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Dichloroacetyl Chloride

    • Product Name Dichloroacetyl Chloride
    • Alias Dichloroacetyl chloride
    • Einecs 211-947-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    634619

    CAS_Number 79-36-7
    Molecular_Formula C2Cl3O
    Molecular_Weight 147.38 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling_Point 106-107°C
    Melting_Point -2°C
    Density 1.563 g/cm³ at 20°C
    Solubility_in_Water Reacts violently
    Vapor_Pressure 23 mmHg at 25°C
    Flash_Point 38°C (closed cup)
    Refractive_Index 1.446 at 20°C
    Odor Pungent, irritating
    Synonyms Dichloroacetyl chloride; Acetyl chloride, dichloro-

    As an accredited Dichloroacetyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Dichloroacetyl Chloride, 500 mL, is packaged in a sealed amber glass bottle within a sturdy, chemical-resistant, foam-padded fiberboard box.
    Shipping Dichloroacetyl Chloride should be shipped in tightly sealed containers made of compatible materials, protected from moisture and heat. It must be labeled as a corrosive, toxic, and lachrymator substance. Shipment should comply with relevant hazardous material regulations, ensuring handling by trained personnel with suitable protective equipment, and with emergency procedures in place.
    Storage Dichloroacetyl chloride should be stored in a tightly sealed container, in a cool, dry, well-ventilated area, and away from moisture, heat, and sources of ignition. It must be kept separate from water, alcohols, strong bases, and oxidizing agents. Use corrosion-resistant containers, and label them clearly. Store under a dry inert atmosphere, such as nitrogen, to avoid decomposition.
    Application of Dichloroacetyl Chloride

    Applications of Dichloroacetyl Chloride in Industrial Manufacturing

    As a specialized producer of dichloroacetyl chloride, we work directly with end-use manufacturers to support high-requirement chemical synthesis processes, focusing only on fields where regulatory compliance, formulation accuracy, and process integration demand strict quality control. Below is a structured overview of the true downstream applications of this intermediate, demonstrating scenario-specific standards, technical details, and industry requirements.

    1. Agrochemical Active Ingredient Synthesis

    Dichloroacetyl chloride is an acylating agent relied upon for the industrial-scale production of selective herbicide actives. In chloracetamide herbicide synthesis, it reacts efficiently with aromatic amines under controlled anhydrous condensation, providing a key intermediate with the required purity for tight environmental and residue regulations. Manufacturers select dosing based on targeted active content and process efficiency, ensuring that product quality remains consistent throughout large-batch agrochemical operations.

    Industry compliance standards

    • FAO/WHO Specification for Plant Protection Products
    • REACH Registration for Agrochemicals (EC)
    • ISO 9001:2015 (Process Manufacturing Quality)
    • China National Standard GB/T 19601 (Pesticide Technical Material)

    Typical usage ratio

    • 0.8–1.2 molar equivalents per molar amine compound, with adjustment based on reaction concentration and batch size

    Downstream process integration

    • Used as an acylation reagent at the condensation stage after amine preparation, prior to work-up, separation, and crystallization

    Final product types

    • Chloroacetamide herbicide actives (e.g., acetochlor, alachlor, butachlor)
    • Pre-mixed emulsion concentrates for agricultural applications
    • Technical-grade herbicide formulations

    2. Pharmaceutical Intermediate Manufacturing

    Our material serves as a controlled acylating component in the production of key pharmaceutical intermediates, particularly for antibiotics and specialty APIs where precision in chlorine substitution patterns is critical for therapeutic efficacy. The addition step requires careful monitoring under GMP conditions to prevent cross-contamination and ensure reaction completeness, with batch sheet documentation and validated cleaning regimes as part of regulatory clearance.

    Industry compliance standards

    • ICH Q7 (GMP for Active Pharmaceutical Ingredients)
    • USP/EP Monograph compliance for related substances
    • China Pharmacopoeia (ChP)
    • FDA CFR 21 Part 211 (Finished Pharmaceutical Manufacturing)

    Typical usage ratio

    • 0.95–1.1 molar equivalents per step, typically optimized by intermediate titration and HPLC purity checks

    Downstream process integration

    • Added during stepwise acylation in protected multi-stage syntheses of β-lactam and cephalosporin intermediates

    Final product types

    • API intermediates for broad-spectrum antibiotics
    • API building blocks for custom synthesis
    • Regulated bulk pharmaceutical intermediates

    3. Specialty Polymer and Resin Modifier Production

    Chemical companies incorporate dichloroacetyl chloride when manufacturing specialty polyamides and advanced resin modifiers, where it introduces chlorinated side chains to control solubility, thermal stability, and adhesive properties. Exact dosing depends on the polymerization degree and targeted modification index, with strict monitoring of residual monomer to comply with polymer end-use regulations. The reagent is staged into the controlled reaction sequence after monomer charging to ensure precise incorporation and uniform product properties.

    Industry compliance standards

    • ISO 9001:2015 (Polymer and Resin Production)
    • EU Regulation (EC) No 1907/2006 (REACH Compliance for Polymers)
    • RoHS/ELV (if for electronics/automotive resin grades)
    • DIN EN ISO 14001 (Environmental Aspects – Chemical Processing)

    Typical usage ratio

    • 5–20% by weight of total monomers, subject to required functionalization and degree of polymerization

    Downstream process integration

    • Fed into batch or continuous polymerization after pre-polymer formation, typically under inert atmosphere

    Final product types

    • Modified engineering plastics for electronics or automotive
    • Specialty adhesives with increased resistance to chemicals or solvents
    • Custom-formulated polyamide copolymers

    4. Fine Chemical Synthesis for Crop Protection Safeners

    Chemical manufacturers use dichloroacetyl chloride as a crucial acylating agent in the synthesis of herbicide safener intermediates. Process engineers control reagent addition to maximize yield for downstream formulation partners. Due to stringent agricultural regulatory checks on auxiliary component residues in final blends, all batch manufacturing is documented under process validation and lot traceability systems for global supply.

    Industry compliance standards

    • FAO/WHO Guidelines for Pesticide Safeners
    • EU Regulation 1107/2009 (Plant Protection Products)
    • ISO 17025 (Analytical QC for Finished Formulations)
    • US EPA Product Chemistry Guidelines (OPPTS 830 Series)

    Typical usage ratio

    • Proprietary to individual formulation, generally 0.7–1.4 equivalents per precursor, finely tuned via pilot plant scale-up trials

    Downstream process integration

    • Charged during acylation or amidation of crop protection adjuvant synthesis, ahead of final purification and crystallization

    Final product types

    • Herbicide safener intermediates for crop protection
    • Custom adjuvant raw materials supplied to agrochemical formulators
    • Industrial reference standards for residue analysis
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    More Introduction

    Dichloroacetyl Chloride: A Manufacturer’s Perspective

    Introduction to Dichloroacetyl Chloride

    Our experience in the chemical manufacturing industry has been shaped by decades spent refining core specialty chemicals to meet modern demands. Dichloroacetyl chloride stands out among these products for its balance of reactivity and selectivity in processes that require fine-tuned intermediates. We manufacture dichloroacetyl chloride under controlled conditions to maximize purity and maintain consistent supply, a standard that industry partners depend on when process reliability can’t be settled for less.

    This product appears in chemical plants across the world as a vital intermediate. Its structure, characterized by two chlorine atoms attached to an acetyl chloride core, differentiates it from simpler monochloro derivatives. As a manufacturer, we understand the physical and chemical rigor needed to produce dichloroacetyl chloride at high purity, and we have invested in specialized equipment to capture and recycle chlorinated byproducts, reducing the environmental load and enhancing resource efficiency.

    Why Dichloroacetyl Chloride Matters

    Dichloroacetyl chloride commands attention thanks to its utility in advanced organic synthesis. Production plants see demand spike where pharmaceutical intermediates, specialty pesticides, or advanced polymers need a precursors that deliver reactivity and processability. Unlike its cousin, chloroacetyl chloride, the dichloro variant introduces a halogenation effect that shifts reaction profiles—critical for building molecules that standard reagents can’t replicate efficiently. Chemists seek this type of building block when a molecule’s selectivity or the introduction of specific functional groups makes or breaks a batch.

    We focus closely on batch-to-batch consistency. Purity sitting below specification can derail a customer’s synthesis or force downstream purification, raising costs and waste. Each manufacturing run receives full analytical support, including chromatographic purity analysis, water content assessment, and byproduct screening. This real-world data ensures that end-users aren’t surprised by hidden impurities that might not show up with standard spot checks.

    Manufacturing Insights: How Experience Shapes the Product

    Experience counts in handling compounds like dichloroacetyl chloride. The reaction control, temperature regime, and precise addition sequences all play a role in achieving a product that won’t introduce instability on a customer’s line. In our factories, conscious investments have gone into automated systems that control hydrogen chloride emissions and recover solvents to match not just production efficiency but also evolving regulatory oversight.

    We recall early production trials, before modern controls, where line operators monitored pressure swings using analog dials, with air scrubbers based on trial-and-error settings. Improvement came with the adoption of real-time detectors and digital feedback systems. Today, these upgrades manifest as less downtime, fewer lost batches, and a safer work environment.

    Despite the challenges, dichloroacetyl chloride produces a clear liquid with a robust, acrid odor common to acid chlorides, but its double halogen backbone means that storage and handling protocols need even greater attention. Over time, we moved from drum storage approaches to custom-engineered tanks, with vapor collection systems and nitrogen padding, keeping both the product and those who work with it safer.

    Key Differences Between Dichloroacetyl Chloride and Other Acid Chlorides

    Not all acid chlorides behave the same. Dichloroacetyl chloride differentiates itself from mono-chloro variants by offering increased electrophilic character and potential for regioselectivity in functional group transformations. Many in the industry lump it together with monochloroacetyl chloride or trichloroacetyl chloride—an oversimplification that paints an incomplete picture. Manufacturers who cut corners here risk cross-contamination or mis-labeled shipments, especially since these chemicals look similar in bulk but act differently under reaction conditions.

    For instance, dichloroacetyl chloride reacts more aggressively with nucleophiles than its mono-substituted cousin, translating to higher yields in certain syntheses or different profiles of byproducts. Trichloroacetyl chloride, with a heavier halogen load, crosses the line toward over-reactivity, making it less practical for many specialized transformations. This is only visible in real-world processing, where a shift in reactivity can gum up a reactor or, for the less prepared, cause safety incidents.

    As a manufacturer, we frequently advise customers to distinguish carefully between these acid chlorides before setting up a process. We offer technical support not just to deliver the product but to ensure users recognize when dichloroacetyl chloride unlocks capabilities that alternatives cannot provide. In pharmaceutical API synthesis, for example, the double-chloro substitution enables derivatization steps that sidestep patent-locked routes or streamline late-stage functionalizations. Only a compound with this balance of reactivity and selectivity meets those specialized needs.

    Applications: On the Line and in the Field

    After years of customer feedback, application trials, and post-market studies, we’ve seen dichloroacetyl chloride slot into a few main categories of industrial use. The most visible involves its function as a building block for pharmaceutical intermediates. These intermediates don’t make headlines, but underpin the manufacturing of medicines that treat infections, neurological disorders, and more. The custom nature of drug syntheses—often developed under pressure and at scale—means that any weakness in intermediate quality brings the risk of failed batches and regulatory headaches.

    Agricultural applications come close behind. The manufacture of certain crop protection agents relies on precisely this dichloroacetyl profile to deliver activity against weeds or pests, while resisting rapid degradation in the field. We’ve partnered with formulation teams to conduct compatibility and storage stability studies, anticipating the stresses chemicals face outdoors under sun and water exposure. Years ago, a customer flagged a tendency for off-spec batches from generic suppliers to break down before use, pushing us to double down on shelf-life testing and real-world aging trials.

    Our own data supports the observation—actual performance in soil, on crops, or during active ingredient synthesis traces back to invisible differences at the purity and isomer level. That kind of detail doesn’t figure in large-scale commodity markets, but matters at the customer’s factory or in the farmer’s field, where every kilogram must perform as specified.

    Specialty polymers mark another usage area, where dichloroacetyl chloride introduces specific chlorinated functionality into chain ends or side groups, bringing desired properties such as flame retardance or chemical resistance. Manufacturers of these polymers need a reliable feedstock without trace contaminants or process-destabilizing byproducts. The physical properties of the final material, such as flexibility, clarity, or weathering performance, often hinge on the quality of input chemicals at each synthetic step.

    The Realities of Logistics and Storage

    Logistics for a chemical like dichloroacetyl chloride presents a unique challenge, familiar only to those who’ve spent time in the shipping yard or storage bunker. Its reactivity with moisture demands a closed-container approach from the reactor all the way to a customer’s drum or tank. We made it standard practice to use lined containers and vapor-proof seals. Routine sampling of atmospheric moisture inside tanks, plus staff training on rapid leak diagnosis, has prevented supply interruptions and costly remediation efforts.

    Over the years, dramatic incidents—such as blocked railcars during summer heat waves or unexpected customs hold-ups—have forced us to review and fine-tune our distribution methods. Most recently, after a container breach at an overseas port, we transitioned to specialized inner-layer packaging and added RFID-enabled tracking to know product status at all stops. These steps do not merely check a compliance box; they keep product safe and performant after it leaves our plant, directly impacting a customer’s uptime.

    Managing Hazards: Safety Is Built In, Not Added Later

    Handling acid chlorides involves hazards, plain and simple. It isn’t just about regulatory paperwork—extended experience on factory floors confirmed that only robust engineering controls tame corrosive vapors and manage exothermic reactions. Our lines use double-containment piping and wear-resistant, corrosion-resistant pumps. Detailed standard operating procedures spell out strict transfer rates, required protective equipment, and rapid response protocols. Regular training and accident drills keep crews sharp and have prevented incidents that once seemed almost inevitable.

    The biggest risks do not always come from acute exposures or tank leaks. Over the years, we have seen how impurities—introduced via poorly sealed equipment or unwashed storage drums—could seed runaway reactions in downstream processes. Customers with less experience have learned the hard way that “off-spec” acid chlorides can jeopardize not just process efficiency, but physical safety for line operators.

    We have seen competing suppliers treat safety standards as paperwork. In harsh contrast, every batch leaving our site comes with a detailed, transparent record of manufacture, storage, and testing. We field periodic third-party audits, open our lines to customer inspections, and maintain open data channels both upstream and down. By building safety measures directly into every part of the operation, safety and reliability become part of the product itself.

    Environmental Stewardship: Real Accountability, Not Greenwashing

    Manufacturing dichloroacetyl chloride generates chlorinated byproducts and acidic residues with real environmental impact. We have invested over the years in advanced scrubber assemblies, solvent recovery units, and brine treatment systems to capture, neutralize, and recycle materials. Local water quality monitoring stations installed at our perimeter provide early warning for escape points; emissions reporting goes beyond legal minimums. Our experience matches what’s found in independent industry studies—upgrades in containment and treatment pay for themselves through reduced remediation cost and higher process yield.

    In practice, we supply returnable drums and encourage partners to send back empty containers for thorough decontamination and reuse, closing more loops. Every year, audits and tests measure the real reductions in waste produced per ton shipped, and results guide changes in process management and investment targets. Our annual public disclosures of solvent recovery rates have set us apart from less rigorous competitors, earning trust from customers and regulators alike.

    We pick up best practices at global industry meetings and implement lessons learned from both success and failure—ours and others’. A focus on genuine transparency has cut through much of the noise and built relationships with local communities sometimes wary of large-scale chemical operations.

    Meeting Today’s Regulatory and Quality Demands

    Regulatory standards for chemicals like dichloroacetyl chloride have tightened rapidly. Nations and trading blocs adopt stricter measures on purity levels, classifying byproducts, allowable emissions, and transportation protocols. As a direct supplier, by keeping our ears to the ground, we have pre-empted rule changes. Plant upgrades align with new limits on emissions, and our quality labs routinely hold themselves to standards above just the statutory norm. As a result, we have avoided late-stage market withdrawals, unexpected product recalls, and customer shutdowns related to out-of-compliance shipments.

    By implementing barcoded traceability on every container—down to the retail-level batch—we ensure that any issue can be tracked to its source and contained before it grows. Regulatory inspections rarely catch us unprepared because our team not only teaches compliance but also writes and revises the policies that get adopted as industry practice. We have created a dedicated group within our company to monitor shifting international regulations and update documentation and process standards. This brings peace of mind to downstream partners, who depend on us to anticipate marketplace and regulatory shifts.

    Supporting Innovation and Customer Collaboration

    We know the difference between simply supplying a chemical and partnering for successful commercial outcomes. Over the years, many of our most enduring relationships started with on-site troubleshooting or process optimization seminars at a customer’s plant. Dichloroacetyl chloride, with its distinctive behavior and reactivity, invites discussion and expert guidance. Some of the world’s most prominent pharmaceutical and agrochemical syntheses benefited from joint pilot programs, custom blend investigations, or tweaks to order frequencies.

    Technical staff visit customer facilities regularly with real feedback and case studies, not just brochures and quotations. We invite customer R&D teams to our site to run trial reactions using our in-house reactors under simulated commercial conditions. These collaborations foster richer product knowledge, allowing upstream tweaks to unlock increased yield, reduce waste, or solve vexing process bottlenecks downstream.

    As the market evolves and dichloroacetyl chloride finds new footholds in bioprocessing, advanced materials, or green chemistry applications, the lessons from the past drive our investment in flexible infrastructure and application support. The right manufacturer invests not only in molecules, but in the people and expertise who can help customers succeed.

    Reflections: Experience Counts

    Time in the trenches teaches that real-world performance can’t be reduced to numbers on a data sheet. Dichloroacetyl chloride’s true value unfolds in commercial kitchens, on pharma production lines, and in field applications, where every detail counts—handling, quality consistency, product support, environmental accountability, and robust documentation. Each improvement comes from years of hands-on feedback, technical setbacks, regulatory changes, and partnership with downstream users.

    As regulatory, environmental, and market pressures accumulate, safe, dependable, and high-quality dichloroacetyl chloride production demands knowledge, constant vigilance, and accountability. Our company’s experience drives every decision, from plant investment to customer support. We see ourselves as more than just suppliers, taking pride in turning the lessons of the past into better practices, better products, and stronger results for every user of dichloroacetyl chloride.