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HS Code |
434462 |
| Chemical Name | Diethyl ether |
| Chemical Formula | C4H10O |
| Molecular Weight | 74.12 g/mol |
| Cas Number | 60-29-7 |
| Appearance | Colorless, volatile liquid |
| Odor | Sweet, ether-like |
| Boiling Point | 34.6°C (94.3°F) |
| Melting Point | -116.3°C (-177.3°F) |
| Density | 0.7134 g/cm³ at 20°C |
| Solubility In Water | 6.9 g/L (20°C) |
| Flash Point | -45°C (-49°F, closed cup) |
| Autoignition Temperature | 160°C (320°F) |
| Vapor Pressure | 442 mmHg at 20°C |
| Refractive Index | 1.3526 at 20°C |
| Viscosity | 0.224 cP at 20°C |
As an accredited Diethyl ether factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Diethyl ether is packaged in a 2.5-liter amber glass bottle with a secure cap, labeled with hazard warnings and safety instructions. |
| Shipping | Diethyl ether must be shipped as a Class 3 Flammable Liquid, UN1155, in well-sealed, chemically compatible containers. It requires proper labeling and documentation, and must be kept away from heat, sparks, and open flames. Ventilation and grounding are essential; ship only with compatible materials per regulatory guidelines (DOT, IATA, IMDG). |
| Storage | Diethyl ether should be stored in tightly sealed containers made of compatible materials such as glass or metal. The storage area must be cool, dry, well-ventilated, and away from sources of heat, sparks, or open flames, as diethyl ether is highly flammable and volatile. Containers must be clearly labeled and protected from direct sunlight and moisture to prevent peroxide formation. |
Applications of Diethyl Ether in Industrial ManufacturingDiethyl ether plays a crucial role as a chemical raw material in specialized industrial chains. Its solvent properties and reactivity make it essential across several manufacturing sectors, where strict regulatory standards and precise process integration determine end-product quality. Below are the main downstream applications based on verified industrial usage scenarios. 1. Pharmaceutical Synthesis and Active Ingredient ExtractionOur diethyl ether supports API production, particularly for alkaloid and steroid extraction. Pharmaceutical-grade fractions enable selective solubilization and phase separations during active ingredient isolation, where pentane-based or methylene chloride alternatives do not deliver comparable volatility or partitioning. Operators utilize it during intermediate purification to ensure exclusive separation of bioactive moieties while meeting acute toxicity guidelines and solvent residue cutoffs. Manufacturers monitor residual solvent levels to comply with ICH Q3C guidelines, perform lot traceability, and ensure that diethyl ether meets the required levels of purity for processing APIs, intermediates, and parenteral actives. Industry compliance standards
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2. Production of Grignard Reagents for Fine ChemistryChemical manufacturers employ diethyl ether as a critical solvent for Grignard reagent formation and downstream reactions in fine organic synthesis. Its low polarity and rigorous anhydrous properties maintain the sensitive magnesium-halide bond, enabling efficient organomagnesium compound formation. Batch and continuous processes keep water content and peroxide impurities within tight limits, with in-line drying and quality checks to avoid side reactions and byproduct contamination. The blend ratio and solvent recycling protocols are defined according to the downstream coupling or condensation steps, directly impacting the purity of pharmaceutical, agrochemical, and flavor compound intermediates. Industry compliance standards
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3. Laboratory and Industrial Extraction Processes in Analytical ChemistryAnalytical and industrial laboratories utilize diethyl ether in extraction protocols for separating organic acids, precious metal complexes, and environmental contaminants from various matrices. It provides sharp phase separation and rapid extraction kinetics for methods demanding high recovery, including environmental monitoring, ore assay, and clinical residue tests. Quality-controlled distribution ensures consistency in density, purity, and partitioning behavior, minimizing background signal in downstream GC, HPLC, or AAS analysis. Good laboratory practice (GLP) and environmental assurance dictate limitations on volatile organic compound (VOC) emissions and require closed extraction systems. Industry compliance standards
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4. Fuel Blending and Starting Fluid ManufacturingDownstream in fuel blending and automotive supply, diethyl ether acts as an ignition accelerator and volatility enhancer in starting fluid formulations. Blenders add it under controlled conditions to ensure compatible mixing with hydrocarbon bases while preventing atmospheric vapor losses and static electricity hazards. QC teams monitor purity, vapor pressure, and water content to comply with national hazard transport codes and product labeling laws. The blend ratio depends on ambient temperature performance requirements and regional flammability regulations, affecting cold-start performance for diesel engines, generators, and heavy-duty vehicles. Industry compliance standards
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5. Collodion and Cellulose Ether Manufacturing for Film and Medical SuppliesSpecialty film and medical supply sectors use diethyl ether to dissolve and gelatinize cellulose nitrate in the production of collodion and cellulose ethers. Blend design and solvent control maintain regulated viscosity and evaporation rates during film formation, directly impacting finished material performance in photographic, coating, and wound care applications. Process teams monitor solvent residual levels against food-contact and medical device directives, employing closed systems and vapor recovery to comply with occupational and environmental standards. Industry compliance standards
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6. Laboratory-Scale Anaesthetic Preparation (Research Use Only)Universities and research institutions employ diethyl ether in laboratory anaesthesia protocols for non-human animal studies. Veterinary teams prepare it under controlled environments using advanced ventilation and fume extraction systems. Handling practices meet institutional safety guidelines and national statutes governing controlled substances. The stock concentration and exposure duration vary, determined by animal weight and specific research design, with detailed documentation and waste recovery requirements. Industry compliance standards
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Over the years, our team has put in relentless effort to ensure that each batch of diethyl ether meets the purity and consistency standards that busy laboratories and industrial plants require every day. In our process, we focus on a purity level that stands above most regional averages. Typical lots consistently show a GC assay of not less than 99.5%. It’s common for us to hear from partners who use it as an extraction solvent in biotech labs or in organic synthesis—what they notice first is the clarity and stability of our product over extended storage compared to generic stocks.
We handle every step in-house: from raw alcohol distillation to rigorous moisture removal. All steps carefully tracked, with every drum sealed until it hits your receiving dock. Moisture and peroxides count among the problems that can spoil reactions or compromise lab safety. Our extra dehydration phase, added a few years ago, pushed peroxide levels well below industry guidelines. This means when you open a container, you receive diethyl ether that hasn’t picked up stray contaminants during transit.
Customers use our standard laboratory grade ether—refined to standard GC-purity—primarily in dissolution and extraction work. Industrial buyers, especially in the pharmaceuticals sector, have requested custom blends with lower aromatic residue or customized stabilizer content. We support these special requests, since the way ether interacts with solutes or pharmaceuticals hinges on fine purity margins.
Some call for a peroxide-free version for delicate catalyst systems or to avoid downstream risks in scale-up operations. The plant layout includes dedicated lines for stabilizer-free production, and peroxide checks. Our technical staff takes product sampling seriously: ongoing in-path testing ensures that each batch meets agreed-upon spec sheets, so there’s no headache at the customer site.
Diethyl ether’s volatility always challenges safe bottling and distribution. Over time, we refined our drum-venting system and transport logistics. Local fire codes serve as the foundation of our safety plan. Our team doesn’t just package and move cans: technicians monitor vapor levels and test for leaks as part of daily ops. Thanks to investment in specialized tank farms with grounded storage and explosion-proof lighting, we’ve lowered incident rates well below the regional industry average. We still review our protocols every year. A simple oversight can turn a routine transfer into a severe accident. Everyone working near the loading bays gets hands-on hazmat training, refreshed quarterly instead of annually.
Feedback from the academic sector highlighted an all-too-common pain: leaky cans and inconsistent shelf life. To address that, we commission specially lined drums to minimize oxygen ingress. Stability testing runs for months before we ship a new product format. The day a batch leaves the plant, our QC team pulls a control sample to retain in climate-controlled storage, ready for customer review or investigation. This isn’t just about ticking regulatory boxes. A university once paused an ether-heavy extraction project for weeks due to bad solvent from another supplier. After switching, their feedback focused on the reliability of shelf life and minimal peroxide growth—even after months in storage with repeated openings. Over the years, these small wins have built trust that no single posting on a certificate could match.
Chemists count on ether for its clean extraction cuts or the way it pulls polar compounds out of tangled mixtures. It acts as an unrivaled solvent for Grignard and other sensitive organometallic reactions. Medical device firms appreciate its high volatility when making specialized plastics, where it leaves no residue. Several fragrance makers turn to us for small-lot diethyl ether to fix volatile scents or extract delicate plant essences. Each of these uses calls for reliability at different volumes: where academic labs use liter bottles, production-scale producers need bulk containers that avoid cross-contamination. Our facility adapts filling and cleaning schedules to keep cross-trace levels to nearly undetectable amounts, as confirmed by our analytical chemistry group.
In industrial settings, diethyl ether helps produce cellulose plastics, starter fluid blends, and is valued by emerging battery developers testing unconventional electrolytes. Customers routinely ask us about byproducts, waste returns, or on-site training. Over time, we grew a technical support program offering advice directly from our process engineers—usually by sharing insights from our day-to-day experience with bottling challenges or residue minimization, not just reading out datasheets.
No other common solvent rivals the risk profile of diethyl ether. Just one unchecked transfer or missed peroxide test can bring fresh production to a halt—something we’ve experienced firsthand. This risk forces us to control every input and environmental variable from the moment we receive ethanol or methanol all the way to the final filtered batch. Heat management and static charge reduction sit at the core of our system upgrades during hot summer months, which, in one memorable season, forced us to halt manufacturing for a week after static in a tank triggered a local alarm. We doubled down on grounding, personnel ESD training, and tank linings at that point.
Storage creates its own set of constraints. Peroxide crystal formation during long-term storage or open-drum use threatens both product quality and operator safety. To fight that, we run a batch aging study each quarter—testing drum ether that’s purposely stored under representative conditions—and alter stabilizer levels based on findings from our own accelerated aging experiments. Some years, we even tweak blend ratios if atmospheric reports show humidity swings likely to affect the region’s storage sites.
Many solvent users compare diethyl ether to hexane, tetrahydrofuran (THF), and methyl tert-butyl ether (MTBE). Hexane has a lower polarity and dissolves oils more readily, but it lacks the volatility that ether offers for rapid evaporation. THF boasts better solubility for some polar polymers, but comes with more toxicity concerns and stricter handling rules. MTBE resists peroxide formation, making it less volatile, but doesn’t match ether’s role as a historical staple in pharmaceutical processes.
Our chemists have run side-by-side trials with these products over the years, both on the lab bench and with production-scale gear. They note that only diethyl ether offers the unique mix of volatility, solvating power, and low boiling point that makes it irreplaceable in tasks like dissolving zinc or magnesium organics, or rapid distillation-purification schemes. In process safety briefings, we emphasize that ether’s strengths double as hazards: its rapid evaporation rate demands that users work in well-ventilated spaces and observe strict fire-control vigilance. Our experience shows that customers wishing to substitute away from ether in traditional extraction regimes usually return after seeing reduced recovery yields or increased impurities with alternatives.
Small research groups come to us looking for support beyond simple supply. Over the last decade, we’ve helped university partners select the best grade or blend of diethyl ether for advanced chromatography and neural probe fabrication work. Some researchers tackle microgram-scale separations and rely on the ultra-low impurity threshold of our custom-distilled lots. In pilot projects, where kilogram quantities matter, our technical reps frequently assist with safe handling and waste disposal—sharing firsthand accident-prevention strategies that cut across theory and practical experience.
We have even been called in when startups need “driest-possible” batches for bench-top battery development or when someone launches a new route in one-pot multi-step synthesis. Our chemical engineers walk customers through oxidation risk, canning procedures, and waste tank cleaning drawn directly from our daily practice on the shop floor. Researchers and process leads appreciate this boots-on-the-ground orientation; they trust we’ve seen every failure scenario and have honed the fix, not just in the manuals but in actual events.
In response to growing pressure for cleaner, greener manufacturing, our production shifts have changed significantly over the last decade. Early efforts cut fugitive VOC emissions by upgrading our condenser arrays and investing in more tightly sealed drum-tracking systems. Several years later, we moved all routine tank cleaning from open-pit to closed-system washes, improving air quality for our operators and reducing off-gassing into the local environment. Continued ISO audits led us to post emissions logs available for regulator review within days instead of weeks. On visits, our site managers talk openly about progress and setbacks, addressing questions from customers or local health officials about solvent loss, accidental releases, or storage improvements.
Local community concerns guide many of our latest investments. We’ve responded to feedback by completely enclosing the canning line and switching forklift fleets to electric, slashing cold-start emissions around storage areas. The effort spans the entire supply train: for example, we recently moved to using more recycled-content steel in drum fabrication, lowering our carbon impact from shipping and disposal. Each of these operational changes comes from seeing firsthand how solvent releases or lost drums affect not just workflow but the neighborhood around our facility. We’ve learned the hard way—the best safety record grows from tight communities, open communication, and continual sharing of best practices.
Getting ether into a customer's plant or lab goes far beyond a sale. Our after-delivery service includes direct consultation with process engineers and EHS staff. We keep records that can track a problem batch back to a specific shift, temperature, and even cleaning cycle—data we routinely share to help a partner fix an issue without delay. In one instance, a repeated streak of micro-leaks in returnable cans led our operators to identify a new drum molding failure. Sharing this pattern early, we removed the batch and replaced all relevant drums, limiting exposure and rebuilding trust.
Customers often reach out to ask about new regulatory compliance measures or safe storage architecture. Drawing on decades of inspection and process experience, we walk buyers through process changes, proper neutralization, and safe venting. Our regulatory affairs staff never deliver abstract answers; they pair each reply with a practical example—how we solved or handled the very same challenge—and advise on next steps in plain language. Sharing real stories, we help customers steer clear of risks and keep their teams informed, no matter how experienced they may be.
As a manufacturer, the opportunity for ongoing improvement never ends. Each year, emerging challenges—be it new emission standards, raw material price shocks, or a close call in storage—spark operational change. Investments in monitoring equipment or batch automation come from a bottom-up approach: plant operators meet with management, sharing what slows them down or what worked better during a recent incident drill. From these discussions, the upgrade ideas flow directly back into capital project lists.
Customer feedback drives product fine-tuning. Requests for improved drum seals or new stabilizer levels rapidly move from suggestion to pilot-batch trial, with shared progress updates until the new product format proves itself in the field. Unlike a supply chain middleman, as a manufacturer, we don’t just push standard-formula product—our intention is to make diethyl ether that adapts to solve tangible problems for end users. We’ve noticed the difference: customer loyalty improves, operational headaches on both sides fade, and team pride in the product’s performance keeps motivation strong year after year.
We stand by the belief that every improvement, whether it shows up as a tighter seal, a clearer batch record, or a more honest advisory call, builds a foundation for lasting partnerships. Manufacturing diethyl ether on a large scale brings unique hazards and obligations, but also real opportunities to build confidence and push industry standards higher. Connecting with people who use these solvents daily and sharing our manufacturing story forms the root of our work—each drum shipped marks another round in a long-lived collaboration, not a one-off transaction.