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Aniline Hydrochloride

    • Product Name Aniline Hydrochloride
    • Alias Aniline hydrochloride; Aniline chloride
    • Einecs 208-051-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    308073

    Chemical Name Aniline Hydrochloride
    Chemical Formula C6H5NH2·HCl
    Molar Mass 129.59 g/mol
    Appearance White to slightly grey crystalline powder
    Melting Point 198-203 °C
    Solubility In Water Soluble
    Density 1.22 g/cm³
    Cas Number 142-04-1
    Odor Slight fishy odor
    Ph Value Approximately 3.0 (10% solution)
    Storage Conditions Keep in a cool, dry, well-ventilated place
    Boiling Point Decomposes before boiling

    As an accredited Aniline Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Aniline Hydrochloride, 500g, is securely packed in a sealed, labeled amber glass bottle with safety information and hazard warnings.
    Shipping Aniline Hydrochloride should be shipped in tightly sealed containers made of compatible materials, clearly labeled, and protected from moisture and physical damage. It must comply with regulations for hazardous materials, often requiring classification as a corrosive substance. Proper documentation, secure packaging, and appropriate transport guidelines should be strictly followed to ensure safe delivery.
    Storage Aniline Hydrochloride should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from incompatible substances such as oxidizers and strong bases. Protect it from moisture and light to prevent degradation. Proper labeling and secure storage are essential to avoid accidental exposure. It should also be kept away from sources of ignition and direct heat.
    Application of Aniline Hydrochloride

    Applications of Aniline Hydrochloride in Industrial Manufacturing

    Aniline hydrochloride serves as a critical chemical intermediate across multiple industries, owing to its reactivity and high level of purity. The following sections outline the main downstream industrial applications, with focus on regulatory compliance, real-world processing integration, and commercially relevant finished goods.

    1. Dye and Pigment Manufacturing

    The textile and printing ink sectors utilize aniline salts extensively in azo dye synthesis, particularly for yellow, orange, and red chromophores. The material functions in diazotization reactions to produce diazonium intermediates under controlled acidic conditions. Process engineers closely monitor reagent ratios, pH levels, and temperature to achieve desired color strength and reproducibility. Trace impurities can adversely impact final hue and batch consistency, making strict compliance and raw material traceability essential for large-scale pigment plants.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile input chemicals)
    • REACH Regulation (EC) No 1907/2006
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals)
    • ISO 9001:2015 (Quality Management Systems for production sites)

    Typical usage ratio

    • Used in a 1:1.05 molar ratio with sodium nitrite during diazotization; actual concentration ranges from 9%–15% by weight in aqueous acidic media, adjusted according to dye batch volume and targeted pigment intensity.

    Downstream process integration

    • Reacts during diazotization step, prior to azo-coupling, typically in vertical glass-lined reactors; precise feeding ensures full conversion and minimizes by-product formation.

    Final product types

    • Azo dyes for cotton and polyester textiles
    • High-purity pigments for offset and gravure inks
    • Specialty colorants for high-performance coatings and plastics
    • Reactive dye intermediates for further synthesis

    2. Pharmaceutical Intermediates Synthesis

    APIs and bulk pharmaceutical intermediates manufacturers depend on aniline salts for stepwise synthesis of active compounds, particularly antihistamines, analgesics, and local anesthetics. Regulatory and quality demands in this segment are stringent; professional plants employ validated processes, frequent trace contaminant analyses, and documentation to ensure GMP traceability. Compounders adjust aniline salt charge based on target molecule and reaction selectivity, reducing excess and optimizing yields for multistep synthesis workflows.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP), 21 CFR Parts 210–211
    • European Pharmacopoeia (Ph. Eur.) guidelines for intermediates
    • ICH Q7 (Active Pharmaceutical Ingredients Quality Guidelines)
    • USP–NF monographs (where applicable)

    Typical usage ratio

    • In batch processes, charge rates typically range from 0.8 to 1.2 molar equivalents, dependent on product profile and byproduct risk. Manufacturers reduce excess to minimize downstream purification steps.

    Downstream process integration

    • Introduced as an amination or diazotization component in multi-step syntheses, often as an early-stage reagent; feeds into conversion to aromatic amine intermediates.

    Final product types

    • Lidocaine and benzocaine pharmaceutical intermediates
    • Chlorpheniramine and methylphenidate precursor molecules
    • High-purity amide derivatives for generic drugs
    • Fine chemicals for veterinary and biosimilar synthesis

    3. Rubber Chemical Additives Production

    Tire and technical rubber manufacturers incorporate aniline hydrochloride when synthesizing accelerators and antioxidants, such as diphenylguanidine and phenyl-β-naphthylamine (PBN). Accurate proportioning of the aniline source is vital for consistent polymer cross-linking agents, as well as to prevent nitrosamine release in finished vulcanizates. QC experts conduct batchwise analysis of input chemical purity to ensure full compliance with region-specific consumer product regulations governing process chemicals in elastomers.

    Industry compliance standards

    • Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Annex XVII
    • US TSCA chemical inventory, EPA requirements for rubber compounding agents
    • ISO 9001:2015 (rubber compounding sector)
    • Automotive OEM substance requirement lists (e.g., GADSL, VDA 232-101)

    Typical usage ratio

    • Optimal charge varies by formulation; generally, 8%–14% of total accelerator intermediate mass for guanidine-based accelerators, adjusted based on targeted vulcanization speed and required antidegradant potency.

    Downstream process integration

    • Combined with carbon disulfide, aldehydes, or other amine reagents in closed mixing tanks; entered during synthesis of primary accelerator or antioxidant prior to compounding with elastomers.

    Final product types

    • Vulcanization accelerators for tire tread and sidewall rubber
    • Antioxidant masterbatches for industrial hoses and belts
    • Automotive and conveyor belt polymer additives
    • Processed black rubber sheets for extrusion industries

    4. Electroplating and Metal Surface Treatment

    Electrochemical and metal finishing industries use aniline hydrochloride in specialty plating baths and as a grain refiner for copper and nickel deposits. The salt controls metallic crystal growth and surface gloss, where operators maintain strict dosing relative to metal salt concentrations. Contamination or overdosing can lead to non-uniform deposits or bath instability. All process parameters must comply with hazardous substance and effluent management standards to reduce worker exposure and wastewater treatment burden.

    Industry compliance standards

    • ISO 8308 and ISO 2081 (Electroplated coatings standards)
    • EN 1811 (metal release qualification for surfaces in contact with skin)
    • EU REACH and RoHS substances directive
    • Local industrial wastewater discharge standards

    Typical usage ratio

    • Ranges from 0.5–2.0 g/L of bath volume, optimally adjusted by electrochemical testing and surface quality targets; fine-tuning depends on workpiece size and plating speed.

    Downstream process integration

    • Added to plating tanks during bath make-up or as an interim replenishment; incorporated alongside copper sulfate, nickel sulfate, and brighteners in automated line systems.

    Final product types

    • High-gloss decorative plating on electrical connectors and hardware
    • Precision copper and nickel coatings for printed circuit boards (PCBs)
    • Corrosion-resistant fasteners and automotive parts
    • Specialty plated jewelry and optical components

    5. Specialty Agrochemical Intermediate Manufacture

    Crop protection and plant growth regulator producers employ aniline hydrochloride mainly as a synthetic intermediate in the formation of phenylurea and phenoxy herbicides. Reaction routes require strict molar calculations and closely-monitored temperature profiles to prevent byproduct formation. Global pesticide regulations necessitate raw material tracking from source to formulated active, including impurity assessment to avoid off-label residue risks for food crops.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • EPA 40 CFR Part 180 (Tolerances and exemptions for pesticide residues)
    • ISO 9001:2015 (Agrochemical manufacturing quality)
    • Globally Harmonized System (GHS) for hazard communication

    Typical usage ratio

    • Introduced at 0.85–1.1 mole per mole of targeted phenylurea or phenoxy backbone; final charge rates influenced by batch yields, impurity levels in crop protection end product, and required conversion efficiency.

    Downstream process integration

    • Enters as an early intermediate, typically in condensation or amination steps; frequently partnered with isocyanates or alkyl halides for formation of urea or ether linkages.

    Final product types

    • Diuron and linuron herbicide technical concentrates
    • 2,4-D and 2,4-DB precursor chemicals
    • Intermediate blocks for plant growth regulators
    • Custom crop protection actives for regional markets

    6. Laboratory Reagent and Analytical Use

    Accredited laboratories and analytical service providers leverage high-purity aniline salt as a certified reagent for colorimetric and spectrophotometric assays. Analysts use standard solutions to calibrate equipment and establish benchmarks for environmental, pharmaceutical, and food safety testing. Reagent-grade requirements tightly regulate metallic, organic, and moisture impurity profiles to eliminate analytical errors and ensure reproducibility of measurement data.

    Industry compliance standards

    • ISO 17025 (Laboratory competency in chemical analysis)
    • Reagent purity as specified in ACS Reagent Chemicals guidelines
    • European Pharmacopoeia reagent standards
    • USP–NF for analytical reagents (where applicable)

    Typical usage ratio

    • Prepared as 1–5% (w/v) solution for spectrophotometric calibration or titration; final concentration determined by target assay type and instrument dynamic range.

    Downstream process integration

    • Prepared as standard solutions or calibration reagents; dispensed manually or by automated workstation for multi-sample runs and QC lot certification.

    Final product types

    • Certified assay kits for water and waste testing
    • Reference standards for pharmacological impurity assessment
    • Control solutions for food contaminant screening
    • Analytical grade reagents for academic and contract testing labs
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    Certification & Compliance
    More Introduction

    Aniline Hydrochloride: Practical Insights from the Production Line

    A Closer Look at Aniline Hydrochloride

    From our daily experience working with aromatic amines, Aniline Hydrochloride stands among the more specialized products in our range. Manufactured through a reaction of aniline with hydrochloric acid, it forms a colorless to white crystalline powder. The chemistry behind Aniline Hydrochloride may seem straightforward on paper, but getting it right in the plant requires steady hands, solid raw materials, and consistent process control. We're talking about a compound that's sensitive to moisture and requires genuinely tight handling all the way from synthesis to packing.

    Typical specifications for the material we supply center around high purity, generally above 98 percent, and minimal water content. We monitor traces of free aniline, total impurities, and residual acid. The physical specifications are tight because customers are sensitive to even minor fluctuations in melting point and solubility. The finished powder packs easily into sealed polyethylene-lined bags—our packing crew always makes sure it leaves the plant bone-dry, with little to no clumping or dust-off.

    Everyday Uses in Industry

    Aniline Hydrochloride occupies a specific niche where simple aniline or other aromatic amine salts don't fit the bill. The dye industry, long reliant on these raw materials, uses this compound as a critical intermediate in the synthesis of azo and triarylmethane dyes. In the lab, it plays a part in organic syntheses—usually as a reagent for diazotization reactions, which form the starting step for many colorants and pharmaceuticals. Laboratory technicians prefer it for its ready solubility in water and its ability to react smoothly at low temperatures without fuss.

    Electroplating technicians have their uses for Aniline Hydrochloride as well—it helps to reduce certain metal salts during the plating process, giving products a cleaner deposit. Agrichemical research incorporates it during the early-stage screening of active ingredients, as its salt form sometimes makes certain intermediates easier to handle in solution.

    From a manufacturer’s standpoint, we often get calls from research houses and quality control labs asking about the fine points: Is the batch truly colorless? Does it dissolve quickly at room temperature? Are there any metallic contaminations from reactor walls? In real-world production, even minute rusty residues from equipment can trigger unwanted side-reactions downstream, especially in sensitive dye-making or pharmaceutical syntheses.

    Consistent Quality: A Manufacturer’s Perspective

    Consistent quality stems not only from raw material sourcing but also from the fine-tuned adjustments we make during production. For instance, during neutralization, it’s easy for a temperature spike or uneven mixing to create so-called “hot spots”—patchy regions that can char the product or form colored byproducts. Our plant engineers developed a staged addition protocol that limits mechanical shear and maintains a steady reaction temperature. Each batch is analyzed for chloride ion content, color, and trace impurities before we sign off on shipping. This level of vigilance comes from long experience: even a single off-spec shipment can create headaches for both us and our customers.

    We use stainless steel, glass-lined vessels, and inert atmosphere conditions to keep contamination in check. This isn’t just to meet specifications on paper; it’s about learning what the market expects and delivering a material that actually performs in real applications. Each customer visit and feedback cycle gives us stories about batches that dissolved smoothly in water, had no trace odor, and didn’t introduce yellow coloration into sensitive reactions. That tells us where we’re hitting the mark and where we might tighten controls further.

    Comparing Aniline Hydrochloride to Other Aniline Salts

    While it shares the arylamine backbone with related salts like aniline sulfate and aniline acetate, Aniline Hydrochloride stands out for its robust stability in the solid state and easy solubility in polar solvents. Its melting point is higher than the sulfate, making it a better choice where stable storage for lengthy periods is required. This matters most to smaller dye makers and research chemists who may not run through stock rapidly.

    Aniline sulfate can deliver some advantages in water solubility but tends to cake more readily in storage, especially under humid conditions. The acetate salt often brings a trace acetic odor and less consistent color purity. In our reactors, we've observed that hydrochloride batches maintain a finer crystalline structure and are less prone to clumping. These may sound mundane, but feedback from customers tells us that an easy-to-handle powder can save them time, reduce operator exposure, and cut down on cleaning runs.

    While some labs experiment with using the free aniline base for those same reactions, the hydrochloride’s stability—in both the lab and the warehouse—tips the balance in its favor for multi-step organic synthesis. Having handled and stored hundreds of batches over the years, we see firsthand that properly packed hydrochloride remains free-flowing and colorless much longer. In contrast, unbuffered aniline base can darken, pick up odors, or polymerize, especially during hot, humid summers.

    Challenges in Production and Handling

    Getting Aniline Hydrochloride to customers in top shape demands focus at every process step. Hydrochloride's hygroscopic nature means any slackness in drying or storage causes trouble later: caking, discoloration, or variable purity. We keep a close eye on plant air humidity and seal finished product in dry rooms. If the packing line runs slow, or if bags linger open, moisture creeps in. These are points we drive home in operator training sessions. Decades of experience have shown that product made on a dry winter morning handles far differently than a midsummer batch, even at the same process settings.

    Some customers run performance checks on incoming batches, so we audit random lots with them to benchmark against competing imports and previous stocks. Most often, it's the quick dissolve time and clean reactions that convince them the batch is right. Frustrations arise when competitors’ material comes packed with extra fines or in lumpy clods that won’t spread well in solution. Extra grinding or sifting always brings risks: contamination, static charges, or simple product loss.

    Responding to Customer Needs

    Chemical manufacturers hear plenty from end-users about practical needs: precise weighing, rapid solubility, and safe handling. Over the years, we’ve invested in automated bagging lines and micro-filtering units to deliver a product that meets those demands batch after batch. Lab techs appreciate the uniform texture that scoops easily, and production chemists comment on how quickly our product dissolves in water and alcohols with no fuss.

    Another big request: no strange odors and no color surprises. We apply tight thermal and vacuum drying controls to keep the product as close to water-free and odorless as technically possible. In earlier years, we struggled keeping every batch snow-white. Over several production cycles, switching to high-grade filtrants and a new filter-press configuration brought the improvement customers wanted.

    Product traceability remains non-negotiable. Each bag we ship carries a clear batch print and internally, we can track each batch right back to the raw aniline drum and acid lot number. If there’s ever a question about seed impurities, our laboratory can pinpoint where in the process they might’ve come in. This level of batch control wasn’t always standard industry practice, but feedback from dye and pharma buyers pushed us to raise our internal bar.

    Optimizing for Downstream Chemistry

    Our key customers operate across a wide spectrum: dyes, pharmaceuticals, research, and plating. We’ve learned to tailor our process to avoid introducing metallic ions—especially iron, manganese, or copper—that can mess up palladium-catalyzed steps or poison sensitive reactions. The vigilance applies whether we’re manufacturing a two-ton lot or small specialty charges for R&D use.

    Storage stability for Aniline Hydrochloride has improved steadily over recent years. Our shift to more robust packaging solutions—layered PE-liners, vacuum-sealed pallets, and high-barrier sacks—cuts down wastage, especially for customers in tropical climates. It also lets end users store material for longer without worrying about color drift or clumping, which once made day-to-day handling a hassle.

    Pushing for Higher Standards

    Getting ahead of global quality and regulatory requirements has never been optional. Customers now expect REACH-compliant material, with RFID-enabled traceability and up-to-date documentation. Recent years brought a wave of audits from multinational buyers. They want site visits, not just paperwork. We respond honestly: showing everything from the raw material warehouse to the finished-goods despatch room, demonstrating why and how our Aniline Hydrochloride meets their needs.

    We hear from users in textile auxiliaries about the real impact of small color changes, especially in sensitive dye recipes. For pharma buyers, it’s the difference between a reliably clean reaction and hours lost troubleshooting. Getting each batch as close as possible to “neutral” starts long before packing—the reasons for discoloration often go right back to early process controls, not only in isolation but in reactor vessel prep, liner inspection, and even in cleaning protocols before each batch.

    Safety: More Than Just a Data Sheet

    Production and handling safety ranks as our first checkpoint. Direct skin contact or accidental inhalation shouldn’t happen, but real-world plant work sometimes brings unpredictable leaks, spills, or packaging faults. We designed all process steps so dry powder generation stays inside closed, vented enclosures and transfers occur under negative pressure. New employees complete rigorous hands-on training, learning how to manage not just emergencies but routine cleanup without putting themselves or others at risk.

    We don’t rely on rules alone. We review near-misses in weekly meetings—what went right, what could turn bad, and where bottlenecks create real possibility for dosing errors or operator exposure. Our attitude grows out of long-haul, boots-on-the-ground experience: procedures must be lived, not just filed away.

    Experience Drives Us Forward

    Running a chemical plant day in, day out teaches plenty about materials that never finds its way into textbooks. Shifts in raw material quality, changes in weather, small but meaningful upgrades to reactor design: each makes a difference to what customers receive. Over time, steady work with Aniline Hydrochloride brings familiarity—a quick glance at the fresh batch tells an experienced operator if anything’s off in color, texture, or consistency.

    Old hands remember times when it was common to lose half a tonne of product to caking or off-colors, but today’s plant prioritizes controls, routine monitoring, and smart investments in drying, handling, and trace analysis equipment. That’s experience paid forward.

    Looking to the Future

    Materials such as Aniline Hydrochloride won’t disappear anytime soon. The demands from textile technology, new dyes, and pharmaceutical intermediates keep growing. While from the outside, these look like “commodity chemicals,” our experience on the shop floor tells a different story—minute variations in purity and color, even at the low parts-per-million level, have an impact on the final product.

    What we’ve learned: ongoing collaboration with both large and small buyers brings essential feedback. Every request for a tighter spec, every phone call about product oddities, makes us rethink, refine, and sometimes overhaul familiar process steps. The best improvements respond directly to user needs rather than just lab benchmarks or pure theory.

    Summary

    Our experience manufacturing Aniline Hydrochloride, batch in and batch out, gives us a close-up view of where strict controls, experienced teams, and open feedback can make the greatest difference. The result: a material trusted by colorant chemists, plating specialists, and researchers alike. Whether the application calls for easy handling, reliable purity, or consistent supply, we see every batch as an opportunity to reinforce what steady experience and attention to detail brings to the industry. Each drum that rolls off our floor aims to deliver exactly what our customers require—safe, consistent, and fit for purpose.