open dialogue with buyers helps navigate shortages or increased lead times. We invest in stockpiles of both feedstocks and finished product as safety nets for these unpredictable events.

    Market volatility—price, demand, shipping—presses on long-term planning. Warehousing, cold storage costs, and container shortages all affect how fast we get product to the right destination. Our logistics team keeps real-time eyes on global freight and route disruptions. Over time, these experiences reinforced how flexible (but disciplined) production planning supports product availability and smooth order fulfillment even when the outside world turns muddy.

    Why Direct Manufacturer Supply Matters

    Talking with buyers, there’s a clear preference for direct contact with a real producer rather than through chains of agents. Plant stories, technical background, and willingness to accommodate new spec requests don’t travel well through extra hands. If you want assurance about solvent residue, heavy metal content, or special container preferences, direct manufacturer relationships beat consultant phone calls. We share real product data, offer test samples, and organize technical calls with process staff when new projects arise.

    Manufacturing isobutyric acid isn’t just running a process. It’s years of troubleshooting, adapting to process tweaks, protecting staff and environment, and maintaining customer confidence. What gets bottled up in those drums is more than a chemical; it is a testament to practical material science, hands-on skill, and an open-door approach to continuous improvement.

    Looking Ahead: Innovation and Commitment

    We see new applications and tighter specifications coming up each year. Environmental regulations push us constantly to reduce waste and emissions, while supply chain disruptions force nimble adjustments. The team’s collective skills—operators, lab technicians, engineers—keep us competitive. We upgrade purification steps as clients demand new levels of trace purity and respond to calls for safer and smarter packaging.

    Every time a new inquiry hits the inbox, plant-floor experience counts as much as professional credentials. As the team who makes the acid, sells it, and answers for it, we’re fully invested in delivering a product you can use without concern. Our reputation grows not from certificates, but from direct results in your process. Isobutyric acid may not make headlines outside technical circles, but done right, it keeps thousands of production lines running smoothly and products meeting high quality bars. That’s a source of pride from the reactor to the warehouse, year in and year out.