Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Diethyl ether

    • Product Name Diethyl ether
    • Alias Ethoxyethane
    • Einecs 200-467-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    434462

    Chemical Name Diethyl ether
    Chemical Formula C4H10O
    Molecular Weight 74.12 g/mol
    Cas Number 60-29-7
    Appearance Colorless, volatile liquid
    Odor Sweet, ether-like
    Boiling Point 34.6°C (94.3°F)
    Melting Point -116.3°C (-177.3°F)
    Density 0.7134 g/cm³ at 20°C
    Solubility In Water 6.9 g/L (20°C)
    Flash Point -45°C (-49°F, closed cup)
    Autoignition Temperature 160°C (320°F)
    Vapor Pressure 442 mmHg at 20°C
    Refractive Index 1.3526 at 20°C
    Viscosity 0.224 cP at 20°C

    As an accredited Diethyl ether factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Diethyl ether is packaged in a 2.5-liter amber glass bottle with a secure cap, labeled with hazard warnings and safety instructions.
    Shipping Diethyl ether must be shipped as a Class 3 Flammable Liquid, UN1155, in well-sealed, chemically compatible containers. It requires proper labeling and documentation, and must be kept away from heat, sparks, and open flames. Ventilation and grounding are essential; ship only with compatible materials per regulatory guidelines (DOT, IATA, IMDG).
    Storage Diethyl ether should be stored in tightly sealed containers made of compatible materials such as glass or metal. The storage area must be cool, dry, well-ventilated, and away from sources of heat, sparks, or open flames, as diethyl ether is highly flammable and volatile. Containers must be clearly labeled and protected from direct sunlight and moisture to prevent peroxide formation.
    Application of Diethyl ether

    Applications of Diethyl Ether in Industrial Manufacturing

    Diethyl ether plays a crucial role as a chemical raw material in specialized industrial chains. Its solvent properties and reactivity make it essential across several manufacturing sectors, where strict regulatory standards and precise process integration determine end-product quality. Below are the main downstream applications based on verified industrial usage scenarios.

    1. Pharmaceutical Synthesis and Active Ingredient Extraction

    Our diethyl ether supports API production, particularly for alkaloid and steroid extraction. Pharmaceutical-grade fractions enable selective solubilization and phase separations during active ingredient isolation, where pentane-based or methylene chloride alternatives do not deliver comparable volatility or partitioning. Operators utilize it during intermediate purification to ensure exclusive separation of bioactive moieties while meeting acute toxicity guidelines and solvent residue cutoffs. Manufacturers monitor residual solvent levels to comply with ICH Q3C guidelines, perform lot traceability, and ensure that diethyl ether meets the required levels of purity for processing APIs, intermediates, and parenteral actives.

    Industry compliance standards

    • USP/NF and Ph. Eur. solvent specifications
    • ICH Q3C Guidelines for Residual Solvents
    • GMP (Good Manufacturing Practice) for pharmaceuticals
    • FDA CFR Title 21 Section 211 – Manufacturing, Processing, Packing Controls

    Typical usage ratio

    • Solvent-to-feed ratios: 2:1 to 10:1 by volume for extractions
    • Adjustment based on solute solubility, temperature, and reaction step

    Downstream process integration

    • Initial crude extraction of plant-derived alkaloids
    • Purification step in steroid synthesis
    • Solvent swap and washing during crystallization and API isolation
    • Precipitation and partitioning phases in pharmaceutical intermediate purification

    Final product types

    • Active pharmaceutical ingredients (APIs) with assured solvent residue control
    • Purified alkaloid drug preparations
    • Synthetic steroid hormones
    • Sterile parenteral drug APIs with validated impurity profiles

    2. Production of Grignard Reagents for Fine Chemistry

    Chemical manufacturers employ diethyl ether as a critical solvent for Grignard reagent formation and downstream reactions in fine organic synthesis. Its low polarity and rigorous anhydrous properties maintain the sensitive magnesium-halide bond, enabling efficient organomagnesium compound formation. Batch and continuous processes keep water content and peroxide impurities within tight limits, with in-line drying and quality checks to avoid side reactions and byproduct contamination. The blend ratio and solvent recycling protocols are defined according to the downstream coupling or condensation steps, directly impacting the purity of pharmaceutical, agrochemical, and flavor compound intermediates.

    Industry compliance standards

    • ISO 9001-certified production for traceability
    • REACH registered as a reaction solvent
    • Quality control under ASTM E398 – Ether solvent purity
    • Grignard process SOPs for residual moisture and peroxide limits

    Typical usage ratio

    • Solvent charge: 3 to 15 parts diethyl ether per part halide by volume
    • Adjustment based on scale, concentration targets, and desired yield

    Downstream process integration

    • Grignard reagent synthesis (e.g., RMgX preparation)
    • In situ solvent feed for batch and continuous stirred reactors
    • Solvent recycle and purification after reaction completion
    • Transfer to downstream carbonyl addition or quenching steps

    Final product types

    • Organomagnesium intermediates
    • Pharmaceutical building blocks (e.g., secondary alcohols, esters)
    • Flavor and fragrance aldehyde derivatives
    • Synthesized agrochemical precursors

    3. Laboratory and Industrial Extraction Processes in Analytical Chemistry

    Analytical and industrial laboratories utilize diethyl ether in extraction protocols for separating organic acids, precious metal complexes, and environmental contaminants from various matrices. It provides sharp phase separation and rapid extraction kinetics for methods demanding high recovery, including environmental monitoring, ore assay, and clinical residue tests. Quality-controlled distribution ensures consistency in density, purity, and partitioning behavior, minimizing background signal in downstream GC, HPLC, or AAS analysis. Good laboratory practice (GLP) and environmental assurance dictate limitations on volatile organic compound (VOC) emissions and require closed extraction systems.

    Industry compliance standards

    • GLP (Good Laboratory Practice)
    • EPA Method 3510C (liquid-liquid extraction)
    • ISO 17025 for laboratory competence
    • OSHA 1910.1000 exposure limits for laboratory use

    Typical usage ratio

    • Extraction ratios: 1:1 to 5:1 (solvent:sample) by volume
    • Optimization according to target analyte solubility and matrix type

    Downstream process integration

    • Sample preparation for trace organic residue analysis
    • Phase separation for metallurgical assays and multi-residue pesticide tests
    • Solvent evaporation in micro-extraction workflows
    • Post-extraction filtration and solvent exchange before instrumental measurement

    Final product types

    • Extracted environmental samples for regulatory reporting
    • Purified mineral concentrate solutions
    • Concentrated residues for GC/MS or HPLC quantification
    • Prepared laboratory standards and calibrators

    4. Fuel Blending and Starting Fluid Manufacturing

    Downstream in fuel blending and automotive supply, diethyl ether acts as an ignition accelerator and volatility enhancer in starting fluid formulations. Blenders add it under controlled conditions to ensure compatible mixing with hydrocarbon bases while preventing atmospheric vapor losses and static electricity hazards. QC teams monitor purity, vapor pressure, and water content to comply with national hazard transport codes and product labeling laws. The blend ratio depends on ambient temperature performance requirements and regional flammability regulations, affecting cold-start performance for diesel engines, generators, and heavy-duty vehicles.

    Industry compliance standards

    • UN ADR/RID regulations for flammable liquids
    • EN 228 Automotive Fuels – Blending specifications
    • NFPA 30 for Flammable and Combustible Liquids Code
    • CFR Title 49 – Hazardous Materials Regulations

    Typical usage ratio

    • 10% to 70% by weight in engine starting fluids
    • Ratio modified based on lower ambient temperature targets and volatility profiles

    Downstream process integration

    • Metered blend with hydrocarbon propellants in aerosol filling lines
    • QC sampling for vapor pressure and flash point
    • Pressurization and can-sealing under inert conditions
    • Final labeling with GHS hazard information

    Final product types

    • Commercial engine starting fluids in aerosol packaging
    • Blended cold-start diesel additives
    • Portable generator starter sprays
    • Industrial engine cold start service kits

    5. Collodion and Cellulose Ether Manufacturing for Film and Medical Supplies

    Specialty film and medical supply sectors use diethyl ether to dissolve and gelatinize cellulose nitrate in the production of collodion and cellulose ethers. Blend design and solvent control maintain regulated viscosity and evaporation rates during film formation, directly impacting finished material performance in photographic, coating, and wound care applications. Process teams monitor solvent residual levels against food-contact and medical device directives, employing closed systems and vapor recovery to comply with occupational and environmental standards.

    Industry compliance standards

    • ISO 10993 for medical device biocompatibility
    • 21 CFR Parts 175–178 for food-contact coatings
    • OSHA 29 CFR 1910.106 Flammable Liquids
    • EN 14065 for hygiene in healthcare textiles

    Typical usage ratio

    • Solvent content: 30% to 60% by volume in cellulose nitrate dissolving baths
    • Ratio adjusted for film thickness, drying time, and required viscosity

    Downstream process integration

    • Primary dissolution of cellulose nitrate in multi-solvent blends
    • Film casting onto glass or support substrates in controlled environments
    • Vapor phase control and solvent recovery after film formation
    • Integration with secondary plasticizers or crosslinkers for medical applications

    Final product types

    • Photographic films and coatings
    • Medical collodion for wound closure applications
    • Cellulose ether–based laboratory films
    • Protective coatings for food and pharmaceutical packaging

    6. Laboratory-Scale Anaesthetic Preparation (Research Use Only)

    Universities and research institutions employ diethyl ether in laboratory anaesthesia protocols for non-human animal studies. Veterinary teams prepare it under controlled environments using advanced ventilation and fume extraction systems. Handling practices meet institutional safety guidelines and national statutes governing controlled substances. The stock concentration and exposure duration vary, determined by animal weight and specific research design, with detailed documentation and waste recovery requirements.

    Industry compliance standards

    • OECD Guidance Document for Acute Toxicity Testing
    • Institutional Animal Care and Use Committee (IACUC) protocols
    • NIH Laboratory Safety Guidelines
    • EU Directive 2010/63/EU on animal testing

    Typical usage ratio

    • Induction chamber atmosphere: 15% to 30% v/v ether in air
    • Precise concentration adjusted based on species and exposure duration

    Downstream process integration

    • Pre-measured charge into anaesthetic induction chambers
    • Continuous air/ether mixing for short-term induction
    • Active ventilation and vapor scavenging during application
    • Solvent collection and reuse or controlled disposal post-procedure

    Final product types

    • Prepared research-grade anaesthetic vapors for laboratory studies
    • Archived biological specimens for academic analysis
    • Temporary immobilization agents in animal research
    • Research publications referencing validated exposure protocols
    Free Quote

    Competitive Diethyl ether prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Diethyl Ether: Straight from Our Plant Floor

    What Sets Our Diethyl Ether Apart

    Over the years, our team has put in relentless effort to ensure that each batch of diethyl ether meets the purity and consistency standards that busy laboratories and industrial plants require every day. In our process, we focus on a purity level that stands above most regional averages. Typical lots consistently show a GC assay of not less than 99.5%. It’s common for us to hear from partners who use it as an extraction solvent in biotech labs or in organic synthesis—what they notice first is the clarity and stability of our product over extended storage compared to generic stocks.

    We handle every step in-house: from raw alcohol distillation to rigorous moisture removal. All steps carefully tracked, with every drum sealed until it hits your receiving dock. Moisture and peroxides count among the problems that can spoil reactions or compromise lab safety. Our extra dehydration phase, added a few years ago, pushed peroxide levels well below industry guidelines. This means when you open a container, you receive diethyl ether that hasn’t picked up stray contaminants during transit.

    Model Variants and Their Role in the Field

    Customers use our standard laboratory grade ether—refined to standard GC-purity—primarily in dissolution and extraction work. Industrial buyers, especially in the pharmaceuticals sector, have requested custom blends with lower aromatic residue or customized stabilizer content. We support these special requests, since the way ether interacts with solutes or pharmaceuticals hinges on fine purity margins.

    Some call for a peroxide-free version for delicate catalyst systems or to avoid downstream risks in scale-up operations. The plant layout includes dedicated lines for stabilizer-free production, and peroxide checks. Our technical staff takes product sampling seriously: ongoing in-path testing ensures that each batch meets agreed-upon spec sheets, so there’s no headache at the customer site.

    Practical Experience: Safe Handling and Delivery

    Diethyl ether’s volatility always challenges safe bottling and distribution. Over time, we refined our drum-venting system and transport logistics. Local fire codes serve as the foundation of our safety plan. Our team doesn’t just package and move cans: technicians monitor vapor levels and test for leaks as part of daily ops. Thanks to investment in specialized tank farms with grounded storage and explosion-proof lighting, we’ve lowered incident rates well below the regional industry average. We still review our protocols every year. A simple oversight can turn a routine transfer into a severe accident. Everyone working near the loading bays gets hands-on hazmat training, refreshed quarterly instead of annually.

    Feedback from the academic sector highlighted an all-too-common pain: leaky cans and inconsistent shelf life. To address that, we commission specially lined drums to minimize oxygen ingress. Stability testing runs for months before we ship a new product format. The day a batch leaves the plant, our QC team pulls a control sample to retain in climate-controlled storage, ready for customer review or investigation. This isn’t just about ticking regulatory boxes. A university once paused an ether-heavy extraction project for weeks due to bad solvent from another supplier. After switching, their feedback focused on the reliability of shelf life and minimal peroxide growth—even after months in storage with repeated openings. Over the years, these small wins have built trust that no single posting on a certificate could match.

    Critical Uses: Tradition and Innovation

    Chemists count on ether for its clean extraction cuts or the way it pulls polar compounds out of tangled mixtures. It acts as an unrivaled solvent for Grignard and other sensitive organometallic reactions. Medical device firms appreciate its high volatility when making specialized plastics, where it leaves no residue. Several fragrance makers turn to us for small-lot diethyl ether to fix volatile scents or extract delicate plant essences. Each of these uses calls for reliability at different volumes: where academic labs use liter bottles, production-scale producers need bulk containers that avoid cross-contamination. Our facility adapts filling and cleaning schedules to keep cross-trace levels to nearly undetectable amounts, as confirmed by our analytical chemistry group.

    In industrial settings, diethyl ether helps produce cellulose plastics, starter fluid blends, and is valued by emerging battery developers testing unconventional electrolytes. Customers routinely ask us about byproducts, waste returns, or on-site training. Over time, we grew a technical support program offering advice directly from our process engineers—usually by sharing insights from our day-to-day experience with bottling challenges or residue minimization, not just reading out datasheets.

    Challenges Unique to Diethyl Ether Manufacturing

    No other common solvent rivals the risk profile of diethyl ether. Just one unchecked transfer or missed peroxide test can bring fresh production to a halt—something we’ve experienced firsthand. This risk forces us to control every input and environmental variable from the moment we receive ethanol or methanol all the way to the final filtered batch. Heat management and static charge reduction sit at the core of our system upgrades during hot summer months, which, in one memorable season, forced us to halt manufacturing for a week after static in a tank triggered a local alarm. We doubled down on grounding, personnel ESD training, and tank linings at that point.

    Storage creates its own set of constraints. Peroxide crystal formation during long-term storage or open-drum use threatens both product quality and operator safety. To fight that, we run a batch aging study each quarter—testing drum ether that’s purposely stored under representative conditions—and alter stabilizer levels based on findings from our own accelerated aging experiments. Some years, we even tweak blend ratios if atmospheric reports show humidity swings likely to affect the region’s storage sites.

    Comparing Diethyl Ether to Similar Products

    Many solvent users compare diethyl ether to hexane, tetrahydrofuran (THF), and methyl tert-butyl ether (MTBE). Hexane has a lower polarity and dissolves oils more readily, but it lacks the volatility that ether offers for rapid evaporation. THF boasts better solubility for some polar polymers, but comes with more toxicity concerns and stricter handling rules. MTBE resists peroxide formation, making it less volatile, but doesn’t match ether’s role as a historical staple in pharmaceutical processes.

    Our chemists have run side-by-side trials with these products over the years, both on the lab bench and with production-scale gear. They note that only diethyl ether offers the unique mix of volatility, solvating power, and low boiling point that makes it irreplaceable in tasks like dissolving zinc or magnesium organics, or rapid distillation-purification schemes. In process safety briefings, we emphasize that ether’s strengths double as hazards: its rapid evaporation rate demands that users work in well-ventilated spaces and observe strict fire-control vigilance. Our experience shows that customers wishing to substitute away from ether in traditional extraction regimes usually return after seeing reduced recovery yields or increased impurities with alternatives.

    Supporting Research and Development

    Small research groups come to us looking for support beyond simple supply. Over the last decade, we’ve helped university partners select the best grade or blend of diethyl ether for advanced chromatography and neural probe fabrication work. Some researchers tackle microgram-scale separations and rely on the ultra-low impurity threshold of our custom-distilled lots. In pilot projects, where kilogram quantities matter, our technical reps frequently assist with safe handling and waste disposal—sharing firsthand accident-prevention strategies that cut across theory and practical experience.

    We have even been called in when startups need “driest-possible” batches for bench-top battery development or when someone launches a new route in one-pot multi-step synthesis. Our chemical engineers walk customers through oxidation risk, canning procedures, and waste tank cleaning drawn directly from our daily practice on the shop floor. Researchers and process leads appreciate this boots-on-the-ground orientation; they trust we’ve seen every failure scenario and have honed the fix, not just in the manuals but in actual events.

    Process Transparency and Ethical Commitments

    In response to growing pressure for cleaner, greener manufacturing, our production shifts have changed significantly over the last decade. Early efforts cut fugitive VOC emissions by upgrading our condenser arrays and investing in more tightly sealed drum-tracking systems. Several years later, we moved all routine tank cleaning from open-pit to closed-system washes, improving air quality for our operators and reducing off-gassing into the local environment. Continued ISO audits led us to post emissions logs available for regulator review within days instead of weeks. On visits, our site managers talk openly about progress and setbacks, addressing questions from customers or local health officials about solvent loss, accidental releases, or storage improvements.

    Local community concerns guide many of our latest investments. We’ve responded to feedback by completely enclosing the canning line and switching forklift fleets to electric, slashing cold-start emissions around storage areas. The effort spans the entire supply train: for example, we recently moved to using more recycled-content steel in drum fabrication, lowering our carbon impact from shipping and disposal. Each of these operational changes comes from seeing firsthand how solvent releases or lost drums affect not just workflow but the neighborhood around our facility. We’ve learned the hard way—the best safety record grows from tight communities, open communication, and continual sharing of best practices.

    Supporting Customers Beyond Sale

    Getting ether into a customer's plant or lab goes far beyond a sale. Our after-delivery service includes direct consultation with process engineers and EHS staff. We keep records that can track a problem batch back to a specific shift, temperature, and even cleaning cycle—data we routinely share to help a partner fix an issue without delay. In one instance, a repeated streak of micro-leaks in returnable cans led our operators to identify a new drum molding failure. Sharing this pattern early, we removed the batch and replaced all relevant drums, limiting exposure and rebuilding trust.

    Customers often reach out to ask about new regulatory compliance measures or safe storage architecture. Drawing on decades of inspection and process experience, we walk buyers through process changes, proper neutralization, and safe venting. Our regulatory affairs staff never deliver abstract answers; they pair each reply with a practical example—how we solved or handled the very same challenge—and advise on next steps in plain language. Sharing real stories, we help customers steer clear of risks and keep their teams informed, no matter how experienced they may be.

    Continuous Improvement from the Manufacturer’s Perspective

    As a manufacturer, the opportunity for ongoing improvement never ends. Each year, emerging challenges—be it new emission standards, raw material price shocks, or a close call in storage—spark operational change. Investments in monitoring equipment or batch automation come from a bottom-up approach: plant operators meet with management, sharing what slows them down or what worked better during a recent incident drill. From these discussions, the upgrade ideas flow directly back into capital project lists.

    Customer feedback drives product fine-tuning. Requests for improved drum seals or new stabilizer levels rapidly move from suggestion to pilot-batch trial, with shared progress updates until the new product format proves itself in the field. Unlike a supply chain middleman, as a manufacturer, we don’t just push standard-formula product—our intention is to make diethyl ether that adapts to solve tangible problems for end users. We’ve noticed the difference: customer loyalty improves, operational headaches on both sides fade, and team pride in the product’s performance keeps motivation strong year after year.

    We stand by the belief that every improvement, whether it shows up as a tighter seal, a clearer batch record, or a more honest advisory call, builds a foundation for lasting partnerships. Manufacturing diethyl ether on a large scale brings unique hazards and obligations, but also real opportunities to build confidence and push industry standards higher. Connecting with people who use these solvents daily and sharing our manufacturing story forms the root of our work—each drum shipped marks another round in a long-lived collaboration, not a one-off transaction.