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Dimethylchloroacetal

    • Product Name Dimethylchloroacetal
    • Alias Acetal (DMA)
    • Einecs 203-498-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    152227

    chemical_name Dimethylchloroacetal
    synonyms 2-Chloro-1,1-dimethoxyethane
    molecular_formula C4H9ClO2
    molar_mass 124.57 g/mol
    appearance Colorless liquid
    boiling_point 108-110 °C
    density 1.036 g/cm3
    refractive_index 1.397-1.400
    flash_point 19 °C
    solubility_in_water Slightly soluble
    cas_number 97-97-2
    odor Pungent, ether-like

    As an accredited Dimethylchloroacetal factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Dimethylchloroacetal is packaged in a 500 mL amber glass bottle with a secure cap and hazard labeling for safe handling.
    Shipping Dimethylchloroacetal should be shipped in tightly sealed containers, compatible with organic solvents, and kept away from moisture, acids, and oxidizing agents. Transport in accordance with applicable regulations for flammable and irritant chemicals. Ensure labels indicate hazardous contents, and protect from physical damage during shipping to prevent leaks or contamination.
    Storage Dimethylchloroacetal should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep separate from strong oxidizers, acids, and moisture. Use only in well-ventilated areas and store under inert gas if possible. Proper chemical-resistant gloves and eye protection should be used when handling.
    Application of Dimethylchloroacetal

    Applications of Dimethylchloroacetal in Industrial Manufacturing

    As a direct manufacturer specializing in high-purity Dimethylchloroacetal, we supply this intermediate to a select range of industrial segments where its unique functional reactivity and volatility control enable precision chemical synthesis. The following real-world downstream applications reflect our core B2B partnerships and technical support for continuous production systems seeking strict compliance, defined formulation accuracy, and reliable final product performance. Each scenario details field-verified integration data from actual customer use.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    Dimethylchloroacetal serves as an essential C1-protecting group reagent in the production of key pharmaceutical building blocks, especially heterocyclic and aromatic compounds used in API synthesis. GMP-compliant manufacturers use it during protection and deprotection steps to improve yield and selectivity in processes for commercial drug substances such as anti-infective agents and CNS-active compounds.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • U.S. Pharmacopeia (USP) General Chapter <797>
    • European Pharmacopoeia (Ph.Eur.) monographs for APIs
    • FDA 21 CFR Part 211 (CGMP for finished pharmaceuticals)

    Typical usage ratio

    • Generally 1.0–1.5 molar equivalents relative to the substrate; ratio adjusted by stoichiometric requirements of specific API synthetic routes and scale of batch.

    Downstream process integration

    • Introduced in early- or mid-step protection phases during multi-step synthesis of drug intermediates; subsequent removal via hydrolysis or cleavage immediately prior to final API coupling or purification.

    Final product types

    • Bulk pharmaceutical actives: antibiotics, antiepileptics, CNS pharmaceuticals
    • Pharmaceutical intermediates for contract drug synthesis

    2. Agrochemical Intermediate Production

    Technical-grade Dimethylchloroacetal is used in agrochemical manufacturing as an alkylating agent for creating specialty intermediates in the synthesis of crop protection chemicals like fungicides and seed treatment products. Its performance provides reproducible batch consistency and supports strict quality audits in agrichemical plants.

    Industry compliance standards

    • ISO 9001:2015 (Quality management for process chemicals)
    • FAO/WHO Specifications for Pesticides
    • REACH Regulation (EC 1907/2006) for chemical safety
    • Chinese GB standards for chemical pesticides

    Typical usage ratio

    • Used between 0.8–2.2 molar equivalents; precise quantity determined based on specific active moiety and reaction pathway in target fungicide precursor synthesis.

    Downstream process integration

    • Added to chlorination or alkylation steps in batch or continuous flow reactors; usually consumed completely in intermediate formation prior to final pesticide molecule assembly.

    Final product types

    • Key intermediates for triazole and strobilurin fungicides
    • Seed treatment agents and pest-resistant coatings

    3. Light-Stabilizer and Resin Additives Manufacturing

    Formulation chemists incorporate Dimethylchloroacetal as a raw material for preparing acetal-functionalized light stabilizers and crosslinking agents used in automotive and industrial coatings. Its use ensures high purity additive streams and optimal branching in polymeric matrices required for advanced resin blend durability and UV resistance.

    Industry compliance standards

    • ASTM D5402 (Standard for chemical additives in coatings)
    • ISO 9001:2015 (Additives and resins)
    • EU Regulation (EC) No 1272/2008 (CLP))
    • ECHA guidelines for classification and labeling

    Typical usage ratio

    • Commonly incorporated at 0.5–1.2% by weight in light stabilizer formulation batches; ratio adjusted for molecular weight and end-use coating viscosity requirements.

    Downstream process integration

    • Mixed in post-polymerization modification of resins or during in situ synthesis of UV absorber masterbatches prior to compounding and packaging.

    Final product types

    • Polymer-compatible light stabilizer additives (e.g., HALS and UV absorbers)
    • Cross-linked acrylate and polyester resin blends for automotive and protective coatings

    4. Aroma Chemical Synthesis for Flavors and Fragrances

    Manufacturers in aroma chemical sectors employ Dimethylchloroacetal as a masked aldehyde intermediate for the synthesis of aldehydic and musky notes found in premium flavors and fragrances. Its reactivity profile makes it suitable for large-scale controlled release of critical aldehyde building blocks during complex flavor construction, adhering to food and cosmetic safety requirements.

    Industry compliance standards

    • European Union Regulation (EC) No 1334/2008 (Flavourings and certain food ingredients)
    • IFRA Code of Practice (Fragrance ingredient safety)
    • U.S. FEMA GRAS List (Flavor & Extract Manufacturers Association)
    • ISO 9001:2015 (Flavor and fragrance ingredient manufacturing)

    Typical usage ratio

    • Batch use at 0.25–1.0% by mass for aldehydic ester synthesis; may be fine-tuned based on the volatility and retention goals in formulated flavors or perfumery bases.

    Downstream process integration

    • Employed during initial condensation or acetal exchange steps, ensuring precise aldehyde release within multi-step aroma molecule synthesis prior to final blending and compounding.

    Final product types

    • Blended artificial flavoring bases for food and beverage
    • Fine fragrance accord components for perfumes and colognes
    • Cosmetic additive components for skincare and personal care bases

    5. Specialty Solvent and Extractant Manufacturing

    Industrial solvent producers use Dimethylchloroacetal as a stabilizer and component in the manufacture of specialty extraction agents for fine chemical purification, especially where acid-sensitive working solutions or trace water control are required. This application supports high-demand settings such as pharmaceutical and electronic material purification.

    Industry compliance standards

    • ISO 16128 (Natural and organic cosmetic ingredients)
    • ASTM D1078 (Distillation range of organic liquids)
    • USP-NF (for solvent residues in pharmaceutical processing)

    Typical usage ratio

    • Typical concentration of 1.0–3.0% in extraction formulations; levels are tailored to acidity of matrix and removal rates desired in high-value purification workflows.

    Downstream process integration

    • Incorporated at solvent blending or stabilization stage prior to application in column chromatography, liquid-liquid extraction, or sensitive component isolation protocols.

    Final product types

    • High-purity specialty solvent blends for pharmaceutical and electronic material extraction
    • Stabilizing agents for moisture-sensitive extraction columns
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    Certification & Compliance
    More Introduction

    Introducing Our Dimethylchloroacetal: Experience and Knowledge Behind Every Molecule

    Proud Producer of Reliable Dimethylchloroacetal

    Working with chemicals for decades, we’ve always aimed to keep our promises not just with quality, but with knowledge rooted in real experience. Many customers seek dimethylchloroacetal because of its well-established role in organic synthesis, especially when building complex molecules for pharmaceuticals, agricultural products, and advanced materials. Unlike a volatile trading market or shifting supply chains, we set out to provide consistent results batch after batch.

    Overview: Model, Purity, and Key Properties

    Every kilo of dimethylchloroacetal that leaves our facility is the product of rigour and process control. Our current production focuses on the model DMCA-99, which meets a minimum purity of 99%. We learned quickly that traces of water or alcohol create headaches in downstream reactions, so we follow a drying and purification sequence that puts tight grip on impurities. The chemical formula C4H9ClO2 may look simple, but any deviation in the process—the condensation, the controlled chlorination—can knock a reaction off course. Our technical staff tests every drum for content, acidity, and residue solvents because these things matter in a real process, not just on paper.

    Critical Applications: What Real Users Value

    Synthetic chemists often reach for dimethylchloroacetal as a protecting agent, shielding reactive aldehydes from unwanted side reactions. In practice, small differences in handling can decide whether a synthesis yields grams or milligrams. From our work with pilot lots, we've seen that pharmaceutical labs prefer DMCA when developing APIs, especially where functionality on aromatic rings or complex skeletons demands selectivity. In our own experience, getting high-conversion in acetalation means controlling both the water content and the sequence of addition. Industries crafting specialty flavors and fragrances turn to this molecule not because it sounds exotic, but because it offers a clean, fast reaction and resolves out of mixtures without leaving stubborn residues.

    In agrochemical intermediates, customers noticed that dimethylchloroacetal participates in route-scouting for new herbicides. It keeps sensitive functional groups safe under harsh esterification or alkylation conditions. Usually, we deal with quantities measured in tons, and we’ve observed that engineers working at scale face different headaches from the bench chemist. Availability, steady quality, and predictable reactivity win out over marginal cost savings.

    Practical Handling — Built on Experience

    Having filled and shipped thousands of containers, we know that real work in a chemical plant rarely follows the textbook. Dimethylchloroacetal requires care because it reacts with water, forming corrosive hydrochloric acid. One minor oversight—a leaky drum or a humid tank—can compromise purity and corrode equipment. Our packaging uses high-barrier drums, and we inert containers with nitrogen before sealing. We share safety data and protocols with our customers because over the years, those who ignored ventilation or gloves learned lessons the hard way. We always stress the need for fume extraction systems and appropriate neutralization strategies.

    Our production runs produce consistent material with a faint, almost fruity odor, typical of low-molecular acetal compounds. We always advise storing away from direct sunlight, as this minimizes the gradual hydrolysis which can otherwise creep up unnoticed. Customers storing drums for more than a few weeks find our shelf-life recommendations useful, as overlooked degradation translates to problems during scale-up.

    Differences from Other Acetals: It’s in the Details

    Having worked with a wide range of acetal products, including diethoxymethane, ethylene glycol acetal, and others, we often get asked: what sets dimethylchloroacetal apart? From years in the lab and pilot plant, we’ve seen that methyl derivatives typically react faster and clean up easier than ethyl or propyl analogs. The choice of methyl groups also minimizes side reactions in acid-catalyzed processes—an important edge for high-purity pharmaceuticals. Dimethylchloroacetal brings a volatility curve that suits both batch and continuous distillation methods, allowing smoother recovery and purification.

    Some customers shifted from using diethoxymethane or 1,1-dimethoxyethane and later reported that the shorter chain and smaller steric bulk of dimethylchloroacetal avoids sluggishness in condensation steps. In reactions producing flavoring esters, methyl groups tend to yield sharper, more defined profiles. Each acetal has its own role, but we observed that certain limitations in hydrolytic stability and by-product formation with larger alkyl chains can unravel a process’s economics during scale-up.

    Supply Chain: Advantages of Vertical Integration

    We make our own intermediates for dimethylchloroacetal, rather than buying in bulk from outside markets. This long-term investment means we manage raw material quality from the very start. Fluctuations in methanol or trichloroacetaldehyde supply occasionally create headaches, but manufacturing each precursor on-site lets us flatten out spikes in cost and volatility. Logistics staff in our operation track temperature, transit times, and pressure ratings, making sure that every container arrives not just intact, but also uncompromised by long storage or transport.

    Our customers work in time-sensitive industries. Missed delivery dates can stall entire production lines. Our in-house warehouse and nearby logistics partners allow us to promise realistic lead times. Strained supply chains, especially in a world of international tension, have taught us to keep contingencies for critical components. Every ton of dimethylchloroacetal that leaves our plant reflects not only chemical knowledge but an understanding of what it means to risk a delay at scale.

    Quality Assurance: Real-World Rigor

    In our factory, quality doesn’t just mean passing an assay or hitting a chromatogram target. We invest in batch reproducibility, which pays off during technology transfer or regulatory registration. Some of our long-term partners have walked their own customers through inspections and audits, with our material logs and analytical data close at hand to reassure procurement managers and compliance officers. Every year, we update certificates of analysis, not simply to tick a box, but because tight compliance with regulatory norms heads off regulatory risks for everyone involved down the chain.

    Our laboratory people rotate frequently between synthesis and quality control roles, which helps keep both disciplines grounded. By talking to both groups, we catch trends before paperwork turns into a problem—such as rising trace metals or organic impurities linked to a specific supplier. No plant runs perfectly, and occasional line hiccups surface. Each time this occurs, we issue transparent disclosures rather than hiding the news or blaming outside vendors. Our experience shows that honest feedback builds long-term trust far more than glossy certificates.

    Environmental Responsibility: Practice Over Promises

    Making dimethylchloroacetal inevitably produces waste acids and organic residues. Over the years, we’ve upgraded treatment facilities, shifting from basic neutralization tanks toward closed-loop recycling where possible. Every solvent drum we collect feeds a broader effort to minimize landfill streams and cut fugitive emissions. Our air abatement systems now trap over 95% of chlorinated vent gases thanks to scrubbers and thermal oxidation. Rather than pursuing zero-impact slogans, we focus on measured reduction of actual output, because inspectors—and neighbors—notice the difference.

    Responsible chemical manufacturing goes beyond compliance audits. For us, this means working ahead of regulation where possible, such as installing online pH monitors in effluent channels or treating returned packaging with validated protocols. We invite local environmental agencies to survey our plant annually and act on their recommendations as quickly as possible. In the chemical business, shortcuts have a way of catching up, both financially and reputationally. As the team that deals with every consequence of delayed or neglected maintenance, we invest steadily so each shipment of dimethylchloroacetal represents progress, not just output.

    Supporting Customers: Knowledge-Driven Advice

    We support buyers with application notes, handling guidelines, and troubleshooting advice. Over time, our technical staff compiled a library of reaction case studies—what worked in development labs, mistakes that cost precious hours, and ingenious tweaks that saved entire batches. We know that sometimes users call us hours before a production run looking for last-minute recommendations. We treat each query as a partnership, drawing on real-factory experience, not just theory.

    Sometimes, a buyer lands a new project that stretches dimethylchloroacetal’s capabilities in an unexpected reaction. We listen, test, and report honestly about feasibility and risks. For those with regulatory hurdles, we’ve helped prepare impurity profiles and stability data to underpin agency submissions. Manufacturing is more than just containers and invoices—our job continues long after delivery.

    How We Innovate: Insights From Real Production

    Improvement often starts at the margins, not in grand launches. Many new ideas have come from engineers spotting recurring issues—such as a particular by-product building up after a heat exchanger change, or an intermittent odor traced to valve downtime. We fix processes not as a one-off event, but as an ongoing conversation between plant operators, lab analysts, and end-users. Over the years, we’ve introduced improved filtration steps, finer temperature control, and better automation, each tweak backed up by real gain in product consistency.

    Our long-standing relationships with academic labs, often in joint development projects, allows us to collect field data on how dimethylchloroacetal performs in new syntheses. We host multi-disciplinary roundtables that gather chemists from different sectors to share reaction tips and identify future pain points. The feedback loop—problem, solution, validation—keeps our product updated to match modern requirements, not stuck in past recipes.

    Market Demands: Stability and Adaptation

    The global demand for dimethylchloroacetal reflects ongoing growth in fine chemicals and advanced intermediates. We supply users ranging from boutique flavor labs to large multinational pharmaceutical plants. Each customer sees the same product specs, but in practice, the needs diverge. Some demand regulatory-grade traceability and multi-step documentation; others want reliable shipping more than paper trails. We adapt to both.

    In recent years, regulatory rules on trace impurities and volatility of organic chlorides pushed us to tighten process controls. Our investments in analytical equipment—GC, NMR, mass spec—mean we measure what we promise. This has sometimes meant turning away orders that required shortcuts. We saw firsthand that chasing volume over quality undermines trust quickly, and so our sales policies follow real technical capability rather than chasing the market’s every upturn.

    Looking Ahead: Reliability in Changing Times

    No chemical plant stands still. As part of a global industry facing new economic and environmental pressures, our role as a reliable producer of dimethylchloroacetal goes beyond making a single molecule. We play our part in driving best practices—sharing data, learning from client experiences, and staying alert to regulatory shifts. Consistency builds value, not just for us, but for commercial partners counting on every delivery to underpin their own production lines.

    With roots in hands-on manufacturing, we remain committed to running a transparent, consultative business. Technology, safety, quality, and environmental responsibility all tie back to experienced people paying attention not only to molecules, but to outcomes in the world outside our plant gates. We take pride in every success that our dimethylchloroacetal helps achieve, knowing that behind each container stands not a formula, but practiced dedication and proven know-how.