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Hexamethyleneimine

    • Product Name Hexamethyleneimine
    • Alias Azinane
    • Einecs 211-162-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    946292

    Cas Number 111-49-9
    Molecular Formula C6H13N
    Molecular Weight 99.17 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Ammonia-like
    Melting Point -8 °C
    Boiling Point 139-141 °C
    Density 0.862 g/cm3 at 25 °C
    Solubility In Water Miscible
    Flash Point 33 °C (closed cup)
    Vapor Pressure 10 mmHg at 37.7 °C
    Refractive Index 1.447 at 20 °C

    As an accredited Hexamethyleneimine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Hexamethyleneimine is packaged in a 500 mL amber glass bottle with a secure screw cap and appropriate hazard labeling.
    Shipping Hexamethyleneimine should be shipped in tightly sealed containers, clearly labeled, and protected from physical damage. It must be kept away from strong oxidizers, sources of ignition, and moisture. Comply with all relevant chemical transportation regulations (e.g., DOT, IMDG, IATA). Use appropriate protective packaging and ensure proper ventilation during shipping.
    Storage Hexamethyleneimine should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from heat, sparks, open flames, and incompatible substances such as strong oxidizers and acids. Protect from moisture and direct sunlight. Appropriate safety labeling and secondary containment are recommended to prevent leaks or spills. Always follow local regulations and guidelines for chemical storage.
    Application of Hexamethyleneimine

    Applications of Hexamethyleneimine in Industrial Manufacturing

    Hexamethyleneimine serves as a critical intermediate in the chemical supply chain, powering precise roles across multiple industrial sectors. As a direct manufacturer of this raw material, we ensure reliable, specification-compliant supply tailored to the stringent requirements of advanced polymer, agrochemical, surfactant, and fine chemical syntheses. The following sections detail its dedicated applications, handling standards, use levels, downstream integration points, and real-world product outputs for each industrial scenario.

    1. Polyamide and Polyimide Monomer Synthesis

    Many specialty polyamides and high-temperature polyimides rely on hexamethyleneimine as a key ring structure builder. Industrial polymerization plants use it during condensation reactions to introduce flexible six-membered nitrogen-containing units, which contribute to the polymer’s mechanical and thermal performance profiles. Downstream formulators strictly control the dosage and reaction timing to achieve the targeted chain architectures for demanding technical plastics and high-performance fibers.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Polymer Synthesis
    • REACH Regulation (EC) No 1907/2006 (Europe), Annexes VII–XIV
    • FDA 21 CFR 177.1500 (for certain food-contact polyamides, US)
    • GB/T 3647-2019 (China National Standard for Polyamides)

    Typical usage ratio

    • Between 3% and 30% by monomer molar ratio; precise addition aligned to the target backbone flexibility and end-use specification for the polymer resin type.

    Downstream process integration

    • Direct introduction as a monomer or comonomer into melt or solution polycondensation systems, following precise metering and temperature control before catalyst addition.

    Final product types

    • High-temperature-resistant polyimide films
    • Flexible polyamide fibers and engineering plastics
    • Specialty adhesive resins
    • Polymer coatings for electronics substrate applications

    2. Crop Protection Active Ingredient Manufacture

    Hexamethyleneimine participates as an essential building block in the synthesis pathways for several cyclic nitrogen-based herbicide and fungicide actives. Major agrochemical manufacturers use it in closed-loop reactors under controlled nitration or halogenation, followed by downstream derivatization to achieve potent biologically active species. Its reactivity profile allows for precise substitution at defined molecular positions, ensuring batch-to-batch active consistency.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • China GB 2763-2023 Maximum Residue Limits
    • ISO 9001:2015 Quality for Agrochemical Synthesis

    Typical usage ratio

    • 10–18% by mass in semi-batch synthesis; adjusted for stoichiometry and yield optimization depending on downstream molecular target and purification scheme.

    Downstream process integration

    • Charged during the first reaction stage to generate the core heterocycle under basic or catalytic conditions, followed by functionalization and purification via solvent extraction and crystallization.

    Final product types

    • Triazine-based herbicide actives
    • Cyclic imine fungicide intermediates
    • Finished formulated crop protection chemicals (wettable powders, emulsifiable concentrates)
    • Bulk technical-grade actives for contract formulation

    3. Cationic Surfactant Intermediate Production

    Formulation plants manufacturing specialty cationic surfactants for textile processing, water treatment, and antistatic finishes use hexamethyleneimine as a precursor for quaternization reactions. Its cyclic structure imparts unique surface-active properties when reacted with alkyl halides, generating molecular architectures that balance hydrophobic and hydrophilic domains, ensuring high charge density and process-specific wetting or dispersing power.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals (Biodegradability, Ecotoxicity)
    • GB/T 26396-2011 (China: Industrial Cationic Surfactant Standard)
    • EU Detergents Regulation (EC) No 648/2004
    • ISO 14001:2015 Environmental Management for Surfactant Plants

    Typical usage ratio

    • 5–14% by weight in the surfactant synthesis batch, modulated based on alkyl chain length and final product charge profile.

    Downstream process integration

    • Added following initial solvent charge, then subjected to alkylation (quaternization) prior to neutralization and distillation; process sequence fine-tuned to maximize conversion and minimize by-product formation.

    Final product types

    • Cationic softeners for textile finishing
    • Coagulation agents for industrial wastewater treatment
    • Antistatic agents for plastics processing
    • Dispersants in mineral flotation processes

    4. Fine Chemical Synthesis—Pharmaceutical Intermediates

    Advanced pharmaceutical synthesis operations rely on hexamethyleneimine as an intermediate for developing six-membered cyclic amine fragments within high-purity API (active pharmaceutical ingredient) synthesis. The material’s performance hinges on absolute traceability, enantiomeric purity control, and adherence to pharmacopeia monographs. Production lines integrate it early in the scaffold-building stage, then optimize reaction yield and impurity profile according to validated GMP protocols.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) and European Pharmacopeia (Ph. Eur.) requirements for relevant intermediates
    • FDA 21 CFR Part 210–211 cGMP Guidelines
    • EDQM CEP Certification Protocols

    Typical usage ratio

    • 10–26% by molar input in scaffold-generating steps, with dosing set based on desired API yield and patent-protected route constraints.

    Downstream process integration

    • Charged as a key scaffold element to either batch or semi-continuous systems at the initial heterocycle assembly phase; introduces cyclic amine functionality prior to advanced coupling and purification.

    Final product types

    • Template structures for antihypertensive APIs
    • Chiral intermediates for neuromodulator agents
    • Bulk pharmaceutical intermediates (regulated as category B substances in several jurisdictions)
    • Advanced intermediates for research and pilot-scale drug development

    5. Corrosion Inhibitor Formulation for Oilfield Applications

    Oilfield chemical manufacturers employ hexamethyleneimine for the synthesis of cyclic amine-based corrosion inhibitors, providing high film persistency on steel surfaces in aggressive brine and acidic well conditions. Its chemistry enables the formation of compact, adherent molecular layers that protect high-value downstream assets during secondary oil recovery and pipeline transit operations.

    Industry compliance standards

    • API RP 14E (Recommended Practice for Design and Installation of Offshore Production Platform Piping Systems)
    • ASTM G170-13 (Measuring Corrosion Inhibitors in Oilfield Environments)
    • CFR 40 Part 435 (Effluent Limitations for the Oil and Gas Extraction Point Source Category)
    • ISO 15544:2000 (Petroleum and natural gas industries—Offshore production installations)

    Typical usage ratio

    • 6–12% by weight in the inhibitor concentrate, with dosage adjusted according to brine composition and exposure temperature.

    Downstream process integration

    • Dosed during the formulation stage in oilfield chemical blending units, followed by dispersion into oil/water mixtures and subsequent quality control testing for corrosion protection efficiency.

    Final product types

    • Cyclic amine-based corrosion inhibitors (concentrates and ready-to-use blends)
    • Protective films for drilling tubulars
    • Pipeline batch treatment chemicals
    • Temporary preservation agents for equipment lay-up in oilfields
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    Certification & Compliance
    More Introduction

    Hexamethyleneimine: Reliable Quality Direct from an Experienced Manufacturer

    Introduction to Hexamethyleneimine Production and Application

    Direct manufacturing of Hexamethyleneimine comes with a unique set of challenges and a responsibility to both the industries we supply and the environment around us. Working every day at the core of synthesis and purification, we see firsthand the importance of tight process control and deep experience. Hexamethyleneimine, sometimes referenced as hexamethylenimine or HMI, has secured its place in chemical synthesis, polymer intermediates, oilfield applications, corrosion inhibition, and fine chemical research. For those who depend on reliable downstream performance, the subtle details during its production set apart average material from dependable supply.

    Overview of Specifications, Purity, and Technical Parameters

    In our facility, Hexamethyleneimine typically reaches purity levels above 99%. This comes from a series of fractional distillation steps, not just a single pass. Monitoring parameters like water content, color, and amine value does not amount to ticking boxes—it involves understanding how small deviations can shape the next customer's yield. What the buyer gets is a clear, colorless liquid with a distinct amine odor, consistent melt point, and stable reactivity profile.

    We have seen frequent requests for variant specs, especially for moisture control and trace metal reduction. Here, hands-on monitoring during synthesis and storage becomes essential. Reducing iron and nickel content stops unwanted side reactions downstream, especially in polymer and catalyst production. An assorted catalog of packaging options accommodates direct synthesis requirements and bulk operations: from corrosion-resistant drums to sealed IBCs, everything is selected for zero contamination and safe handling.

    Application Experience: Real-World Value

    Hexamethyleneimine has never been a one-trick chemical. Customers in nylon and polyamide synthesis often rely on it as a loop-structure builder. Polymer researchers have stopped chromatic defects and improved mechanical consistency after switching to our material, mostly because of precise impurity control. Oilfield customers, on the other hand, focus heavily on its versatility as an intermediate for corrosion inhibitors, where consistent reactivity and low water content prevent treatment failures.

    We’ve worked directly with teams producing epoxy curing agents, finding that shifting the balance between main product and by-products at the reactor level alters downstream blending and curing kinetics. Every ton shipped has been checked via both batch analytics and real operational feedback, not just paperwork.

    Differences from Commodity and Third-Party Sources

    Backed by decades running reactors and distillation towers, we can say without hesitation: direct manufacturing can differ widely from trading or repacking. We have dismantled enough drum returns from repackagers to recognize what goes wrong—mixed lots, oxygen ingress, and cross-contamination. Reputable traders play a part in the market, but for applications tied to critical output—such as engineered plastics or electronic-grade intermediates—direct material control proves decisive.

    One key difference lies in analytical transparency. We run full spectrum analyses with batch-level traceability, tracking any deviation in real time. Commodities bought through secondary channels often lack this type of fingerprint. This affects synthetic reliability for pharmaceutical end users, who need to pass strict audit trails, and polymer developers, who face batch mismatch and off-grade frequency. We run internal audits and cross-tests to spot trace residues that other parties routinely overlook.

    Drawing on past collaborations, such as custom orders for specialty diamines or complicated supply chain blending, we implement direct line-of-sight from starting raw material to finished drum. Our lab team correlates test data, such as IR spectra, to production records that stay linked to sales batches. If a downstream issue arises—odors, color instability, off-spec reactions—customers can trace results directly to a specific production date, and get live process feedback from chemists who ran the actual synthesis.

    Supporting Sustainable and Safe Production

    Running our own reactors for Hexamethyleneimine gives us a front-row seat to the environmental and safety issues involved. Hexamethyleneimine does not handle like most common organics; it brings health hazards, flammability, and sensitivity to air and light. Our operational routines enforce staged venting, continuous monitoring for amine vapor, and strict PPE policy. Years of production data have led us to redesign bulk storage and loading docks for zero-loss transfers and minimized worker exposure.

    Direct manufacturing allows us to implement closed-loop recycling and solvent reclamation that gets missed by bulk traders. Every by-product stream is characterized and, when possible, recycled back into pre-cursor synthesis or sold for neutralization. We manage waste amines using controlled incineration backed by real-time emission monitoring. No trade intermediary without full plant oversight has that kind of control.

    We also actively seek solvents, corrosion inhibitors, and fuel additives with the lowest possible total toxicity. Every reformulation means validating how Hexamethyleneimine will react, break down, or persist across a range of field conditions. As regulations evolve for amines in both Europe and North America, those lessons learned during full-scale manufacturing—like optimizing vent scrubbing and waste reduction—offer an immediate, practical advantage.

    End-User Collaboration: The Value of Direct Technical Dialogue

    Some end-users approach us directly with troubleshooting on unexpected outcomes: inconsistent polymer performance, coating defects, or off odors in finished batches. Here, we find the difference between generic product sales and real partnership. Since most third parties focus only on moving inventory, on-site manufacturer support draws on actual experience with the chemical. We have walked teams through stepwise adjustments to pH, drying conditions, and impurity management, increasing end-use reliability.

    Our technical specialists work at the interface between the plant and the customer’s R&D teams. When handling Hexamethyleneimine for specialized pharmaceutical routes, we’ve tailored impurity profiles below standard benchmarks. For instrument manufacturers, who require high-purity amines with ultra-low salt levels, we respond with transparent data and pilot-scale test samples. This engagement builds trust and gives buyers confidence that changes in their formulations will not cause costly production upsets or regulatory non-compliance.

    Requests for design-of-experiments support keep coming, particularly from advanced materials scientists. These engagements deepen both our know-how and the reliability of the customer’s final product. We have supplied stability studies, custom-blended standards, and advice on critical holding times—none of which makes sense in a spot-trading network. Working directly shortens feedback loops and transforms product tweaks into process improvements that benefit every batch.

    Challenges of Market Fluctuation and Supply Chain Assurance

    As experienced manufacturers, we know Hexamethyleneimine pricing and availability often rise and fall with upstream amine production, global solvent balances, or plant outages. This chemical cannot be “made to order” overnight because the supply chain for raw cyclohexanone, hydrogen, and catalysts is rarely perfect. Over the years, we have had to run extra inventory “buffers” and coordinate tightly with logistics partners, especially for hazardous goods compliance. In times of global supply turbulence—such as tightening amine regulations or regional shipping bottlenecks—direct manufacturing stands out for stability.

    We routinely conduct stress tests on both input procurement and finished stock holding, making sure that customers do not face last-minute gaps in critical supply. Proactive communication about plant turnarounds and capacity constraints gives partner buyers the ability to plan confidently. This culture of accountability and direct line-of-sight stretches far beyond what a paper only supply chain provides.

    Bulk users appreciate verified lead times, input on batch scheduling, and—if asked—custom formulations to soften shocks from global demand swings. The visibility into actual forecast data and safety stocks means smoother production at both ends. Our direct relationships with transportation and warehousing reduce spoilage and returns, while minimizing the risk of regulatory non-compliance due to mis-labelling or mishandling.

    Product Innovations and Process Improvement—A Manufacturer’s Insights

    Years spent fine-tuning Hexamethyleneimine production bring home the reality that no plant process stays “finished.” Ongoing R&D investments let us tweak catalyst systems, try alternative hydrogen sources, and test new condensation approaches. We analyze reactor fouling and heat transfer data to keep purity and yield high, energy use low, and waste controlled. Operators and lab staff feed continuous process improvement back into each scaleup, rather than listing product specifications and leaving it there.

    A recent example: by switching to a multi-stage packed-column system, we have further reduced trace aldehyde and ketone burdens that trigger downstream color problems. New NIR and GC/MS techniques let us spot even minor shifts in the impurity profile. These process controls matter for users with tight constraints—especially electronics, pharmaceuticals, and performance polymers where any off-flavor or color can ruin a batch.

    Our on-staff chemists invest time running pilot tests for novel applications, such as cyclization agents in specialty polymers and high-reliability corrosion inhibitors. Tests run at the plant scale generate more reliable results, as opposed to “trial-and-error” sourcing from fragmented suppliers. By staying close to real production variables, we anticipate customer needs and keep revising work practices to match the environments where Hexamethyleneimine is actually put to use.

    User Experiences: Patterns and Lessons from the Field

    We hear often from production teams switching from multi-source Hexamethyleneimine to our directly manufactured material. Typical results include fewer batch deviations, less plant downtime, and easier compliance with environmental reporting. Engineers at resin manufacturing plants report smoother extruder start-up and lower cleaning frequencies due to reduced deposit and residue build-up, which comes directly from consistent impurity removal.

    Feedback from oilfield service operators echoes the same: the more consistent and low-water Hexamethyleneimine arrives, the more predictable their batch performance, especially for high-activity anti-corrosive blends. We’ve also supplied research groups striving for greener solvent substitutions, where iterative changes in supply purity materially altered toxicity profiles and solvent lifecycles.

    Listening to end-users has shaped how we approach quality management. It informs our investment in real-time batch analytics and encourages continued open dialogue between plant and lab. Behind every shipment stands a production record, with operators and chemists ready to translate experience directly into the next innovation.

    The Value of Experience-Driven Production

    Hexamethyleneimine’s impact as a chemical intermediate depends on deeper factors than a specification sheet will ever show. From experience, subtle batch-to-batch variability can drive up rework costs and cause frustration on client production lines. Continuous process optimization, stringent hazard control, and tight quality feedback establish the kind of long-term performance customers expect but can rarely pinpoint in contract terms.

    The world of specialty amines demands flexibility, accountability, and genuine technical engagement. We have witnessed firsthand how direct-sourced product outperforms generic bulk inventory in application-critical areas—polymers, coatings, oil additives, and research labs. Our plant investments and R&D integrations keep formulation options wide open for buyers facing new regulatory requirements, innovative end-use markets, or supply volatility.

    How Manufacturers Shape Better Outcomes for Hexamethyleneimine Users

    Product innovation in our business does not rest on producing once and selling for years. Iteration matters. Listening to the real-world needs of polymer scientists, corrosion experts, and R&D chemists, we modify our process flow and purification strategy. The combination of practical experience, advanced analytical tools, and honest customer feedback lets us consistently supply Hexamethyleneimine that meets both established industry demands and rapid changes in application spaces.

    Our commitment goes beyond shipment tracking: it extends from raw material selection, through full-control processing, to final technical support at the point of use. The result is sustained reliability for users in every field where Hexamethyleneimine makes a difference, grounded in the details only a working manufacturer can provide.