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Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime

    • Product Name Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime
    • Alias Clocvane
    • Einecs 401-090-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    278602

    ChemicalName Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime
    CASNumber 67664-93-1
    MolecularFormula C9H10ClN3O2
    MolarMass 227.65 g/mol
    Appearance White to off-white crystalline solid
    MeltingPoint 161-163°C
    Solubility Slightly soluble in water
    BoilingPoint Decomposes before boiling
    StorageTemperature Store at 2-8°C
    Purity Typically ≥ 98%
    HazardClass Irritant
    Synonyms Clocvician, Exo-3-chloro-6-cyano-2-norbornanone oxime methylcarbamate
    StructuralFormula Available upon request as a 2D/3D image

    As an accredited Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed 10g amber glass bottle with tamper-evident cap. Labeled with product name, CAS, hazard pictograms, and handling instructions.
    Shipping **Shipping Description:** Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime is shipped in tightly sealed, chemically resistant containers. It should be transported under ambient or controlled temperatures, protected from moisture and direct sunlight. Shipping must comply with applicable chemical safety and hazardous material regulations, including appropriate labeling and documentation for safe handling and delivery.
    Storage Store Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime in a tightly sealed container, away from light, heat, and moisture. Keep in a cool, dry, and well-ventilated area, separate from incompatible materials such as strong acids and bases. Ensure proper labeling and restrict access to authorized personnel. Use appropriate spill containment measures and wear suitable protective equipment when handling.
    Application of Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime

    Applications of Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime in Industrial Manufacturing

    As a specialized manufacturer, we focus on the integration of Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime into real, industrial-scale chemical value chains. Below, we breakdown its application in key sectors, providing details on regulatory compliance, working dosage, plant integration, and downstream products. This overview guides technical teams seeking performance, safety, and full industry alignment through each phase of adoption.

    1. Active Pharmaceutical Ingredient Synthesis (Carbamate Family APIs)

    Pharmaceutical manufacturers use this compound as a key intermediate for the synthesis of specific carbamate-structure APIs, especially in the development of acetylcholinesterase inhibitors. The material enters multistep organic syntheses, meeting purity and traceability expectations for regulated drug manufacturing lines. The adjustment of charge order and reaction selectivity depends directly on the integration point during the synthetic route, which is validated batchwise in accordance with Good Manufacturing Practice systems and global pharmacopoeia requirements.

    Industry compliance standards

    • ICH Q7 Guidelines for Active Pharmaceutical Ingredients
    • US FDA cGMP (21 CFR Parts 210/211)
    • European Pharmacopoeia (Ph. Eur.) monographs applicable to the target API
    • USP <795> and <797> for compounding quality management

    Typical usage ratio

    • 0.6–1.2 molar equivalents relative to the downstream coupling partner, adjusted based on process yield studies and stoichiometry optimisation in pilot transfer

    Downstream process integration

    • Initial charge in the condensation stage of active moiety assembly, typically following in situ generation of an imine or oxime intermediate under inert atmosphere and controlled temperature conditions

    Final product types

    • Carbamate-based active pharmaceutical ingredients (e.g., analogues of oxime-acetylcholine reactivators)
    • Research-grade reference materials for pharmacological studies

    2. Agricultural Insecticide Formulation (Carbamate Oxime Insecticides)

    The agrochemical sector applies this raw material as a highly selective synthon for advanced carbamate oxime insecticides, targeting pests with unique neural modes-of-action. The compound’s structure provides critical resistance management features by introducing nitrile and chloro functionalities, leading to tightly controlled bioactivity. Licensed pesticide formulators integrate it during the actives’ synthesis and further blend it to standardized concentration for global registration packages.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • US EPA 40 CFR Part 180 (Tolerances and Exemptions for Pesticide Chemical Residues)
    • China GB 2763 Food Safety National Standard for Maximum Residue Limits
    • ISO 9001:2015 Quality Management for agrochemical manufacturing

    Typical usage ratio

    • 3–8% w/w in active ingredient batches prior to formulation; final field concentration adjusted to regulatory requirements based on LD50 and pest target spectrum validation

    Downstream process integration

    • Incorporated in the post-chlorination step of actives’ synthesis, followed by microencapsulation or wettable powder/formulation blend, under solvent-controlled and dust management systems

    Final product types

    • Carbamate oxime-based insecticidal active substances
    • Emulsifiable concentrates and wettable powder formulations for field crop protection

    3. Fine Chemical Synthesis for Medicinal Chemistry Research

    Contract research organizations (CROs) and early-stage pharmaceutical development labs incorporate this compound as a synthon in custom molecule assembly for SAR (structure-activity relationship) exploration, especially in ligand and scaffold design for neurological and enzymatic pathway modulation. The nitrile and carbamoyl functional groups serve as reactive handles for further derivatization in medicinal chemistry campaigns.

    Industry compliance standards

    • OECD GLP for research substance handling
    • ISO 17025 Laboratory Accreditation requirements
    • REACH Annex XVII compliance for R&D chemical usage in the EU

    Typical usage ratio

    • 0.2–2 mmol per batch, with precise dosage determined by target analogs’ synthetic route and reaction scale

    Downstream process integration

    • Activated in the nucleophilic substitution or cyclization steps of compound library synthesis, commonly in anhydrous polar aprotic solvents under nitrogen

    Final product types

    • Novel norbornanone analogues and oxime-carbamate derivatives for bioassay screening
    • Small-molecule intermediates for patent application support

    4. Advanced Material Intermediates for Specialty Polymers

    Manufacturers of high-performance specialty polymers utilize the oxime-bearing norbornanone structure as an intermediate for producing functionalized copolymers exhibiting enhanced resistance properties. Its unique bicyclic skeleton, combined with reactive groups, enables the creation of material grades suited for demanding applications, including engineering plastics used in environments requiring superior solvent and thermal resistance. Downstream processing tightly monitors the purity and incorporation level of the intermediate for product consistency.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for polymer manufacturing
    • RoHS Directive (2011/65/EU) for restricted substances
    • REACH Registration for polymer intermediates

    Typical usage ratio

    • 0.5–3% w/w of overall monomer/feedstock mass, continually optimized in pilot and commercial batches to balance functionalization with material performance targets

    Downstream process integration

    • Added at the bridging monomer introduction stage in solution or suspension polymerization, prior to initiator dosing and temperature ramp-up

    Final product types

    • Functionalized norbornanone copolymers for engineering plastics
    • Specialty coatings and solvent-resistant films
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    Certification & Compliance
    More Introduction

    Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime: A Closer Look from the Manufacturing Floor

    Rooted in Precision: Our Approach to Synthesis

    At our manufacturing sites, we craft Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime with a clear understanding of its role in complex chemical systems. Every day, our technicians watch over a process that reflects hours of methodical reaction monitoring, constant filtration checks, and sunlight-scarce shifts. Uniformity in quality doesn’t begin in the lab; it grows from decisions made on the production floor—decisions about solvent selection, temperature controls, and dozens of subtle process levers sharpened by years in this field.

    This compound, sometimes described within our walls by shorthand or as "Exo-Carbamoyl Oxime," belongs to a family of nitrogen heterocycles. Several the botanicals in the wider world mirror its active sites, which often serve as intermediates in the development of plant-protective agents and other specialties. The product’s unique skeleton owes much to the norbornane core—a rigid, intricately bridged ring system. Handling this substrate during synthesis requires patience and a willingness to adjust process parameters during each lot.

    How Specification Drives Leave No Room for Compromise

    Years of consistency-building have forced us to understand the importance of fine details in producing Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime. From the first kilogram on, each batch is defined by specifications such as purity, particle size, and moisture content. Our in-house analysts run HPLC and GC assays routinely, rejecting any lot that drifts by even a fraction from the standard curve we mapped out long ago.

    Our quality habits arise from pure necessity: downstream reactions just do not tolerate off-spec intermediates. Unwanted byproducts snarl reactors, gum up feed lines, and put investment at risk. When end-users rely on consistent reactivity and stability, it forces us to tighten specifications at the source. In one case, we detected a trace impurity after a new filtration protocol—our lead engineer halted production, switched to inert gas purging, and solved the problem for every future lot.

    Comparisons with Neighboring Compounds

    The molecular tweaks that set Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime apart from siblings in the norbornanone analog lineup might not look grand on paper, though small shifts in halogen or nitrile position produce enormous changes in physical and chemical characteristics. Over the years, our process engineers have watched how slight substitution differences affect solubility, storage stability, and downstream adaptability.

    In the hands of a skilled formulator, this oxime delivers sharper control over target reactions. Compared to similar norbornanone-based intermediates lacking the methylcarbamoyl oxime group, our product tends to resist photodegradation more effectively and requires less stabilizer in finished form, translating to cleaner, more predictable performance. Many have attempted to swap in less refined analogs for short-term budget gains. These moves rarely pay dividends; separation and purification costs pile up down the line.

    Real-World Use Cases: From Synthesis Bench to Field

    Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime commands attention in several sectors, though crop chemistry illustrates its utility best. Here, formulation teams value this intermediate for its ability to anchor more elaborate fused-ring systems and deliver desired selectivity in mode-of-action. Field trials run by our clients have shown superior residual activity and minimized off-target effects—a goal every manufacturer hears about in feedback loops from regulatory and agronomy partners alike.

    In practical synthesis, users benefit from its balance of reactivity and handling safety. Unlike more volatile norbornanone derivatives, our compound maintains its integrity during storage and transport under typical warehouse conditions. Customers prefer packaging that acknowledges real supply-chain interruptions. We responded by shifting to multilayered containment and tailored drum linings to extend shelf life without relying on extreme cold storage.

    Production Problems—and Lessons Learned

    Several years back, our team hit a snag with crystallization. The compound began precipitating as a fine, persistent dust—not the dense, uniform crystals our downstream partners need. Yields dropped, filters clogged, and frustration built across shifts. Troubleshooting led us to investigate solvent evaporation rates, then the temperature windows programmed into reactor controls. No fix arrived until operators noticed minor changes in raw feedstock—an out-of-spec solvent supplier. We adjusted our incoming quality validation, improved on-site solvent distillation, and restored the product to optimal form.

    Those lessons stick with production-minded teams. Manufacturers do not approach Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime as a generic, interchangeable intermediate; making this molecule consistently takes vigilance at each step. Other plants have reported similar headaches: off-brand variants often cause more trouble than their upfront savings suggest. Unreacted starting material in alternative routes has been known to poison catalysts or force extra purification steps, putting entire batch cycles at risk.

    Regulatory Reality: Meeting Standards Ahead of Time

    We’ve come to appreciate how regulatory frameworks shape production at every turn. Even before the first full-scale batch comes off the line, we run trials to mirror current environmental and workplace health expectations. Increasingly, authorities scrutinize precursor stability, trace byproducts, and endpoint toxicity. Our lab teams built robust test panels years before required—a choice that cost money upfront but built lasting trust with long-term partners.

    Unlike some intermediates, Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime stands up well in rigorous regulatory review, provided the supply chain stays honest from start to finish. The unique norbornanone ring resists breakdown far better than open-chain counterparts, minimizing environmental carry-through. This echoes in field data, helping our partners stay ahead of risk assessments during registration and scale-up approval.

    Our Ongoing Commitment to Technical Excellence

    Over time, every product line encounters external pressure—climbing raw material costs, regulatory changes, or supply shocks. We learned long ago that waiting for problems to show up in finished product complaints means risking valuable contracts. Instead, we keep cross-discipline teams turning over data points every week, focusing on the tiny quality signals that predict long-term process drift.

    As a manufacturer, honest feedback drives improvements much faster than internal targets alone. Pulling data not only from our QC lab but from downstream client feedback, we see trends emerging before they become failures. By rotating team members between analytical, process, and customer support roles, we foster an atmosphere where issues get flagged and solved quickly, long before large-batch rejections eat into capacity.

    Why the Details Matter for Safety and Use

    Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime enjoys a reputation among technical users for reliability in high-stakes applications, but it doesn’t earn this on lab notebooks alone. Technicians who weigh and handle this compound speak up about their experiences—the ease of transfer, tendency to cake or dust, rate of dissolution. Feedback like this leads us to schedule repeated small-scale pilot runs, making sure we’ve designed a product form that won’t turn a routine weighing or dilution into a safety incident.

    The physical profile of the product—free-flowing, minimal static build-up, and a quiet persistence even after long-term storage—was shaped directly by listening to colleague and client reports. If workers reported issues with clumping or dust, we visited the packaging lines ourselves, running side-by-side tests against previous lots and making real-time extrusion or granulation changes.

    Real Lessons from Competitive Batches

    Not every batch in the broader marketplace can hit the needed notes. Several major projects tried switching to generic versions sourced from quick-turnaround suppliers. Results fell short—customers noted slower kinetics in pilot runs, with greater risk of byproduct formation and added clean-up steps in downstream reactors. These lessons push us to invest more in root-cause analysis and share best practices across production lines, even when that means pausing output for deeper dives into failed lots.

    Innovation in Handling and Storage

    Safe, practical handling doesn’t take shape in the boardroom. A storeroom worker watching for color shift and caking patterns can reveal more than external audits. Our team invests in strengthened drum linings and desiccant packs not on theory, but because repeated real-world incidents revealed early warning signs—such as faint odors or shifting physical state—signaling unwanted hydrolysis or oxidation.

    Years ago, supply chain routines operated on assumptions about warehouse transit times and climate. Once, an unexpected summer heatwave impacted the stability of several shipments. We responded, not with reactive quality holds, but with augmented shipping insulation and faster in-transit stability checks, even shipping partial loads to meet critical deadlines. That choice shaped client trust more than any official product certification.

    The Role of Process Chemistry: Making Complex Look Simple

    Building Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime at reliable scale requires patience on the part of every chemist and operator involved. Experienced staff members know the subtle color changes at each stage—peach-tan to white, crisp precipitation rather than faint haze. Training the next generation means not just teaching them the science, but sharing quiet warnings passed down from reactor-side veterans: never rush the exotherm, trust the scent of fresh filtrate, and always recheck the distillation columns after any hardware upgrade.

    It’s one thing to meet a written spec. Real-world use means never looking away from the thermal data, the filtration drag, or the first-glance appearance of cake on tray dryers. Only by documenting—and acting on—these daily minutiae do we keep quality higher than batch-to-batch variation found in more transactional supply chains.

    Continuous Improvement Through Direct Observation

    Direct observation has changed more about our plant routines than any set of external standards. By walking the lines and testing random product pulls, our supervisors see firsthand how the batch crystallizes, packs, and arrives in cooled bins. Such involvement turns every staff member into a silent inspector.

    In one notable incident, a newly qualified technician’s routine inspection caught a minor clump in a batch that still cleared all metrics on paper. Rather than dismiss this as an outlier, we reassessed drying times, recalibrated moisture sensors, and adjusted ventilation—raising the overall bar for future output. That choice fed back not only into the manufacturing protocol for this compound, but others using related norbornanone chemistries.

    Setting Apart the Genuine Product

    Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime comes to users with an origin that matters. Wherever this compound goes, the first question is whether it can deliver reliable, reproducible results each time. Outsourced alternatives drag along risks not always marked on paperwork; unknown impurity profiles, unintended reactivity, or just a faintly different crystalline habit—a worry that only experience can spot.

    On our side, we test retained samples against archived batches, maintain up-to-date certificate libraries, and adapt our documentation in response to real-life feedback—not regulatory minimalism. This ongoing investment in knowledge and process gives users more than just technical reassurance; it minimizes costly surprises on their own lines, keeping launch dates on time and waste to a minimum.

    The Push for Sustainability—A Plant Perspective

    Production teams across the industry now see sustainability less as a slogan than as a lived reality. Raw ingredient sourcing, solvent recycling, and energy use shape the final footprint of every molecule. We reengineered distillation loops to draw less power, introduced closed solvent cycles where possible, and support local feedstock suppliers, which shaves weeks off purchasing timelines and shrinks transportation carbon output.

    These changes didn’t come from executive mandates, but suggestions from operators watching energy meters or tracking tank cycle times. As a result, we’ve supported client efforts to highlight greener sourcing on their end-product certifications without sacrificing yield, speed, or safety for headline claims.

    Looking Forward—Technical Evolution from Experience

    Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime stands as a product of continuous refinement, pushed forward by both challenge and necessity. Technical users will continue to drive change through feedback and application notes, just as our teams evolve the workflows behind every delivered drum. In our experience, open channels for quality feedback, cross-plant learning, and direct-from-floor inspection keep standards rising even as production volumes swell.

    Whether used in complex agrochemical formulations, specialty syntheses, or pilot plant experiments, the compound’s true reliability comes from decisions made dozens of steps upstream—by the hands and eyes of those committed to true, bottom-up process mastery.

    Shared Responsibility: Partnering for Better Chemical Outcomes

    Those of us who shape and ship every lot of Exo-3-Chloro-6-Cyano-2-Norbornanone O-(Methylcarbamoyl)Oxime realize that real accountability rarely ends at our warehouse door. We keep open lines with technical contacts—not just procurement officers—trading hands-on feedback about solubility quirks, unexpected side reactions, or subtle differences in solid form. Real solutions take form at this interface between manufacturer and formulator, not at abstract specification tables.

    Better product outcomes depend on manufacturers treating each batch as more than commodity output. In our practice, the sum of every shift, quality checkpoint, and customer problem shapes a more adaptable, reliable chemical partner. As external demands rise for both performance and traceability, this mix of vigilance and openness keeps our product above the rest.