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HS Code |
698589 |
| Chemical Name | Acetyl Chloride |
| Chemical Formula | C2H3ClO |
| Cas Number | 75-36-5 |
| Molar Mass | 78.50 g/mol |
| Appearance | Colorless liquid |
| Odor | Pungent, strong |
| Density | 1.104 g/cm³ |
| Melting Point | -112 °C |
| Boiling Point | 51 °C |
| Solubility In Water | Reacts violently |
| Vapor Pressure | 203 mmHg (20 °C) |
| Refractive Index | 1.389 (20 °C) |
As an accredited Acetyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Acetyl Chloride is packaged in a 500 mL amber glass bottle with a sealed, corrosion-resistant cap and appropriate hazard labeling. |
| Shipping | Acetyl chloride must be shipped in tightly sealed, corrosion-resistant containers, typically glass or Teflon-lined steel, under a dry inert gas such as nitrogen. It should be packed in accordance with hazardous material regulations, clearly labeled, and kept away from moisture, acids, and bases. Use secondary containment to prevent leaks or spills. |
| Storage | Acetyl chloride should be stored in a cool, dry, well-ventilated area away from heat, moisture, and incompatible substances such as water, alcohols, and bases. It must be kept in tightly sealed, corrosion-resistant containers, preferably made of glass or PTFE-lined material. Proper labeling, secondary containment, and access only to trained personnel are essential for safe storage. |
Applications of Acetyl Chloride in Industrial ManufacturingAcetyl chloride plays a critical role in specialty chemical synthesis, pharmaceuticals, agricultural chemicals, dyes, and polymer modification. As a direct manufacturer, we provide this raw material to multiple sectors requiring precise reaction control, compliance with stringent standards, and consistent supply chain documentation. 1. Pharmaceutical Intermediate SynthesisMajor pharmaceutical companies and contract manufacturers use acetyl chloride for acetylation reactions in active pharmaceutical ingredient (API) production, such as the synthesis of acetaminophen and other acetanilide derivatives. Production mainly utilizes microwave or traditional reflux reactors, and reaction parameters require strict moisture exclusion and precise temperature regulation for consistent yield. All records of material traceability and change controls are retained for regulatory auditing. End-to-end GMP management is implemented from incoming raw material checks through to packaging of pharmacopeia-grade APIs for regulated markets. Industry compliance standards
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2. Agrochemical Active Ingredient ProductionProducers of crop protection chemicals use acetyl chloride to introduce acetyl groups into herbicide and pesticide molecules, such as the synthesis of phenoxyacid esters. Production lines feature anti-corrosive reactors and dedicated neutralization systems due to by-product HCl formation. The process includes validated hazardous reaction protocols, in-line pH measurement, and batch documentation. Cost-driven formulation flexibility and regulatory records retention extend through toll manufacturing partners and end product release. Industry compliance standards
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3. Dye and Pigment ManufacturingDye manufacturers rely on acetyl chloride for the acetylation of aromatic amines to produce acetanilide derivatives that serve as key colorant precursors. Continuous flow reactors with corrosion-resistant linings and in-line FTIR spectroscopy maintain product quality. Implementation of emission control for HCl and safe drum/tank unloading is standard on site. All production batches are logged against customer color index numbers with traceability from raw materials through to shipment. Industry compliance standards
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4. Polymer and Resin ModificationSpecialty resin producers use acetyl chloride to modify cellulose, polyvinyl alcohol, and other polymeric matrices to enhance solubility and thermal resistance or to control the degree of acetyl substitution. Closed-system handling paired with microfiltration and in-process viscosity monitoring ensure batch uniformity. All production is validated with customer-specific formulation records, and residual solvent or by-product management aligns with local environmental discharge laws. Industry compliance standards
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5. Flavors and Fragrances Ingredient ManufacturingFlavor and fragrance houses employ acetyl chloride for the controlled esterification of alcohols and aromatic compounds, offering enhanced volatility, shelf-life, and olfactory character. Production occurs in small to medium, batch-controlled vessels with strict documentation for product security and allergen traceability. Raw material lots are managed to conform to IFRA recommendations and national flavor safety acts, with in-house GC-MS testing for quality release. Industry compliance standards
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6. API Laboratory-Scale Custom SynthesisSpecialty labs and pilot facilities order acetyl chloride for rapid prototyping and route scouting in small to mid-scale API research projects. It is handled under local containment hoods, with powder and liquid handling SOPs, and batch-specific safety datasheets accompany each shipment. Integration includes strict chemical hygiene documentation, and reference standards are maintained for analytical comparison. Industry compliance standards
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For anyone running an active chemical operation, acetyl chloride remains one of those workhorse reagents that proves its value day in and day out. In our experience as direct producers, meeting consistent purity and performance standards is where the real challenge lies. Some laboratory products, often sourced through resellers or smaller bulk outfits, might suffice for bench-scale experiments. On an industrial scale, issues such as trace water content, inconsistent acidity, or variable color quickly turn from minor nuisances to expensive downtime. We understand this well, having addressed customer feedback from both batch and continuous processes needing clear, reactive, and reliably pure acetyl chloride.
Our acetyl chloride commonly ships at concentrations above 99.5%, confirmed lot by lot through in-house gas chromatography. Even subtle off-odors, occasionally present in competitor materials, don't appear in our runs. That attention to small details helps avoid unexplained process deviations when you scale up into tens or hundreds of metric tons each year. Most customers notice the absence of by-product peaks or haze during standard hydrolysis and acylation reactions. This saves time otherwise lost on column cleanups or, even worse, losing partial batches.
A production site that handles thousands of tons each year does not treat acetyl chloride as an afterthought. For us, it’s both a flagship product and a canary in the coal mine: any blip in purity or stability leads to troubleshooting that catches wider plant risks. Our as-manufactured model features a colorless liquid, and unlike lower-grade variants from general-purpose resellers, maintains minimal iron and free chlorine. Each drum, IBC, or tanker leaves our gate after full inspection, including melt-point, specific gravity, and compatibility with stainless and glass-lined vessels.
From synthesis onward, every batch travels in inerted systems—no recycled solvents pollute the end product. Tank rinses between each run mean there's never a lingering shadow of former loads. Operators hold to closed-system handling, using pressurized nitrogen blankets and monitored temperature controls from the very start. Our own technical crew spends a fair amount of time reviewing unloading facilities and fitting guidelines with downstream partners; we see too many smaller users struggling with problematic seals and hardware that degrade in chloride environments.
Anyone working in acylation reactions recognizes the difference between a thoughtfully prepared reagent and something blended up by a third-party stockist. Our acetyl chloride becomes a backbone for acetanilides, esters, acyl amides, pharmaceuticals, and specialty intermediates. Many customers process it directly into herbicides, dyes, or even active drug ingredients. Process chemists have told us about wild batch swings from off-the-shelf material. With us, the composition never drifts outside the tight GC limits promised in each certificate.
For industrial end-users, off-flavors or residue often suggest contamination by thionyl chloride or unreacted acetic acid—failings common with less-stringently made chlorinating agents. Acetyl chloride from our line avoids these issues, so product yields stay high without recurring filter, column, or purification headaches. Storage stability exceeds competitors; even after a year, unopened drums retain clarity and reactivity. Of course, no one runs acetyl chloride stock without strict temperature and moisture controls, but the improvements we see even in user error scenarios point to the benefits of chemical rigor at the manufacturer level.
Large-volume chemical processes rarely respect shortcuts. Pharmaceutical producers and agrochemical formulators depend on critical reagents staying pure and reactive batch after batch. Our acetyl chloride supports high-throughput applications; nothing leaves the facility unless it passes our final impurity scan and water quantification step. Whether the demand comes from a local resin plant or a multinational’s API facility, we focus on minimizing contaminants that can lead to unwanted color bodies, odor, or formation of problematic side products.
Compared to competing options, our product tolerates storage and shipping without forming hazes, residues, or off-colors. Some buyers, frustrated with previous failures, tell us the difference becomes clear during high-shear mixing or heat-up stages—no formation of persistent oil layers or residue crusts inside process equipment. Paint manufacturers leaning on acetyl chloride as an acylation agent tend to struggle less with filter blockages or subsequent polymer yellowing. The lesson learned from walking customer plants is that attention at the manufacturing step saves a downstream crew from hours of troubleshooting bad input stock.
We publish our acetyl chloride specifications with a focus on what's crucial for end-users—not just tight numbers for their own sake. Standard specs for us go beyond color, density, and chemical assay. Each lot has its moisture content measured to parts per million, and the absence of halogenated by-products gets confirmed against well-known reference markers. This means less surprise corrosion, lower risk for adverse reactions during scale-up, and fewer headaches when it comes to pressure venting or fume control.
Customers in the pharmaceutical and electronic chemicals sector speak up most about the need for batch-to-batch repeatability. They can't afford inconsistencies in mechanical finishes, residual pH values, or solubility rates. Our process always incorporates a drying phase under vacuum, so the delivered liquid is as close to anhydrous as you’ll find without running a lab prep. Every drum gets closed under dry-room conditions. For electronics or pharma production, this level of control translates into stable reactions and fewer rejected lots further down the supply chain.
No large-scale acetyl chloride operation runs trouble-free without respect for the chemical’s behavior. Issues like unexpected hydrolysis or unwanted HCl evolution become headaches in packaging, transfer lines, and final mixing vessels. Our support team consists of engineers who’ve worked on installations in everything from API synthesis suites to paint resin reactors. We help end users step through real-world setups: joint integrity checks, correct valving, gas scrubbing, and site-specific cooling solutions.
Whether the order ships in 250-kilogram drums or full-tanker loads, every customer gets detailed unloading and storage guidance. We advise on vented drum adaptors and the muscularity of well-tested joint sealants; neglect in these areas often leads to fugitive emissions and corrosion. Over the years, we've helped several plants install improved acid scrubbers and vapor-capture heads—small changes that paid for themselves by reducing raw material losses and keeping HSE regulators satisfied.
Beyond purity, customers care about compliance and supplier accountability. As a primary producer, our acetyl chloride batches come traceable right back to their reaction dates, shift teams, and even raw material lot codes. Each step from synthesis to filling runs under a documented system, full batch logs always available for partner audits. Regulatory compliance means more than ticking a box; it means real confidence for end-users who need to trace every kilo of acetyl chloride in their own audits.
Imports and third-party material regularly fail to live up to established standards under GMP or ISO guidelines. Distributors sometimes find themselves fielding complaints about re-bottling or contamination they never saw on incoming paperwork. Our model keeps full chain-of-custody information in-house—no risk of silent substitutions by brokers or degraded quality from unnecessary repackaging.
Seasoned plant operators know that true value in a raw material comes out only after months and years of continuous use. We measure success by customer retention and how few process disruptions get traced back to basic reagent failure. Several customers shifted their acetyl chloride supply after process upsets using cheap, inconsistent imports. Their move to in-house production for crucial pharmaceuticals or polymers depended on a stable supply partner at the source.
Our attitude has always been to put effort into understanding the fine details—the link between upstream storage tank conditions and the impact on vacuum distillation yield, or how a trace mineral impurity in raw acetyl chloride can ruin final color in dye intermediates. By keeping the conversation with end users direct and always open to feedback, we have helped dozens of plants tighten up their QA and avoid expensive troubleshooting hunts.
No distributor or third-party repacker can guarantee the same level of accountability that comes when you buy direct from us. For most buyers, switching away from the reseller means faster issue resolution and ongoing technical support from a team that's seen problems in the field firsthand. Plants dealing with hazardous materials value quick-turn documentation, live troubleshooting help, and ongoing tweaks to delivery and storage setups.
On more than one occasion, a sudden global shortage or port delay forced customers to rely on their supplier’s flexibility. Our own team has kept customers in operation by rerouting tankers, running extra weekend shifts, or finding interim holding sites closer to the user’s plant. A third-party seller never delivers that level of real-time partnership, nor the ability to fix quality issues at the source.
Handling and producing acetyl chloride safely takes strict discipline and real-world experience. Our plant invests in modern emission control, compliant effluent handling, and staff training to prevent both unseen leaks and large-scale incidents. Our environmental audits go beyond paperwork exercises, involving routine flue testing and third-party air sampling around tank farms.
In the event a customer reports venting or odor, our safety advisory service reviews the site’s practices, recommends improvements to drum handling, and if necessary, helps install additional fume extraction or scrubbing. Unlike traders or third-party logistics companies, we know exactly how each barrel traveled—avoiding long transits in poor conditions that can degrade chemical stability.
Acetyl chloride occupies a special place compared to other acylating chlorides. Unlike thionyl chloride or phosphorus trichloride, acetyl chloride typically delivers cleaner, less persistent by-products. Many production chemists prefer it over acetic anhydride for acylations where evolving HCl provides easier process tracking and side-product removal. Compared to bulk acetic acid or acetic anhydride, acetyl chloride gives much faster reactivity in non-aqueous systems, with manageable evolution of hydrogen chloride.
For certain specialties, such as reactive dyestuffs or advanced polymer monomers, the switch to acetyl chloride from bulkier, more moisture-sensitive agents like benzoyl chloride streamlines process controls and cuts costs in side-product isolation. We have helped customers rationalize their chlorinating reagent inventories by selecting acetyl chloride where practical, often resulting in lower process corrosion and easier line cleaning.
We remain closely connected with the research and development arms of our large clients. Customer input shapes ongoing refinements in production, transport, and technical support protocols. For research groups seeking low-volume specialized lots, our team routinely develops customer-focused sampling plans—always keeping future scale-up in mind. Several of our clients work in green chemistry, searching for more energy-efficient and cleaner acylation routes; our technical engineers contribute to joint process studies and regularly publish findings on improved handling, waste minimization, and safe venting options.
In our own labs, we have tested numerous possible stabilizers, drum liners, and alternative packing protocols, responding to feedback about long-haul stability or unique process needs. The real measure of quality never comes from slick branding or generic claims, but in a traceable history of supporting successful, large-scale industrial reactions.
The way we see it, direct producers should act as partners, not just suppliers. Every drum, tank, or specialized batch reflects not only our process control but also years of dialogue with chemists, plant managers, and on-the-ground operators. Customers interested in continuous process improvement find our technical team open to site visits, troubleshooting, and plant audits, leading to lasting relationships and practical adoption of new handling or dosing technology.
Anyone working with acetyl chloride on an industrial scale learns quickly where the most common problems lie—drum swelling from trace water, thermal decomposition during summer transit, filter blockages from heavy metals, or loss of batch yield due to minor impurity spikes. We’ve gathered enough feedback and site experience to intervene with advice that cuts straight to the practical: from specifying high-integrity valve selections to custom-designing nitrogen-blanketed tank farms and setting up emergency acid catchment. Our deep manufacturing bench solves today’s problems, while our listening keeps us ahead for tomorrow’s needs.
No matter how far automation and digitization evolve the chemical business, the fundamentals of good manufacturing—rigor in process, honesty in testing, promptness in support—never stop paying dividends. We view every contract as the starting point for a conversation, not the end of the job. Acetyl chloride, in all its unique hazards and utility, deserves that level of focus from direct producers. That approach keeps our customers running smoothly, batch after batch, with far fewer surprises down the line.