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Butyl Chloroacetate

    • Product Name Butyl Chloroacetate
    • Alias Chloroacetic acid butyl ester
    • Einecs 203-303-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    839382

    Chemical Name Butyl Chloroacetate
    Cas Number 916-31-6
    Molecular Formula C6H11ClO2
    Molecular Weight 150.60 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 191-193°C
    Melting Point -54°C
    Density 1.095 g/cm³ at 20°C
    Refractive Index 1.425 - 1.431
    Flash Point 85°C (closed cup)
    Solubility In Water Insoluble
    Odor Pungent, fruity odor

    As an accredited Butyl Chloroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Butyl Chloroacetate is packaged in a 250 mL amber glass bottle with a tightly sealed screw cap and hazard labeling.
    Shipping Butyl Chloroacetate should be shipped in tightly sealed containers, away from heat, sparks, and open flames. It is classified as a hazardous chemical, typically transported as a flammable liquid. Ensure proper labelling and compliance with relevant regulations (such as DOT or IATA). Use protective packing to prevent leaks or spills during transit.
    Storage Butyl Chloroacetate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from heat, sparks, and open flames. It should be kept away from incompatible substances such as strong oxidizers, acids, and bases. Storage areas should be clearly labeled, and containers protected from physical damage and moisture to ensure safety.
    Application of Butyl Chloroacetate

    Applications of Butyl Chloroacetate in Industrial Manufacturing

    Butyl chloroacetate serves as a key chemical building block across several specialized industrial sectors. Its unique reactivity enables precise synthesis pathways for pharmaceuticals, agrochemicals, flavors and fragrances, and plastic additives. As the original manufacturer, we maintain production standards that meet the rigorous needs of downstream processors.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers use butyl chloroacetate for the controlled synthesis of advanced intermediates, especially in producing active pharmaceutical ingredients (APIs) like antispasmodics and local anesthetics. Its reactivity with amines and alcohols enables efficient esterification and alkylation, providing access to customized intermediates that must meet stringent purity and traceability requirements. Production staff usually carry out this step under closed conditions with in-process analytical controls to minimize impurities and ensure regulatory compliance for medical end-use.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP) per FDA 21 CFR Parts 210/211
    • ICH Q7 guidelines for API manufacturing
    • European Pharmacopoeia monograph guidelines for intermediates
    • Mandatory full traceability and cleaning validation records

    Typical usage ratio

    • Ranges from 1.1 to 1.5 molar equivalents relative to co-reactant per batch
    • Lab-scale optimization then scaled to tonnage for pilot and commercial lines
    • Dosing adjusted according to reactivity of nucleophile and required conversion yield

    Downstream process integration

    • Charged during early alkylation or esterification steps
    • Reacted with active amines or alcohols using phase-transfer catalysis or polar aprotic solvents
    • In-line HPLC or GC monitors endpoint and impurity profile

    Final product types

    • Pharmaceutical intermediates for API synthesis
    • Finished APIs including anesthetic compounds and antispasmodics
    • Bulk intermediates for subsequent multi-step syntheses

    2. Agrochemical and Pesticide Intermediate

    Leading agrochemical firms incorporate butyl chloroacetate in the synthesis of ester-based herbicides, insecticides, and fungicide intermediates. The product participates in O-alkylation reactions essential for constructing oxygen-based linkers within important agroactive molecules. Quality assurance laboratories regularly monitor trace halide levels and unreacted acid content to fulfill both export regulations and local stewardship standards for downstream crop protection manufacturing.

    Industry compliance standards

    • ISO 9001:2015 and ISO 14001:2015 certification for agrochemical manufacturing
    • EPA Pesticide Registration requirements (40 CFR Part 152, USA)
    • REACH Annex VII-VIII registration and SDS compliance (Europe)
    • Good Laboratory Practice (GLP) for formulation screens

    Typical usage ratio

    • O-alkylation: 0.95–1.2 mole per mole of phenolic substrate
    • Process R&D teams fine-tune dosage based on substrate reactivity and target conversion
    • Pilot trials adjust charge amount to control byproduct levels and batch reproducibility

    Downstream process integration

    • Fed as neat liquid or solvent solution into jacketed glass-lined reactors
    • Batch or semi-continuous addition synchronized with temperature and pH control
    • Post-reaction aqueous workup to remove inorganic chloride salts

    Final product types

    • Key structures for herbicide esters (e.g., phenoxyacetic acid derivatives)
    • Custom pesticide intermediates shipped for on-site synthesis
    • Industrial crop protection raw premixes

    3. Flavors and Fragrances Building Block

    The specialty flavors and fragrances sector utilizes butyl chloroacetate to construct fruity ester notes in fine fragrances, as well as to serve as an intermediate for fragrance-active alcohols in food and personal care products. Formulation chemists value its ability to support gentle esterification under controlled pH, minimizing unwanted side products that could impact final aroma purity. Dosing and sequence within batch processing is commonly tailored for the required chromatographic profile and regulatory approval of downstream aroma formulations.

    Industry compliance standards

    • IFRA (International Fragrance Association) guidelines for allowable substances
    • EU Regulation (EC) No. 1334/2008 on flavorings for food use
    • HACCP and ISO 22000 for food-grade intermediates
    • Cosmetic Product Safety Reports (CPSR) for personal care applications

    Typical usage ratio

    • 0.8–1.2 equivalents per targeted hydrophilic alcohol, adjusted for desired aroma profile
    • Lower ratios used in food additive contexts to minimize residual content
    • Full-scale blending trials validate optimal concentration for target market

    Downstream process integration

    • Initial introduction into esterification kettles under catalyst or acidic conditions
    • Subsequent neutralization and fractional distillation for purity enhancement
    • Trace level QC by GC-FID to verify compliance and sensory reproducibility

    Final product types

    • Ethyl and butyl ester flavor concentrates
    • Fragrance accords for perfumes and eaux de toilette
    • Food-grade aroma intermediates supplied to beverage and confectionery manufacturers

    4. Plasticizer and Polymer Additive Precursor

    In the plastics compound and polymer additive industry, butyl chloroacetate supports the development of specialty plasticizers and impact modifiers that enhance flexibility, durability, and processability of advanced resins. Process engineers favor it for introducing ester side-chains into acrylic and vinyl copolymers during reactive extrusion or as a precursor in producing sulfonated esters for thermoplastic and thermoset resins. Batch analytics focus on consistent conversion efficiency and minimizing volatile organic impurity carryover into final polymer blends.

    Industry compliance standards

    • ISO 9001:2015 for QC in polymeric materials
    • REACH compliant use for polymer additive registration
    • RoHS Directive 2011/65/EU (Europe/UK)
    • FDA 21 CFR 177.1010 for components in approved food contact plastics

    Typical usage ratio

    • 0.6–1.2 parts by weight per 100 parts polymer base, depending on flexible chain requirements
    • Lower loading in medical or food-contact compounds per additive safety thresholds
    • Masterbatch and compounding lines optimize dosing per end-use application

    Downstream process integration

    • Introduced directly in plasticizer synthesis before melt compounding
    • Added at pre-polymerization or at reactive extrusion stage for copolymer functionalization
    • Batchwise or continuous dosing controlled through mass flow and downstream IR analytics

    Final product types

    • Flexible vinyl and acrylic copolymers for cable insulation, automotive trim, and packaging film
    • Plasticizer blends for moldable thermoplastic elastomers
    • Performance polymer additives for engineered resins
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    Certification & Compliance
    More Introduction

    Butyl Chloroacetate: Quality from the Manufacturer’s Perspective

    Understanding Butyl Chloroacetate

    Butyl chloroacetate remains a core chemical intermediate for many industrial processes. Speaking as a manufacturer, we know its performance boils down to consistency, purity, and process reliability. Our facilities produce butyl chloroacetate with a typical purity of not less than 99.0%, colorless and transparent in appearance, and carefully controlled physical properties. The chemical formula, C6H11ClO2, puts butyl chloroacetate in a niche between small esters and longer-chain alkyl esters. With a balancing act between reactivity (from the chloroacetate function) and volatility (from the butyl chain), the compound carves a specific space in manufacturing pipelines.

    Specifications Rooted in Real-World Production

    Our batches show a boiling point in the 186-188°C range and a density close to 1.06 g/cm³ at 20°C. From years in production, we have seen how critical these properties are during downstream synthesis. Water content, always below 0.1%, keeps hydrolysis at bay. Low acidity and color numbers guard against unexpected byproduct formation. We use refined raw materials—each drum can be traced by lot for backward verification. These methods reflect years of working with both end-users and process engineers.

    A typical batch exhibits high miscibility with organic solvents, but stays relatively resistant to water. This behavior matters most to formulators who need to ensure compatibility with other reactants or tightly control moisture levels. In a reaction vessel, our butyl chloroacetate reacts smoothly, shows high yield, and minimizes the risk of corrosion or polymerization byproducts, thanks to tightly maintained impurity levels.

    From Synthesis to Application: What Sets Butyl Chloroacetate Apart

    We manufacture butyl chloroacetate through the esterification of monochloroacetic acid and butanol using a catalytic process. Our methods optimize for speed and nearly complete conversion, resulting in only trace residuals. Daily operations confirm that even minor fluctuations in temperature or acid catalysis can impact the product’s reactivity profile or impurity burden.

    Compared with methyl or ethyl chloroacetate, butyl chloroacetate brings a longer hydrocarbon chain. Chemically, this difference alters the product’s solubility profile and volatility—our experience shows it evaporates more slowly and offers extended working times in resin and plasticizer manufacturing. Downstream users in agrochemicals and pharmaceuticals notice fewer handling issues due to its relatively lower vapor pressure.

    Some customers compare our butyl chloroacetate with n-propyl chloroacetate. We’ve seen that the higher molecular weight and slightly increased hydrophobicity give butyl chloroacetate distinct advantages in certain formulations, particularly where slower volatility or enhanced material compatibility benefit the end-use product. We regularly test side-by-side and adjust our process to maintain that margin of quality.

    Why Users Choose Direct Manufacturer Supply

    Companies often contact us after facing inconsistent quality or late shipments from third parties. Our customers receive material that comes straight from our reactors—stored and shipped under appropriate conditions, not languishing in warehouses picking up moisture or color. We steer clear of drum swapping or untraceable blending, which sometimes occurs in distribution channels. That’s vital for users with tight acceptance specs.

    We support our partners by providing access to production data, COA originals, and an open line to our technical team. Many engineers consult us prior to major plant runs or new synthesis scale-ups, wanting to talk through phase compatibility, reactivity, or special handling guidelines. This open approach reflects how we partner with users who want results, not just chemical sales.

    Troubleshooting and Real-World Challenges

    Manufacturing butyl chloroacetate takes more than hitting numbers on a lab report. The real world of scale-up means dealing with resin cross-contamination, unexpected raw material shifts, and varying steam quality. Our plant managers have learned the hard way about trace acid build-up affecting downstream polymer yields. We fine-tune distillation cuts, and monitor every batch for byproduct chlorides or unwanted residual starting material. Each improvement was driven by a customer’s process pain, and we regularly back-analyze complaint samples for root cause.

    There are times when even a small off-specification episode—residual acidity slightly above target, or faint yellowing—can cause headaches for those making specialty pharmaceuticals or high-grade coatings. We invest in additional in-line spectroscopy and advanced colorimetry because we know one step in our plant can ripple through an entire pharmaceutical batch. Repeat issues often start with raw material supply inconsistency. Our logistics team has built relationships not only with major butanol producers but also reviews shipment conditions at every transfer point.

    Supporting Safety and Environmental Responsibility

    Butyl chloroacetate, like most chloroacetates, poses risks during production and use. We prioritize worker safety with well-ventilated reactors and sealed transfer lines. Leaks and accidental exposure quickly get flagged by in-plant controls and human oversight. We’ve worked side by side with local emergency response teams to run drills and stay ahead of regulatory changes. All liquid waste streams run through treatment—no shortcut dumping. This attitude comes from years spent troubleshooting old incidents, not from following minimum standards.

    Plant emissions tighten every year. Our facility continuously upgrades air and wastewater controls, far exceeding local requirements. By switching to lower-emission boilers and investing in multi-step scrubbers, we have reduced volatile releases by over 60% since 2018. Employees on the plant floor see these improvements as part of their routine, not a government-imposed chore. Many of our operators came up through internal training; they learn practical troubleshooting for spill response and equipment cleaning, not just theoretical compliance.

    Application Insights: What End Users Value

    Pharmaceutical, agrochemical, and polymer manufacturers demand predictable chemistry. In our experience, drug intermediates rely on high-purity butyl chloroacetate to avoid unplanned impurity builds, which can trigger regulatory re-tests or batch discards. Agrochemical teams use the product as a building block for synthesis, appreciating the lower volatility which gives more control during exothermic reactions. Polymer producers comment that our raw material speeds up batch transitions with shorter down-time due to cleaner processing.

    We keep close tabs on how downstream storage conditions, even outside our control, impact oxidation or hydrolytic stability. Some users found that heat-cycled storage tanks degrade standard grades within weeks. As a response, we offer enhanced packaging and guidance on nitrogen blanketing. These protocol improvements grew directly from customer trouble tickets and hands-on follow-ups, not from theoretical recommendations.

    Every application comes with nuances. In plastics, our product supports esterification where color or odor can't bleed through. In pharmaceuticals, residual acidity or trace organochlorine levels cause concern—down to the ppm. Our R&D teams have actively partnered with these users to refine process adjustments, aiming for a product that drops seamlessly into their reactor or formulation tank.

    Differences from Other Chloroacetate Esters: What We See on the Factory Floor

    Direct comparisons often happen between butyl chloroacetate and methyl or ethyl varieties. Butyl’s longer carbon chain boosts partitioning into organic phases and expands application potential in nonpolar or solvent-rich systems. Our customers in coatings and resins choose butyl chloroacetate for its moderate volatility, which helps tune the rate of solvent evaporation and improves the film-forming profile. In contrast, methyl or ethyl chloroacetate acts faster but sometimes causes loss of control in temperature-sensitive processes.

    Handling differences stand out, too. Butyl chloroacetate’s lower vapor pressure appeals to operations with worker exposure concerns. We notice fewer odor complaints on our production line and during product transit compared with lighter-chain esters. Waste management teams report easier containment and less loss through evaporation. Often, this translates into cleaner plant floors and simpler environmental management downstream for our end users.

    In resins and specialty polymers, manufacturers sometimes encounter gel issues or runaway reactions when using shorter-chain chloroacetates due to higher reactivity. Butyl chloroacetate brings a balance—they get enough reactivity for efficient ester or amide formation, without the instability that can derail a batch or cause fouling in heat exchangers. We have documented case studies from users reporting higher yields and consistent product profiles after switching to our product from a methyl-based alternative.

    Quality Assurance Built into the Process

    Instead of relying on statistical averages or occasional spot checks, our approach tracks conditions from reactor charging to final filling. Every shift logs temperatures, pressures, and quality data, keeping tight historical records for trend spotting. We train operators not just to follow checklists, but to spot deviations early—a small color shift, tiny phase separation in the storage tank, or an odor change. Management pays attention to these frontline reports because decades in manufacturing taught us that quality slips usually start small.

    We validate every lot against not just industry norms, but direct customer feedback. Voluntary audits let customers trace product batches, inspect laboratory records, and discuss any production anomalies. For the rare product hold or deviation, we call affected users directly—not after a formal investigation closes. The goal: no surprises, and no sales spin.

    Product consistency isn’t about slogans; it’s about customers knowing what comes off the truck matches the last ten years’ worth of shipments. Chemistry at scale throws constant curveballs—shifts in raw material purity, temperature swings affecting reaction rates, logistics hiccups in delivery. Our response: never relaxing on specification control, staying vigilant to market changes, and holding our final product up to both our standards and those of the toughest users in our network.

    Chemical Manufacturing: Lessons Learned and Looking Ahead

    Making and supplying butyl chloroacetate taught us plenty of hard lessons about attention, flexibility, and open communication. Chemical production lines cannot run on autopilot. Decades of feedback from users pushed us to invest in improved batch automation, expanded reactor capacity, and deeper root cause analysis for outlier batches. We log as much about the “why” behind deviations as about the “what.” This discipline cuts through recurring errors and strengthens supplier-user trust.

    As downstream requirements tighten—lower impurity thresholds, tougher storage stability, trace origin documentation—we step up our process scrutiny. Rather than chasing just the present order, we partner with end users at the technical level, sharing ideas for process tweaks or material handling. This partnership builds durability for everyone: faster troubleshooting when something goes wrong, flexibility with formulations, and trust that the next drum will behave like the last.

    Suppling globally brings unique challenges. Certain countries call for extra layers of compliance—lab confirmation on heavy metals or organochlorine limits not yet mandatory at home. Instead of debating specs, we adapt, tune-up filtration and QA checks, and implement sampling programs that match the export destination’s strictest requirements. Experience tells us this approach not only protects everyone’s business, it speeds up market access for our customers.

    Final Thoughts: Value in Direct and Transparent Manufacturing

    After years of working with butyl chloroacetate, we see every batch as part of a broader industry chain. The true value lies in understanding the details: spec control, on-time delivery, and hands-on support during unexpected challenges. Big reactors and bulk tanks do not solve user headaches on their own; thoughtful process management, transparency, and shared purpose do.

    We encourage customers—large and small—to reach out, ask questions, and even tour our plant if needed. Real manufacturing relationships grow on shared results and problem-solving, not just delivered shipments. While global markets shift and specifications change, our commitment stays grounded in experience, direct engagement, and doing the job right every time. Supplying butyl chloroacetate remains a technical and operational challenge, but it’s a challenge we meet every day with care, pride, and open doors.