Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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4-Thiopentanal

    • Product Name 4-Thiopentanal
    • Alias 4-Mercaptobutanal
    • Einecs 211-876-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    125811

    Name 4-Thiopentanal
    Cas Number 1071-12-7
    Molecular Formula C5H10OS
    Molecular Weight 118.20 g/mol
    Appearance colorless to pale yellow liquid
    Boiling Point 190-192 °C
    Density 1.040 g/cm³
    Refractive Index 1.478
    Flash Point 70 °C
    Smiles CCCCS=O
    Pubchem Cid 178689
    Melting Point -37 °C

    As an accredited 4-Thiopentanal factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 4-Thiopentanal, tightly sealed with a screw cap and labeled with hazard and identification information.
    Shipping 4-Thiopentanal is shipped following standard procedures for hazardous chemicals. It is packed in tightly sealed containers, protected from moisture and light, and clearly labeled. Transport is conducted under regulated conditions, adhering to international and local guidelines to ensure safe handling and delivery, with appropriate documentation provided for safety compliance.
    Storage 4-Thiopentanal should be stored in a tightly sealed container, away from light, moisture, and incompatible substances such as strong oxidizers and acids. Store it in a cool, dry, and well-ventilated area, ideally in a chemical fume hood or flammable storage cabinet. Ensure proper labeling, and handle with appropriate personal protective equipment to prevent exposure to vapors or accidental spills.
    Application of 4-Thiopentanal

    Applications of 4-Thiopentanal in Industrial Manufacturing

    As a direct manufacturer focused on specialty intermediates, we supply 4-Thiopentanal exclusively to industrial partners utilizing its unique thiocarbonyl-aldehyde structure in precision chemical synthesis. Below we identify verified downstream sectors integrating this raw material into their operations, outlining regulatory alignment, precise formulation ratios, specific production steps, and the ultimate commercial products enabled by its function.

    1. Pharmaceutical Intermediate Synthesis

    4-Thiopentanal finds application as an essential synthon within the active pharmaceutical ingredient (API) manufacturing chain, particularly for sulfur-containing heterocycles which underpin certain anti-infectives and CNS drug candidates. Our clients use this input in regulated multi-step organic synthesis routes, where its reactive aldehyde and thio groups are harnessed for sequential cyclization and substitution steps, directly impacting the purity and bioactivity of the pharmaceutical end products.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • U.S. FDA 21 CFR Part 211—Current Good Manufacturing Practice for Finished Pharmaceuticals
    • European Pharmacopoeia (Ph. Eur.) current edition
    • Chinese Pharmacopoeia (ChP) for local submissions

    Typical usage ratio

    • 0.5%–4% molar equivalent as a key building block, depending on target API yield and process scale-up efficiency; amount adjusted based on desired purity and step-wise reactivity controls.

    Downstream process integration

    • Batchwise addition during early-stage or mid-stage API synthesis, often under inert atmosphere, preceding cyclization or acylation steps; typically purified post-reaction through phase separation and crystallization techniques prior to final product isolation.

    Final product types

    • Thiazole-based antibacterials
    • Sulfur-modified antineoplastic intermediates
    • Custom CNS agent intermediates
    • API precursors for clinical R&D trials

    2. Agrochemical Intermediate Production

    Within crop protection chemical manufacturing, 4-Thiopentanal acts as a building block for specific classes of sulfur-rich pesticide intermediates where its molecular scaffold facilitates downstream formation of thiolactones and thioethers. This segment demands consistency in physical and chemical profile to comply with agricultural chemical synthesis and environmental safety benchmarks covering both the intermediate and the formulated actives.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 Quality Management Systems in chemical plants
    • REACH Regulation (EC) No 1907/2006 Article 31 (Safety Data Sheet Requirements)
    • U.S. EPA Pesticide Registration (40 CFR Part 158)

    Typical usage ratio

    • 0.3%–2% by mass of synthesis batch; precise amount adjusted according to specific thiolactone or pyrethroid intermediate yield targets and impurity controls.

    Downstream process integration

    • Introduced during initial coupling or thiolation steps involving acylation or condensation in closed reactor systems, followed by in-process refining and solvent exchange tailored to the downstream pesticide active synthesis requirements.

    Final product types

    • Selective herbicide intermediates
    • Insecticidal thioether prototypes
    • Fungicide precursor molecules
    • Custom step intermediates for patent-specific actives

    3. Flavors & Fragrance Synthesis (Specialty Aldehyde Derivatives)

    Commercial flavor and fragrance houses incorporate 4-Thiopentanal into the creation of sulfurous aldehyde derivatives, introducing nuanced organoleptic attributes widely applied in savory formulations, meaty flavors, and certain exotic perfumery bases. The compound’s reactive nature demands rigorous control within batch or continuous processes to avoid unwanted oxidation and to meet global food safety thresholds.

    Industry compliance standards

    • FEMA GRAS (Flavor and Extract Manufacturers Association—Generally Recognized As Safe)
    • U.S. FDA 21 CFR Part 172—Food Additives Permitted for Direct Addition to Food for Human Consumption
    • EU Regulation (EC) No. 1334/2008 on flavorings
    • ISO 22000 Food Safety Management for manufacturing environments

    Typical usage ratio

    • 0.05%–0.5% of finished flavor blend mass; titrated according to final aroma intensity, volatility requirements, and regulatory thresholds for sulfur compounds.

    Downstream process integration

    • Added during primary synthesize or after initial distillation, under inert gas, with immediate downstream derivatization (e.g. alkylation or esterification) to generate the target aldehyde or thioester, followed by blending and GC confirmation prior to commercial blending.

    Final product types

    • Savory flavor concentrates (meat, onion, garlic notes)
    • Fine fragrance accords (complex sulfur base notes)
    • Flavor enhancers for processed snacks
    • Specialty aroma chemicals for food masking

    4. Polymer Additive & Crosslinking Agent

    In the performance polymer industry, 4-Thiopentanal serves as a functional crosslinker and chain-modifying agent in specialty sulfur-cured elastomers and selected thermoplastic composites. Downstream processors introduce this material at carefully controlled concentrations, where the aldehyde’s reactivity toward polymer backbones and sulfur-cure systems enables modified mechanical, barrier, or chemical resistance properties in the ultimate article.

    Industry compliance standards

    • ISO 9001 or IATF 16949 for automotive and industry-grade polymers
    • RoHS Directive 2011/65/EU on hazardous substances for E&E applications
    • ASTM D3182 for rubber compounding and preforming quality
    • REACH Regulation for polymer additives safety

    Typical usage ratio

    • 0.1%–1.5% of polymer formulation mass; dosage determined by targeted crosslink density, compatibility with base resin, and final product performance tests.

    Downstream process integration

    • Metered addition during melt-mixing, blending, or pre-polymerization alongside sulfur donors or accelerators; followed by controlled curing/crosslinking cycles prior to article forming (e.g. extrusion or molding).

    Final product types

    • Sulfur-cured elastomeric seals
    • Specialty automotive compound components
    • Chemically resistant hoses and sheets
    • Functionalized rubber parts for electronics
    Free Quote

    Competitive 4-Thiopentanal prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    4-Thiopentanal: Direct from Our Manufacturing Lines

    Understanding 4-Thiopentanal in Our Production Environment

    For decades, we've handled the demands of both specialty and fine chemical markets. 4-Thiopentanal holds a special position not just because of its chemistry, but because factories don’t adopt this niche building block without intent. As a chemical producer, we've developed a line of 4-Thiopentanal with specific focus on reliability, material purity, and reproducibility, which makes a big difference when researchers and industrial operators move from the lab to pilot scale.

    The molecular signature of 4-Thiopentanal—C5H10OS—is clear and consistent. We learned early that even trace impurities could set back costly synthesis steps. So, purity checks start long before material fills the drum. Over the years, our lines have dialed in a purity range that consistently exceeds 98%, batch after batch. There's no mystery behind our protocol: each lot goes through gas chromatography and NMR, confirmed by dedicated analysts. These procedures came as a response to repeated feedback from R&D teams at both large and small enterprises, where a single deviation meant wasted time and resources.

    Why 4-Thiopentanal is More Than Just a Chemical Name

    Factories ask about economic and supply-side stability, not just the molecule itself. With our investment in vertical integration of precursor supply and downstream packaging, we address risk at the production floor, not just in technical papers. The raw materials for ethanedithiol and butyraldehyde derivatives, for instance, are tracked and sourced with control—no outside brokers. Shortages, fluctuations, and inconsistent grades find no foothold here because our purchasing is designed to buffer the real-world demand cycles of commercial-scale chemistry. We keep inventory on-hand to prevent both bottlenecks and over-supply, which helps maintain steady pricing. Our operators know firsthand how switching to 4-Thiopentanal from alternative aldehydes can open new synthetic pathways—mainly for sulfur-based ligands and certain flavor or fragrance intermediates—but only if the supply matches the promised quality.

    End users, whether at R&D benches or in process vessels, want results they can bank on. 4-Thiopentanal gives chemists a distinct entry into thioaldehyde chemistry, which translates to efficient, high-yield reactions in thiazole synthesis, agricultural compound exploration, and sulfur-flavor ensemble creation. Our years on the floor demonstrate that lab-grade and technical-grade versions do not deliver the same process benefits, even though both claim high purity. Only by keeping precise control over batch temperature, distillation parameters, and atmosphere do we keep sulfur impurities and over-oxidized byproducts in check.

    The Distinction Between Our Model and What’s Out There

    The chemical market likes shortcuts, but shortcuts lead to variability. We manufacture our 4-Thiopentanal under inert atmosphere, both for quality preservation and for worker safety. Sulfurous intermediates can oxidize or form off-odors if exposed to air for even short periods. Many importers and repackers will bulk-handle open-drum materials to cut costs—an approach that often escapes the attention of buyers until after a batch fails in downstream chemistry. We built our model around direct filling, sealed containment, and environmental controls. There’s no magic to this; it’s a willingness to do the harder work because it pays off in customer retention and reduced claims for defective material.

    The difference between manufacturer and reseller or trader becomes clear with 4-Thiopentanal. Resold bottles age in transit, sometimes compromised by light and air. Stability decreases, and the end user sees this as a dropped yield or side reactions. As a producer, every drum of our 4-Thiopentanal moves straight from synthesis vessel to quality lab, then to its bunker, then out to the customer with temperature logging in place. It’s not only about what’s in the container—it’s how it got there, with a documented chain of custody that’s earned us trust from repeat partners in pharmaceuticals, flavors, and advanced material segments.

    Specification That Aligns With Operational Demands

    Many reference guides only list melting points, boiling points, and densities. A reliable supplier reveals more: we call out solvent residuals, total sulfur content, and define the water-max threshold by Karl Fischer titration. Some companies take for granted minor impurity levels, but for us, every ppm matters. Even at low levels, water interferes with sensitive alkylation steps or sulfonation. By maintaining a water content below 0.10%, and keeping non-thioaldehyde sulfur below 0.02%, we fit into advanced process needs without the user having to run additional purifications or waste time with QC surprises.

    Not all customers measure purity in the same way. Specialty application users—such as those in medicinal or agrochemical syntheses—often request custom grade modifications. Our standard model, produced at batch sizes suitable for pilot and commercial scale, includes both analytical certificates for compliance auditing and sample retentions for any dispute analysis. We anticipate questions about batch variance and have the runs documented for traceability to raw material sources, which supports both regulatory and internal review.

    One of the biggest distinctions we bring as a manufacturer is transparency. Differences in storage containers and logistics could seem minor, but for a sensitive thioaldehyde, they lead to real differences in assay results and performance. Our knowledge—earned in real-world settings, not by theoretical design—helped shape a supply model that industrial labs come back to, season after season.

    Applications We’ve Seen, and Where 4-Thiopentanal Excels

    Direct experience is irreplaceable in the field. Time and again, our 4-Thiopentanal enters as a selective reactant for heterocyclic synthesis, especially in pharmaceutical steps where sulfur atoms form the critical part of the bioactive group. We’ve supported flavor chemists who report sharper, true-to-source sulfur traces in savory and tropical note formulations. Industrial groups in the polymer world value 4-Thiopentanal for the precision it brings to cross-linking reactions, where side chain modification of precursor chains demands predictability.

    One unique property—its dual reactivity at the aldehyde and thio sites—gives our customers flexibility. Some produce thiazoles through cyclization with α-halo carbonyls; others take advantage of the ability to introduce sulfur atoms to elaborate backbone materials. The alternative route, using simple pentanal and post-functionalizing, leads to lower efficiency and greater environmental footprint. Our facility’s batch consistency lets researchers focus on innovation, not troubleshooting lot-to-lot difference or managing off-odor complaints.

    Safe, Responsible Handling In and Beyond the Factory

    We work with materials that don’t tolerate casual mistakes. That's why our team follows protocols that go beyond basic statutory compliance. At manufacturing scale, spills or uncontrolled emissions not only endanger workers—they compromise batch integrity with real cost to our clients. All production and filling zones for 4-Thiopentanal are run as closed systems with continuous air monitoring for volatile sulfur compounds. Storage areas receive regular turnover to avoid material degradation, and staff are trained to spot the first sign of instability, whether in color change or odor shift. We also share real-world guidelines with users: ventilated hoods for all transfer steps, cleanroom-grade PPE, and regular vessel inspection cycles, because safe handling is a culture, not a checklist.

    For customers scaling up from grams to hundreds of kilograms, our experience is plain: mishandling sensitive thiols can shut down a facility. We back every shipment with technical support drawn from lived production stories, not just instructions. This approach yields smoother plant trials and fewer emergency calls.

    Choosing 4-Thiopentanal Over Other Aldehydes or Thiols

    The options for carbon-sulfur building blocks aren’t interchangeable. Taking shortcuts with generic aliphatic thiols introduces risk due to volatility and odor, and generic aldehydes don’t provide the right combination of functional groups for selectivity in targeted syntheses. Our 4-Thiopentanal stands apart by giving chemists both the aldehyde and thio functions in the same molecule, reducing steps and cleaning up downstream processing. This cuts waste and limits hazardous byproduct streams—a fact our downstream partners appreciate given the tightening controls on effluent and emission in both food and pharma sectors.

    Since we control both the precursor chain and the final bottling process, our team can maintain tighter specs than what’s available through traders or open-market sources. Some customers approached us after failed scale-ups with off-spec batches bought from bulk resellers. Our runs passed where others didn’t because of steady control over both the chemistry and the containerization process—no surcharges, no swaps, just one product from one chain of custody.

    We don’t promote 4-Thiopentanal based on price competition with bulk traders. Instead, our emphasis lands where it matters: functionally superior product, safe delivery, and honest service. Industry partners cite our technical data support, responsive turnaround, and willingness to collaborate on pilot batch customizations as reasons for partnership longevity. This comes not from boardroom meetings but from shared success stories at the reactor scale.

    The Demand For Quality Under Pressure: How We Respond

    Unexpected challenges—weather, transport strikes, sudden shifts in global raw materials—sometimes hit the chemical industry without warning. Over the years, we’ve invested in redundancies where it matters, including backup storage for critical feedstocks, multiple reaction lines to absorb rush orders, and robust Quality Assurance frameworks that flag out-of-trend parameters early. We learned from hard experience that contingency plans matter little if the raw material pipeline isn’t robust. In our practice, premium 4-Thiopentanal means nothing unless we can repeat successful syntheses during both lean and high-demand cycles.

    New regulations can shift the market quickly. EU and North American standards increasingly focus on trace elements, worker safety, and environmental impact from chemical production and use. We keep our 4-Thiopentanal process ahead of these regulations, running routine audits on effluent streams and maintaining data portfolios on every lot for customer access. These aren’t just boxes for compliance; regulatory one-upmanship means nothing to a customer who needs an on-time, reliable shipment to keep a pilot line running or to secure a regulatory filing.

    Practical Solutions to Real-World Problems in 4-Thiopentanal Production and Application

    No supply chain runs without hiccups. We’ve seen logistic disruptions and have responded by offering just-in-time delivery for core clients with validated storage, plus batch reservation options. This limits storage risk on the user end without sacrificing security of supply. Some partners experience sporadic project rollouts or urgent development sprints. We keep technical support in-house with staff who know the chemical and the process, so troubleshooting covers both the theory and the practical application.

    Packaging matters. Our team knows that storing 4-Thiopentanal in HDPE or specific glass containers protects it from light degradation and unintended reactions with metal. Down the line, this translates to fewer stability issues at customer sites. By auditing our packaging continuously, we spot trends—like spiking temperature events during summer warehousing—that drive container upgrades and logistical reroutes in real-time. The right package keeps the product at its intended potency and function.

    We go where our customers need us. Some require product on consignment for R&D phases; others demand locked-in pricing to hedge budget risk during new launches. Our willingness to share analysis methods, operational tips, and troubleshooting results forms the core of long-term partnerships. Customers aren’t looking for hands-off, one-way supply—they come back to teams who engage with their process struggles and improvement ideas. Our field-engineered solutions aren’t available from third parties and are only possible from decades of direct manufacturing experience with real consequences for sub-optimal outcomes.

    Building Trust from Reactor to Application

    Over years of production, we’ve seen how every stage—sourcing, synthesis, containment, documentation, and customer support—connects to form trust. Shipping 4-Thiopentanal means owning the outcome as much as the output, and that responsibility lives at every level of our operation. We’ve adjusted specifications based on receiving lab studies, not just internal goals. Our lab staff collaborates with customer quality teams to resolve open questions, fine-tune batch handling, or walk through analytical discrepancies. We don’t aim for one-time sales—we look for sustained partnerships where long-term performance matters more than any contract term.

    Our commitment to quality isn’t only visible in the product as shipped. It shows up in repeat sample testing, customer site visits, and the willingness to engage peers in technical and environmental forums. Feedback loops tighten with each season—improvements might be as minor as labeling durability or as significant as reducing process emissions through raw material pre-treatment. No solution stands still, and the demands our customers bring to each 4-Thiopentanal batch push us to keep raising the bar.

    Continuous Improvement, Never a Finished Job

    Every chemical producer faces pressure to lower costs or cut corners, but our production philosophy leans on steady, incremental improvement rather than cost-driven compromise. We regularly review batch data for underlying drift—physical properties, chemical assay, byproduct profile—and tune the process in collaboration with our technical and HSE teams. The complexity of thioaldehyde chemistry means surprises sometimes surface, and the only practical approach is honest data and quick action. Customers place their orders with confidence, not because of claims, but from their past results and the consistency they experience at their own benches.

    As makers, not intermediaries, our take on any product—4-Thiopentanal especially—comes back to a simple premise: each batch, each shipment, and each technical discussion mark our reputation. The product is more than what’s on the label. It’s the trust built by those who work directly with the chemistry, every day, in settings where success is measured both in material and in the stories told by those who use it.