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Butyronitrile

    • Product Name Butyronitrile
    • Alias 1-Butanenitrile
    • Einecs 202-481-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    526548

    Cas Number 109-74-0
    Chemical Formula C4H7N
    Molar Mass 69.11 g/mol
    Iupac Name Butanenitrile
    Appearance Colorless liquid
    Odor Sweet, ether-like
    Boiling Point 116-118 °C
    Melting Point -112 °C
    Density 0.803 g/cm3 at 20 °C
    Solubility In Water 4.4 g/100 mL at 20 °C
    Flash Point 24 °C (closed cup)
    Refractive Index 1.398 at 20 °C
    Vapor Pressure 13 mmHg at 25 °C

    As an accredited Butyronitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Butyronitrile is packaged in a 500 mL amber glass bottle with a secure screw cap and warning hazard labels.
    Shipping Butyronitrile should be shipped in tightly sealed containers, protected from physical damage, heat, and incompatible substances. It is classified as hazardous; therefore, transport must comply with relevant regulations, including proper labeling. It should be kept away from sources of ignition, oxidizers, and acids during shipping to ensure safety.
    Storage Butyronitrile should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Store separately from oxidizing agents, acids, and bases. Properly label the storage area and ensure spill containment measures are in place. Use only approved containers and keep away from incompatible substances.
    Application of Butyronitrile

    Applications of Butyronitrile in Industrial Manufacturing

    Butyronitrile enables targeted chemical synthesis in several high-value industrial sectors. As the direct producer, we support downstream partners with material definition, formulation guidance, and integration support for precise production outcomes. Below we detail the principal industrial use-cases and technical considerations for deployment in active manufacturing environments.

    1. Synthesis of Pharmaceutical Intermediates

    Butyronitrile serves as a reactant for the preparation of specialty pharmaceutical intermediates, including pyrimidine derivatives and precursors for antihypertensive active pharmaceutical ingredients. Manufacturers implement closed-system processes to minimize residuals and ensure material traceability from batch validation through intermediate compound formation. Process chemists adjust reactant feed rates and side stream management based on intended pharmacological end points. Extensive in-process testing confirms removal of unreacted nitrile species prior to downstream conversion to final APIs or advanced intermediates.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia Monographs for Intermediates
    • 21 CFR Part 211 – Current Good Manufacturing Practice for Finished Pharmaceuticals
    • EDQM Guidelines for Solvent Residues

    Typical usage ratio

    • 10–40 mol% of total reactant load; adjusted according to process route, target intermediate structure, and impurity specification limits

    Downstream process integration

    • Homogenized charge to reactor vessel during primary condensation or alkylation phases
    • Continuous monitoring of nitrile conversion rates and side-product formation
    • Post-reaction phase separation and purification (liquid-liquid extraction, distillation)
    • Transfer to subsequent hydrogenation or cyclization modules for further derivatization

    Final product types

    • Pharmaceutical intermediates (pyrimidines, substituted amines)
    • Advanced building blocks for antihypertensive agents
    • API precursors for cardiovascular and CNS applications
    • Specialty research chemicals for medicinal chemistry

    2. Production of Rubber Chemicals (Vulcanization Accelerators)

    Butyronitrile functions as a key input for the manufacture of rubber vulcanization accelerators, such as thiuram and dithiocarbamate derivatives. Downstream users drive selectivity and conversion with tightly controlled batch profiles, balancing throughput with impurity thresholds relevant to high specification tires and industrial rubbers. Its chemical reactivity enables customization of performance additives that enhance mechanical properties and resistance profiles in synthetic rubber compounds.

    Industry compliance standards

    • ISO 9001 Quality Management for Rubber Chemicals
    • ASTM D4678 – Standard Practice for Rubber Compounding Materials
    • REACH Registration – EU Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals
    • China GB/T 21865 for Vulcanization Accelerators

    Typical usage ratio

    • 15–25% of the total mass of accelerator synthesis feedstock; tuning required based on target accelerator type and downstream rubber grade

    Downstream process integration

    • Charged at measured intervals to batch reactors with sulfur and other organics
    • Closely monitored temperature and pH profile during reaction
    • Product separation using liquid phase extraction and vacuum distillation
    • Finished accelerator transferred for direct blending in downstream rubber compounding lines

    Final product types

    • Thiazole and thiuram class accelerators
    • Dithiocarbamate vulcanization agents
    • Rubber processing additives for manufacturing tires, conveyor belts, and hoses
    • Performance-modified elastomeric seals and automotive parts

    3. Manufacture of Specialty Solvents

    Butyronitrile is employed in the synthesis of specialty polar aprotic solvents for the electronics and advanced materials sector. Solvent producers optimize input ratios according to flash point, toxicity, and residual monomer specifications demanded by printed circuit board production and microfabrication. Downstream integration involves azeotropic distillation and fractional condensation to achieve the solvency profile suitable for degreasing, extraction, or high-purity carrier fluid applications.

    Industry compliance standards

    • Electronic Industry Alliance (EIA) QC Guidelines
    • UL 94 Testing for Flammability
    • ROHS Directive 2011/65/EU limitations on hazardous substances
    • JIS K 8951 – Testing Methods for Organic Solvents

    Typical usage ratio

    • 60–90% basis in solvent blend, adjusted due to purity, flash point, and downstream evaporation rate requirements

    Downstream process integration

    • Precursor introduction during multi-stage distillation units
    • Routine purity testing for trace nitrile content
    • Post-distillation stabilization with molecular sieves if required for ultra-dry grades
    • Quality assurance prior to dispatch to electronics and advanced manufacturing plants

    Final product types

    • Specialty polar aprotic solvents
    • High-purity degreasing agents for microelectronics
    • Extractant fluids for advanced material processing
    • Carrier solvents in specialty coatings

    4. Synthesis of Pesticide Intermediates

    Within agrochemical manufacturing, butyronitrile acts as a functional building block for specific pesticide intermediates, including triazole and pyridine derivatives. Formulators regulate introduction parameters to balance reactivity and mitigate toxic byproduct accumulation. Dedicated process control measures ensure alignment with regulatory residue limits and purity requirements enforced for crop-protection registration. Rapid in-line analysis is often deployed to confirm conversion rates and downstream process readiness.

    Industry compliance standards

    • ISO 9001 for Agrochemical Production
    • FAO/WHO Specifications for Plant Protection Products
    • EU Regulation (EC) No 1107/2009 on market placement of plant protection products
    • China GB 4839 National Standards for Pesticide Intermediates

    Typical usage ratio

    • 8–22% of total mole input; batch-specific adjustment depending on downstream active compound structure and targeted impurity specification

    Downstream process integration

    • Added to targeted cyclization or aminolysis steps during multi-stage synthesis
    • Controlled quench and solvent exchange following nitrile reaction
    • Automated sampling for nitrile residue and reaction completion
    • Preparation of intermediate for downstream transformation into registered actives

    Final product types

    • Pyridine and triazole-based pesticide intermediates
    • Active ingredient precursor compounds
    • Herbicide and fungicide building blocks
    • Component materials for agricultural chemical mixtures

    5. Specialty Polymer Additive Manufacturing

    Specialty polymer facilities use butyronitrile as a modifier to tailor mechanical and chemical resistance properties in engineering plastic grades such as acrylonitrile-butadiene copolymers. Operators manage raw feed mix ratios and reactor residence times to optimize copolymer architecture for downstream extrusion and compounding. Careful monitoring ensures the minimization of free nitrile and byproduct monomers to comply with strict end-use safety and environmental regulations.

    Industry compliance standards

    • ISO 9001:2015 for Quality Management in Polymer Additives
    • FDA 21 CFR Section 177.1040 for food contact polymers (if applicable)
    • UL Yellow Card for Polymer Materials
    • China GB/T 12670-2008—Acrylonitrile Copolymer Specifications

    Typical usage ratio

    • 2–12% of initial monomer feed; percentage modulated based on targeted polymer physical and chemical properties

    Downstream process integration

    • Metered dosing during initial polymerization feed
    • In-process real-time viscosity and conversion tracking
    • Sequential downstream purification and stabilization
    • Compounding with fillers and additives prior to pelletizing or shaping

    Final product types

    • Impact-modified acrylonitrile-based copolymers
    • High-strength engineering plastics for automotive, E&E housings
    • Customized plasticizer and modifier masterbatches
    • Polymer blends for specialty extrusion and molding
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing Our Butyronitrile: Quality Matters from the Source

    What We Make: Butyronitrile by Direct Production

    Every drop of butyronitrile we ship has its roots in our own facility. We don’t source from third parties; we design the process, scrutinize every reaction stage, handle all purification, and fill each drum under our roof. This lets us keep a level of control that distributors and trading houses never see. For every customer, that direct line back to the reactor gives peace of mind—full traceability and the knowledge that no step has been skipped or fudged.

    Our Approach to Butyronitrile Synthesis

    Making butyronitrile isn’t just about mixing up chemicals and letting them react. We run a continuous process, keeping tight watch over temperature profiles, reactant feed rates, and reactor pressures. This ensures our product achieves the high purity the market demands—usually running above 99.5%. By producing everything ourselves, we have full knowledge of the feedstock chain. Our team regularly evaluates alternatives for cost and performance, but we stick to sourcing from regions where we have active partnerships and rigorous oversight. Cost savings never come at the expense of process integrity or product purity.

    Purity Profile and Physical Specs

    Customers need chemical consistency. Our butyronitrile comes as a clear, colorless to light yellow liquid. We ensure extremely low impurity levels: water typically stays under 0.05%, with common side-products—acetonitrile, propionitrile, crotononitrile—kept at controlled trace concentrations. Specific gravity, refractive index, and boiling point can vary with production run, but they always fall within published industry norms (boiling point: near 116°C, for example). For packaging, we offer steel drums and IBCs, both well-tested for chemical compatibility. Because we run quality checks batch by batch, deviations get caught early. That’s how we avoid sticky issues down the pipeline, like residue buildup in downstream equipment or off-odors that could threaten product acceptance.

    How Our Butyronitrile Gets Used

    We’ve been supplying butyronitrile to industries that turn it into a host of end products. Paints, coatings, rubber, pharmaceuticals, and specialty solvents all tie back to it. Most often, butyronitrile acts as a precursor. For example, in pharmaceuticals, our material often finds its way into the synthesis of active ingredients or key intermediates, where unpredictable impurity profiles could cripple the next production step or undermine product registration. Polymer customers count on our butyronitrile for the synthesis of specialty elastomers and plastics. Here, any variation in feedstock purity can send mechanical properties veering off spec and create huge headaches during quality audits.

    Another strong market: the agrochemical sector. Many crop protection ingredients use butyronitrile as a building block. End users in this space face tight scrutiny from regulators, so small impurities left unchecked or batch-to-batch inconsistency can endanger both final product registration and the reputation of the supply chain. By keeping everything in-house, we don’t just sell a commodity; we deliver a chemical with a pedigree that stands up under tough examinations—whether from government inspectors, big pharmaceutical auditors, or outside analysts.

    Model and Variants: Why Granularity Matters

    Our standard offering is industrial-grade butyronitrile, with a purity specification around 99.5% or higher. We also run special campaigns for pharmaceutical and electronic customers who demand tighter specs or customized impurity profiles. Drawing on decades of experience with process adjustment, we manipulate distillation cut points to yield a super-pure fraction, with water content and volatile organics driven even lower. While some argue that one grade fits all, our plant team has learned the hard way that “close enough” often isn’t. Feedback from adhesive formulators, API plants, and elastomer bottlers keeps us on our toes: sometimes they need lower aldehyde content, sometimes a certain additive can’t be present. We tune the profile to support each special request, always aiming for repeatability.

    From First Principles: What Sets Butyronitrile Apart

    Compared to simple nitriles like acetonitrile or propionitrile, butyronitrile brings structural length and chemical options to the table. With its four-carbon backbone, it serves as an excellent starting point for chain-elongation reactions, which our R&D team often discusses with custom project clients. That gives it a flexibility that shorter nitriles can’t match. Neither acetonitrile nor propionitrile achieve the same solubility range or reactivity in certain catalytic systems—beta selectivity and longer fragments offer clear advantages for synthetic chemists.

    Our experience with multi-ton synthesis projects points to another difference: volatility and toxicity profiles. Butyronitrile carries manageable vapor pressure and boiling point, making it easier to handle than acetonitrile, where emissions and operator exposure create headaches, especially in warm climates. Relative to longer nitrile analogues—like valeronitrile—the production economics and supply chain robustness work in favor of butyronitrile. Global feedstock access and plant-level process reliability keep costs balanced while short lead times avoid supply crunches. These factors matter during plant turnarounds or market upswings, when traders can get tempted to cut corners; our direct-from-manufacturer approach keeps blind spots out of the equation.

    Chemical Safety and Operator Experience

    In our own shop floor, we have learned that no safety manual ever captures every nuance of handling butyronitrile. Nobody understands its quirks better than the folks who work with it every day. We equip all handling and filling points with active vapor extraction and run personal exposure checks at least weekly. While butyronitrile is flammable and carries certain toxicity risks, our generation of operators has developed best practices for loading, storage, and transfer. This reduces chances of accidental exposure or process upsets. If a customer asks about storage tanks, line cleaning, or spill recovery, we don’t simply repeat textbook answers. Instead, we pass on what our own crews have discovered works—and what doesn’t—under real plant conditions. Knowing the chemical firsthand means we provide practical advice, not generic platitudes.

    Beyond the Shipment: Customer Support and Troubleshooting

    We see firsthand the frustrations that come from inconsistent supplies. Take the case of a coatings plant that switched between two suppliers, then saw their gloss readings drifting off spec. The culprit? Invisible trace residues unique to each vendor’s synthesis method. These headaches don’t show up in the main purity number but can still ruin batches or trigger expensive revalidation processes. Because we produce butyronitrile ourselves, our technical staff can answer the kinds of questions that only come from walking the floor: What byproducts might show up if a solvent gets heated too long? Do metal tanks introduce flavor taints or color pickup? How low-temperature shipping can lead to temporary haziness, and what actually triggers this phenomenon. Instead of guessing, we share our plant history and test experience, giving customers advice grounded in reality.

    Sustainability and Responsible Production

    We acknowledge the rising focus on environmental stewardship across the chemical industry. Our butyronitrile plant operates under a closed water loop, and we don’t leave solvent vapors to chance—we reclaim and incinerate process emissions to curb environmental load. By managing the solvents and energy cycles on site, we lower the risk of offsite accident and demonstrate to auditors that we care about both immediate site safety and the broader climate picture. A side benefit is fewer worries for our partners, who must pass supplier audits and align with global “green chemistry” directives.

    Waste handling also reveals the difference between direct producers and resellers. Having full control means we know the origin—and fate—of all process byproducts. Uncontrolled or recycled chemical supplies often hide legacy contamination, which can unexpectedly show up in finished formulations. By owning the process, we offer a cleaner, traceable chain of custody. This wins trust, especially for customers under growing pressure to verify supply origins and reduce risks to their own brands.

    Pricing and Value: Lessons from Real-World Markets

    As feedstock and energy markets swing up and down, customers naturally focus on cost. We take a steady approach, focusing on smoothing out input price swings over time, rather than handing out artificially low prices that snap back with the next supply crunch. Price transparency breeds stability—our buyers know up front how cost structure is built, where volatility exists, and what measures we’ve taken to reduce risk. Years of market experience have taught us that sudden cost drops often stem from shortcuts or fading quality behind the scenes. When prospective clients inquire about bottom-dollar deals, we point to our documented quality, consistent supply, and traceable records. Cutting corners may look good for a quarter, but it can set back a production line for months.

    Logistics Insights: What Direct Shipping Brings

    Shipping butyronitrile safely and swiftly requires more than a booking agent. We run our own logistics operation and have learned how temperature, time, and transit mode interact. Some routes stress occasional customs holdups—so we allow buffer and avoid relying on a last-minute patchwork. Drum condition matters too: slight rust or old gaskets can lead to headaches at the customer’s dock, so we replace hardware well in advance and negotiate with hauliers based on actual experience, not generic terms. Our plant coordinates with shipping teams daily; we keep open lines for troubleshooting and adapt schedules to client needs. Customers who’ve weathered a missed shipment or two with us know that we care as much about on-time arrival as they do about the product inside.

    Building Long-Term Relationships

    In our decades in the chemical industry, we’ve learned that customer satisfaction depends as much on responsiveness and honesty as it does on purity specs or pricing sheets. We field technical questions promptly—even about problems not caused by our own batches—and we share data willingly. Repeat buyers return not just for the butyronitrile itself, but because they value a supplier with skin in the game. We get that the line between “commodity” and “strategic raw material” sometimes blurs, especially when regulatory filings or new product launches hinge on consistent supply. Being up front, providing our own test data, and being able to invite clients for plant walkthroughs strengthens mutual trust and provides reassurance that every canister, drum, or bulk shipment traces back to a single, transparent source.

    Responding to Changing Needs

    Markets and applications for butyronitrile shift each year. We see it in the requests we receive—from biobased solvent manufacturers looking to blend traditional chemistry with sustainability, to electronics firms demanding contaminant levels below ever-tighter limits. By running our own plant, we react to these trends directly. Plant modifications and new purification steps come from real demand, not just marketing hype or outsider pressure. We balance innovation with stability; every production tweak gets tested at lab and pilot scale before it ever touches a customer shipment.

    Why Supply Chain Integrity Starts with Direct Production

    Among our clients, distrust of opaque supply chains runs deep. Recalls, regulatory surprises, and hidden contaminants make headlines more often than anyone likes to admit. A chemical’s paper trail shouldn’t end at a warehouse in a port city. By owning the process and handling, not just shipping, we stamp clear accountability onto every delivery. For us, a chain of custody isn’t a buzzword, but a series of real actions—shipments tied back to exact reactor batches, documents generated in house, and storage validated by our own staff. When clients run tracebacks or audits, we have answers, not excuses. That peace of mind carries real value—and often means the difference between on-time product launches and missed deadlines.

    Continuous Improvement—Lessons from the Production Floor

    Our production staff doesn’t just take orders and run the plant. Each operator, technician, and supervisor has the authority—and responsibility—to halt the process at any hint of trouble. Over the years, we’ve implemented changes based directly on the experience of those who work hands-on, day after day. Examples include modified distillation packing to improve separation efficiency, streamlined lab test protocols to catch impurities faster, and custom-designed cleaning regimens that reduce product cross-contamination. This feedback loop from plant to management to customers ensures small learnings turn into major gains in safety, consistency, and final product value.

    A Manufacturer’s Perspective: What Customers Tell Us

    We learn plenty from the downstream users of our butyronitrile. Some need an explanation of how blending different lots impacts final product performance. Others want to talk about potential reaction byproducts and the best options for minimizing side reactions. Still others look for reassurance that supply stays robust during global disruptions—from shipping blockages to feedstock shortages to regulatory shifts. Over time, these conversations have influenced how we run our plant. Responsive communication and honest answers have built lasting partnerships, often turning single transactions into yearlong collaborations. That mutual understanding means the difference between endless firefighting and productive, long-term planning.

    Final Thoughts on Butyronitrile’s Role Today and Tomorrow

    From our vantage point as the manufacturer, butyronitrile is more than a commodity or a chemical formula. Each run, each drum, each technical support call draws from a history of direct production knowledge, evolving customer needs, industry trends, and lessons learned through hands-on work. The reputation of our product isn’t built on promises, but on every challenge met and every batch delivered. From purchase through delivery to end use, our butyronitrile reflects what direct, full-cycle manufacturing produces: reliability, traceability, and solutions that work where the need is real.