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Cyanogen Chloride

    • Product Name Cyanogen Chloride
    • Alias CK
    • Einecs 200-653-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    180742

    Chemicalname Cyanogen Chloride
    Chemicalformula ClCN
    Casnumber 506-77-4
    Molarmass 61.47 g/mol
    Physicalstate Colorless liquid or gas
    Boilingpoint 13.5 °C (56.3 °F)
    Meltingpoint -6.8 °C (19.8 °F)
    Density 1.18 g/cm³ (at 0 °C)
    Solubilityinwater Moderately soluble
    Odor Strong, irritating, pungent odor
    Vaporpressure 360 mmHg (20 °C)
    Autoignitiontemperature 535 °C (995 °F)

    As an accredited Cyanogen Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cyanogen Chloride is packaged in 500-gram sealed, corrosion-resistant metal cylinders, featuring hazard labels, secure valve, and tamper-evident seals.
    Shipping Cyanogen Chloride must be shipped as a highly toxic and hazardous material. It is transported in secure, airtight, corrosion-resistant containers, labeled according to international regulations (UN 1051, Class 6.1, Packing Group I). Proper documentation and handling precautions are essential, and only trained personnel should manage its transport due to severe health risks.
    Storage Cyanogen chloride should be stored in tightly sealed, corrosion-resistant containers in a cool, dry, and well-ventilated area, away from direct sunlight, moisture, and incompatible substances such as water, acids, bases, and oxidizers. Clearly label all containers and ensure storage areas are secure and equipped with proper ventilation and emergency equipment to prevent leaks, contamination, and toxic exposure.
    Application of Cyanogen Chloride

    Applications of Cyanogen Chloride in Industrial Manufacturing

    Cyanogen chloride is a specialized chemical intermediate with a significant role in selected industrial sectors, primarily for synthesizing advanced intermediates, agrochemicals, and specialty products. We supply this material with strict adherence to international manufacturing and quality standards, prioritizing safe handling and precise formulation for downstream customers.

    1. Synthesis of Cyanuric Chloride for Agrochemical Intermediates

    Leading producers of agrochemicals actively use cyanogen chloride as a controlled precursor in the synthesis of cyanuric chloride—a core intermediate for manufacturing modern herbicides, pesticides, and fungicides. Only certified industrial-scale producers employ this process, using batch or continuous gas-phase chlorination reactors specifically engineered to safely convert cyanogen chloride into downstream high-purity triazine derivatives essential for crop protection chemistries. This application demands extensive quality assurance to prevent cross-contamination and maintain regulatory traceability at each stage.

    Industry compliance standards

    • EU REACH Annex XVII (Regulation on Manufacture, Marketing and Use)
    • US EPA TSCA (Toxic Substances Control Act) chemical data requirements
    • ISO 9001:2015 certified quality management systems
    • FAO/WHO Guidance for the Manufacture of Pesticide Intermediates

    Typical usage ratio

    • Feeds into reactors at 90–100% concentration; molar ratios calibrated against triazine ring formation requirements, generally ranging from 1.05:1 to 1.15:1 versus starting diamide substrates, based on in-line monitoring of conversion and impurity profile

    Downstream process integration

    • Introduced in gas or liquid feed directly before the chlorination step; integral to the temperature-controlled exothermic reaction systems with online acid gas scrubbing and containment infrastructure

    Final product types

    • Cyanuric chloride (for use in s-triazine herbicides like atrazine, simazine, terbuthylazine)
    • High-purity triazine derivatives for selective pesticide intermediates

    2. Production of Pharmaceuticals via Glycine and Guanidine Derivatives

    Active pharmaceutical ingredient (API) manufacturers integrate cyanogen chloride for the conversion of glycine and substituted amines to advanced guanidine and nitrile intermediates, which underpin several essential pharmaceuticals, including antidiabetic agents and antiviral compounds. Stringent documentation of process steps, traceability, and dedicated closed systems are required for this synthesis route because of the toxicity and reactivity of the raw material, with special emphasis on QC to ensure no unreacted cyanogen chloride remains in the final API.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA cGMP 21 CFR Part 210/211
    • EU EMA Guideline on Setting Health-Based Exposure Limits
    • Ph. Eur., USP or JP Monographs for specific APIs

    Typical usage ratio

    • Optimal charge between 1.0–1.2 molar equivalents per target amine or glycine substrate, carefully titrated to reduce excess and rigorously monitored to ensure full, controlled conversion

    Downstream process integration

    • Added during amination reactions in jacketed, inerted glass-lined reactors under negative pressure, with in situ neutralization and volatile organic capture

    Final product types

    • Guanidine-based pharmaceutical intermediates
    • Nitrile-containing precursor APIs (used in antidiabetic, antiviral, or anti-ulcer drugs)

    3. Synthesis of Dye and Pigment Intermediates for Specialty Colorants

    Several leading colorant and pigment manufacturers utilize cyanogen chloride within integrated aromatic nitrile and amidine derivative synthesis platforms, vital for high-fastness dyes employed in textile, plastics, and specialty ink industries. Deployment in this sector focuses on closed-system processing and robust downstream purification to achieve the chromophore quality required for next-generation pigment dispersions. All handling takes place within containment to comply with industry standards and maintain end-user safety.

    Industry compliance standards

    • Oeko-Tex® Standard 100 Annex 6, Class I-IV (textile chemicals)
    • ISO 14001:2015 for environmental controls
    • REACH Substances of Very High Concern (SVHC) compliance for aromatic amines
    • GMP for industrial colorants (where applicable for food-contact textiles)

    Typical usage ratio

    • Normally 0.95–1.1 molar equivalents to aromatic amine/amine hydrochloride substrates, with strict flow monitoring and chemoselective catalyst optimization for high yield

    Downstream process integration

    • Dosed inline to pre-purified amine substrates, facilitating clean nitrilation/amidination steps prior to diazotization and chromogen coupling in closed reactors with multistage batch filtration

    Final product types

    • Azo and phthalocyanine dye intermediates
    • Pigment precursors used for plastics and inkjet colorant formulations
    • Textile dye components requiring specialty fastness and purity profiles

    4. Chemical Synthesis of Reagents for Laboratory and Diagnostic Use

    Producers of analytical and diagnostic reagents leverage cyanogen chloride as a coupling and activation agent in high-purity, small-batch production for chromatography, protein modification, and specific laboratory detection kits. The process involves precise metering under inert atmospheres with extensive post-reaction workup to assure reproducibility, batch purity, and safe elimination of residual reactants. Analytical and test kit manufacturers require complete batch records aligned with best practice manufacturing guidance from the diagnostics sector.

    Industry compliance standards

    • ISO 13485:2016 for quality management in medical device and diagnostics
    • CLSI GP5-A guidelines for laboratory reagents
    • US FDA 21 CFR Part 820 (where kits are regulated as medical devices)
    • REACH Title IV data requirements for specialty reagent manufacturers

    Typical usage ratio

    • Dosed at 1.0–1.05 equivalents relative to target protein or substrate group, with adjustments depending on protein modification target and reaction scale; frequently prepared as dilute solutions below 5% w/w for handling safety

    Downstream process integration

    • Introduced just prior to coupling reactions or labeling steps in high containment suites, with downstream purification utilizing preparative chromatography to assure full removal of byproduct traces

    Final product types

    • Protein coupling reagents for immunoassay development
    • Derivatization agents for HPLC and GC analytical chemistry
    • Diagnostic reagent kits requiring high-purity and traceability documentation
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    Certification & Compliance
    More Introduction

    Cyanogen Chloride: A Closer Look from the Manufacturer’s Perspective

    Our Experience with Cyanogen Chloride Production

    Working at the core of chemical manufacturing, we encounter substances that play crucial roles in industries far beyond our facilities. Cyanogen chloride stands out as one of the more powerful entries in our product lineup—not only for its sharp reactivity, but also for the strict control and technical rigor required to produce and handle it safely. Every ton that leaves our site reflects decades of technical refinement, hazard management, and practical knowledge passed through careful training and attention to evolving standards.

    Technical Model and Form of Supply

    We produce cyanogen chloride under strictly managed conditions, supplying it in compressed gas cylinders or as a liquefied gas. The product typically meets purity above 99%, with trace moisture and acid levels strictly limited by in-process analysis at several stages. Our monitoring process starts with raw material intake and proceeds through each reactor and purification column. Chromatographic checks on every batch ensure not just regulatory compliance, but confidence that our partners can rely on a consistent product profile over time.

    The material presents as a colorless gas, sometimes described as having a faint almond-like odor, though no one here would recommend relying on sensory cues. Protective systems and detection instruments remain the only safe way to confirm the presence of cyanogen chloride during loading and transfer. Specialized containers rated for toxic, reactive gases get paired with robust tracking—serial numbers, shipment logs, and digital chain-of-custody validation.

    Applications: A Product with Edge and Responsibility

    Cyanogen chloride’s main uses draw on its potency and reactivity. In industrial work, it comes into play for the synthesis of intermediates needed for products ranging from agricultural chemicals to pharmaceuticals, polymer precursors, and certain specialty reagents. In laboratories, it may serve as a reagent for nitrile introduction or halogenation, though such activities demand high-level containment and skilled staff with experience in hazardous material management.

    Diagnostic and sterilization processes exploit its capacity to disrupt biological molecules, but the efficiency comes at a price: every step requires engineered safeguards. Several downstream users incorporate the product as a controlled-use intermediate, meaning it does not remain in the final product, but instead acts as a highly specific reactant or a means to trigger desired transformations under closely controlled conditions.

    Some legacy applications—for example, in military or defense contexts—underscore the high bar for access and distribution. National chem defense authorities maintain lists of buyers and rigorous end-use certification. For us as producers, this means periodic audits, robust inventory protocols, and regular direct review with regulators to ensure our compliance stands up to scrutiny.

    Difference from Other Common Cyanides and Halides

    Cyanogen chloride often enters conversations near other cyanide derivatives, particularly sodium cyanide, potassium cyanide, and related halogenated compounds. From a production viewpoint, the main distinctions relate to both chemical volatility and hazard profile. Unlike solid cyanides that handle as granular powders or pellets, cyanogen chloride exists as a volatile, highly toxic gas. Moving and storing it calls for more advanced equipment, higher integrity container engineering, and enhanced training for all team members involved in handling.

    Chemical behavior diverges as well. The reactivity profile of cyanogen chloride—its rapid hydrolysis in water, aggressive alkylation, and volatile offgassing—creates different opportunities for synthetic chemistry, but also different risks along the supply chain and in waste management. We see a strong technical case for using gas-phase cyanogen chloride in certain reactions where traditional cyanides do not provide the needed activation energy or where a halide leaving group is essential for downstream chemistry.

    Manufacturing Insight: Why Production Matters

    In our day-to-day, process discipline means everything. Cyanogen chloride ranks among the most challenging materials in our catalogue, not just because of its lethal dosage or regulatory scrutiny, but because producing it requires real vigilance to prevent cross-contamination and unwanted byproducts. The synthesis, typically reliant on high-purity chlorine and hydrogen cyanide with controllable temperature and pressure regimes, proceeds within closed systems purpose-built to prevent escape. Vented gases pass through multiple scrubbing systems containing sodium hydroxide or sodium thiosulfate, designed to neutralize and trap harmful components.

    Over the years, we’ve fine-tuned our equipment—upgrading seals, revising gassing protocols, and integrating remote sensors that alert us even to fractional leaks. Team training does not end once certification comes through; we run drills, bring in outside experts, and conduct scenario testing on a rolling basis. This improves not only our safety record, but also product reliability, which for us equals customer trust.

    Handling and Safety Practices: What Experience Teaches

    Anyone producing or using cyanogen chloride must take the hazard profile seriously. From our perspective, experience changes the way people think about chemical risk. The most authoritative textbooks cannot convey the urgency of controlled access, regular equipment checks, and real-time atmosphere analysis when you see, first-hand, the consequence of even a minor exposure. Gloveboxes, fume hoods, and gas detection arrays represent only part of the infrastructure. We reinforce the human factor—clear communication protocols, direct lines to local responders, and mandatory reporting of every near-miss.

    Safe logistics extend beyond the plant gates. Cylinders receive inspection and refurbishment per international standards, with rigorous leak testing before release. All movement of cyanogen chloride pairs with full manifest tracking, including secure encrypted reports to relevant authorities with every shipment. Customers working with this product often send technicians here for pre-acceptance training, or request that our safety staff observe their commissioning runs.

    Waste management requires separate discussion. Cyanogen chloride breaks down in the presence of alkalis, allowing scrubbing systems to neutralize residual content before venting. Effluent and contaminated vessels go through staged washing and chemical neutralization processes, with real-time pH and cyanide monitoring throughout. Years of process optimization resulted in waste streams below permitted standards and a cooperative relationship with local environmental authorities. Our experience shows that honest external review strengthens practices more than any box-checking audit.

    Product Development and Continuous Improvement

    We regularly revisit our process analytics, reviewing batch-to-batch consistency and adjusting protocols to suit new technical or regulatory demands. Customers often bring us specialized purity requirements or request specific delivery formats for integration with closed-system reactors. In response, our team redesigned cylinder valves and introduced new filling manifolds that reduce transfer losses and exposure risk. Periodic revalidation of analytical methods—by independent labs as well as internal QA—forms a defensive wall against complacency.

    Technology is part of the solution, but feedback from the field also drives change. An example: one partner flagged tiny fluctuations in impurity levels that standard QC missed, impacting their downstream yields. Our chemists cross-referenced process logs, traced a minor upstream equipment degradation, and rewrote maintenance protocols to prevent repeats. The lesson stuck—frontline staff view customer issues not as complaints, but as guides for where to focus our next round of precision upgrades.

    Regulatory factors have become increasingly dynamic. New national and international protocols affect acceptable impurity levels, cylinder durability, shipment limits, and tracking requirements. We assign staff to maintain close contact with safety authorities and industry working groups. Commitment to regulatory dialogue improves our own competitiveness: when new standards appear, we are in a position to adapt ahead of deadlines, rather than react under pressure.

    Quality, Traceability, and User Accountability

    Quality management depends on more than a paper certificate. Each batch of cyanogen chloride features a full analytical report signed by both production and safety staff. Trace data follows the batch from raw material through synthesis, purification, and cylinder loading, with secure logs on transport and recipient. Customers may request historic data audits or on-site review; we consider this level of transparency non-negotiable.

    Our concern does not end with shipment. Field service representatives keep open lines with purchasers, especially those engaging new applications or handling processes with especially low tolerance for deviation. We encourage open disclosure of any incident or out-of-spec material, offering analytic support and, if needed, site visits to assist with root cause analysis.

    End users bear a serious responsibility, reflected in government regulations and professional ethics. Our regular communication with customer safety directors reinforces this shared expectation. If any party along the supply chain cannot document storage or handling to acceptable standards, shipments are suspended. In our experience, shared accountability raises the bar for safety, product quality, and industry reputation.

    Potential Issues in the Value Chain

    Working with toxic gases, we face realities that paper risk assessments sometimes overlook. Cylinder transportation still carries residual risk from weather, traffic incidents, or unauthorized entry. Our logistics partners receive ongoing training for hazardous cargo, and emergency plans sit ready along transport routes. We make site visits to audit downstream storage and connection points, taking the same hard line on compliance as regulators would.

    Security cannot be an afterthought. A product like cyanogen chloride, with its historical potential for misuse, prompts us to vet purchasers, check licensing, and update chain-of-custody protocols on a rolling basis. Regular reviews with law enforcement representatives and industry peers allow new threat patterns to be discussed before they become real problems. Security cameras, restricted access, and digital logs combine with a culture that emphasizes integrity at every level.

    Looking Forward: Opportunities and Challenges

    Cyanogen chloride remains in demand for several industries striving to innovate, but the climate is shifting towards ever-more stringent health, safety, and environmental controls. Our role is to supply the molecule, but just as important, to work hand in hand with users, regulators, and the community to minimize risk and maximize compliance. This challenge suits us; it frames the task not just as a job, but as stewardship over a potent and potentially dangerous resource.

    We see growth coming from sectors that value process transparency, advanced analytics, and reliability. Feedback loops run both ways—new technical demands push us to innovate, while improvements in production and logistics help our customers develop new products safely. The increasing sophistication of synthetic techniques—continuous flow reactors, single-use transfer lines, advanced modeling—influence our thinking about future upgrades and investments.

    We stay in this business because we believe responsible production does more than keep people safe; it also opens doors to collaboration and technical progress that safer, simpler chemistry cannot reach. No story about cyanogen chloride is complete without acknowledging both its hazards and the rigorous systems built to manage them. Chemical manufacturing demands personal commitment, constant improvement, and, above all, a deep respect for the compounds we send beyond these gates.