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HS Code |
899679 |
| Chemical Name | 5-Nitro-2-Aminophenol |
| Synonyms | 2-Amino-5-nitrophenol |
| Molecular Formula | C6H6N2O3 |
| Molecular Weight | 154.13 g/mol |
| Cas Number | 121-88-0 |
| Appearance | Yellow to orange-brown powder |
| Melting Point | 174-176°C |
| Solubility In Water | Slightly soluble |
| Pka | 5.48 (amino group) |
| Boiling Point | Decomposes before boiling |
| Density | 1.51 g/cm³ |
| Pubchem Cid | 66201 |
As an accredited 5-Nitro-2-Aminophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The chemical is packaged in a 100g amber glass bottle with a screw cap, featuring hazard labeling and product identification details. |
| Shipping | **Shipping Description for 5-Nitro-2-Aminophenol:** 5-Nitro-2-Aminophenol should be shipped in well-sealed, labeled containers, protected from moisture and incompatible substances. Store and transport at ambient temperature, in compliance with all applicable regulatory requirements. Handle as a hazardous chemical, using appropriate personal protective equipment. Ensure packaging prevents leaks and damage during transit. |
| Storage | 5-Nitro-2-Aminophenol should be stored in a tightly sealed container, away from light, moisture, and incompatible substances such as strong oxidizers and acids. Keep it in a cool, dry, and well-ventilated area, preferably in a dedicated chemical storage cabinet. Proper labeling and secure storage to avoid accidental release or exposure are essential for safety. |
Applications of 5-Nitro-2-Aminophenol in Industrial Manufacturing5-Nitro-2-Aminophenol serves as a critical intermediate in specialized chemical synthesis across several downstream sectors. As a direct manufacturer, we support demanding process requirements for these industries, providing stable product batches with reliable purity and documented traceability. 1. Hair Dye Intermediates for Oxidation Coloring SystemsDownstream cosmetic formulators use 5-Nitro-2-Aminophenol in the development of permanent and semi-permanent hair dye products, particularly as a coupler in oxidative coloring processes. It enables formulation of dark red, auburn, and mahogany shades through its reactive amine and nitro groups. The material integrates during the primary mixing step with other aromatic amines and developers, reacting under controlled pH and oxidation with hydrogen peroxide. Allergen management and skin compatibility require precision QC and batch documentation at each stage. The intermediate must comply with banned and restricted lists in major cosmetic markets before commercialization. Industry compliance standards
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2. Synthesis of Azo and Nitro Dyes for Textile PrintingIn the textile and specialty dye sector, manufacturers employ this intermediate to synthesize certain direct, acid, and disperse dyes. Its functionality supports colorfast yellow, orange, and red shade development for cotton and polyester substrates. The process involves diazotization and subsequent coupling reactions with aromatic amines, demanding exact stoichiometry and pH controls for consistency and yield. Product safety and effluent standards drive documentation for all raw materials and by-products in large-scale dye operations. Industry compliance standards
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3. Active Pharmaceutical Ingredient (API) Intermediate ProductionPharmaceutical process engineers utilize 5-Nitro-2-Aminophenol as an advanced intermediate in multi-step synthesis of specific APIs for anti-infective and antipyretic drugs. Reactions include reduction, acetylation, or coupling with heterocyclic agents, requiring GMP-grade control and comprehensive impurity profiling. Each lot runs through validated cleaning and changeover procedures in compliance with ICH and local medical authority guidance. Our supply chain supports full backward traceability and process disclosure demanded by regulated pharmaceutical manufacturers. Industry compliance standards
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4. Electrochemical Sensor and Dye Marker ManufacturingAdvanced materials companies use 5-Nitro-2-Aminophenol in formulating colorimetric and electrochemical sensor markers. The molecule’s redox activity offers utility in enzyme labeling, diagnostic strip reagents, and as a chromogenic substrate in bioassays. Manufacturing includes precision blending with binders and stabilizers under controlled conditions to avoid premature oxidation. Sensor and diagnostic brands require ISO13485-certified supply chains and full regulatory filing data for analytic validation and international shipment. Industry compliance standards
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Producing chemicals isn’t just about mixing raw materials and sending them out in drums. Every batch has to reflect years of acquired skill, careful control of reaction conditions, and a genuine respect for our customers’ technical needs. 5-Nitro-2-Aminophenol, known for its relevance in dye manufacture and pharmaceutical synthesis, remains a testament to what a dedicated factory setting achieves. This isn’t merely a niche product. For a long time, folks running colorant lines or working in analytical labs have relied on a consistent, high-quality supply of this raw material to maintain their processes’ stability.
We don’t cut corners with 5-Nitro-2-Aminophenol. Sourcing the base aniline and appropriate nitrating agents, controlling exothermic reactions, keeping everything oxygen-free—these aren’t optional steps. They guarantee purity, fine crystals, and the freedom from unwanted byproducts that can disrupt downstream uses. Any manufacturer will tell you that yield matters less than quality with this molecule. It’s no shock that synthetic dyes demand precise hues, and trace contaminants change the undertone or strength. With careful process controls and vigilant in-process QC, we hit typical assay levels above 99% and keep residual moisture well below 0.5%. Consistently bright orange-yellow appearance and ease of dissolution reflect these controls. The reality is, process impurity profiles mirror the plant’s experience and discipline.
Our chemists work closely with teams who make dyes for hair coloring, textiles, and inks. 5-Nitro-2-Aminophenol acts as a fundamental building block for oxidative and direct colorant systems. Its functional groups—one nitro and one amino—make it a versatile intermediate, useful for coupling and diazotization steps. Typical applications span:
Large-scale chemical production is rarely glamorous, but there’s pride in knowing each drum reflects hands-on work from a trained factory team. In-house production lines allow for faster troubleshooting and process tweaking. Supply schedules stay predictable. Running our QC lab next to production lets us catch off-specification material before anything gets packed. Over the years, customers have told us they see the difference in their formulations—a batch that performs identically every time, no surprises in raw material behavior, no mysterious impact on final product color quality.
Selling direct, as the manufacturer, brings several advantages. We own the plant and run our own reactors—no outsourcing or repackaging means customers always know exactly what they’re getting. Full knowledge of the synthesis route, all the way down to the raw input quality, lets us tighten specifications with each season. Some buyers request extra analytical documentation showing absence of heavy metals or unreacted nitro compounds; in a plant-run setting, running these tests becomes routine. We don’t have to pass these requests up a chain and wait for an answer. This kind of transparency is hard for traders or brokers to offer.
Mainstream technical literature covers the basic data: melting points, solubility curves, molecular weight, etc. But for buyers lining up for high-stakes use cases—such as those in regulated cosmetics or certified colorants—unique experience matters more than textbook repetition. 5-Nitro-2-Aminophenol with off-color, irregular particle size, or a lower assay can cause entire lines to pause or fail. In our facility, drying profiles get optimized batch by batch to prevent caking and ensure the product flows smoothly in automatic feeders. It may seem a small point, but in automated dye mixing, a lump of material that doesn’t dissolve or a stray speck that isn’t the right hue means production lines stop.
Moisture control matters almost as much as chemical purity does. Over-dried crystals become brittle dust; under-dried and material clings to silo walls, causing losses and skewing weighing lines. Over years of operation, the finishing stage has learned to adjust air flow, temperature, and timing not by the clock, but by what each batch’s texture and appearance tell trained hands. This level of real-world adaptation doesn’t show up in standard specifications but it defines reliability for the end user.
A lot of market confusion comes from resellers and jobbers marketing 5-Nitro-2-Aminophenol under broad claims: “high purity”, “strict QC”, “guaranteed consistent”. Those words are only as good as transparency about production. From this side of the business, the main advantage of plant-direct supply is granular knowledge of every input and every tank. As a factory team, we know exactly which batch of raw aniline went into which day of production. If an equipment calibration shifts reaction temperature by a fraction, the final product tells us. Real factory logs feed modern traceability tools—auditors want to see in-house printouts and sample retains, not a generic COA stamped by an anonymous reseller.
Some buyers keep detailed performance logs—how their colorant produces in each lot, whether there’s drift in spectral readings, how their regulatory filings fare. Those clients come back with detailed questions about our filtration steps, crystallization procedures, and packaging atmosphere. We answer these from direct plant experience rather than vaulting back and forth to contract processors. Our view? Consistency in specification comes from knowing, at the factory level, what the process looks like on any given day.
Running a modern plant means more than just meeting assurance standards for the end product. Handling nitro-aniline intermediates requires specific environmental and safety infrastructure built up over decades. We maintain scrubbers, closed-loop solvent recovery, personal protective measures, and ongoing staff training. The equipment receives regular maintenance, every vent is monitored, and all effluent checks respect local regulatory standards. This isn’t just for compliance. Downstream users have grown more sensitive to hidden risks, like cross-contamination with aromatic amines or trace nitrosamines. All these controls help limit the risk of those undesirable compounds being brought along into the end product.
We’ve invested in automation, real-time environmental sensors, and digital batch records so every step has an auditable trail. This isn’t a one-off effort; it’s woven into our plant’s culture. Buyers visiting the facility notice the difference: trained operators at every post, regular air and water quality reports, transparent documentation instead of shortcuts. The factory’s stable operation guarantees long-term supply, low risk of upsets, and calm in the face of changing regulatory frameworks. No corners are cut in disposal of spent acids or solvents; local communities expect strict compliance, and we operate with that trust in mind.
We’ve built long relationships with buyers in sectors like hair dye manufacturing, advanced colorant blending, and specialty pharmaceutical intermediates. They come back year after year not because we offer the lowest price, but because our batches behave predictably in their lines. Over time, the biggest issues we’ve seen are rarely about brochure purity numbers or melting points. What matters is consistency in tinting strength, rate of dissolution, and the handling of minor impurities—or the lack of them.
Some end users in cosmetics are under increasing regulatory scrutiny, especially on topics like trace amine content and potential sensitizers. Reporting to those standards means demonstrating detailed analysis: residual solvents, metals checks, aromatic amine traces all counted and controlled. Having everything produced under our roof, with access to every working batch and archived sample, makes this feasible without costly outsourcing. In our plant, lab techs work alongside production. If a new regulatory question arises, testing can start without bureaucratic back-and-forth. This, in turn, supports our customers’ need for speed and certainty when dealing with changing legal frameworks worldwide.
The chemistry behind colorant intermediates involves a family of nitro- and amino-substituted phenols, each with different properties and uses. 5-Nitro-2-Aminophenol stands out for the position of its groups on the aromatic ring. Unlike its isomers or basic nitrophenols, this specific orientation brings particular benefits in dye manufacture. Reactivity shifts subtly; certain coupling reactions proceed faster or offer better yields. The color produced by derivatives is more stable in oxidative conditions and sunlight exposure, two critical factors in hair dye and fabric industries.
In side-by-side trials, alternatives like 4-nitro or 3-nitro aminophenols show different solubility patterns, reaction velocities, and color strengths. Switching between these compounds can force major changes downstream: new approvals, altered product formulations, even requalified equipment. Not every plant can adapt quickly to such differences in application. For us, focusing production on a tightly controlled 5-Nitro-2-Aminophenol streamlines scale-up, keeps waste down, and minimizes risk of cross-product contamination—critical for users wary of any source variation.
Every chemical plant faces challenges: sourcing raw materials amid volatile markets, maintaining equipment, staying ahead of regulations, and holding down hidden losses from waste or rework. Running 5-Nitro-2-Aminophenol on a continuous basis means having backup supplies for key inputs, robust process monitoring, and operators who spot deviation early. New entrants sometimes underestimate the risk posed by mismanaged exotherm, solvent loss, or reaction fouling—all can knock output off spec and introduce real headaches for end users.
We work on reducing operational downtime, investing in modern reactors, maintaining skilled labor, and automating routine QC. Success in this business flows from hard-won stability in both operation and workforce. Tight-knit factory teams, working side-by-side for years, spot irregularities that no manual or automation can catch. This reliability pays off for every customer looking for both regular shipments and responsive problem-solving.
Feedback from buyers shapes our process evolution. Demand for better documentation and advanced contaminant screening has lifted our lab standards. Requests for unique packaging—smaller drums, lined bags, moisture-barrier films—help us prevent caking or unintended exposure during transit. Customers voice concerns about trace levels of heavy metals or residual solvents. Our plant has built extra cleanup steps, filtration enhancements, and regular external lab audits into the routine. These incremental improvements emerge from plant-floor discipline, not generic instructions from a distant office.
End uses continue to evolve. As customers seek to lower exposure to problematic aromatic amines, we push for better purification. Collaborations with major dye and pharma users give us insight into latest application needs, changing specifications, and new regulatory hurdles. Our own R&D works on pathway tweaks, greener synthesis, and waste neutralization—none of which happens in isolation but always in dialogue with users’ real problems on the ground.
To keep pace, plant upgrades focus on more efficient reactors, smarter dosing equipment, upgraded filtering, and advanced in-line moisture controls. Each improvement, once tested and proven, rolls out across all future production. Customers notice faster lead times, reduced lot-to-lot variation, and QC records that withstand global scrutiny.
Every shipment of 5-Nitro-2-Aminophenol carries a history—raw inputs traced to reputable partners, batches logged minute by minute, and materials checked at each step for color, purity, and performance. Buyers who visit our facility walk through the entire process; they meet the people crafting each lot. No layer of abstraction. Years of careful routine—reactor charging to final drum labeling—turn trusted products into industry mainstays.
Market conditions will always shift: global supply chains stretch thin, regulatory rules multiply, and competition pushes for lower costs. Still, the chemical industry often comes down to long-term relationships built on delivered promises and transparent operations. We hold to the belief that plant-run chemical manufacturing remains central to the reliability of specialty ingredients like 5-Nitro-2-Aminophenol. Every user downstream—whether mixing dyes on an industrial line or formulating a pharmaceutical batch—benefits from suppliers grounded in hands-on experience, committed to ongoing process improvement, and open to direct feedback.
After years in the business, the biggest lesson is that experience behind each specification matters to customers. 5-Nitro-2-Aminophenol offers more than a set of numbers on a sheet. It stands for reliable process control, timely delivery, and the peace of mind that comes from open-book supply. It’s not the easy way to do business, but true in-house manufacturing brings confidence to every buyer who counts on their materials working the same way every batch.
Putting in the time, training, and investment doesn’t just serve the bottom line—it keeps our customers up and running, ensures strict final product compliance, and lets users focus on their own innovation and growth. Year after year, that’s how real value is built.