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Chloroacetaldehyde

    • Product Name Chloroacetaldehyde
    • Alias Chloracetaldehyde
    • Einecs 203-498-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    384843

    Chemicalname Chloroacetaldehyde
    Casnumber 107-20-0
    Molecularformula C2H3ClO
    Molarmass 78.50 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Pungent, irritating
    Meltingpoint -66°C
    Boilingpoint 87°C
    Density 1.184 g/cm³ at 20°C
    Solubilityinwater Miscible
    Vaporpressure 64 mmHg at 25°C
    Flashpoint 44°C (closed cup)
    Refractiveindex 1.424 at 20°C
    Synonyms Chloroethanal, Monochloroacetaldehyde
    Unnumber 1135

    As an accredited Chloroacetaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Chloroacetaldehyde is supplied in a 500 mL amber glass bottle with a screw cap, labeled with hazard warnings and safety instructions.
    Shipping Chloroacetaldehyde should be shipped in tightly sealed, clearly labeled containers, protected from moisture, heat, and incompatible substances. It must comply with all relevant regulations for hazardous chemicals. Shipments require proper documentation, safety labeling, and compliance with DOT, IATA, or IMDG guidelines due to its toxic, corrosive, and volatile nature.
    Storage Chloroacetaldehyde should be stored in a cool, well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as oxidizers and strong bases. Keep it in tightly closed, corrosion-resistant containers clearly labeled and protected from moisture. Store in a secure chemical storage cabinet designed for hazardous materials, and ensure emergency spill containment and ventilation systems are in place.
    Application of Chloroacetaldehyde

    Applications of Chloroacetaldehyde in Industrial Manufacturing

    Chloroacetaldehyde serves as a key intermediate in multiple industrial sectors. Our production expertise ensures consistency and high purity for large-scale downstream synthesis. The following application scenarios highlight real, major industrial uses based on current process and regulatory requirements.

    1. Pharmaceutical API Synthesis

    This raw material functions as an essential building block in synthesizing pharmaceutical intermediates, including active ingredients for antiviral and anticancer compounds. It enters amidation, acylation, and cyclization reactions, forming heterocyclic cores critical in patented drug molecules. Batch records require tight control of residual content, achieved by accurate dosing and validated analytical methods. Process engineers calibrate reaction stoichiometry based on the substrate load and the sensitivity of final APIs to side-products, particularly halogenated residues. End-users demand full traceability and compliance with international monograph and impurity thresholds.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP, EP, JP pharmacopoeial monographs for APIs
    • 21 CFR Part 210/211 (cGMP for finished pharmaceuticals)
    • REACH registration (EU)

    Typical usage ratio

    • 0.5–1.2 molar equivalents relative to core amine or nucleophile substrates
    • Precise adjustment according to API route, batch scale, and impurity limits

    Downstream process integration

    • Charged during stepwise cyclization in heterocycle formation
    • Dosed in jacketed reactor systems under nitrogen with online pH monitoring
    • Quenched with excess reactant to minimize hydrolysis by-products

    Final product types

    • Antiviral agents (nucleoside analogues)
    • Cytotoxic chemotherapeutics
    • Pyrimidine and purine based intermediates
    • Synthetic pharmaceutical precursors

    2. Agrochemical Active Ingredient Production

    Manufacturers use this compound as an intermediate to introduce chloroacetyl and aldehyde functions into key pesticide and herbicide structures. The material reacts under controlled temperature to minimize the formation of unwanted polychloro by-products. Process engineers optimize batch concordance to harmonize with regulatory containment systems. Responsible use in synthesis requires full batch record documentation according to crop protection registration needs. Product stewardship includes environmental discharge controls and isolation step purification technologies.

    Industry compliance standards

    • ISO 9001:2015 certified production for crop protection actives
    • FAO/WHO pesticide specifications
    • EU REACH and CLP Regulation for agrochemical intermediates
    • US EPA TSCA (Toxic Substances Control Act)

    Typical usage ratio

    • 0.8–1.0 part by weight for every part of base compound in acetylation/cyclization
    • Adjusted for each active’s synthesis path to regulate yield and purity

    Downstream process integration

    • Added in microdosing to stirred tank with controlled exotherm
    • Followed by immediate neutralization and solvent extraction
    • Intermediate purified on column or crystallized before formulation

    Final product types

    • Pre-emergence herbicide actives
    • Insecticidal base compounds
    • Fungicide intermediates
    • Synthetic plant growth regulators

    3. Dyes and Pigment Manufacturing

    This precursor enters condensation reactions in the synthesis of specific anthraquinone and azo dyes. It reacts with aromatic amines, controlling chromophore insertion and functional group orientation. Batch engineers fine-tune charge ratios to tailor shade intensity and fixation behavior on various substrates. Outbound shipments require detailed batch certificate tracking, underpinned by spectroscopic and chromatographic analysis. Producer quality management addresses both occupational safety during handling and environmental compliance for effluent management.

    Industry compliance standards

    • OEKO-TEX Standard 100 for restricted substances
    • REACH Annex XVII listing for dye intermediates
    • GMP for pigment manufacturing (ISO 22716 when exported for cosmetic use)
    • Wastewater discharge regulations (local and EU)

    Typical usage ratio

    • 0.5–0.9 parts by mass per dye batch
    • Adjusted according to dye molecular weight and target loading on textile fibers

    Downstream process integration

    • Mixed with aromatic amines in jacketed reactors at 40–60°C with slow addition
    • Condensation proceeds under reduced pressure to limit off-gassing
    • Downstream oxidation and filtration before isolation

    Final product types

    • Anthraquinone dyes for synthetic fibers
    • Azo pigments for plastics and coatings
    • Pigment dispersions for printing inks
    • Technical textile dye formulations

    4. Biocide and Disinfectant Intermediate

    This input provides a reactive aldehyde group essential for advanced biocide production. Chemical process teams employ strict inventory control and PPE protocols due to its reactivity and workplace threshold limits. The compound undergoes nucleophilic substitution with secondary amines, driving the synthesis of highly potent quaternary ammonium biocides. In order to meet downstream legal restrictions, manufacturers closely document incoming purity, monitor residual content, and implement rigorous in-process analytical testing. Customers in water treatment and industrial hygiene require that production facilities follow cleaning validation and batch containment as per chemical hygiene plans.

    Industry compliance standards

    • BPR (EU Biocidal Products Regulation 528/2012)
    • OSHA workplace safety standards (US)
    • ISO 14001 Environmental Management for secondary containment
    • GHS labeling and MSDS provision

    Typical usage ratio

    • 1.1–1.5 moles per mole of downstream amine functional substrate
    • Ratio fluctuates with target active species purity goals and antimicrobial potency

    Downstream process integration

    • Introduced in semi-batch reactors with inline safety interlocks
    • Sequentially combined with amines to control exothermicity
    • Product stream isolated via solvent extraction and crystallized

    Final product types

    • Industrial water treatment biocides
    • Surface disinfection actives
    • Anti-fouling additives for coatings
    • Responsibly formulated household disinfectants

    5. Epoxy Resin and Polymer Modifier

    Chloroacetaldehyde introduces reactive chloro and aldehyde groups into specialty epoxy systems and advanced polymer modifiers. Its inclusion facilitates post-polymerization cross-linking, enhancing end-use chemical resistance and adhesion properties in formulated coatings. Quality control teams measure reactive group usage and verify batch stability via titration. Operators regulate feed and mixing speed to maintain safe working conditions and achieve desired polymer chain extension. Only properly validated batch records permit release for use in industrial paints, flooring compounds, or resin-impregnated tapes.

    Industry compliance standards

    • ISO 9001:2015 quality management for polymer production
    • ASTM D1655 for cured resin specification
    • REACH registration obligations for polymer additives
    • RoHS compliance for electronics-related products

    Typical usage ratio

    • 0.2–0.6% by weight in epoxy formulations
    • Fine-tuned based on desired cross-link density and performance targets

    Downstream process integration

    • Charged to pre-polymerized resin with metered addition
    • Mixed under agitation to guarantee homogeneous distribution
    • Post-reaction degassing followed by cooling and packaging

    Final product types

    • Two-component industrial epoxies
    • Polymer modified flooring resins
    • Anti-corrosive protective coatings
    • Composites for advanced manufacturing
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    Certification & Compliance
    More Introduction

    Chloroacetaldehyde: Behind the Scenes in Industrial Chemistry

    Our Direct Experience Manufacturing Chloroacetaldehyde

    Decades on the manufacturing floor have shown us that not all industrial chemicals are created equal. Chloroacetaldehyde rises to the surface as a versatile player, yet one that demands respect from the hands that handle it. We’ve worked with this transparent liquid through cycles of innovation, supply chain crunches, and stricter environmental controls. Each batch we produce reflects our insistence on reliable raw materials, precise process controls, and fully documented production records.

    At its core, what sets chloroacetaldehyde apart is a reactive aldehyde group joined directly to a chlorine atom. Our facility produces it mainly as an aqueous solution—typically in concentrations between 40 and 50 percent—to balance reactivity with safe transport and storage. We draw on directly sourced ethylene or acetaldehyde, react it under meticulously controlled conditions, and then stabilize the product to minimize degradation and unwanted by-products.

    Roles in Industry

    There’s little room for error with chloroacetaldehyde. In our business, it serves most commonly as an intermediate worth more than the sum of its parts. For years, its chief use has been in the synthesis of pharmaceuticals and active pharmaceutical ingredients. Here, our customers depend on the consistent reactivity and purity of every drum. Other manufacturers come to us because they need a reliable input for products like dyestuffs, fungicides, and water treatment chemicals. The chemical’s high reactivity makes it useful for cyclization and condensation reactions, fitting needs that few other reagents cover with the same efficiency.

    Our team has seen an uptick in custom requests from research institutions and specialty synthesis firms. Researchers are tapping into chloroacetaldehyde’s role in heterocyclic compound formation, which underpins everything from diagnostic stains to certain sedative drug bases. We listen directly to feedback on every lot—whether concerns about side reactions or requests for higher stability—and use that to fine-tune our process and delivery timeline.

    Specification Standards Grown from Experience

    Every run passes through our on-site quality control lab. We verify aldehyde content, chlorination level, and restrict haloform or diol by-products. Laboratory results do not just serve regulation; they sharpen our process, guiding us to tweak fractionation or neutralization as needed. If a client flags yellowing in the solution or hints of polymerization, our chemists dig through batch records and refine the next run accordingly. Water content, acid value, and trace impurities trace back directly to process optimization and operator training. Over the years, hard lessons have taught us to check these values at multiple points: after reaction, following purification, and at loading.

    Compared to downstream traders, we see the raw material risks. Sourcing unreliable feedstocks can throw off the ratio between chloro and acetaldehyde groups, creating off-grade batches that don’t serve their purpose in pharmaceuticals. That’s why building long-term trust with our raw suppliers directly shapes the outcome you see in your barrel.

    Comparing Chloroacetaldehyde to Its Peers

    In conversations with formulation teams, questions often come up—why not use monochloroacetic acid, chloral, or even the less hazardous acetaldehyde itself? The direct answer lies in molecular structure and reactivity. Chloroacetaldehyde’s properties sit in a unique middle ground. Its aldehyde group offers more control during condensation reactions than fully substituted chlorinated ethanes, and the single chlorine substituent gives a useful selective reactivity.

    Take monochloroacetic acid. This compound works well for certain carboxylic reactions but fails to offer the aldehyde’s reactivity for cyclization steps. Chloral, on the other hand, possesses three chlorines, upping the toxicity and shifting the reactivity profile away from those selective steps needed in pharmaceutical and agricultural synthesis. Acetaldehyde may seem safer, but it lacks the necessary chlorination—so processes that call for the introduction of a chlorine atom in a sensitive spot fall short. In the end, each molecule tells us where it fits: when a reaction demands a direct, one-step addition of a chloro group adjacent to an aldehyde, our chloroacetaldehyde solution pulls its weight.

    Handling, Safety, and the Human Factor

    No chemical manufacturer with eyes on long-term business takes shortcuts when it comes to safety. We run training sessions every six months, walking operators through safe transfer procedures, containment troubleshooting, and up-to-date regulatory compliance. Unlike simple solvents, chloroacetaldehyde carries irritant and harmful properties that warrant layered precautions. We work only with closed transfer systems, local exhaust ventilation, and pressure-rated containers.

    On site, we choose personal protective equipment based on risk analysis. Goggles, face shields, chemical-resistant suits and gloves are standard, paired with emergency showers at every corner. Beyond that, our maintenance crew checks flange seals and valve integrity daily—sniffers and vapor alarms back up human judgment, catching the leaks that years of experience warn us to expect before they disrupt operations.

    Spills and off-gassing present ongoing risks in both small and bulk volumes. That’s no abstraction for our team—it means having foam blankets on hand, tested containment kits, and a patch on the wall reminding us of a case, years ago, where a pressure surge sent vapors into the package staging bay. Incidents like these don’t just result in tighter checklists—they drive upgrades in monitoring software and valve interlocks throughout the entire plant.

    Regulations That Shape Manufacturing Practice

    Years ago, chloroacetaldehyde sat on regulatory lists only in footnotes. Times have changed. Our compliance team tracks local and international rules—REACH in Europe, EPA listings, and worker safety codes—injecting those standards directly into our operating procedures. Each export lot gets a certificate showing not just compliance, but traceability from raw input to finished drum.

    We document every delivery: tank cleaning, nitrogen blanketing, and sampling results are logged in real time. If a jurisdiction tightens emission limits, as we saw with air monitoring for chlorinated compounds, we invest in new scrubber stages and emissions reporting.

    Industry consortia play an increasing role. We help fund shared studies on toxicity, waste treatment, and process byproducts. More often now, downstream users question the environmental profile of every input. The pressure is welcome—it pushes us to innovate, cut down residual chlorides, and improve closed-loop water use inside the plant.

    Supply Chain and Logistics Unfiltered

    Shipping chloroacetaldehyde always brings up questions: stability, container selection, transit times, customs protocols. As the direct manufacturer, we have to think months ahead. We run stability trials—some to satisfy international customers and others to back up our own transport policies. Insulated tanks, pressure testing, stabilized formulations, and pre-cooled shipments are all part of daily practice.

    If weather throws off timelines or customs detain a shipment, we pivot—extra buffer stocks and local warehousing help limit risk. Our logistics team reviews routes every quarter, revising carrier selections based on real-world delays. One storm in Southern China last year forced us to reroute product through inland depots, and lessons learned from those kinds of disruptions shape how we respond to uncertainty now.

    Potential buyers often ask about shelf life and chemical changes during storage. We share real data: past monitoring shows that, stored in sealed, light-proof containers at ambient temperatures, our product retains ideal performance for several months. Most drift comes from temperature spikes and accidental water dilution, both managed better in-house than down-chain. These are not just claims; records from returned drums help us refine advice and update labeling on outgoing shipments.

    Research, Development, and Continuous Improvement

    Every chemical, even a workhorse like chloroacetaldehyde, can surprise us in the lab. We dedicate significant time and scale to pilot runs, finding safer substitutes for hazardous reagents or new catalysts that make our production cleaner and faster. Recent internal projects have reduced detectible diol byproducts by over 20 percent—good for everyone down the line.

    In collaboration with academic labs, we’ve tested modifications to keep oxygen and light exposure to a minimum during production, reducing risk of tar formation and byproduct reactivity. External audits by technical experts keep us honest: every year, we break down and share our process improvements, with details on waste reduction, emissions management, and energy use targets.

    Customers planning new syntheses value real feedback from the producer. They ask: will traces of impurities affect yield? Does the solution separate on standing? These don’t get generic answers. Instead, our technicians break out data from the last ten batches, check in with plant operators, and come back with actual numbers, timelines, and photos from production trials. We learn as much from these exchanges as from any internal review.

    Sustainability and the Path Ahead

    No industry escapes the wave of sustainability, and we accept that challenge head-on. Chlorinated intermediates have a reputation that will never be spotless, but constant process upgrades help blunt the impact. We recover and treat process water, neutralize waste at multiple stages, and capture gas emissions through two-stage scrubbers before release. Our plant went through a full lifecycle footprint analysis last year, identifying where energy demands and fugitive emissions still need tackling.

    Our purchasing department sources feedstocks from regional suppliers using certified sustainable practices. Renewable energy initiatives offset part of our on-site power load. Waste minimization doesn't just happen at the back end—it begins with minimizing off-spec batches through real-time controls and investing in better sensors on the production line.

    Clients downstream feel the push as much as we do. EU and US partners demand chain-of-custody records and declarations of green chemistry steps taken along the way. Practical action means tighter coordination, faster sharing of process data, and a willingness to rethink old methods in light of new science. We see this not as burden, but as proof that manufacturing can learn, evolve, and protect both business interests and the broader environment.

    Conclusion: Why Experience Matters

    In-house production of chloroacetaldehyde centers on more than formulas and inventory levels. It threads together the hands of operators, the judgment of chemists, the vigilance of engineers, and the direct accountability of business managers. We listen to the market, react to regulatory shifts, and invest daily in process improvements that push safety and product performance ever higher.

    As the direct manufacturer, each drum carries a story—from the sourcing of raw inputs and the hum of pumps on the production line, to the data streams verifying every specification and the trained eyes packing containers for shipment. Chloroacetaldehyde, in our experience, offers not just a reactive intermediary but a testament to what careful, responsible manufacture can bring to the chemical industry.

    Future Challenges and Solutions

    Looking ahead, the main challenges remain: safeguarding worker health, lowering residual contaminants, and keeping pace with ever-stricter regulatory demands. We’re responding by investing in smarter process controls. Machine learning now flags batch anomalies before a human would spot them. A dedicated R&D program explores lower-impact catalysts and tries to engineer out hazardous side streams entirely.

    We are pushing upstream towards supplier certifications, ensuring that every crate of input aligns with international best practices. Downstream, we support partners moving to closed-loop processes and provide direct consulting when they revamp their synthesis routes. Industry alliances open the door to shared problem-solving—a trend we foster by volunteering data and testing support whenever possible.

    As expectations rise, we keep the core lesson from years at the plant’s edge: diligence, transparency, and adaptability don’t just bring better product—they sustain trust across the entire value chain. Chloroacetaldehyde is more than a molecule leaving our gates. It’s the product of careful hands, hard science, and a commitment to outpacing problems before they start.