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Diethyl Sulfide

    • Product Name Diethyl Sulfide
    • Alias DES
    • Einecs 203-729-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    751455

    CAS_Number 110-36-1
    Molecular_Formula C4H10S
    Molecular_Weight 90.19 g/mol
    IUPAC_Name Diethyl sulfide
    Appearance Colorless liquid
    Odor Unpleasant, garlic-like
    Boiling_Point 92-93 °C
    Melting_Point -100 °C
    Density 0.844 g/cm³ at 20 °C
    Solubility_in_Water Slightly soluble
    Flash_Point 2 °C (closed cup)
    Vapor_Pressure 72 mmHg at 25 °C
    Refractive_Index 1.423 at 20 °C
    PubChem_CID 8031
    UN_Number 2381

    As an accredited Diethyl Sulfide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Diethyl Sulfide is packaged in a 500 mL amber glass bottle, sealed with a screw cap and labeled with hazard warnings.
    Shipping Diethyl Sulfide should be shipped in tightly sealed containers, away from sources of ignition and incompatible substances such as oxidizers and acids. It must be labeled as a flammable liquid and transported according to relevant hazardous material regulations. Proper ventilation, secondary containment, and compliance with local and international shipping laws are essential.
    Storage Diethyl sulfide should be stored in a cool, dry, well-ventilated area, away from sources of ignition, heat, and incompatible materials such as oxidizers and acids. The container must be tightly closed and clearly labeled, preferably made of glass or compatible plastics. Ensure the storage area has proper spill containment and is equipped with fire extinguishing equipment due to its flammable nature.
    Application of Diethyl Sulfide

    Applications of Diethyl Sulfide in Industrial Manufacturing

    Diethyl sulfide serves as a specialized intermediate and process additive across several industrial production sectors. Manufactured to stringent purity requirements, it finds established usage in controlled environments where its physical and chemical properties bring targeted benefits to downstream processing and finished product performance. Below, we detail its real-world deployment in key segments, providing scenario-specific compliance, formulation, integration, and product information.

    1. Agrochemical Synthesis – Sulfur-Based Pesticide Production

    In agrochemical manufacturing, diethyl sulfide acts as a sulfur donor and reaction intermediate for selective herbicide and fungicide synthesis. Production facilities incorporate this intermediate within closed-loop, multi-stage synthesis trains, primarily to introduce or transfer sulfur atoms in the molecular structure of target actives like thiocarbamates and dithiocarbamates. Consistent product quality and regulatory traceability are closely monitored, as the use of process intermediates is strictly controlled under agriculture chemical regulations.

    Industry compliance standards

    • EPA Registration (US CFR 40 Part 158)
    • EU Regulation 1107/2009/EC on Placing of Plant Protection Products
    • China’s GB/T 1604-2019 Technical Standard for Pesticide Production
    • OECD Product Chemistry Data Requirements

    Typical usage ratio

    • Applied at 0.5%–3% molar equivalent relative to the principal synthesis substrate, adjustable based on targeted sulfur content of end compound and process yield optimization studies.

    Downstream process integration

    • Introduced in mid-stage batch reactor synthesis, with in-process monitoring for sulfur incorporation and excess removal during subsequent purification.

    Final product types

    • Herbicides (e.g. EPTC, thiobencarb)
    • Fungicides (e.g. thiram, ziram)
    • Seed treatment formulations

    2. Pharmaceutical Intermediate Manufacturing

    Within the pharmaceutical industry, diethyl sulfide is a functional intermediate in the synthesis of organosulfur compounds, particularly thioethers and thiazoles critical for active pharmaceutical ingredients (APIs) development. Facilities observe high-purity standards to avoid extraneous sulfide contamination. Manufacturers integrate this raw material in controlled batch or continuous-flow processes inside Good Manufacturing Practice (GMP) environments, especially in molecules where targeted sulfur substitution defines biological activity or pharmacokinetics.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF and European Pharmacopoeia monographs for intermediates
    • FDA 21 CFR Parts 210/211 for finished pharmaceuticals
    • Chinese Pharmacopoeia (CHP) requirements for API intermediates

    Typical usage ratio

    • Ranges from 0.2%–1.5% molar input, precisely regulated based on the synthetic route, with process analytical technology (PAT) confirming complete conversion and elimination of undesired residuals.

    Downstream process integration

    • Dosed during key condensation, alkylation, or ring closure stages, generally in temperature-controlled jacketed glass-lined reactors, followed by phase separation and solvent swap purifications.

    Final product types

    • API intermediates for cephalosporins, thiazole-class drugs
    • Sulfur-bridged heterocyclic compounds
    • Custom organosulfur building blocks

    3. Petrochemical Industry – Sulfur Scavenging Agent

    Diethyl sulfide is used in the petrochemical sector as part of sulfur-scavenging formulations to manage hydrogen sulfide and mercaptan impurities in middle distillates, LPG streams, and natural gas liquids. Operators add this material upstream of key purification or catalytic conversion units to mitigate corrosion, odor, and catalyst poisoning. Its fast reactivity profile enhances removal efficiency under site-specific processing parameters, requiring careful dosage control to maintain product specification compliance and equipment longevity.

    Industry compliance standards

    • ASTM D5504 for Sulfur Compounds in Light Hydrocarbons
    • API Specification 5L for pipeline quality
    • REACH Regulation (EC) No 1907/2006 for registered use cases
    • National Fuel Quality Standards: ULSD sulfur content (e.g., EN590, EPA Tier 3)

    Typical usage ratio

    • Typically injected at 20–100 ppm (weight/weight) depending on the contaminant load; final dosage refined through real-time gas chromatographic monitoring of sulfur levels.

    Downstream process integration

    • Dosed inline ahead of hydrotreater or sweetening units, with feed blending controlled via automated metering pumps synchronized to process analytics.

    Final product types

    • Low-sulfur diesel and jet fuels
    • LPG and NGL meeting odor and corrosion standards
    • Pipeline-transport fuels

    4. Industrial Solvent and Extraction Agent in Fine Chemical Synthesis

    Manufacturers of fine chemicals and specialty intermediates rely on diethyl sulfide as a specialty solvent and selective extraction agent in organic phase transfer and alkylation steps. Its efficacy comes from controlled polarity and sulfur coordination, allowing precise extraction of metal ions or separation of desired reaction fractions during multi-phase production workflows. Handling protocols focus on ventilation and containment due to low odor thresholds and volatility.

    Industry compliance standards

    • ISO 9001:2015 for Fine Chemical Production
    • Responsible Care Global Charter (chemical stewardship)
    • Local workplace chemical handling regulations (e.g., OSHA 29 CFR 1910.1200)
    • Custom client-specific supply chain audits

    Typical usage ratio

    • Generally 2–10% v/v, tailored to process throughput, temperature, and phase-transfer equilibrium requirements during pilot and large-scale production; minimized in final downstream formulations after separation and recovery steps.

    Downstream process integration

    • Added in solvent extraction columns or jacketed mixing tanks during post-reaction separation, with recovery via distillation enabled after extraction efficiency validation.

    Final product types

    • Electronic-grade organosulfur intermediates
    • Custom catalysts and ligands for chemical synthesis
    • Specialty fine chemical blends

    5. Polymer Modifier for Vulcanization Accelerator Synthesis

    Rubber and elastomer producers employ diethyl sulfide in the preparation of select vulcanization accelerators, where controlled introduction of ethylthio groups improves cross-linking performance. The raw material is directly incorporated in closed-system reactions to synthesize intermediates such as thiuram and dithiocarbamate salts, with formulation and handling designed for strict emission controls and in-process validation to meet market-specific compound performance.

    Industry compliance standards

    • ISO 9001 and ISO 14001 Quality and Environmental management
    • EU Regulation (EC) No 1907/2006 (REACH) for pre-registered rubber additives
    • ASTM D4678 Standard Practice for Rubber Chemical Accelerator Evaluation
    • GB/T 21805-2008 (Rubber Chemicals Technical Standard, China)

    Typical usage ratio

    • Dosed at 1–5 mol% relative to precursor amines or carbon disulfide reactants in closed reactor synthesis batches; adjusted per desired enhancer performance and downstream formulation compatibility.

    Downstream process integration

    • Charged during pre-polymerization additive synthesis steps, prior to neutralization and filter-press isolation, followed by downstream blending into masterbatch compounders or direct shipment to tire and rubber goods factories.

    Final product types

    • Vulcanization accelerators (e.g. TMTD, TETD)
    • Rubber masterbatches for tire and O-ring production
    • Specialty elastomer additives targeting abrasion and compression set
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    Certification & Compliance
    More Introduction

    Diethyl Sulfide: A Manufacturer’s Perspective on a Spirited Industrial Ingredient

    Understanding Our Commitment to Quality in Diethyl Sulfide Production

    Every chemical producer faces crucial decisions about source materials, process reliability, and product purity. Day after day in our diethyl sulfide facility, these factors shape every drum and bulk shipment leaving our gates. Diethyl sulfide, sometimes called ethyl thioether, represents both challenge and opportunity in sulfur chemistry, and we have learned from years of hands-on manufacturing exactly where its strengths shine and how it stands apart from similar sulfur compounds.

    What Sets Diethyl Sulfide Apart in Practice

    Among the sulfur-containing organics available to industry, diethyl sulfide fills a distinct need. Its structure (C2H5)2S favors reactions demanding a lighter, less polluting, and lower boiling alternative to longer-chain sulfides or thiols. In our reactors, this means fewer byproducts and simpler distillation sequences, resulting in more predictable outcomes for downstream customers.

    Experience shows that diethyl sulfide’s volatility distinguishes it from heavier sulfur solvents or odorants. Its moderate boiling point (around 92°C) limits residue build-up, facilitates consistent material transfers, and enables straightforward purification. Other thioethers like dipropyl sulfide or dibutyl sulfide introduce greater handling complexity, risk of residual contamination, and environmental controls, especially in enclosed facilities. By contrast, our diethyl sulfide batches demonstrate reliable removal via standard condensation, reducing both downtime and maintenance costs.

    Specifications That Matter on the Production Floor

    Production of diethyl sulfide at scale involves close control of purity, odor profile, water content, and sulfur distribution. We target a chemical purity above 99% as determined by gas chromatography, because anything less threatens the performance in applications like flavor formulation, hydrocarbon process engineering, and research chemistry. Water content remains another prime metric—excess water or inorganic residue complicates organic syntheses, so we monitor and minimize this during final purification. Years of batch analysis underscore that well-made diethyl sulfide should not impart off-notes or haze, especially when destined for flavor research or sensitive catalysis.

    Storage and handling guidelines inform not just product stability but operator safety. Diethyl sulfide comes as a clear, colorless liquid, carrying a recognizable—but more manageable—odor profile compared to potent thiols or mercaptans. Its vapor density and flammability mean we dedicate closed-loop delivery, specific vented tanks, and anti-static grounding during shipment and transfers. These controls keep our staff safe and safeguard customer installations, while regular inspection avoids small leaks that would otherwise cause odor issues or workplace complaints.

    Why End Users Return to Diethyl Sulfide

    Process engineers and R&D chemists keep turning back to diethyl sulfide for its selective solvency and manageable odor character. In selective extraction methods, such as the removal of mercury or arsenic from refinery streams, this compound displays a favorable balance between solubility and volatility. A single pass through a sulfur scrubber, aided by diethyl sulfide, typically leaves downstream units cleaner, meaning less fouling and fewer expensive shutdowns. Alternatives like tetrahydrothiophene or longer alkyl thioethers show slower mass transfer, sluggish regeneration, or much more pungent odors that travel beyond vent stacks, drawing regulatory scrutiny.

    In aroma chemistry, trace levels of diethyl sulfide impart a signature green, savory note to select flavor compositions. Its intermediate odor threshold and mild persistence provide desirable effects without overpowering other components or causing compliance problems with flavor standards. Flavorists favor its clarity compared with “skunky” lower thiols or the dense oiliness of longer thioethers. Our process ensures these sensory features remain consistent bottle to bottle, batch to batch.

    Beyond pure extraction or flavor blending, another area of demand comes from the synthesis of organosulfur intermediates. Diethyl sulfide acts as a building block in the production of specialized catalysts, ligands, and even certain pharmaceuticals. In catalytic alkylation or complexation chemistry, higher purities and trace metal control reduce the risk of unpredictable batch failures. Years spent tracing back failed synthesis runs have reinforced this for our team: any deviation in diethyl sulfide quality becomes very obvious as downstream yields begin to dip. Our raw material control and closed-system reactors work to minimize such costly surprises.

    Production Reality: Factoring Safety and Environmental Responsibilities

    Anyone who bottles and ships diethyl sulfide knows that safety and compliance drive daily decision-making. Its flammable classification draws immediate attention, from fire marshals to insurers. Our safety team invests hours into verifying electrical grounding, vapor detection, and spill response throughout the plant. Larger orders mean routing through dedicated transportation service providers trained in hazardous material handling. These routines grew from hard experience: any shortcut increases risk for both producers and end-users, so meticulous compliance has become part of the daily rhythm in the loading bay.

    On the environmental front, diethyl sulfide handling and storage create their own challenges. Light sulfur organics, even though less odorous than related mercaptans, still attract regulatory interest. We operate refrigeration and vapor recovery systems that capture fugitive emissions, both for workplace comfort and regulatory reporting. Our waste treatment and recycling operations close the loop, turning spent or out-of-spec material into feedstock for sulfuric acid and other process streams. This reduces waste volumes and plays into broader sustainability goals.

    Comparing Diethyl Sulfide with Other Sulfur Chemicals

    Markets sometimes treat thioethers, sulfides, and thiols in similar conversations, but industry know-how highlights differences that have significant knock-on effects throughout the supply chain. The short-chain thiols, like ethanethiol or propanethiol, demand much stricter control; their aggressive odor profile sticks to packaging, tools, and even protective gear, often requiring replacements after a few spills. In contrast, diethyl sulfide remains more forgiving in regular handling, sticking less to surfaces and quickly clearing from transfer lines with standard solvents or purges.

    Diethyl sulfide also brings a more neutral chemical character; its vapor pressure allows easier containment, and its lower toxicity score means less intensive risk management protocols compared to aromatic or halogenated sulfur chemicals. By careful calibration, our process limits mixed sulfur species to trace levels. Our experience handling both classes of compounds means our customers can trust samples that fall within exacting purity windows with simpler ventilation or filtration requirements.

    Technicians in process industries have also noted that diethyl sulfide, by virtue of its boiling and flash point, integrates more safely into solvent blends compared with lower- or higher-boiling analogs. In batch reactors and pilot plants, this translates to fewer thermal management headaches and lower risk of runaway conditions. The pressure-relief and flare systems in our plant reflect these lessons: specifications are set for the precise volatility and density of diethyl sulfide, not extrapolated from generic sulfur solvents.

    Practical Solutions Developed Through Decades of Experience

    Producing diethyl sulfide at scale has taught us many valuable lessons under real-world conditions. Early batches, drawn off aging columns or rushed through impressionable equipment, revealed the importance of stainless alloys and high-purity glassware—anything else led to unwanted side reactions or metallic sulfur notes that downgraded the product. Today, we emphasize tight process control, both in feedstock and temperature regime, to manage reaction kinetics and steer away from heavy byproduct formation.

    Material compatibility means every transfer valve, pump seal, and storage tank lining faces regular scrutiny; even trace corrosion can introduce contamination that impacts entire delivery bladders. Tank farm managers maintain periodic isolation and cleaning schedules. Leak checks use not just visual or instrument detection, but also trained nose inspections, since certain odors can only be recognized by those steeped in chemical production environments.

    On the shipment side, we have tuned our packaging to align with the volatility and corrosivity of diethyl sulfide. Polymer selection for drum linings, venting strategies in transport containers, and double sealing standards follow from direct experience with both favorable runs and costly product recalls triggered by inferior capping or cleaning. Our logistical partners receive regular training on safe offloading, and we maintain open dialogue with return customers about product handling improvements observed in the field.

    Looking Toward Market Trends and Emerging Applications

    In the last decade, demand for diethyl sulfide has shifted incrementally from commodity solvent use toward more specialized market segments. Environmental regulations have moved many producers to favor lighter sulfur solvents that blend quickly, evaporate with less residue, and flag fewer disposal issues. Growing research interest in sulfur-based pharmaceuticals, advanced catalysts, and specialty flavors means purity and trace impurity documentation have become top priorities for purchasing agents.

    Newer catalytic transformation methods, such as transition metal-catalyzed C–S bond formation, now rely on high-purity starting thioethers. Any deviation in sulfur distribution or unreacted base material impacts catalyst lifetimes and product selectivity. Our process teams run thorough impurity profiling using updated analytical methods, updating production targets to reflect customer feedback about critical specifications. This ongoing feedback loop reflects a healthy producer-customer dynamic, ensuring that our diethyl sulfide remains attuned to the latest technical and regulatory needs.

    Meanwhile, in flavor and fragrance industries, unique green-sulfur notes have seen renewed interest for consumer products aiming at authenticity and complexity. Toxicology constraints limit the allowable use levels, so our sales and lab support teams work with customers to document all aroma and trace impurity properties thoroughly. Our insight into sensory science allows better troubleshooting support for formulators wanting consistency and regulatory peace of mind.

    Maintaining Trust in an Evolving Chemical Supply Chain

    Reputation shapes every successful chemical manufacturer’s business. Having walked through batch startup crises and customer audits, we know that trust builds from clear communication about material properties, batch variation, and logistical realities. Our largest customers rely on lot-by-lot documentation and traceability back to the raw feed barrels, expecting photographic records and updated retention samples for dispute resolution. These routines stem from countless negotiated contracts and compliance discussions, not just back-office paperwork.

    In today’s ownership-driven climate, customers expect rapid responses to questions about residue, odor, and even obscure trace elements. Our lab and technical support divisions emphasize transparency, offering not only certificates of analysis but explanations based on real factory experience. This quiet consistency underwrites both large and small-volume customer partnerships, preventing surprises down the road and fostering mutual respect.

    As chemical supply chains become more complex, unexpected events such as raw material shortages, logistics slowdowns, or regulation updates can create headaches for planners and process managers. Our scheduling and production teams built contingency plans based on hard-learned lessons from past disruptions. Bulk storage buffers, flexible shipping partners, and close relationships with upstream suppliers buffer against these swings, so customers see fewer delays or unplanned product switches.

    Continuous Improvement in Diethyl Sulfide Manufacturing

    Feedback from process operators and lab analysts drives our continuous improvement efforts. Years of noting quirks in distillation curves, odor fluctuations, or unusual color tints led to incremental process tweaks. Small changes—such as switching an upstream filter medium or extending column residence time—stem directly from field observations and customer insight, not just theory. Each iteration aims for clean, clear, and consistent material. This habit of continuous review keeps our diethyl sulfide aligned with not just specifications, but the real requirements of busy labs and demanding process units.

    Our investment in instrumentation—gas chromatography, sulfur speciation, moisture analysis—reflects a hard-nosed approach to product consistency. Factory technicians understand these checks are not optional extras, but daily requirements for shipping. Discarding or reworking off-spec material always yields greater long-term returns than pushing questionable stock to the market. By maintaining the discipline to prioritize batch integrity, we reinforce our market reputation and retain returning customers who know the difference between sloppily delivered solvent and a carefully made chemical ingredient.

    Final Thoughts from the Factory Floor

    Years spent working amid the tanks and distillation stacks have shown us that diethyl sulfide rewards careful handling, clear communication, and a grounded approach to technical problem-solving. Its role as a practical, efficient sulfur solvent and building block continues to grow, with customers recognizing the value of consistent quality, clean odor profile, and straightforward processing. Each lot we send out contains a small piece of this accumulated factory knowledge.

    If industrial users succeed with our product, it reflects their trust in both material properties and the people behind them. It’s a practical relationship, built batch by batch, customer by customer, with lessons learned from both successes and mistakes. By sticking to the practices and priorities that come from hard experience, we deliver diethyl sulfide that delivers for industry. That process never truly finishes, but each passing season brings new insight and improved outcomes, both for us and for the markets we support.