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Butyraldoxime

    • Product Name Butyraldoxime
    • Alias N-Butyraldoxime
    • Einecs 246-807-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    543095

    ChemicalName Butyraldoxime
    CASNumber 623-56-3
    MolecularFormula C4H9NO
    MolarMass 87.12 g/mol
    Appearance Colorless to pale yellow liquid
    BoilingPoint 149-150 °C
    Density 0.889 g/cm3
    MeltingPoint -55 °C
    SolubilityInWater Moderate
    FlashPoint 54 °C
    Synonyms Butanal oxime, n-Butyraldoxime
    Structure CH3CH2CH2CH=NOH

    As an accredited Butyraldoxime factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Butyraldoxime is packaged in a 100-gram amber glass bottle, securely sealed, with a chemical hazard label and clear product identification.
    Shipping **Butyraldoxime** should be shipped as a chemical substance in accordance with local and international regulations. Use tightly sealed containers to prevent leakage, and package with appropriate labeling. During transport, store in a cool, well-ventilated area, away from sources of ignition and incompatible materials. Consult the relevant SDS for complete guidelines.
    Storage Butyraldoxime should be stored in a cool, dry, well-ventilated area, away from heat sources and incompatible substances such as strong oxidizing agents and acids. Keep the container tightly closed and protected from light. Store in a chemical-resistant container, clearly labeled, and avoid contact with moisture. Ensure that appropriate safety and spill containment measures are in place within the storage area.
    Application of Butyraldoxime

    Applications of Butyraldoxime in Industrial Manufacturing

    As the original producer of Butyraldoxime, we supply this raw material for several specialized industrial applications. Downstream users rely on its reactivity and selectivity in defined manufacturing routes, especially in chemical synthesis and extractive metallurgy. Below, we detail how Butyraldoxime integrates into process flows, formulation strategies, and final product delivery across different industry sectors.

    1. Copper Extraction in Hydrometallurgical Mining

    Hydrometallurgical copper refineries use Butyraldoxime as an essential chelating agent during solvent extraction. Miners introduce it in the organic phase to preferentially bind with copper ions in acidic aqueous solutions. As a result, operators enhance copper selectivity and loading, while limiting transfer of competing metals. To achieve stable phase separation, plant engineers actively monitor pH, temperature, and phase ratios, adjusting process parameters on-line. Handling teams conduct quality checks to ensure compliance with environmental discharge rules and maintain solvent integrity, avoiding any exceeded residue limits in raffinate streams.

    Industry compliance standards

    • ASTM E1607: Standard Test Method for Determination of Copper in Ore and Concentrates
    • ISO 14001: Environmental management systems in mining operations
    • REACH Regulation (EC) No. 1907/2006 for chemical safety reporting
    • Local effluent discharge and occupational exposure regulations (e.g., US EPA NPDES permits)

    Typical usage ratio

    • Usually 10–25 g/L in the organic phase, depending on ore grade and copper tenors
    • Operators fine-tune concentration based on phase disengagement and copper loading targets

    Downstream process integration

    • Introduced with diluents as the extractant in mixer-settler solvent extraction circuits
    • Stays in the organic phase; after copper stripping, the chelating agent is recycled to extraction feed

    Final product types

    • High-purity copper cathode (via subsequent EW or cementation)
    • Copper-rich electrolyte feedstock

    2. Pharmaceutical Intermediate Synthesis (API Building Block)

    Chemical process development teams select Butyraldoxime as a vital intermediate in the multi-step synthesis of active pharmaceutical ingredients, especially for certain antibacterial and antineoplastic agents. Chemists rely on its reactivity for forming heterocyclic structures and functionalized intermediates. Batch manufacturing requires close monitoring of byproduct levels and impurity profiles, with each stage verified by in-house QC based on validated analytical methods. Documentation covers raw material traceability, cross-contamination control, and qualification protocols under strict cGMP systems.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals
    • European Pharmacopoeia monographs for specified APIs
    • ISO 9001:2015 Quality Management Systems for chemical synthesis plants

    Typical usage ratio

    • Stoichiometric to slight excess (1.0–1.2 equivalents) relative to substrate
    • Adjusted based on reaction kinetics and downstream purification yields

    Downstream process integration

    • Charged as a reagent or coupling partner in the first or second synthetic step
    • Purification by extraction, crystallization, or chromatography; residuals monitored in API assay

    Final product types

    • API intermediates for cephalosporin antibiotics
    • Precursors for anticancer compounds
    • Heterocyclic starting products for proprietary pharmaceuticals

    3. Agrochemical Intermediate Production

    Agrochemical manufacturers routinely employ Butyraldoxime as a precursor for herbicide and insecticide synthesis, especially for oxime-containing actives. It enters controlled synthesis lines, with robust analytical monitoring backing regulatory compliance for product registration. Engineering teams optimize solvent, temperature, and pH conditions for maximum conversion efficiency. Environmental personnel ensure proper capture and handling of off-gases and liquid waste, aligning plant operations with crop protection standards and import regulations.

    Industry compliance standards

    • OECD Good Laboratory Practice (GLP)
    • EU Regulation (EC) No 1107/2009: Placing of Plant Protection Products on the Market
    • FAO/WHO specifications for technical material and formulated products
    • National pesticide registration guidelines (e.g., US EPA, Chinese MARA)

    Typical usage ratio

    • 1.1–1.3 equivalents versus key aldehyde substrate
    • Optimized for yield, purity, and downstream formulation compatibility

    Downstream process integration

    • Feeds into intermediate coupling or condensation reactions
    • Utilized in process steps prior to formulation, granulation, or emulsion preparation

    Final product types

    • Selective herbicide actives (e.g., certain oxime-based molecules)
    • Pesticide intermediates for further downstream derivatization

    4. Analytical Reagents for Metal Ion Detection

    Laboratory chemical suppliers prepare specific analytical reagents using Butyraldoxime as a chelating agent for colorimetric and separation-based metal ion detection kits. In application, technicians mix it into buffer solutions or immobilize it onto solid matrices for selective copper determination in soil, water, and process samples. Each batch must conform to certificate of analysis requirements, including limits on heavy metals and solvent residues. QA labs validate analytical performance to underpin calibration and regulatory acceptance in mining, environmental, and industrial hygiene monitoring.

    Industry compliance standards

    • ISO/IEC 17025: Testing and calibration laboratories competence
    • EPA Methods (e.g., EPA 6010C for Inductively Coupled Plasma-Atomic Emission Spectroscopy)
    • USP/NF reagent grade specifications
    • REACH Annex II SDS and labeling for laboratory reagents

    Typical usage ratio

    • 0.01–1% w/v in prepared analytical solutions
    • Concentration varies with detection protocol and matrix interference profile

    Downstream process integration

    • Formulated into ready-to-use test kits and calibration standards
    • Applied by end-user laboratories in batch or flow injection modes

    Final product types

    • Colorimetric metal ion test kits
    • Laboratory reference standards for copper
    • Solid phase extraction media for environmental analysis

    5. Polymer Stabilizer Additive Manufacturing

    Specialty plastics and elastomer producers blend Butyraldoxime derivatives as process stabilizers or functional monomers for advanced polymer systems. Process engineers evaluate addition at compounding or polymerization stages to control polymer chain microstructure, thermal stability, and metal-catalyst residue scavenging. Cumulative dosage and blending regimes are validated by spectroscopic and mechanical testing. Production lines enforce batch-level traceability and recordkeeping for compliance with customer and industry-specific quality requirements.

    Industry compliance standards

    • ISO 9001:2015 Quality management for polymer additive suppliers
    • ASTM D6288: Standard Guide for Describing Processing, Recycling, and Reuse of Additives
    • Regulations (EU) No 10/2011: Plastic materials and articles intended to come into contact with food (if relevant)
    • Customer-specific material compliance audits

    Typical usage ratio

    • 0.05–2% by weight of total polymer matrix, determined by target stabilization effect and compatibility with base resin
    • Dosage adjusted depending on processing temperature and exposure risks

    Downstream process integration

    • Dry-blended or melt-compounded with base resin, or added directly during polymerization
    • Monitored in-line for dispersion and final product property validation

    Final product types

    • Stabilized polyethylene and polypropylene copolymers
    • Specialty engineering plastics with enhanced resistance profiles
    • Polymer masterbatch concentrates
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    Certification & Compliance
    More Introduction

    Butyraldoxime: A Reliable Chemical Building Block from a Manufacturer’s Perspective

    Trusting the Production Process

    In chemical manufacturing, consistency shapes every outcome. We understand that subtle changes in purity or moisture can affect entire finished batches, so our butyraldoxime comes off the line with tight control at each step. The process starts with sourced n-butyraldehyde. Purification passes reduce unwanted byproducts, and oxime formation gets careful attention to temperature and pH, which means each drum of butyraldoxime meets the specifications demanded by our customers without guessing at batch quality. Years of running these syntheses gave us an intimate familiarity with how minor parameter shifts show up later, and that’s why every tank and filter receives regular checks—these are not theoretical guardrails, but practices learned from many real-world corrections and success stories.

    From Raw Materials to Finished Product

    Butyraldoxime’s path starts in our blending area, where n-butyraldehyde reacts with hydroxylamine. Operators work at monitored temperatures so the oxime bond is correctly formed. Stirring speed and reaction time are kept within strict margins, since overlooked exothermic reactions can cause color changes and even impact downstream reactivity. Our plant upgrades let us keep water content under watch, which matters for storage and use in further synthesis reactions. Having run these vessels under different loads and weather conditions, we know where to watch for condensation or purge issues—practical experience helps us catch these details where theory alone might fall short.

    This attention leads to specifications most users need: colorless to pale yellow liquid, purity often above 98 percent, low moisture, and well-documented by-product levels. Customers appreciate predictable performance because many downstream intermediates won’t tolerate even a small difference in residual starting material. The emphasis on process discipline comes from learning—sometimes the hard way—that small impurities create headaches for end-users who make pharmaceuticals, pesticides, or plasticizers. Our technical staff remain closely involved with production, reviewing batch records daily instead of chasing issues after shipment, since a returned drum is always costlier and more disruptive.

    What Butyraldoxime Brings to Synthesis

    Its popularity owes much to butyraldoxime’s function as an intermediate in creating agricultural and pharmaceutical ingredients, especially where precise molecular transformations are key. Customers producing crop protection agents often use butyraldoxime to build oxime ether herbicides or as a precursor to key lactam or amide structures. Pages of our process logs reflect the troubleshooting needed to get it right—excessive acidity in the reaction mix can reduce selectivity, as can slight temperature overshoots. Everything down to drum lining selection came out of real cases where reactivity or corrosion reared up and forced redesigns.

    Each customer’s use case brings its own expectation. The pharmaceutical sector pushes hard for ultra-low impurities, since unforgiving process validations mean out-of-spec material could delay a full product launch. Our experience showed us how crucial it is to avoid trace contaminants, so we fine-tuned every washing and drying protocol after plenty of hands-on lessons. On the other end, agrochemical producers sometimes weigh throughput over maximum purity, but even there, a cleaner starting oxime saves costly filtration and purification downstream—a lesson reinforced each time we fielded questions about haze or unexpected residues masking the target compound.

    Specifications and Handling from Direct Experience

    Each drum of our butyraldoxime reflects hundreds of hours of plant trials and feedback from customer complaints and successes. Deliveries leave the plant with final purity nearly always above 98 percent, moisture less than 0.5 percent, and tightly controlled side-product content. While the smell and volatility require closed systems for safe transfer, we stress not just safety but also process reliability—loose lids or unsealed valves taught us years ago how quickly even a small leak wastes product and creates hazards.

    Viscosity and pour points matter during cold weather. More than a few winter shipments led us to pilot new heating pads and change our drum insulation approach. Climate affects storage, so we coach our partners on temperature control and offer storage guidelines based on lessons from mishandled batches. The anti-corrosion lining inside every drum resulted from early encounters with pitting or slight leaching—customer feedback pushed us to shift vendors and inspect tanks more often. Every improvement was rooted in real challenges, and we take pride when customers remark on the difference.

    Real-World Differences: Butyraldoxime vs Other Oximes

    Butyraldoxime stands apart from more common or compact oximes like acetaldoxime or cyclohexanone oxime. The molecular chain affects reactivity and downstream options—our records show that butyraldoxime’s slightly longer carbon chain creates a balance between volatility and reactivity that suits several chemical processes, especially where selectivity or solubility create hurdles for smaller oximes. Customers who tested acetaldoxime for similar transformations found yield or selectivity often fell short, while cyclohexanone oxime’s different stability profile meant longer processing times, especially under heat.

    Feedback from active ingredient manufacturers found butyraldoxime less prone to forming certain problematic byproducts. Laboratory studies and scaled-up batches confirmed these trends, though the difference can easily slip past if the manufacturing source gets careless with purification—one advantage of being a primary producer is seeing how such small changes affect customers’ final product. We know, for example, that the slight difference in boiling point between butyraldoxime and shorter-chain analogs allows for finer temperature gradients in multi-step syntheses, resulting in more predictable outcomes when scaling from pilot to commercial runs.

    Supporting Customer Innovation

    Our technical support team spends much of its time not selling, but understanding the changing needs of our partners. Research groups contact us about custom blends or modified grades, and every request translates to more learning for our plant staff. We test new purification methods and update our equipment because we’ve seen first-hand how small tweaks let customers unlock different applications. Even if one grade dominates the volume, flexibility in process design becomes a real competitive edge, and our on-site teams routinely visit customer sites, sometimes joining troubleshooting sessions by the reactors themselves.

    Staying close to laboratory researchers helps us anticipate changes in demand or specification. Pharmaceutical innovation, often guided by evolving regulatory demands or new synthesis routes, means we adjust, sometimes quickly, to new impurity requirements. Agrochemical innovation pushes us to support scale-up, which means navigating supply chain constraints and efficiency improvements. Experience taught us to hold safety stock and build extra analytical checks—these precautions pay off every time a new performance criterion arrives on a tight deadline.

    Safety, Storage, and Environmental Care

    Handling butyraldoxime safely grew out of both regulatory standards and the lived experience of managing sensitive chemicals. From the factory floor to the warehouse, storage solutions rely on lessons learned—drums always get stored out of direct sunlight and in temperature-controlled areas to prevent decomposition or color change. We document every incident and near-miss because previous generations of plant staff were first-hand witnesses to the risks of mishandling volatile compounds.

    Waste stream management remains crucial, especially since butyraldoxime breaks down to potentially hazardous byproducts if not handled correctly. Our plant upgraded scrubbing and ventilation systems after a series of air quality monitoring runs identified trace releases during high throughput days. Training programs run at regular intervals, not just for compliance reasons, but because team members’ stories and practices ensure safer outcomes—a lesson reinforced after observing both the benefits and shortcomings of generic safety manuals.

    Industry Trends: Sustainability and Transparency

    Demands for more sustainable and transparent production increased rapidly in the past five years. We opened portions of our supply chain for third-party audits, reflecting a shift from the old model of “just ship and invoice” to deeper partnerships and open dialogue. Some of this pressure came from large downstream buyers needing to trace every step back to origin, while other drivers included government programs rewarding cleaner operations. Even though butyraldoxime itself remains a specialty intermediate, tightening regulations around chemical usage keeps us updating our practices. We now recycle process water and switched to greener solvent systems in parts of the plant, after firsthand review showed both economic and reputational gains for the company.

    Questions about carbon footprint or life cycle analysis used to seem distant, but are now standard in supplier evaluation. Our process data shows real tradeoffs—introducing closed-loop systems and energy-efficient heat exchangers reduced waste noticeably, though took months of adjustment to reach steady production levels. The lessons learned turned into better risk management and more compelling value arguments whenever big customers asked for lifecycle declarations or environmental impact assessments. These efforts didn’t spring from theory, but from real customer requests and industry benchmarking visits where we saw how the leaders in fine chemicals changed their systems for good business reasons.

    Quality Control as a Daily Exercise

    Testing methods evolved alongside the product. Early on, we relied on classic wet chemistry and simple gas chromatography to check for purity and volatile content. Growing customer needs forced us to invest in high-resolution analytical instruments, which catch trace impurities faster and more reliably. Having walked through both old and new labs, the improvement stands out—faster test results let us quarantine suspect batches before they ever leave the plant, and feedback comes back to the process line within hours, not days. Teams took these improvements seriously because the cost of an out-of-spec shipment, both in dollars and brand reputation, can linger for years.

    Audit processes followed suit. Internal teams review every incident of non-conformance, no matter how small, and update operating procedures based on every corrective action. Sometimes that means changing a valve type or revising cleaning schedules; other times, it leads to retraining or even equipment overhaul. These changes stem from concrete cases, not just theoretical best practices.

    Feedback from the Field

    Direct feedback matters. Many of our operational changes originated from customer site visits or troubleshooting sessions. Over the past decade, this two-way dialogue created improvements in both product and process. Crop science companies pushed us to tighten up our water analysis protocols after one shipment arrived with higher moisture readings than expected. Pharmaceutical partners shared detailed impurity profiles, which spurred us to re-examine every phase of washing and storage.

    In practice, every customer application teaches us something new. We now maintain logs of field complaints and internal near-misses, then review them quarterly. This feedback loop sustains process improvements and gives production and sales teams insights that purely theoretical training could never match. Confidence in our butyraldoxime rests as much on these lived experiences as on technical sheets or audit scores.

    Meeting Regulatory Expectations

    Global requirements for intermediates like butyraldoxime become more detailed each year. Whether destined for European, North American, or Asian markets, our logistics and documentation staff track which certifications, declarations, or prior notices apply to every batch. The burden increased, but experience helped us comply without excessive bureaucracy. Plant operators load samples for analytical verification before final drum sealing, so each shipment leaves with a full documentation pack, ready for customs or regulatory spot checks.

    Building this culture of documentation wasn’t always easy. Early regulatory findings—sometimes just paperwork defects—taught us hard lessons about the need for rigor. Now, robust training and regular review sessions reduce those friction points, and front-line staff take as much pride in clean documentation as in product quality itself. Legal and compliance demand strict tracking, but it’s the operational discipline, not just binders and checklists, that keeps us on track.

    Adaptability: Meeting Challenges and Changes

    Markets shift, and so do customer needs. Industrial trends often move faster than standards or specifications can keep up. Our plant does not wait for outside direction but anticipates customer requests by regularly benchmarking production metrics and engaging with R&D teams at major accounts. If a new reaction or processing challenge surfaces—a need for higher stability, a tighter impurity profile, or even logistical flexibility—our response draws from a backlog of plant adjustments and pilot runs.

    Changing a familiar manufacturing process is never trivial. Equipment upgrades, new supplier certification, and modified cleaning regimes all demand real investment. Past shifts proved that adaptation pays off, even if it means scrapping legacy systems or requalifying procedures under new regulatory frameworks. A willingness to experiment, backed by the memory of past improvement cycles, allows us to meet each new customer demand with confidence, not hesitation.

    Commitment Beyond Chemical Supply

    Commercial relationships extend well beyond invoices and logistics. From development projects to troubleshooting production challenges, our staff become partners to end-users, learning just as much as we teach. Hosting site visits, sharing analytical results, and coaching on storage or handling—these are not extras, but hard-won habits shaped by decades of cooperation with industry leaders.

    Butyraldoxime occupies an important place in chemical synthesis routes, but its reliability depends on everything that happens before it arrives at a new facility. Building a record of consistent quality, safety, and adaptability doesn’t come from rote adherence to standards but from staying close to partners and responding to industry movement as it happens, not after the fact.

    Looking Ahead: Innovation Rooted in Experience

    The field of specialty chemical manufacturing changes rapidly. Our commitment rests not just on what we ship today, but on our ability to grow and anticipate new uses for butyraldoxime in the years ahead. Research partners continually explore new ways to use oximes in drug design, advanced materials, and even electronics. These developments guide our own internal R&D investments and show us where investments in purification technology or automated process controls deliver dividends.

    Each day on the plant floor or in the analytic lab brings a fresh opportunity to learn and refine. Staying tapped into global best practices and emerging science challenges us to think beyond the immediate shipment to how our methods enrich customer capability and industry trust. By treating every batch as a testament to hard-earned experience and ongoing improvement, we continue to foster the reliability and responsiveness our partners need in this complex, high-stakes sector.