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4-Nitro-N,N-Diethylaniline

    • Product Name 4-Nitro-N,N-Diethylaniline
    • Alias N,N-Diethyl-4-nitroaniline
    • Einecs 202-918-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    285941

    Chemical Name 4-Nitro-N,N-Diethylaniline
    Cas Number 91-23-6
    Molecular Formula C10H14N2O2
    Molecular Weight 194.23 g/mol
    Appearance Yellow crystalline solid
    Melting Point 67-69 °C
    Boiling Point 320 °C
    Density 1.14 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in ethanol, ether, and chloroform
    Purity Typically ≥98%
    Storage Conditions Store at room temperature, away from light
    Odor Odorless
    Refractive Index 1.605

    As an accredited 4-Nitro-N,N-Diethylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle, tightly sealed, labeled "4-Nitro-N,N-Diethylaniline," features hazard warnings and chemical identification details.
    Shipping 4-Nitro-N,N-Diethylaniline should be shipped in tightly sealed containers, away from sources of ignition, heat, and incompatible materials. It must be clearly labeled as a hazardous chemical and handled according to relevant regulations. Use appropriate packaging and submit necessary documentation for transport as required by local and international shipping laws.
    Storage **4-Nitro-N,N-Diethylaniline** should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers and acids. Protect it from light and moisture. Proper chemical labeling and secure storage away from food and feedstuffs are essential. Use secondary containment to prevent spills or leaks.
    Application of 4-Nitro-N,N-Diethylaniline

    Applications of 4-Nitro-N,N-Diethylaniline in Industrial Manufacturing

    4-Nitro-N,N-Diethylaniline serves as a crucial intermediate in several specialized industrial sectors. Our direct synthesis ensures quality consistency, allowing integration into demanding downstream routes. Below, we detail key application scenarios, addressing sector-specific standards, formulation ratios, process placement, and finished product varieties.

    1. Azo Dye Intermediates for Textile Pigment Synthesis

    Azo dye manufacturers use 4-Nitro-N,N-Diethylaniline as an essential precursor in the diazotization and coupling stages for brilliant yellow to red pigments. Careful process control ensures compliance with textile ecolabel requirements, color fastness, and heavy metal limits. Feed ratio directly influences dye purity and intensity. Use in batch or continuous synthesis lines, where its nitro group activates subsequent reduction steps for high-yield pigment formation. End products serve in spinning, printing, and finishing of textiles.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • REACH Annex XVII (Textile Dye Restrictions)
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 105 Series (Color Fastness Testing)

    Typical usage ratio

    • 3–8 wt% of total azo dye batch, adjusted for shade and substrate demand

    Downstream process integration

    • Charge during primary coupling reaction, after diazotization—process stage determines pigment output scale

    Final product types

    • Reactive dyes for cotton fabrics
    • Disperse dyes for polyester
    • Direct dyes for viscose
    • Printing pigments for blended textiles

    2. Photographic Chemical Syntheses

    Specialty photographic chemical producers employ 4-Nitro-N,N-Diethylaniline as a controlled electron donor in color photographic couplers. The compound's structure imparts precision tone development for photographic emulsions used in professional films, plates, and digital photo papers. Adherence to photographic grade purity is critical to avoid film fog and color distortion. Integration follows strict process validation, focusing on minimizing trace metal impurities to ensure optical clarity in final imaging products.

    Industry compliance standards

    • ISO 18902 (Imaging Material Storage)
    • ANSI IT9.19 for Photographic Chemicals
    • RoHS (Restriction of Hazardous Substances, silver halide only)
    • Customer-specific photographic chemical QC protocols

    Typical usage ratio

    • 0.5–2% by weight of the photographic coupler blend, tuned for color balance

    Downstream process integration

    • Added during late-stage solvent blending; introduction point varies per formulation for negative or positive imaging products

    Final product types

    • Color developing agents
    • Photographic emulsions (professional film, color paper)
    • Instant snapshot chemicals
    • Photo-grade dye couplers

    3. Intermediate for API (Pharmaceutical Active Ingredient) Synthesis—Local Anesthetic Precursors

    Pharmaceutical chemical plants source 4-Nitro-N,N-Diethylaniline to produce intermediates for certain local anesthetics following validated chemical conversions. The consistent electron distribution of this nitro aniline structure supports reductive and alkylation reactions, leading to regulated bulk drug intermediates. Strict adherence to cGMP and pharmacopeial impurity profiles controls batch-release criteria and trace contaminant limits throughout scale-up and validation. All process stages undergo documentation for regulatory filings and API traceability.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211 (US FDA cGMP for Pharmaceuticals)
    • EP, USP, JP monograph impurity and quality specifications
    • DMF (Drug Master File) submission protocols as required

    Typical usage ratio

    • 1.4–5.5 molar equivalents relative to the next reaction step, adjusted by yield optimization studies

    Downstream process integration

    • Entry during initial nitro reduction followed by subsequent alkylation in multi-step API precursor synthesis routes

    Final product types

    • Benzocaine intermediate
    • Procaine intermediate
    • Other local anesthetic pharmaceutical precursors
    • Regulated bulk APIs (post-processing)

    4. Synthesis of Fuel and Lubricant Additives

    Industrial additive manufacturers utilize 4-Nitro-N,N-Diethylaniline to construct stabilizers and performance additives for fuel refining and specialty lubricants. Its nitro functionality acts as a reactive scaffold for anti-knock and antioxidant formulation development. Product purity and residue levels conform to automotive and lubricant additive norms, with careful formulation to meet toxicity and ash requirements. Process lines require pre-blending, followed by high-shear incorporation into base chemical streams.

    Industry compliance standards

    • ASTM D5769 (Automotive Fuel Additive Testing)
    • ACEA Oil Sequences (Engine Lubricant Specifications)
    • REACH registration for additive importers
    • OECD Safety Assessment for Chemical Additives

    Typical usage ratio

    • 0.1–3% of additive blend by weight, fine-tuned through performance bench testing

    Downstream process integration

    • Blended at the pre-polymerization step or before final anti-knock agent formation, depending on additive type

    Final product types

    • Anti-knock gasoline additives
    • Lubricant antioxidant boosters
    • Pour point depressant intermediates
    • Specialty fuel system cleaners

    5. Polymerization Moderator in Rubber Manufacturing

    Synthetic rubber factories adopt 4-Nitro-N,N-Diethylaniline as a polymerization retarder and scavenger during emulsion polymerization processes. It stabilizes radical reactions, supporting consistent polymer molecular weights for specialty rubbers, notably in applications where precise elasticity and resilience properties are needed. Material is subject to elastomer-grade impurity controls and trace heavy metal screening, in line with downstream automotive and industrial rubber part users. Integration point and batch level closely follow process batch validation history.

    Industry compliance standards

    • ISO 9001 Quality Management for Rubber Manufacturers
    • ASTM D2000 (Classification for Rubber Products in Automotive Applications)
    • REACH pre-registration for rubber auxiliaries
    • Customer-specific polymer grade purity standards

    Typical usage ratio

    • 0.02–0.15% based on total polymerization mass, tailored for rubber grade and process type

    Downstream process integration

    • Dosed at the start of emulsion polymerization to modulate radical speed and prevent chain overgrowth

    Final product types

    • SBR (Styrene-Butadiene Rubber) for tires
    • NBR (Nitrile-Butadiene Rubber) for oil seals
    • IR (Isoprene Rubber) for vibration-damping parts
    • High-performance elastomer sheets

    6. Analytical Reagent Production for Laboratory Diagnostics

    Laboratory reagent formulators select 4-Nitro-N,N-Diethylaniline for preparation of colorimetric detection kits and analytical standards, leveraging the compound's chromophoric properties. Raw material meets high-purity and trace contaminant specifications demanded by analytical chemistry suppliers. Blend ratios optimize detection sensitivity and stability for spectroscopic and clinical diagnostic applications. Integration requires rigorous QC including HPLC and trace metals analysis to guarantee batch-to-batch reproducibility in regulated diagnostic environments.

    Industry compliance standards

    • ISO 17034 (Reference Material Producers)
    • CLSI EP Standards (Clinical and Laboratory Standards Institute)
    • ISO 9001 and ISO/IEC 17025 (Testing Lab Accreditation)
    • FDA 21 CFR 820 (Quality System Regulation for Medical Devices and Diagnostics)

    Typical usage ratio

    • 0.01–0.25 g/L for solution-phase standards, determined by analytical application and detection limits

    Downstream process integration

    • Dissolved with buffer or solvent mix, then aliquoted into single-use or bulk analytical kits

    Final product types

    • Colorimetric diagnostic reagents
    • Laboratory calibration solutions
    • Analytical reference standards
    • Reagents for trace metal or pesticide detection
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    Certification & Compliance
    More Introduction

    Exploring 4-Nitro-N,N-Diethylaniline from the Manufacturer’s Perspective

    Product Introduction: Deep-Rooted Experience Behind Every Batch

    Working on chemical production lines for years, it becomes clear very quickly which compounds reward careful, hands-on expertise the most. 4-Nitro-N,N-Diethylaniline is one of those products. On our shop floor, we recognize it by its distinctive yellow to orange crystalline appearance and a precisely managed batch process that shapes each lot to a consistent, high-value output.

    We label our main model as 4-Nitro-N,N-Diethylaniline 99%. The figure reflects more than a number on a certificate. It’s a practicality. Our batches rarely fall below that level because the sequence of steps, filtration conditions, and stir times have become second nature for our team. It’s a material shaped by lived-in technical discipline, not by remote theory. We stick to granular purity improvements because most downstream users need that level to minimize reprocessing headaches.

    Specifications That Have to Work in the Field

    Customers come to us looking for a tightly managed melting point and a clear UV-visible absorbance profile in 4-Nitro-N,N-Diethylaniline. Those things matter when fine-tuning for dyes, colorants, and intermediate formations. Melting point runs between 71 and 74°C when handled as designed, which signals both proper synthesis and real removal of process impurities. Visual purity isn’t enough—UV analysis tells the rest of the story, and our in-house checks routinely align with the needs of specialty pigment and color developers.

    Dialing in the right parameters wasn’t an overnight process. There’s trial and sweat in hitting specs while scaling batches from pilot to commercial. Storage itself needs discipline, kept away from light, tightly sealed, with an eye for any early sign of photo-degradation or color changes. Getting this right means less waste, fewer surprises at the customer end, and satisfied repeat business.

    Where 4-Nitro-N,N-Diethylaniline Proves Its Value

    If a pigment blender or dye formulator needs consistent chromophore performance, this compound makes a compelling base. Routinely, our 4-Nitro-N,N-Diethylaniline finds its place in flexographic, offset, and specialty inks because it bridges stability and color richness. It doesn’t just fade quietly into the matrix of other intermediates; it shapes final output through its electron-donating and withdrawing groups.

    Other segments use it as a feedstock to construct azo dyes with bright, lasting coloration. Its role in the formation of photographic chemicals and certain niche pharmaceuticals comes up every production quarter. Working closely with these groups, we learned to identify what makes a batch “difficult” downstream: inconsistent particle sizes, micro-traces of byproducts, or even improper packaging. Our modifications over several product cycles led to a more granular control in those areas, raising conversion rates at partner sites.

    In application fields where small differences cause cascading effects—think specialty dye lots for textiles or regulated food packaging inks—a slightly off-grade batch can create a string of problems. So, conversations around specifications turn pragmatic and technical, not theoretical. It’s about material behavior under specific environmental or process pressures, not a list of numbers.

    Industry Uses Explained Through Manufacturer Eyes

    Dye intermediates aren’t just a category in our sales charts—they’re physical, demanding processes that shape our day-to-day focus. 4-Nitro-N,N-Diethylaniline is central in synthesizing dispersed azo dyes, especially those driving high-resistance properties in technical textiles and premium industrial coatings. Having tight control over the purity minimizes secondary reactions, which saves downstream users from double handling or extensive purification processes.

    In photographic chemicals, the compound supports the creation of developing agents and color couplers, which must meet both speed and sensitivity thresholds set by photo paper and film producers. Only batches with reliable purity and minimal trace contaminants perform as expected in these sensitive settings. Simple color or basic chemical analysis isn’t enough—the proof comes in repeated end user testing, and feedback lands directly on our process change logs.

    As a manufacturer, we also keep tabs on environmental reporting standards for discharge and residue. 4-Nitro-N,N-Diethylaniline, compared to lower molecular weight analogs, brings a balance of reactivity and process manageability. Product recovery rates and waste reduction remain on our metrics list for each production year. Decision-making often comes down to real savings and cleaner end-of-pipe results, both due to the core chemistry and the discipline built into each run.

    Direct Differences: 4-Nitro-N,N-Diethylaniline Versus Related Compounds

    It’s tempting to see aniline derivatives as interchangeable, but our experience says otherwise. The diethyl substitution on nitrogen in 4-Nitro-N,N-Diethylaniline gives it less basicity and a higher degree of solubility in organic media compared to mono-alkyl counterparts or unsubstituted 4-nitroaniline. This affects compatibility in solvent systems and reactivity when building up to final dye structures. There’s also a marked difference in volatility and handling risk, with this compound behaving predictably under standard storage conditions.

    Our own side-by-side field tests routinely highlight that alternatives, like 4-nitroaniline or N-ethyl analogs, produce less stable intermediates when subjected to downstream heat cycles in ink and textile plants. Color yield, consistency in tone under UV exposure, and physical stability all tip in favor of diethyl substitutions. These outcomes are confirmed both internally and through years of customer feedback. It’s not theory—it’s a conclusion drawn from tracking hundreds of batches over several years.

    Beyond technical contrasts, there’s also a difference in regulatory approach; diethylaniline-based nitro intermediates attract specific scrutiny under local and regional REACH programs. We’ve responded with process transparency and regular test reporting that gives purchasing managers and compliance officers the data they actually reference, rather than difficult-to-use, generic certificates.

    Addressing Practical Challenges in Production

    Nobody in the lab or on the production floor wants to talk about yield losses, but that’s where the most valuable improvements happen. Our story with 4-Nitro-N,N-Diethylaniline took a sharp turn several years ago when a series of small, untraceable impurities caused dye lots at customer sites to fail quality control mid-way. Instead of treating it as a single-incident fluke, we rebuilt our purification columns and monitored not just direct waste but vapor phase losses and micro-extraction residues.

    Now, our facilities use sequential recrystallization and tighter monitoring to clamp down on these problem points. These may sound like incremental changes, but the result is clear in repeatable batch properties and cleaner, more process-safe handling for our customers. As a result, our team spends less time firefighting, and our partners see fewer delays in production schedules.

    Waste management also moved up our agenda. Older approaches treated spent wash water as a disposable cost. We now routinely recycle, reprocess, or reduce streams wherever chemistry allows. This not only saves raw material costs but improves our facility’s standing with local regulators—real-world gains that feed back into customer trust and repeat business.

    Why Producer Insight Matters in Material Selection

    Buyers often depend on paperwork when assessing chemical intermediates. In the field, it’s regular production that uncovers what certificates can’t spell out—batch-to-batch consistency, transparent response to technical queries, and the depth of experience to solve small but costly issues as they arise. 4-Nitro-N,N-Diethylaniline production, on our end, survives by supporting long-term users through both process tweaks and new regulations.

    Communicating process history honestly makes a difference. Sharing the realities of what’s worked—and what hasn’t—gives development chemists and operations managers more than just an invoice. We’ve learned to build shared protocols for sensitive labeling, moisture controls, and light protection. Those practices didn’t originate in a trade manual. They originated through problem-solving with frontline workers and alert customers.

    Feedback loops are a necessity. When customers report grain size deviations or unexpected solution haze, our teams audit immediately—reviewing everything from reagents to packing processes. Improvements don’t stick if they aren’t verified both in the lab and under industrial conditions.

    Supporting Sustainability and Responsibility in the Supply Chain

    With new sustainability metrics sweeping through the chemical sector, manufacturers sit on the front lines. The synthesis route for 4-Nitro-N,N-Diethylaniline, in our case, shifted in response to market demand for greener chemistry options. We’re phasing in methods that cut raw material excess, lower air emissions, and reduce byproduct hazards.

    From running waste audits to investing in automated monitoring, it’s clear that every improvement made upstream impacts everyone downstream. We've prioritized working with suppliers who can guarantee traceable, high-quality starting materials. Over the years, we’ve dropped supply chains that couldn’t guarantee contaminant-free inputs.

    Our customers—whether in ink, pigment, or intermediate manufacture—often ask for both performance and reliable safety documentation. Delivering those means steady investment in updated analytics and more frequent environmental checks, not shortcuts or generic compliance documentation. Long term, these practices add value by building trust and ensuring smooth annual audits with customers and regulators alike.

    Collaborative Approaches for Technical Progress

    Few innovations arrive fully formed. In ongoing projects, especially in dye intermediate fields, knowledge sharing makes the difference between reactive firefighting and forward planning. We host regular process reviews with partner firms developing novel pigment systems, using real production and failure data to identify incremental gains.

    For 4-Nitro-N,N-Diethylaniline, this means fine-tuning not just the chemical synthesis but also how it interfaces with different solvent and substrate matrices. Collaborative R&D cycles translate lab breakthroughs into production improvements that get embedded in standard practice. Strong records and honest feedback have become the backbone of these partnerships.

    Supporting small-lot sampling and in-depth analysis for specialty customers allows both sides to discover practical adjustments that would be impossible at scale without cooperative trialing. These learnings feedback into the next cycle of process upgrades, closing the loop from idea to implementation.

    Lessons Learned from Real-World Manufacturing

    Producing 4-Nitro-N,N-Diethylaniline in a real factory—with live variables, batch variations, and skilled workers—teaches lessons you won’t read in product handbooks. Mistakes become improvements only because the cost of inaction is so clear. In the past, ignoring minor yields or packaging flaws led to material returns, the kind that hit smaller partners hardest.

    Today, every member of our production group treats the end use as personal. Lab results get reviewed not only by analysts, but by shift leaders and line workers who see how issues in particle size or color can translate to hundreds of hours of rework for customers. Our targets grow from those lessons—chasing both efficiency and reliability in ways that matter most once the product leaves our doors.

    Reputation is built one cycle at a time. We've earned trust by responding transparently to issues and providing deeper analysis when standard reporting falls short. Production is never static, so our team remains ready to adjust routes or specifications to adapt to client needs or regulatory shifts. This commitment reflects our belief that manufacturing chemical intermediates is a living process—driven not by protocol alone but by people improving on every turn.

    Summing Up What Sets Manufacturer-Sourced 4-Nitro-N,N-Diethylaniline Apart

    Making 4-Nitro-N,N-Diethylaniline isn’t just a matter of formula and machinery. It’s about creating relationships between technical reliability, consistent output, and responsible production. Our journey, marked by trial, error, and attention to detail, yields a compound that offers both technical competence and practical peace of mind.

    Every kilogram shipped reflects evidence-based manufacturing, hands-on troubleshooting, and ongoing collaboration up and down the value chain. These realities—impossible to capture in spec sheets or converter catalogues—translate directly into better color performance, fewer interruptions, and higher customer satisfaction.

    We stand by that difference—rooted in every batch and confirmed over years of hands-on experience.