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Furoyl Chloride

    • Product Name Furoyl Chloride
    • Alias Benzoylformyl chloride
    • Einecs 242-875-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    556122

    ProductName Furoyl Chloride
    ChemicalFormula C5H3ClO2
    MolecularWeight 130.53 g/mol
    CASNumber 527-69-5
    Appearance Colorless to pale yellow liquid
    BoilingPoint 73-74 °C at 13 mmHg
    MeltingPoint -12 °C
    Density 1.334 g/cm3
    Solubility Reacts with water
    RefractiveIndex 1.512
    Purity Typically ≥98%
    StorageTemperature Store at 2-8 °C
    HazardClass Corrosive

    As an accredited Furoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Furoyl Chloride is packaged in a 500 mL amber glass bottle, tightly sealed, with hazard labeling and chemical identification on the exterior.
    Shipping Furoyl chloride should be shipped in tightly sealed containers, away from moisture and incompatible substances, under cool and dry conditions. It is a corrosive and hazardous material, typically transported as a dangerous good according to UN regulations. Proper labeling, documentation, and handling procedures must be strictly followed for safe transit.
    Storage Furoyl chloride should be stored in a tightly closed container under a dry, inert atmosphere, such as nitrogen or argon, to prevent moisture and air contact. Store in a cool, well-ventilated area away from incompatible substances like water, strong bases, and oxidizers. Keep away from heat, flame, and direct sunlight. Use approved corrosive storage cabinets when available.
    Application of Furoyl Chloride

    Applications of Furoyl Chloride in Industrial Manufacturing

    As a specialized manufacturer of Furoyl Chloride, we focus on delivering this high-purity acyl chloride to established industrial customers operating in core downstream sectors. Our expertise centers on supporting advanced organic synthesis where performance, compliance, and tight process control are required. The following application scenarios represent real-world industrial uses where Furoyl Chloride plays an integral, differentiated role.

    1. Pharmaceutical Intermediate Synthesis: Antibacterial Agents

    Our Furoyl Chloride serves as a critical acylating agent during the manufacturing of key active pharmaceutical ingredients (APIs) in the antibacterial segment, particularly for the production of furoyl-substituted quinolone derivatives. In this pathway, controlled acylation delivers specific structure-activity relationships essential for downstream biological activity. Compliance mandates, close ratio monitoring, and integration with multi-step organic synthesis define this application’s industrial relevance.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF and European Pharmacopoeia monographs for relevant APIs
    • FDA 21 CFR Part 211 (cGMP Finished Pharmaceuticals)
    • EMA GMP for active substances (Directive 2003/94/EC)

    Typical usage ratio

    • 0.9–1.2 molar equivalence to primary amine substrate, adjusted for target purity and scale in multi-kilogram to tonne batch production

    Downstream process integration

    • Introduced as the acylating reagent after intermediate amine formation step, under chilled and inert-atmosphere conditions to manage exothermic reactivity; followed by aqueous quenching and successive organic work-ups

    Final product types

    • Crystalline active pharmaceutical ingredients in the quinolone and furan derivative classes (e.g., specific antibacterial agents such as Fleroxacin, Furofloxacin)

    2. Agrochemical Active Ingredient Manufacturing: Herbicidal Compounds

    Within the agrochemical sector, Furoyl Chloride features in the synthesis of selective herbicide active ingredients, where its functional group incorporation impacts phytotoxic selectivity and bioavailability. Manufacturers leverage our material for its predictably pure conversion and manageable reactivity with common heterocyclic synthons. Strict industry standards guide recipe setting and scaling decisions.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 Certified Quality Management Systems for Pesticide Production
    • European Union Regulation (EC) No 1107/2009 (Plant Protection Products)
    • China GB 2763-2021 (Maximum Residue Limits for Pesticides in Food)

    Typical usage ratio

    • 0.8–1.1 equivalents to the amine or hydrazine precursor; varies between 5–12% w/w in final active ingredient synthesis batch depending on desired selectivity profile

    Downstream process integration

    • Used in the acylation of core heterocycles during late-stage synthesis under controlled reflux or catalytic conditions, followed by distillation or crystallization to isolate pure active ingredient

    Final product types

    • Technical-grade and formulated furoyl-containing herbicides (e.g., furoyl-triazole or furoyl-urea based actives for broadleaf and grass weed control)

    3. Specialty Polymer Functionalization: Conductive Polymers & Films

    Industrial polymer manufacturers apply Furoyl Chloride to introduce furoyl functionalities onto backbones during the modification of conductive polymers and specialty films. This application leverages nucleophilic aromatic substitution for consistent grafting, enhancing properties such as charge mobility, thermal stability, or specific UV response. Application-specific standards dictate material traceability, emissions, and operator safety.

    Industry compliance standards

    • ISO 14001 Environmental Management for Polymer Processing
    • REACH Annex XVII (Restriction of Hazardous Substances in Polymers)
    • ASTM D638 (Polymer Tensile Properties) and D882 (Film Testing)
    • RoHS 2011/65/EU (when used in electronics-grade films)

    Typical usage ratio

    • 1–8% by polymer weight, titrated to achieve targeted functional group density for specific performance requirements

    Downstream process integration

    • Added during reactive extrusion, solution polymer functionalization, or post-polymerization modification steps; careful stagewise addition ensures uniform substitution without side-chain degradation

    Final product types

    • Conductive furoyl-functionalized polythiophenes and polyimides
    • High-performance films for electronics, optical coatings, or sensor substrates

    4. Fine Chemical Synthesis: Benzofuran and Furanone Derivative Manufacturing

    Producers of high-value fine chemicals and specialty intermediates utilize our Furoyl Chloride as a selective acyl source to generate benzofuran, γ-butyrolactone, and furanone derivatives. The precise introduction of the furoyl group enables downstream transformations for fragrance, flavor, and advanced material markets. This scenario emphasizes robust process documentation and specialty chemical regulatory compliance.

    Industry compliance standards

    • ISO 9001:2015 (Fine Chemical Manufacturing Quality)
    • OECD Guidelines for the Testing of Chemicals (where applicable)
    • GHS (Globally Harmonized System of Classification and Labelling of Chemicals)
    • National inventories: TSCA (US), EU REACH, IECSC (China)

    Typical usage ratio

    • 1.0–1.3 mol eq in acylation or Friedel–Crafts reactions; actual dose set by substrate reactivity and desired yield

    Downstream process integration

    • Directly introduced in stepwise acylation during batchwise or continuous-flow synthesis, typically under Lewis acid catalysis, with quenching and work-up tailored for by-product removal

    Final product types

    • Benzofuran-based aroma chemicals
    • Specialty lactones and furanones for perfumery, flavoring, and advanced analytics

    5. API Impurity Reference Material Production

    Pharmaceutical analysis laboratories and reference standard units engage Furoyl Chloride in the controlled synthesis of specific impurities and degradation products traceable to API metabolism or shelf-life. These reference materials support global regulatory submissions by enabling validated quantification of trace furoyl-linked species. The purity and certification requirements of this application are among the most rigorous in the chemical industry.

    Industry compliance standards

    • USP & EP requirements for impurity reference standards
    • ISO/IEC 17025 (Laboratory Accreditation)
    • ICH Q3A (Impurities in New Drug Substances)
    • FDA/EMA stability and impurity profiling guidelines

    Typical usage ratio

    • Applied at strictly defined stoichiometry (1.0–1.05 eq) to ensure controlled formation of targeted impurity at trace-to-milligram scale

    Downstream process integration

    • Added precisely in step-syntheses, often under glovebox or microreactor conditions, followed by preparative HPLC or crystallization to isolate and characterize the impurity

    Final product types

    • Certified impurity standards and metabolite references for regulatory method validation and stability indicating assay calibration
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    Certification & Compliance
    More Introduction

    Introducing Furoyl Chloride: Insights from the Production Line

    What We Put Into Every Drum of Furoyl Chloride

    Producing furoyl chloride isn’t a simple matter of following a recipe and bottling up the results. From our perspective as chemical manufacturers, every batch matters to us because we see its direct impact in the pharmaceutical and chemical synthesis industries. We treat furoyl chloride as a core building block that deserves attention to every step, right from raw material sourcing through to purification and packaging. In practice, our teams work closely with engineers and chemists on the ground, putting our experience to work every time quality challenges or raw material shifts test us.

    Choosing the Right Grade: 99% and Up

    We offer furoyl chloride in 99% and higher grades. Chemical manufacturing isn’t about headline numbers—it takes hands-on work in the plant to consistently achieve these benchmarks. Freshness, purity, and moisture content shape the results you see in your own synthesis work. We avoid generalities and focus daily on real-world testing, using analytical methods like GC and NMR, not just relying on paperwork or checklists.

    Any material that falls below spec does not move forward in our process, and we take responsibility for routine independent analysis. There’s no patching up a low-purity batch after the fact because downstream users, especially in pharma and agrochemistry, notice the difference instantly.

    From Starting Materials to Finished Chloride: Our Process

    On our line, we begin with pharmaceutical-grade furoic acid. We partner up with trusted upstream suppliers who share our commitment to tracing every bag back to its source. Traditional routes for converting furoic acid to its chloride employ thionyl chloride, but there’s more to repeatability than having the right chemicals on hand. Reactor temperature, humidity control, and efficient removal of byproducts all feed into every run we carry out.

    We know firsthand the value of monitored reaction times and pressure control. Over-chlorination or uncontrolled hydrolysis leads to degraded yield or traces of furan derivatives, which can impair further synthesis. Our plant team double-checks for every side-product, something that offsite traders or resale brokers rarely understand. Batch records live in our digital logbooks, openly accessible for routine audits.

    Physical Properties We Track at Every Stage

    Factory experience has taught us that furoyl chloride’s pale yellow color tells you a story—sometimes more than data sheets reveal. Discoloration often flags minor impurities, and the smell changes with even slight moisture pickup. Our workers note changes to viscosity and fluidity in real time, adjusting storage conditions as the weather shifts with the seasons. We package in airtight containers under dry nitrogen, sealing immediately to prevent hydrolysis.

    Where Customers Use Our Furoyl Chloride

    Most users rely on our furoyl chloride for introducing the furoyl group into nucleophilic substrates, especially amines and alcohols. Applications range from synthesizing pharmaceutical intermediates and advanced agrochemical actives to research laboratories conducting SAR investigations. In our direct interactions, chemists tell us that one inconsistent batch can mean weeks of lost R&D. We build longstanding relationships precisely because supply interruptions or off-specification material cost far more than a few cents per kilo.

    In one noted application, our product serves as a key intermediate for several active pharmaceutical ingredients, including furazolidone derivatives and certain heterocyclic drugs. Batch-to-batch consistency here is not a buzzword; regulation demands that every lot reports the same halide content and reactivity.

    What Sets Our Furoyl Chloride Apart

    Being a manufacturer means we control the standard. We don’t just package pre-made material or relabel barrels. Over time, we have refined the process to minimize residual thionyl chloride and ensure minimal trace acids in the finished product. Our regular clients trust us not because we offer the lowest price, but because our shipments meet the same standard month after month. If we see a trend—whether it’s a rise in chloride content or hints of residual solvents—corrective steps start immediately.

    Competitors who operate as distributers or repackagers often do not have this visibility. They buy what’s cheapest and available, then pass along the product. It leads to a patchwork in quality, and missed performance benchmarks for their customers. In contrast, our plants run 24/7 and lab staff remain on call to tackle issues before they become problems.

    Working Around Common Pitfalls

    Ask anyone in the industry about furoyl chloride, and they’ll mention its moisture sensitivity. We deal with that head-on. Each production batch rolls through high-efficiency drying systems, and we recheck for hydrolysis byproducts before shipment. Our warehouse is climate-controlled, and every drum and canister includes clear handling instructions. We have learned that even the best synthesis work goes awry when logistic partners fail to manage temperature and humidity.

    We hold training for our shipping departments and require signed audits from third-party handlers for sea or air shipments. Mistakes cost us more than fees—they cost us trust built over years.

    What Experience Teaches Us About Safety and Compliance

    We never treat regulatory compliance as paperwork. Our team has seen evolving requirements from EU REACH to US TSCA registrations, and adapts processes right away. Labeling, record-keeping, and batch traceability are non-negotiable. Suppliers and partners who fail these basics don’t make it onto our vendor list. This isn’t just about avoiding fines—it comes from respect for the teams running reactors, pipetting at benches, and delivering end products under pressure. We embed strong environmental and personal safety measures because every incident echoes through the whole site.

    Furoyl chloride emits irritating vapors upon contact with moisture, so personal protective equipment isn’t optional in our plant. We install advanced local exhaust systems above reactor vents and product transfer points, keeping exposure below permissible limits. Occupational health teams review logs and conduct training, because shortcuts result in long-term setbacks for our staff and their families.

    Difference from Other Acid Chlorides

    In conversations with our customers, one of the common questions centers on how furoyl chloride differs from better-known acid chlorides, such as benzoyl chloride or acetyl chloride. Unlike those larger-volume commoditized products, furoyl chloride regularly sees use for its electron-rich furan ring, which imparts certain reactivity profiles and physicochemical features. This structure, in contrast to a phenyl or methyl group, provides distinct patterns in coupling chemistry, which pharmaceutical teams often need for fine-tuned properties within a molecule.

    Its boiling point and handling characteristics diverge enough from more common patterns that we recommend dedicated glassware or reactors, especially when scaling up from grams to kilograms. Many organizations try swapping in benzoyl chloride as an economic substitute, only to find lower yields or unwanted side reactions. Years spent producing both products taught us that reactivity patterns differ, so adjustments in base, solvent, and reaction temperature all affect downstream costs and project timelines.

    Our Responsibility Doesn’t End at the Factory Gate

    We keep open lines with end users, constantly gathering feedback. When a lab finds a batch isn’t reacting as cleanly, or there’s uncharacteristic color or odor, we dive in together to track it down—whether it’s raw material quality, shipping mishap, or lab protocol issue. We have learned that fast, technical conversations solve more problems than paperwork or emails ever do.

    As the manufacturer, our job doesn’t stop at QC tests and shipping labels. It extends to making sure those using our furoyl chloride understand best practices for storage and handling, and have real support if they run into trouble. To us, quality assurance means more than checking boxes—it’s about standing behind every batch and facing challenges head-on with the people who trust us.

    Process Consistency: Why It Matters

    Quality may start with raw materials, but it lives or dies by process consistency. Over years of production, our supervisors have fine-tuned reactor conditions, heat transfer rates, catalyst ratios, and waste stream treatment for furoyl chloride. Seasonal humidity or changes in upstream feedstock don't just hit theoretical yields—they put real pressure on teams downstream. We hold process review meetings to decode every drift in analytic results.

    Production teams see first-hand that even minor deviations at the point of chlorination can spell trouble at the final purification stage. Sometimes, it means taking a production line offline for full cleaning or tweaking order batches to anticipate reactivity differences. No trader can replicate this kind of oversight; it only emerges from lived experience and accountability inside a manufacturing plant.

    Innovation in a “Mature” Product

    At a glance, furoyl chloride looks like a straightforward molecule. But customers keep finding new ways to tweak ligands, block copolymers, or advanced intermediates using its versatile acyl functionality. We listen to these evolving technical demands. When researchers experiment with greener acylating reagents or novel solvents, our plant teams watch for shifts in market trends, sourcing new catalysts or improving energy efficiency where real benefits emerge.

    Backing up every technical specification is a commitment to keeping up with innovation in both chemistry and sustainability. We also investigate cleaner routes for thionyl chloride disposal and solvent reclamation. These details may never appear in end-user documentation, but as the producer, we feel the long-term pressure to balance economics, safety, and global responsible care.

    What It Means to Manufacture, Not Just Supply

    Month after month, we roll out hundreds of kilograms of furoyl chloride, but we see more than raw numbers. We see the technical teams at customer sites, analytical chemists double-checking test results, and R&D projects building on yesterday’s batches. Trust isn’t built by filling orders; it’s earned when the toughest jobs still meet customer expectations. Our engineers talk shop daily—discussing process tweaks, weighing risks, and planning for contingency events like power outages or supply interruptions.

    Every year brings new regulatory measures, customer demands, and unpredictable hurdles—from surging freight costs to rapid shifts in global demand. Our history in this business reminds us that reliability and communication matter just as much as product grade or price list. That’s the difference making furoyl chloride from scratch brings compared to mere trading or repackaging.

    Looking Forward: Sustainable Production and Future Needs

    The world of chemical manufacturing increasingly pushes us toward sustainable, transparent practices. Furoyl chloride production faces its own challenges, from responsible chlorine management to ongoing energy optimization. We invest in plant upgrades that reduce emissions, test regenerative purification columns, and screen for alternative acylation technologies capable of shrinking our environmental footprint. We don’t seek cheap shortcuts; instead, we engage with scientific partners, listen to R&D voices, and push for better solutions.

    We anticipate growing demand from specialty pharma and advanced polymers, so our expansion rests on real data from market feedback and trouble-shooting in live production. Our teams meet changing needs by staying nimble, revalidating every process step with a view to both compliance and real-world results.

    Why Our Manufacturing Model Matters to You

    From our seat on the manufacturing floor, quality, transparency, and innovation don’t come from regulation—they come from taking pride in what we do every shift. Our customers rely on us for more than a chemical barrel. They expect openness about our processes and a readiness to field questions any day of the week. Many have worked with us for years, riding out both smooth and challenging cycles as partners.

    Furoyl chloride isn’t just another commodity for us—it’s a promise that, no matter what changes come, you’ll be able to count on the same technical quality, year in, year out. We welcome every user, researcher, and partner who values genuine manufacturing know-how and the reassurance that comes from dealing with those who create the product from the ground up.